Works by Natarajan, Amarnath

Results: 31

The Novel Anti-Cancer Agent, SpiD3, Is Cytotoxic in CLL Cells Resistant to Ibrutinib or Venetoclax.

Published in:

Hemato, 2024, v. 5, n. 3, p. 321, doi. 10.3390/hemato5030024

By:

Eiken, Alexandria P.;
Schmitz, Elizabeth;
Drengler, Erin M.;
Smith, Audrey L.;
Skupa, Sydney A.;
Mohan, Kabhilan;
Rana, Sandeep;
Singh, Sarbjit;
Mallareddy, Jayapal Reddy;
Mathew, Grinu;
Natarajan, Amarnath;
El-Gamal, Dalia

Publication type:

Article

Recent Advances in EPAC-Targeted Therapies: A Biophysical Perspective.

Published in:

Cells (2073-4409), 2019, v. 8, n. 11, p. 1462, doi. 10.3390/cells8111462

By:

Ahmed, Alveena;
Boulton, Stephen;
Shao, Hongzhao;
Akimoto, Madoka;
Natarajan, Amarnath;
Cheng, Xiaodong;
Melacini, Giuseppe

Publication type:

Article

Symbiotic prodrugs (SymProDs) dual targeting of NFkappaB and CDK.

Published in:

Chemical Biology & Drug Design, 2020, v. 96, n. 2, p. 773, doi. 10.1111/cbdd.13684

By:

Rana, Sandeep;
Kour, Smit;
Sonawane, Yogesh A.;
Robb, Caroline M.;
Contreras, Jacob I.;
Kizhake, Smitha;
Zahid, Muhammad;
Karpf, Adam R.;
Natarajan, Amarnath

Publication type:

Article

Interrupting the repair to stress the enemy.

Published in:

FASEB Journal, 2021, v. 35, p. N.PAG, doi. 10.1096/fasebj.2021.35.S1.02149

By:

Al‐Mugotir, Mona;
Kolar, Carol;
Kelly, David;
Tadayoshi, Bessho;
Natarajan, Amarnath;
Borgstahl, Gloria

Publication type:

Article

Discovery, synthesis and biological evaluation of substituted urea: new activators of heme regulated inhibitor.

Published in:

FASEB Journal, 2013, v. 27, p. lb585, doi. 10.1096/fasebj.27.1_supplement.lb585

By:

Chen, Ting;
Takruri, Khuloud;
Hee‐Hwang, Sung;
Rana, Sandeep;
Chorev, Michael;
Natarajan, Amarnath;
Morisseau, Christophe;
Hammock, Bruce;
Aktas, Bertal H

Publication type:

Article

Pulse design for broadband correlation NMR spectroscopy by multi-rotating frames.

Published in:

Journal of Biomolecular NMR, 2013, v. 55, n. 3, p. 291, doi. 10.1007/s10858-013-9714-1

By:

Coote, Paul;
Arthanari, Haribabu;
Yu, Tsyr-Yan;
Natarajan, Amarnath;
Wagner, Gerhard;
Khaneja, Navin

Publication type:

Article

Anticancer activity of celastrol in combination with ErbB2-targeted therapeutics for treatment of ErbB2-overexpressing breast cancers.

Published in:

Cancer Biology & Therapy, 2011, v. 11, n. 2, p. 263, doi. 10.4161/cbt.11.2.13959

By:

Raja, Srikumar M.;
Clubb, Robert J.;
Ortega-Cava, Cesar;
Williams, Stetson H.;
Bailey, Tameka A.;
Duan, Lei;
Zhao, Xiangshan;
Reddi, Alagarasamy L.;
Nyong, Abijah M.;
Natarajan, Amarnath;
Band, Vimla;
Band, Hamid

Publication type:

Article

Proteolysis targeting chimera (PROTAC)-driven antibody internalization of oncogenic cell surface receptors.

Published in:

Communications Biology, 2024, v. 7, n. 1, p. 1, doi. 10.1038/s42003-024-07439-0

By:

Tolosa, Ezequiel J.;
Yang, Lin;
Ayers-Ringler, Jennifer;
Suzuki, Shinichiro;
Mallareddy, Jayapal Reddy;
Schaefer-Klein, Janet;
Borad, Mitesh;
Kosari, Farhad;
Natarajan, Amarnath;
Mansfield, Aaron S.

