Works by Narla, Goutham

Results: 33

The Transcriptional Activator Krüppel-like Factor-6 Is Required for CNS Myelination.

Published in:

PLoS Biology, 2016, v. 14, n. 5, p. 1, doi. 10.1371/journal.pbio.1002467

By:

Laitman, Benjamin M.;
Asp, Linnéa;
Mariani, John N.;
Zhang, Jingya;
Liu, Jia;
Sawai, Setsu;
Chapouly, Candice;
Horng, Sam;
Kramer, Elisabeth G.;
Mitiku, Nesanet;
Loo, Hannah;
Burlant, Natalie;
Pedre, Xiomara;
Hara, Yuko;
Nudelman, German;
Zaslavsky, Elena;
Lee, Young-Min;
Braun, David A.;
Lu, Q. Richard;
Narla, Goutham

Publication type:

Article

Loss of hepatic aldolase B activates Akt and promotes hepatocellular carcinogenesis by destabilizing the Aldob/Akt/PP2A protein complex.

Published in:

PLoS Biology, 2020, v. 18, n. 12, p. 1, doi. 10.1371/journal.pbio.3000803

By:

He, Xuxiao;
Li, Min;
Yu, Hongming;
Liu, Guijun;
Wang, Ningning;
Yin, Chunzhao;
Tu, Qiaochu;
Narla, Goutham;
Tao, Yongzhen;
Cheng, Shuqun;
Yin, Huiyong

Publication type:

Article

Development and comparison of novel bioluminescent mouse models of pancreatic neuroendocrine neoplasm metastasis.

Published in:

Scientific Reports, 2021, v. 11, n. 1, p. 1, doi. 10.1038/s41598-021-89866-1

By:

Kaemmer, Courtney A.;
Umesalma, Shaikamjad;
Maharjan, Chandra K.;
Moose, Devon L.;
Narla, Goutham;
Mott, Sarah L.;
Zamba, Gideon K. D.;
Breheny, Patrick;
Darbro, Benjamin W.;
Bellizzi, Andrew M.;
Henry, Michael D.;
Quelle, Dawn E.

Publication type:

Article

Sex steroids have differential effects on growth and gene expression in primary human prostatic epithelial cell cultures derived from the peripheral versus transition zones.

Published in:

Carcinogenesis, 2006, v. 27, n. 2, p. 216

By:

Alexander Kirschenbaum;
Xin-Hua Liu;
Shen Yao;
Goutham Narla;
Scott L. Friedman;
John A. Martignetti;
Alice C. Levine

Publication type:

Article

Mistletoe Extract Viscum Fraxini-2 for Treatment of Advanced Hepatocellular Carcinoma: A Case Series.

Published in:

Case Reports in Oncology, 2021, v. 14, n. 1, p. 224, doi. 10.1159/000511566

By:

Lee, Richard T.;
Yang, Peiying;
Alahmadi, Asrar;
McQuade, Jennifer;
Yuan, Eric;
Difeo, Analisa;
Narla, Goutham;
Kaseb, Ahmed

Publication type:

Article

Increased expression of the oncogenic KLF6-SV1 transcript in human glioblastoma.

Published in:

Clinical Chemistry & Laboratory Medicine, 2010, v. 48, n. 8, p. 1167, doi. 10.1515/CCLM.2010.219

By:

Tchirkov, Andrei;
Sapin, Vincent;
Marceau, Geoffroy;
Chautard, Emmanuel;
Narla, Goutham;
Veronese, Lauren;
Friedman, Scott;
Khalil, Toufic;
Vago, Philippe;
Kemeny, Jean-Louis;
Verrelle, Pierre

Publication type:

Article

All roads lead to PP2A: exploiting the therapeutic potential of this phosphatase.

