Works by Nelander, Karin

Results: 15

Phase 1 Pharmacokinetic Study of AZD5718 in Healthy Volunteers: Effects of Coadministration With Rosuvastatin, Formulation and Food on Oral Bioavailability.

Published in:

Clinical Pharmacology in Drug Development, 2020, v. 9, n. 3, p. 411, doi. 10.1002/cpdd.756

By:

Ericsson, Hans;
Nelander, Karin;
Heijer, Maria;
Kjaer, Magnus;
Lindstedt, Eva‐Lotte;
Albayaty, Muna;
Forte, Pablo;
Lagerström‐Fermér, Maria;
Skrtic, Stanko

Publication type:

Article

Non‐clinical and first‐in‐human characterization of ECC5004/AZD5004, a novel once‐daily, oral small‐molecule GLP‐1 receptor agonist.

Published in:

Diabetes, Obesity & Metabolism, 2025, v. 27, n. 2, p. 551, doi. 10.1111/dom.16047

By:

Haggag, Amina Z.;
Xu, Jianfeng;
Butcher, Laurie;
Pagnussat, Sandra;
Davies, Graeme;
Lundqvist, Sara;
Wang, Wenyu;
Van Zuydam, Natalie;
Nelander, Karin;
Jha, Aruni;
Yu, Hongtao;
Boianelli, Alessandro;
Lindmark, Bosse;
Ollerstam, Anna;
Sun, Xuefeng;
Wang, Fan;
Pan, Xiaoliang;
Liu, Haihui;
Chen, Wengang;
Wallenius, Kristina

Publication type:

Article

Disposition of orally administered atuliflapon, a novel 5‐lipoxygenase‐activating protein inhibitor in healthy participants.

Published in:

Pharmacology Research & Perspectives, 2024, v. 12, n. 5, p. 1, doi. 10.1002/prp2.70029

By:

Li, Xue‐Qing;
Lindmark, Bo;
Amilon, Carl;
Samuelsson, Kristin;
Weidolf, Lars;
Nelander, Karin;
Knöchel, Jane;
Heijer, Maria;
Bragg, Ryan A.;
Gränfors, Malin;
Lindstedt, Eva‐Lotte;
Sidhu, Sharan;
Garkaviy, Pavlo;
Ericsson, Hans

Publication type:

Article

The myeloperoxidase inhibitor mitiperstat (AZD4831) does not prolong the QT interval at expected therapeutic doses.

Published in:

Pharmacology Research & Perspectives, 2024, v. 12, n. 2, p. 1, doi. 10.1002/prp2.1184

By:

Parkinson, Joanna;
Sundell, Jesper;
Rekić, Dinko;
Nelander, Karin;
Ericsson, Hans;
Ebrahimi, Ahmad;
Dota, Corina;
Sunnåker, Mikael

Publication type:

Article

The effect of severe renal impairment on the pharmacokinetics, safety and tolerability of mitiperstat.

Published in:

British Journal of Clinical Pharmacology, 2024, v. 90, n. 12, p. 3212, doi. 10.1111/bcp.16205

By:

Bhattacharya, Chandrali S.;
Pizzato, Patricia Ely;
Heijer, Maria;
Sunnåker, Mikael;
Holden, Julie;
Trebski, Monika;
Nelander, Karin;
Ali, Hodan;
Genov, Diyan K.;
Aurell, Malin;
Collén, Anna;
Ericsson, Hans

Publication type:

Article

A drug–drug interaction study and physiologically based pharmacokinetic modelling to assess the effect of an oral 5‐lipoxygenase activating protein inhibitor on the pharmacokinetics of oral midazolam.

Published in:

British Journal of Clinical Pharmacology, 2024, v. 90, n. 9, p. 2180, doi. 10.1111/bcp.16131

By:

Knöchel, Jane;
Panduga, Vijender;
Nelander, Karin;
Heijer, Maria;
Lindstedt, Eva‐Lotte;
Ali, Hodan;
Aurell, Malin;
Ödesjö, Helena;
Forte, Pablo;
Connolly, Kat;
Ericsson, Hans;
MacPhee, Iain

Publication type:

Article

Safety, tolerability, pharmacokinetics and effect on serum uric acid of the myeloperoxidase inhibitor AZD4831 in a randomized, placebo‐controlled, phase I study in healthy volunteers.

Published in:

British Journal of Clinical Pharmacology, 2019, v. 85, n. 4, p. 762, doi. 10.1111/bcp.13855

By:

Gan, Li‐Ming;
Lagerström‐Fermér, Maria;
Ericsson, Hans;
Nelander, Karin;
Lindstedt, Eva‐Lotte;
Michaëlsson, Erik;
Kjaer, Magnus;
Heijer, Maria;
Whatling, Carl;
Fuhr, Rainard

Publication type:

Article

Clinical safety, tolerability, pharmacokinetics and effects on urinary electrolyte excretion of AZD9977, a novel, selective mineralocorticoid receptor modulator.

