Works by Nakaya, Tadashi

Results: 48

Cytoplasmic granule formation by FUS‐R495X is attributable to arginine methylation in all Gly‐rich, RGG1 and RGG2 domains.

Published in:

Genes to Cells, 2021, v. 26, n. 3, p. 190, doi. 10.1111/gtc.12827

By:

Kawahara, Daiki;
Suzuki, Toshiharu;
Nakaya, Tadashi

Publication type:

Article

Trafficking of Alzheimer's Disease–Related Membrane Proteins and Its Participation in Disease Pathogenesis.

Published in:

Journal of Biochemistry, 2006, v. 139, n. 6, p. 949, doi. 10.1093/jb/mvj121

By:

Suzuki, Toshiharu;
Araki, Yoichi;
Yamamoto, Tohru;
Nakaya, Tadashi

Publication type:

Article

Interaction of N-Terminal Acetyltransferase with the Cytoplasmic Domain of β-Amyloid Precursor Protein and Its Effect on Aβ Secretion.

Published in:

Journal of Biochemistry, 2005, v. 137, n. 2, p. 147, doi. 10.1093/jb/mvi014

By:

Asaumi, Makoto;
Iijima, Koichi;
Sumioka, Akio;
Iijima-Ando, Kanae;
Kirino, Yutaka;
Nakaya, Tadashi;
Suzuki, Toshiharu

Publication type:

Article

Dissection of FUS domains involved in regulation of SnRNP70 gene expression.

Published in:

FEBS Letters, 2020, v. 594, n. 21, p. 3518, doi. 10.1002/1873-3468.13924

By:

Nakaya, Tadashi

Publication type:

Article

The cytoplasmic region of the amyloid β‐protein precursor (APP) is necessary and sufficient for the enhanced fast velocity of APP transport by kinesin‐1.

Published in:

FEBS Letters, 2018, v. 592, n. 16, p. 2716, doi. 10.1002/1873-3468.13204

By:

Tsukamoto, Maoko;
Chiba, Kyoko;
Sobu, Yuriko;
Shiraki, Yuzuha;
Okumura, Yuka;
Hata, Saori;
Kitamura, Akira;
Nakaya, Tadashi;
Uchida, Seiichi;
Kinjo, Masataka;
Taru, Hidenori;
Suzuki, Toshiharu

Publication type:

Article

Metabolic stabilization of p53 by FE65 in the nuclear matrix of osmotically stressed cells.

Published in:

FEBS Journal, 2009, v. 276, n. 21, p. 6364, doi. 10.1111/j.1742-4658.2009.07349.x

By:

Nakaya, Tadashi;
Kawai, Tomoko;
Suzuki, Toshiharu

Publication type:

Article

Roles of the intramolecular regions of FE65 in its trans-accumulation and in p53 stabilization in the nuclear matrix of osmotically stressed cells

Published in:

FEBS Letters, 2010, v. 584, n. 4, p. 765, doi. 10.1016/j.febslet.2009.12.040

By:

Kawai, Tomoko;
Nakaya, Tadashi;
Suzuki, Toshiharu

Publication type:

Article

X11 and X11‐like proteins regulate the level of extrasynaptic glutamate receptors.

Published in:

Journal of Neurochemistry, 2019, v. 148, n. 4, p. 480, doi. 10.1111/jnc.14623

By:

Motodate, Rika;
Saito, Haruka;
Sobu, Yuriko;
Hata, Saori;
Saito, Yuhki;
Nakaya, Tadashi;
Suzuki, Toshiharu

Publication type:

Article

Amyotrophic Lateral Sclerosis associated FUS mutation shortens mitochondria and induces neurotoxicity.

Published in:

Scientific Reports, 2018, v. 8, n. 1, p. 1, doi. 10.1038/s41598-018-33964-0

By:

Nakaya, Tadashi;
Maragkakis, Manolis

Publication type:

Article

Amyloid-dependent triosephosphate isomerase nitrotyrosination induces glycation and tau fibrillation.

Published in:

Brain: A Journal of Neurology, 2009, v. 132, n. 5, p. 1335, doi. 10.1093/brain/awp023

By:

Guix, Francesc X.;
Ill-Raga, Gerard;
Bravo, Ramona;
Nakaya, Tadashi;
de Fabritiis, Gianni;
Coma, Mireia;
Miscione, Gian Pietro;
Villà-Freixa, Jordi;
Suzuki, Toshiharu;
Fernàndez-Busquets, Xavier;
Valverde, Miguel A.;
de Strooper, Bart;
Muñoz, Francisco J.