Publication type:

Article

Human Apurinic/Apyrimidinic Endonuclease (APE1) Is Acetylated at DNA Damage Sites in Chromatin, and Acetylation Modulates Its DNA Repair Activity.

Published in:

Molecular & Cellular Biology, 2017, v. 37, n. 6, p. 1, doi. 10.1128/MCB.00401-16

By:

Roychoudhury, Shrabasti;
Nath, Somsubhra;
Heyu Song;
Hegde, Muralidhar L.;
Bellot, Larry J.;
Mantha, Anil K.;
Sengupta, Shiladitya;
Ray, Sutapa;
Natarajan, Amarnath;
Bhakata, Kishor K.

Publication type:

Article

Protein–protein interactions as therapeutic targets in neuropsychopharmacology.

Published in:

Neuropsychopharmacology, 2009, v. 34, n. 1, p. 247, doi. 10.1038/npp.2008.167

By:

Reilly, Matthew T;
Cunningham, Kathryn A;
Natarajan, Amarnath

Publication type:

Article

Systemic Administration of a Brain Permeable Cdk5 Inhibitor Alters Neurobehavior.

Published in:

Frontiers in Pharmacology, 2022, v. 13, p. 1, doi. 10.3389/fphar.2022.863762

By:

Umfress, Alan;
Singh, Sarbjit;
Ryan, Kevin J.;
Chakraborti, Ayanabha;
Plattner, Florian;
Sonawane, Yogesh;
Mallareddy, Jayapal Reddy;
Acosta, Edward P.;
Natarajan, Amarnath;
Bibb, James A.

Publication type:

Article

Protein Structure Inspired Discovery of a Novel Inducer of Anoikis in Human Melanoma.

Published in:

Cancers, 2024, v. 16, n. 18, p. 3177, doi. 10.3390/cancers16183177

By:

Qiao, Fangfang;
Binkowski, Thomas Andrew;
Broughan, Irene;
Chen, Weining;
Natarajan, Amarnath;
Schiltz, Gary E.;
Scheidt, Karl A.;
Anderson, Wayne F.;
Bergan, Raymond

Publication type:

Article

Inhibitors, PROTACs and Molecular Glues as Diverse Therapeutic Modalities to Target Cyclin-Dependent Kinase.

Published in:

Cancers, 2021, v. 13, n. 21, p. 5506, doi. 10.3390/cancers13215506

By:

Rana, Sandeep;
Mallareddy, Jayapal Reddy;
Singh, Sarbjit;
Boghean, Lidia;
Natarajan, Amarnath

Publication type:

Article

PIK3C3 Inhibition Promotes Sensitivity to Colon Cancer Therapy by Inhibiting Cancer Stem Cells.

Published in:

Cancers, 2021, v. 13, n. 9, p. 2168, doi. 10.3390/cancers13092168

By:

Kumar, Balawant;
Ahmad, Rizwan;
Sharma, Swagat;
Gowrikumar, Saiprasad;
Primeaux, Mark;
Rana, Sandeep;
Natarajan, Amarnath;
Oupicky, David;
Hopkins, Corey R.;
Dhawan, Punita;
Singh, Amar B.;
Nateri, Abdolrahman Shams

Publication type:

Article

A Selective MAP3K1 Inhibitor Facilitates Discovery of NPM1 as a Member of the Network.

Published in:

Molecules, 2025, v. 30, n. 9, p. 2001, doi. 10.3390/molecules30092001

By:

Boghean, Lidia;
Singh, Sarbjit;
Mangalaparthi, Kiran K.;
Kizhake, Smitha;
Umeta, Lelisse;
Wishka, Donn;
Grothaus, Paul;
Pandey, Akhilesh;
Natarajan, Amarnath

Publication type:

Article

Domino Reactions Enable Zn-Mediated Direct Synthesis of Spiro-Fused 2-Oxindole-α-Methylene-γ-Butyrolactones/Lactams from Isatin Derivatives and 2-(Bromomethyl)acrylates.

