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Prediction of CYP‐mediated DDIs involving inhibition: Approaches to address the requirements for system qualification of the Simcyp Simulator.
- Published in:
- CPT: Pharmacometrics & Systems Pharmacology, 2022, v. 11, n. 7, p. 822, doi. 10.1002/psp4.12794
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- Publication type:
- Article
Guide to development of compound files for PBPK modeling in the Simcyp population‐based simulator.
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- CPT: Pharmacometrics & Systems Pharmacology, 2022, v. 11, n. 7, p. 805, doi. 10.1002/psp4.12791
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- Publication type:
- Article
Performance Verification of CYP2C19 Enzyme Abundance Polymorphism Settings within the Simcyp Simulator v21.
- Published in:
- Metabolites (2218-1989), 2022, v. 12, n. 10, p. 1001, doi. 10.3390/metabo12101001
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- Publication type:
- Article
More Power to OATP1B1: An Evaluation of Sample Size in Pharmacogenetic Studies Using a Rosuvastatin PBPK Model for Intestinal, Hepatic, and Renal Transporter-Mediated Clearances.
- Published in:
- Journal of Clinical Pharmacology, 2016, v. 56, p. S132, doi. 10.1002/jcph.669
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- Publication type:
- Article
Comment on the Article 'Physiologically Based Modeling of Pravastatin Transporter-Mediated Hepatobiliary Disposition and Drug-Drug Interactions'.
- Published in:
- 2013
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- Publication type:
- Letter
In Vitro to In Vivo Extrapolation Linked to Physiologically Based Pharmacokinetic Models for Assessing the Brain Drug Disposition.
- Published in:
- AAPS Journal, 2022, v. 24, n. 1, p. 1, doi. 10.1208/s12248-021-00675-w
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- Publication type:
- Article
Comparison of Canine and Human Physiological Factors: Understanding Interspecies Differences that Impact Drug Pharmacokinetics.
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- AAPS Journal, 2021, v. 23, n. 3, p. 1, doi. 10.1208/s12248-021-00590-0
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- Publication type:
- Article
Incorporation of the Time-Varying Postprandial Increase in Splanchnic Blood Flow into a PBPK Model to Predict the Effect of Food on the Pharmacokinetics of Orally Administered High-Extraction Drugs.
- Published in:
- AAPS Journal, 2017, v. 19, n. 4, p. 1205, doi. 10.1208/s12248-017-0099-z
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- Publication type:
- Article
Population-Based Mechanistic Prediction of Oral Drug Absorption.
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- AAPS Journal, 2009, v. 11, n. 2, p. 225, doi. 10.1208/s12248-009-9099-y
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- Publication type:
- Article
Physiologically Based Pharmacokinetic Modeling for Maribavir to Inform Dosing in Drug‐Drug Interaction Scenarios with CYP3A4 Inducers and Inhibitors.
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- Journal of Clinical Pharmacology, 2024, v. 64, n. 5, p. 590, doi. 10.1002/jcph.2385
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- Publication type:
- Article
New Approach Methodologies (NAMs) for Human-Relevant Biokinetics Predictions: Meeting the Paradigm Shift in Toxicology Towards an Animal-Free Chemical Risk Assessment.
- Published in:
- Altex, 2020, v. 37, n. 4, p. 607, doi. 10.14573/altex.2003242
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- Publication type:
- Article
Unraveling pleiotropic effects of rifampicin by using physiologically based pharmacokinetic modeling: Assessing the induction magnitude of P‐glycoprotein–cytochrome P450 3A4 dual substrates.
- Published in:
- CPT: Pharmacometrics & Systems Pharmacology, 2021, v. 10, n. 12, p. 1485, doi. 10.1002/psp4.12717
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- Publication type:
- Article
Assessing Potential Drug–Drug Interactions Between Dabigatran Etexilate and a P‐Glycoprotein Inhibitor in Renal Impairment Populations Using Physiologically Based Pharmacokinetic Modeling.
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- CPT: Pharmacometrics & Systems Pharmacology, 2019, v. 8, n. 2, p. 118, doi. 10.1002/psp4.12382
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- Publication type:
- Article
PBPK Model of Morphine Incorporating Developmental Changes in Hepatic OCT1 and UGT2B7 Proteins to Explain the Variability in Clearances in Neonates and Small Infants.
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- CPT: Pharmacometrics & Systems Pharmacology, 2018, v. 7, n. 7, p. 464, doi. 10.1002/psp4.12306
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- Publication type:
- Article
Mass spectrometry‐based abundance atlas of ABC transporters in human liver, gut, kidney, brain and skin.
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- FEBS Letters, 2020, v. 594, n. 23, p. 4134, doi. 10.1002/1873-3468.13982
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- Publication type:
- Article
How PBPK Can Help to Understand Old Drugs and Inform their Dosing in Elderly: Amantadine Case Study.