Published in:

FEBS Journal, 2016, v. 283, n. 6, p. 1004, doi. 10.1111/febs.13573

By:

Sangodkar, Jaya;
Farrington, Caroline C.;
McClinch, Kimberly;
Galsky, Matthew D.;
Kastrinsky, David B.;
Narla, Goutham

Publication type:

Article

Phosphoproteomics Profiling of Nonsmall Cell Lung Cancer Cells Treated with a Novel Phosphatase Activator.

Published in:

Proteomics, 2017, v. 17, n. 22, p. n/a, doi. 10.1002/pmic.201700214

By:

Wiredja, Danica D.;
Ayati, Marzieh;
Mazhar, Sahar;
Sangodkar, Jaya;
Maxwell, Sean;
Schlatzer, Daniela;
Narla, Goutham;
Koyutürk, Mehmet;
Chance, Mark R.

Publication type:

Article

10:30: KLF6 LOH Is Linked to Recurrence and Lower Survival in HNSSC

Published in:

2007

By:

Teixeira, Miriam S.;
Camacho-Vanegas, Olga;
Fernandez, Yolanda;
Narla, Goutham;
Difeo, Analisa;
Schlecht, Nicolas F.;
Brandwein-Gensler, Margaret;
Martignetti, John A.

Publication type:

Abstract

Structural Genetics to Understand Holoenzyme Assembly and Substrate Selection of Diverse Multimeric Serine-threonine Phosphatases.

Published in:

Microscopy & Microanalysis, 2024, v. 30, p. 1, doi. 10.1093/mam/ozae044.354

By:

Huang, Wei;
Veis, Jiri;
Day, Alexander;
Cui, Shouqing;
Leonard, Daniel;
Narla, Goutham;
Ogris, Egon;
Taylor, Derek J

Publication type:

Article

Comment on "PP2A inhibition sensitizes cancer stem cells to ABL tyrosine kinase inhibitors in BCR-ABL human leukemia".

Published in:

Science Translational Medicine, 2019, v. 11, n. 501, p. 1, doi. 10.1126/scitranslmed.aau0416

By:

Perrotti, Danilo;
Agarwal, Anupriya;
Lucas, Claire M.;
Narla, Goutham;
Neviani, Paolo;
Odero, Maria D.;
Ruvolo, Peter P.;
Verrills, Nicole M.

Publication type:

Article

PP2A inhibition is a druggable MEK inhibitor resistance mechanism in KRAS-mutant lung cancer cells.

Published in:

Science Translational Medicine, 2018, v. 10, n. 450, p. 1, doi. 10.1126/scitranslmed.aaq1093

By:

Kauko, Otto;
O'Connor, Caitlin M.;
Kulesskiy, Evgeny;
Sangodkar, Jaya;
Aakula, Anna;
Izadmehr, Sudeh;
Yetukuri, Laxman;
Yadav, Bhagwan;
Padzik, Artur;
Laajala, Teemu Daniel;
Haapaniemi, Pekka;
Momeny, Majid;
Varila, Taru;
Ohlmeyer, Michael;
Aittokallio, Tero;
Wennerberg, Krister;
Narla, Goutham;
Westermarck, Jukka

Publication type:

Article

The impact of phosphatases on proliferative and survival signaling in cancer.

Published in:

Cellular & Molecular Life Sciences, 2018, v. 75, n. 15, p. 2695, doi. 10.1007/s00018-018-2826-8

By:

Narla, Goutham;
Sangodkar, Jaya;
Ryder, Christopher B.

Publication type:

Article

Loss of matrix metalloproteinase-2 amplifies murine toxin-induced liver fibrosis by upregulating collagen I expression.

Published in:

2011

By:

Radbill, Brian;
Gupta, Ritu;
Ramirez, Maria;
DiFeo, Analisa;
Martignetti, John;
Alvarez, Carlos;
Friedman, Scott;
Narla, Goutham;
Vrabie, Raluca;
Bowles, Robert;
Saiman, Yedidya;
Bansal, Meena;
Radbill, Brian D;
Ramirez, Maria Celeste M;
Martignetti, John A;
Alvarez, Carlos E;
Friedman, Scott L;
Bansal, Meena B

Publication type:

journal article

Low PPP2R2A expression promotes sensitivity to CHK1 inhibition in high-grade serous ovarian cancer.