Published in:

Molecules, 2024, v. 29, n. 15, p. 3612, doi. 10.3390/molecules29153612

By:

Mukthapuram, Prathap Reddy;
Natarajan, Amarnath

Publication type:

Article

Computational and experimental studies of the interaction between phospho-peptides and the C-terminal domain of BRCA1.

Published in:

Journal of Computer-Aided Molecular Design, 2011, v. 25, n. 11, p. 1071, doi. 10.1007/s10822-011-9484-3

By:

Anisimov, Victor;
Ziemys, Arturas;
Kizhake, Smitha;
Yuan, Ziyan;
Natarajan, Amarnath;
Cavasotto, Claudio

Publication type:

Article

Erratum to: Inhibition of BRCT(BRCA1)-phosphoprotein interaction enhances the cytotoxic effect of olaparib in breast cancer cells: a proof of concept study for synthetic lethal therapeutic option.

Published in:

2016

By:

Pessetto, Ziyan;
Yan, Ying;
Bessho, Tadayoshi;
Natarajan, Amarnath

Publication type:

Erratum

Inhibition of BRCT(BRCA1)-phosphoprotein interaction enhances the cytotoxic effect of olaparib in breast cancer cells: a proof of concept study for synthetic lethal therapeutic option.

Published in:

Breast Cancer Research & Treatment, 2012, v. 134, n. 2, p. 511, doi. 10.1007/s10549-012-2079-4

By:

Pessetto, Ziyan;
Yan, Ying;
Bessho, Tadayoshi;
Natarajan, Amarnath

Publication type:

Article

Immunogenic Cell Death Traits Emitted from Chronic Lymphocytic Leukemia Cells Following Treatment with a Novel Anti-Cancer Agent, SpiD3.

Published in:

Biomedicines, 2024, v. 12, n. 12, p. 2857, doi. 10.3390/biomedicines12122857

By:

Schmitz, Elizabeth;
Ridout, Abigail;
Smith, Audrey L.;
Eiken, Alexandria P.;
Skupa, Sydney A.;
Drengler, Erin M.;
Singh, Sarbjit;
Rana, Sandeep;
Natarajan, Amarnath;
El-Gamal, Dalia

Publication type:

Article

human AP-endonuclease 1 (APE1) is a DNA G-quadruplex structure binding protein and regulates KRAS expression in pancreatic ductal adenocarcinoma cells.

Published in:

Nucleic Acids Research, 2022, v. 50, n. 6, p. 3394, doi. 10.1093/nar/gkac172

By:

Pramanik, Suravi;
Chen, Yingling;
Song, Heyu;
Khutsishvili, Irine;
Marky, Luis A;
Ray, Sutapa;
Natarajan, Amarnath;
Singh, Pankaj K;
Bhakat, Kishor K

Publication type:

Article

Ferulic acid dimer as a non-opioid therapeutic for acute pain.

Published in:

Journal of Pain Research, 2018, v. 11, p. 1075, doi. 10.2147/JPR.S161161

By:

Priebe, Alaini;
Hunke, Megan;
Tonello, Raquel;
Sonawane, Yogesh;
Berta, Temugin;
Natarajan, Amarnath;
Bhuvanesh, Nattamai;
Pattabiraman, Mahesh;
Chandra, Surabhi

Publication type:

Article

Catalytically inactive Dnmt3b rescues mouse embryonic development by accessory and repressive functions.

Published in:

Nature Communications, 2019, v. 10, n. 1, p. N.PAG, doi. 10.1038/s41467-019-12355-7

By:

Nowialis, Pawel;
Lopusna, Katarina;
Opavska, Jana;
Haney, Staci L.;
Abraham, Ajay;
Sheng, Peike;
Riva, Alberto;
Natarajan, Amarnath;
Guryanova, Olga;
Simpson, Melanie;
Hlady, Ryan;
Xie, Mingyi;
Opavsky, Rene

Publication type:

Article

A mitotic CDK5-PP4 phospho-signaling cascade primes 53BP1 for DNA repair in G1.