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- Clinical Pharmacology & Therapeutics, 2024, v. 116, n. 1, p. 225, doi. 10.1002/cpt.3276
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- Publication type:
- Article
Considerations for Physiologically Based Modeling in Liver Disease: From Nonalcoholic Fatty Liver (NAFL) to Nonalcoholic Steatohepatitis (NASH).
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- Clinical Pharmacology & Therapeutics, 2023, v. 113, n. 2, p. 275, doi. 10.1002/cpt.2614
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- Publication type:
- Article
Clinical Relevance of Hepatic and Renal P‐gp/BCRP Inhibition of Drugs: An International Transporter Consortium Perspective.
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- Clinical Pharmacology & Therapeutics, 2022, v. 112, n. 3, p. 573, doi. 10.1002/cpt.2670
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- Publication type:
- Article
Clinical Implications of Altered Drug Transporter Abundance/Function and PBPK Modeling in Specific Populations: An ITC Perspective.
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- Clinical Pharmacology & Therapeutics, 2022, v. 112, n. 3, p. 501, doi. 10.1002/cpt.2643
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- Publication type:
- Article
Regulation of Drug Transport Proteins—From Mechanisms to Clinical Impact: A White Paper on Behalf of the International Transporter Consortium.
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- Clinical Pharmacology & Therapeutics, 2022, v. 112, n. 3, p. 461, doi. 10.1002/cpt.2605
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- Publication type:
- Article
Was 4β‐hydroxycholesterol ever going to be a useful marker of CYP3A4 activity?
- Published in:
- 2018
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- Publication type:
- Letter to the Editor
Development of a physiologically based pharmacokinetic model of actinomycin D in children with cancer.
- Published in:
- British Journal of Clinical Pharmacology, 2016, v. 81, n. 5, p. 989, doi. 10.1111/bcp.12878
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- Publication type:
- Article
Development of a physiologically based pharmacokinetic model to predict the effects of flavin-containing monooxygenase 3 (FMO3) polymorphisms on itopride exposure.
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- Biopharmaceutics & Drug Disposition, 2017, v. 38, n. 6, p. 389, doi. 10.1002/bdd.2074
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- Publication type:
- Article
Food constituent– and herb–drug interactions in oncology: Influence of quantitative modelling on Drug labelling.
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- British Journal of Clinical Pharmacology, 2021, v. 87, n. 10, p. 3988, doi. 10.1111/bcp.14822
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- Publication type:
- Article
Transporter Regulation in Critical Protective Barriers: Focus on Brain and Placenta.
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- Pharmaceutics, 2022, v. 14, n. 7, p. N.PAG, doi. 10.3390/pharmaceutics14071376
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- Publication type:
- Article
Acamprosate Is a Substrate of the Human Organic Anion Transporter (OAT) 1 without OAT3 Inhibitory Properties: Implications for Renal Acamprosate Secretion and Drug–Drug Interactions.
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- Pharmaceutics, 2020, v. 12, n. 4, p. 390, doi. 10.3390/pharmaceutics12040390
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- Publication type:
- Article
Physiologically‐Based Pharmacokinetic Model of Morphine and Morphine‐3‐Glucuronide in Nonalcoholic Steatohepatitis.
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- Clinical Pharmacology & Therapeutics, 2021, v. 109, n. 3, p. 676, doi. 10.1002/cpt.2037
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- Publication type:
- Article
Intestinal P‐gp and Putative Hepatic OATP1B Induction: International Transporter Consortium Perspective on Drug Development Implications.
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- Clinical Pharmacology & Therapeutics, 2021, v. 109, n. 1, p. 55, doi. 10.1002/cpt.1916
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- Publication type:
- Article
Physiologically‐Based Pharmacokinetic Models for Evaluating Membrane Transporter Mediated Drug–Drug Interactions: Current Capabilities, Case Studies, Future Opportunities, and Recommendations.
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- Clinical Pharmacology & Therapeutics, 2020, v. 107, n. 5, p. 1082, doi. 10.1002/cpt.1693
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- Publication type:
- Article
Use of Physiologically Based Pharmacokinetic Modeling to Evaluate the Effect of Chronic Kidney Disease on the Disposition of Hepatic CYP2C8 and OATP1B Drug Substrates.
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- Clinical Pharmacology & Therapeutics, 2019, v. 105, n. 3, p. 719, doi. 10.1002/cpt.1205
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- Publication type:
- Article
Risk–Benefit Assessment of Ethinylestradiol Using a Physiologically Based Pharmacokinetic Modeling Approach.
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- Clinical Pharmacology & Therapeutics, 2018, v. 104, n. 6, p. 1229, doi. 10.1002/cpt.1085
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- Publication type:
- Article