Published in:

Theranostics, 2024, v. 14, n. 19, p. 7450, doi. 10.7150/thno.96879

By:

Zhaojun Qiu;
Deepika Sigh;
Yujie Liu;
Prasad, Chandra B.;
Bean, Nichalos;
Chunhong Yan;
Zaibo Li;
Xiaoli Zhang;
Narla, Goutham;
DiFeo, Analisa;
Qi-En Wang;
Junran Zhang

Publication type:

Article

KLF6-SV1 Drives Breast Cancer Metastasis and Is Associated with Poor Survival.

Published in:

Science Translational Medicine, 2013, v. 5, n. 169, p. 1, doi. 10.1126/scitranslmed.3004688

By:

Hatami, Raheleh;
Sieuwerts, Anieta M.;
Izadmehr, Sudeh;
Zhong Yao;
Rui Fang Qiao;
Papa, Luena;
Look, Maxime P.;
Smid, Marcel;
Ohlssen, Jessica;
Levine, Alice C.;
Germain, Doris;
Burstein, David;
Kirschenbaum, Alexander;
DiFeo, Analisa;
Foekens, John A.;
Narla, Goutham

Publication type:

Article

IKKα negatively regulates ASC-dependent inflammasome activation.

Published in:

Nature Communications, 2014, v. 5, n. 9, p. 4977, doi. 10.1038/ncomms5977

By:

Martin, Bradley N.;
Wang, Chenhui;
Willette-Brown, Jami;
Herjan, Tomasz;
Gulen, Muhammet F.;
Zhou, Hao;
Bulek, Katarzyna;
Franchi, Luigi;
Sato, Takashi;
Alnemri, Emad S.;
Narla, Goutham;
Zhong, Xiao-Ping;
Thomas, James;
Klinman, Dennis;
Fitzgerald, Katherine A.;
Karin, Michael;
Nuñez, Gabriel;
Dubyak, George;
Hu, Yinling;
Li, Xiaoxia

Publication type:

Article

microRNA-181a has a critical role in ovarian cancer progression through the regulation of the epithelial-mesenchymal transition.

Published in:

Nature Communications, 2014, v. 5, n. 1, p. 2977, doi. 10.1038/ncomms3977

By:

Parikh, Aditya;
Lee, Christine;
Joseph, Peronne;
Marchini, Sergio;
Baccarini, Alessia;
Kolev, Valentin;
Romualdi, Chiara;
Fruscio, Robert;
Shah, Hardik;
Wang, Feng;
Mullokandov, Gavriel;
Fishman, David;
D'Incalci, Maurizio;
Rahaman, Jamal;
Kalir, Tamara;
Redline, Raymond W.;
Brown, Brian D.;
Narla, Goutham;
DiFeo, Analisa

Publication type:

Article

Mistletoe lectin inhibits growth of Myc‐amplified small‐cell lung cancer.

Published in:

Cancer Medicine, 2023, v. 12, n. 7, p. 8378, doi. 10.1002/cam4.5558

By:

Shatat, Mohammad A.;
Gauthier, Betsy;
Yoon, Suzy;
Yuan, Eric;
Yang, Peiying;
Narla, Goutham;
Dowlati, Afshin;
Lee, Richard T.

Publication type:

Article

Ribosome-inactivating proteins isolated from dietary bitter melon induce apoptosis and inhibit histone deacetylase-1 selectively in premalignant and malignant prostate cancer cells.

Published in:

International Journal of Cancer, 2009, v. 125, n. 4, p. 774, doi. 10.1002/ijc.24325

By:

Xiong, Su Dao;
Yu, Kang;
Liu, Xin Hua;
Yin, Li Hui;
Kirschenbaum, Alexander;
Yao, Shen;
Narla, Goutham;
DiFeo, Analisa;
Wu, Jian Buo;
Yuan, Yong;
Ho, Shuk-Mei;
Lam, Ying Wai;
Levine, Alice C.