Published in:

British Journal of Clinical Pharmacology, 2018, v. 84, n. 7, p. 1486, doi. 10.1111/bcp.13562

By:

Erlandsson, Fredrik;
Albayaty, Muna;
Chialda, Ligia;
Ericsson, Hans;
Amilon, Carl;
Nelander, Karin;
Jansson‐Löfmark, Rasmus;
Wernevik, Linda;
Kjaer, Magnus;
Bamberg, Krister;
Hartleib‐Geschwindner, Judith

Publication type:

Article

Prothrombin time is predictive of low plasma prothrombin concentration and clinical outcome in patients with trauma hemorrhage: analyses of prospective observational cohort studies.

Published in:

Scandinavian Journal of Trauma, Resuscitation & Emergency Medicine, 2017, v. 25, p. 1, doi. 10.1186/s13049-016-0332-2

By:

Balendran, Clare A.;
Lövgren, Ann;
Hansson, Kenny M.;
Nelander, Karin;
Olsson, Marita;
Johansson, Karin J.;
Brohi, Karim;
Fries, Dietmar;
Berggren, Anders

Publication type:

Article

On Exact Simulation of Markov Random Fields Using Coupling from the Past.

Published in:

Scandinavian Journal of Statistics, 1999, v. 26, n. 3, p. 395, doi. 10.1111/1467-9469.00156

By:

Haggstrom, Olle;
Nelander, Karin

Publication type:

Article

Early Clinical Experience With AZD4831, A Novel Myeloperoxidase Inhibitor, Developed for Patients With Heart Failure With Preserved Ejection Fraction.

Published in:

CTS: Clinical & Translational Science, 2021, v. 14, n. 3, p. 812, doi. 10.1111/cts.12859

By:

Nelander, Karin;
Lagerstrom‐Fermer, Maria;
Amilon, Carl;
Michaëlsson, Erik;
Heijer, Maria;
Kjaer, Magnus;
Russell, Muir;
Han, David;
Lindstedt, Eva‐Lotte;
Whatling, Carl;
Gan, Li‐Ming;
Ericsson, Hans

Publication type:

Article

Initial Clinical Experience with AZD5718, a Novel Once Daily Oral 5‐Lipoxygenase Activating Protein Inhibitor.

Published in:

CTS: Clinical & Translational Science, 2018, v. 11, n. 3, p. 330, doi. 10.1111/cts.12546

By:

Ericsson, Hans;
Nelander, Karin;
Lagerstrom‐fermer, Maria;
Balendran, Clare;
Bhat, Maria;
Chialda, Ligia;
Gan, Li‐ming;
Heijer, Maria;
Kjaer, Magnus;
Lambert, John;
Lindstedt, Eva‐lotte;
Forsberg, Gun‐britt;
Whatling, Carl;
Skrtic, Stanko

Publication type:

Article

Pharmacokinetics and Tolerability of the Novel Myeloperoxidase Inhibitor Mitiperstat in Healthy Japanese and Chinese Volunteers.

Published in:

Clinical Drug Investigation, 2024, v. 44, n. 11, p. 863, doi. 10.1007/s40261-024-01402-x

By:

Sunnåker, Mikael;
Bhattacharya, Chandrali;
Nelander, Karin;
Aurell, Malin;
Heijer, Maria;
Collén, Anna;
Han, David;
Holden, Julie;
Trebski, Monika;
Garkaviy, Pavlo;
Ericsson, Hans

Publication type:

Article

Pharmacokinetics, Pharmacodynamics, and Tolerability of AZD5718, an Oral 5-Lipoxygenase-Activating Protein (FLAP) Inhibitor, in Healthy Japanese Male Subjects.

Published in:

Clinical Drug Investigation, 2021, v. 41, n. 10, p. 895, doi. 10.1007/s40261-021-01078-7

By:

Knöchel, Jane;
Nelander, Karin;
Heijer, Maria;
Lindstedt, Eva-Lotte;
Forsberg, Gun-Britt;
Whatling, Carl;
Shimada, Hitoshi;
Han, David S.;
Gabrielsen, Anders;
Garkaviy, Pavlo;
Ericsson, Hans

Publication type:

Article

Rationale and design of ENDEAVOR: A sequential phase 2b–3 randomized clinical trial to evaluate the effect of myeloperoxidase inhibition on symptoms and exercise capacity in heart failure with preserved or mildly reduced ejection fraction.

Published in:

European Journal of Heart Failure, 2023, v. 25, n. 9, p. 1696, doi. 10.1002/ejhf.2977

By:

Lund, Lars H.;
Lam, Carolyn S.P.;
Pizzato, Patricia E.;
Gabrielsen, Anders;
Michaëlsson, Erik;
Nelander, Karin;
Ericsson, Hans;
Holden, Julie;
Folkvaljon, Folke;
Mattsson, Andrea;
Collén, Anna;
Aurell, Malin;
Whatling, Carl;
Baldus, Stephan;
Drelich, Grzegorz;
Goudev, Assen;
Merkely, Béla;
Bergh, Niklas;
Shah, Sanjiv J.

Publication type:

Article