Published in:

Nature Communications, 2019, v. 10, n. 1, p. N.PAG, doi. 10.1038/s41467-019-12084-x

By:

Zheng, Xiao-Feng;
Acharya, Sanket S.;
Choe, Katherine N.;
Nikhil, Kumar;
Adelmant, Guillaume;
Satapathy, Shakti Ranjan;
Sharma, Samanta;
Viccaro, Keith;
Rana, Sandeep;
Natarajan, Amarnath;
Sicinski, Peter;
Marto, Jarrod A.;
Shah, Kavita;
Chowdhury, Dipanjan

Publication type:

Article

Irreversible binding of an anticancer compound (BI-94) to plasma proteins.

Published in:

Xenobiotica, 2015, v. 45, n. 10, p. 858, doi. 10.3109/00498254.2015.1025250

By:

Gautam, Nagsen;
Thakare, Rhishikesh;
Rana, Sandeep;
Natarajan, Amarnath;
Alnouti, Yazen

Publication type:

Article

PROTACs in Ovarian Cancer: Current Advancements and Future Perspectives.

Published in:

International Journal of Molecular Sciences, 2024, v. 25, n. 10, p. 5067, doi. 10.3390/ijms25105067

By:

Vorderbruggen, Makenzie;
Velázquez-Martínez, Carlos A.;
Natarajan, Amarnath;
Karpf, Adam R.

Publication type:

Article

Pharmacokinetics, protein binding and metabolism of a quinoxaline urea analog as an NF- κB inhibitor in mice and rats by LC-MS/MS.

Published in:

Biomedical Chromatography, 2013, v. 27, n. 7, p. 900, doi. 10.1002/bmc.2880

By:

Gautam, Nagsen;
Bathena, Sai Praneeth R.;
Chen, Qianyi;
Natarajan, Amarnath;
Alnouti, Yazen

Publication type:

Article

Small molecule induced polymerization of BCL6 facilitates SIAH1 mediated degradation.

Published in:

Signal Transduction & Targeted Therapy, 2021, v. 6, n. 1, p. 1, doi. 10.1038/s41392-021-00556-w

By:

Rana, Sandeep;
Natarajan, Amarnath

Publication type:

Article

DHODH inhibition enhances the efficacy of immune checkpoint blockade by increasing cancer cell antigen presentation.

Published in:

eLife, 2024, p. 1, doi. 10.7554/eLife.87292

By:

Mullen, Nicholas J.;
Shukla, Surendra K.;
Thakur, Ravi;
Kollala, Sai Sundeep;
Dezhen Wang;
Chaika, Nina;
Santana, Juan F.;
Miklavcic, William R.;
LaBreck, Drew A.;
Mallareddy, Jayapal Reddy;
Price, David H.;
Natarajan, Amarnath;
Mehla, Kamiya;
Sykes, David B.;
Hollingsworth, Michael A.;
Singh, Pankaj K.

Publication type:

Article

Selective killing of homologous recombination-deficient cancer cell lines by inhibitors of the RPA:RAD52 protein-protein interaction.

Published in:

PLoS ONE, 2021, v. 16, n. 3, p. 1, doi. 10.1371/journal.pone.0248941

By:

Al-Mugotir, Mona;
Lovelace, Jeffrey J.;
George, Joseph;
Bessho, Mika;
Pal, Dhananjaya;
Struble, Lucas;
Kolar, Carol;
Rana, Sandeep;
Natarajan, Amarnath;
Bessho, Tadayoshi;
Borgstahl, Gloria E. O.

Publication type:

Article

Characterization of Promiscuous Binding of Phosphor Ligands to Breast-Cancer-Gene 1 (BRCA1) C-Terminal (BRCT): Molecular Dynamics, Free Energy, Entropy and Inhibitor Design.

Published in:

PLoS Computational Biology, 2016, v. 12, n. 8, p. 1, doi. 10.1371/journal.pcbi.1005057

By:

You, Wanli;
Huang, Yu-ming M.;
Kizhake, Smitha;
Natarajan, Amarnath;
Chang, Chia-en A.

Publication type:

Article