Publication type:

Article

KLF6 allelic loss is associated with tumor recurrence and markedly decreased survival in head and neck squamous cell carcinoma.

Published in:

International Journal of Cancer, 2007, v. 121, n. 9, p. 1976, doi. 10.1002/ijc.22926

By:

Teixeira, Miriam S.;
Camacho-Vanegas, Olga;
Fernandez, Yolanda;
Narla, Goutham;
DiFeo, Analisa;
Lee, Bryant;
Kalir, Tamara;
Friedman, Scott L.;
Schlecht, Nicolas F.;
Genden, Eric M.;
Urken, Mark;
Brandwein-Gensler, Margaret;
Martignetti, John A.

Publication type:

Article

Functional inactivation of the KLF6 tumor suppressor gene by loss of heterozygosity and increased alternative splicing in glioblastoma.

Published in:

International Journal of Cancer, 2007, v. 121, n. 6, p. 1390, doi. 10.1002/ijc.22809

By:

Camacho-Vanegas, Olga;
Narla, Goutham;
Teixeira, Miriam S.;
DiFeo, Analisa;
Misra, Anjan;
Singh, Gobind;
Chan, Andrew M.;
Friedman, Scott L.;
Feuerstein, Burt G.;
Martignetti, John A.

Publication type:

Article

Allosteric activation of PP2A inhibits experimental abdominal aortic aneurysm.

Published in:

Clinical Science, 2021, v. 135, n. 17, p. 2085, doi. 10.1042/CS20210315

By:

Xianming Zhou;
Chao Zhang;
Fei Xie;
Wei Wei;
Rui Li;
Qian Xu;
Yu Wang;
Klenotic, Philip A.;
Narla, Goutham;
Nianguo Dong;
Zhiyong Lin

Publication type:

Article

Targeting protein phosphatase PP2A for cancer therapy: development of allosteric pharmaceutical agents.

Published in:

Clinical Science, 2021, v. 135, n. 13, p. 1445, doi. 10.1042/CS20201367

By:

Brautigan, David L.;
Farrington, Caroline;
Narla, Goutham

Publication type:

Article

Suppression of glioblastoma tumorigenicity by the Kruppel-like transcription factor KLF6.

Published in:

Oncogene, 2004, v. 23, n. 29, p. 5077, doi. 10.1038/sj.onc.1207662

By:

Kimmelman, Alec C.;
Qiao, Rui F.;
Narla, Goutham;
Banno, Asoka;
Lau, Nelson;
Bos, Paula D.;
Rodriguez, Nelson Nuñez;
Liang, Bertrand C.;
Guha, Abhijit;
Martignetti, John A.;
Friedman, Scott L.;
Chan, Andrew M.

Publication type:

Article

Tumor suppressor activity of KLF6 mediated by downregulation of the PTTG1 oncogene

Published in:

FEBS Letters, 2010, v. 584, n. 5, p. 1006, doi. 10.1016/j.febslet.2010.01.049

By:

Lee, Ursula E.;
Ghiassi-Nejad, Zahra;
Paris, Andrew J.;
Yea, Steven;
Narla, Goutham;
Walsh, Martin;
Friedman, Scott L.

Publication type:

Article

KLF6 degradation after apoptotic DNA damage

Published in:

FEBS Letters, 2006, v. 580, n. 30, p. 6981, doi. 10.1016/j.febslet.2006.10.077

By:

Banck, Michaela S.;
Beaven, Simon W.;
Narla, Goutham;
Walsh, Martin J.;
Friedman, Scott L.;
Beutler, Andreas S.

Publication type:

Article

Targeting Translational Control in Cancer Using Small Molecule Activators of PP2A.

Published in:

FASEB Journal, 2022, v. 36, p. N.PAG, doi. 10.1096/fasebj.2022.36.S1.L7668

By:

Jonas, Kayla A.;
Lum, Michelle A.;
Black, Adrian R.;
Narla, Goutham;
Jennifer, Black D.

Publication type:

Article

Deregulating MYC in a model of HER2+ breast cancer mimics human intertumoral heterogeneity.

Published in:

2020

By:

Risom, Tyler;
Xiaoyan Wang;
Juan Liang;
Xiaoli Zhang;
Pelz, Carl;
Campbell, Lydia G.;
Eng, Jenny;
Koei Chin;
Farrington, Caroline;
Narla, Goutham;
Langer, Ellen M.;
Xiao-Xin Sun;
Yulong Su;
Daniel, Colin J.;
Mu-Shui Dai;
Löhr, Christiane V.;
Sears, Rosalie C.;
Wang, Xiaoyan;
Liang, Juan;
Zhang, Xiaoli

Publication type:

journal article

Deregulating MYC in a model of HER2<sup>+</sup> breast cancer mimics human intertumoral heterogeneity.

Published in:

Journal of Clinical Investigation, 2020, v. 130, n. 1, p. 231, doi. 10.1172/JCI126390

By:

Risom, Tyler;
Xiaoyan Wang;
Juan Liang;
Xiaoli Zhang;
Pelz, Carl;
Campbell, Lydia G.;
Eng, Jenny;
Koei Chin;
Farrington, Caroline;
Narla, Goutham;
Langer, Ellen M.;
Xiao-Xin Sun;
Yulong Su;
Daniel, Colin J.;
Mu-Shui Dai;
Löhr, Christiane V.;
Sears, Rosalie C.

Publication type:

Article

Krüppel-like factor 6 regulates mitochondrial function in the kidney.

Published in:

Journal of Clinical Investigation, 2015, v. 125, n. 3, p. 1347, doi. 10.1172/JCI77084

By:

Mallipattu, Sandeep K.;
Horne, Sylvia J.;
D'Agati, Vivette;
Narla, Goutham;
Ruijie Liu;
Frohman, Michael A.;
Dickman, Kathleen;
Chen, Edward Y.;
Ma'ayan, Avi;
Bialkowska, Agnieszka B.;
Ghaleb, Amr M.;
Nandan, Mandayam O.;
Jain, Mukesh K.;
Daehn, Ilse;
Chuang, Peter Y.;
Yang, Vincent W.;
He, John C.

Publication type:

Article

Targeting the FOXO1/KLF6 axis regulates EGFR signaling and treatment response.

Published in:

Journal of Clinical Investigation, 2012, v. 122, n. 7, p. 2637, doi. 10.1172/JCI62058

By:

Sangodkar, Jaya;
Dhawan, Neil S.;
Melville, Heather;
Singh, Varan J.;
Yuan, Eric;
Rana, Huma;
Izadmehr, Sudeh;
Farrington, Caroline;
Mazhar, Sahar;
Katz, Suzanna;
Albano, Tara;
Arnovitz, Pearlann;
Okrent, Rachel;
Ohlmeyer, Michael;
Galsky, Matthew;
Burstein, David;
Zhang, David;
Politi, Katerina;
DiFeo, Analisa;
Narla, Goutham

Publication type:

Article

KLF6-SV1 overexpression accelerates human and mouse prostate cancer progression and metastasis.

Published in:

2008

By:

Narla, Goutham;
DiFeo, Analisa;
Fernandez, Yolanda;
Dhanasekaran, Saravana;
Fei Huang;
Sangodkar, Jaya;
Hod, Eldad;
Leake, Devin;
Friedman, Scott L.;
Hall, Simon J.;
Chinnaiyan, Arul M.;
Gerald, William L.;
Rubin, Mark A.;
Martignetti, John A.;
Huang, Fei

Publication type:

journal article