Publication type:

Article

Suppression of APP-containing vesicle trafficking and production of β-amyloid by AID/DHHC-12 protein.

Published in:

Journal of Neurochemistry, 2009, v. 111, n. 5, p. 1213, doi. 10.1111/j.1471-4159.2009.06399.x

By:

Mizumaru, Chie;
Saito, Yuhki;
Ishikawa, Takao;
Yoshida, Tomohiro;
Yamamoto, Tohru;
Nakaya, Tadashi;
Suzuki, Toshiharu

Publication type:

Article

Phosphorylation of the amino-terminal region of X11L regulates its interaction with APP.

Published in:

Journal of Neurochemistry, 2009, v. 109, n. 2, p. 465, doi. 10.1111/j.1471-4159.2009.05988.x

By:

Sakuma, Megumi;
Tanaka, Emi;
Taru, Hidenori;
Tomita, Susumu;
Gandy, Sam;
Nairn, Angus C.;
Nakaya, Tadashi;
Yamamoto, Tohru;
Suzuki, Toshiharu

Publication type:

Article

Role of APP phosphorylation in FE65-dependent gene transactivation mediated by AICD.

Published in:

Genes to Cells, 2006, v. 11, n. 6, p. 633, doi. 10.1111/j.1365-2443.2006.00968.x

By:

Nakaya, Tadashi;
Suzuki, Toshiharu

Publication type:

Article

Identification and expression of a novel gene in odour-taste associative learning in the terrestrial slug.

Published in:

Genes to Cells, 2001, v. 6, n. 1, p. 43, doi. 10.1046/j.1365-2443.2001.00397.x

By:

Nakaya, Tadashi;
Kawahara, Shigenori;
Watanabe, Satoshi;
Lee, Dong-Seok;
Suzuki, Toshiharu;
Kirino, Yutaka

Publication type:

Article

Intracellular Trafficking of the Amyloid &bgr;-Protein Precursor (APP) Regulated by Novel Function of X11-Like.

Published in:

PLoS ONE, 2011, v. 6, n. 7, p. 1, doi. 10.1371/journal.pone.0022108

By:

Saito, Yuhki;
Akiyama, Mayu;
Araki, Yoichi;
Sumioka, Akio;
Shiono, Maki;
Taru, Hidenori;
Nakaya, Tadashi;
Yamamoto, Tohru;
Suzuki, Toshiharu

Publication type:

Article

Decrease in p3‐Alcβ37 and p3‐Alcβ40, products of Alcadein β generated by γ‐secretase cleavages, in aged monkeys and patients with Alzheimer's disease.

Published in:

Alzheimer's & Dementia: Translational Research & Clinical Interventions, 2019, v. 5, n. 1, p. 740, doi. 10.1016/j.trci.2019.09.015

By:

Hata, Saori;
Omori, Chiori;
Kimura, Ayano;
Saito, Haruka;
Kimura, Nobuyuki;
Gupta, Veer;
Pedrini, Steve;
Hone, Eugene;
Chatterjee, Pratishtha;
Taddei, Kevin;
Kasuga, Kensaku;
Ikeuchi, Takeshi;
Waragai, Masaaki;
Nishimura, Masaki;
Hu, Anqi;
Nakaya, Tadashi;
Meijer, Laurent;
Maeda, Masahiro;
Yamamoto, Tohru;
Masters, Colin L.

Publication type:

Article

Novel Notch signaling inhibitor NSI-1 suppresses nuclear translocation of the Notch intracellular domain.

Published in:

International Journal of Molecular Medicine, 2019, v. 44, n. 4, p. 1574, doi. 10.3892/ijmm.2019.4280

By:

Shiraishi, Takaya;
Sakaitani, Masahiro;
Otsuguro, Satoko;
Maenaka, Katsumi;
Suzuki, Toshiharu;
Nakaya, Tadashi

Publication type:

Article

IDENTIFICATION OF APOE4-X11L REGULATED DOWNSTREAM GENES RELATED TO THE LATE-ONSET AD.

Published in:

Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2017, v. 13, p. P969, doi. 10.1016/j.jalz.2017.06.1303

By:

Toyoda, Megumi;
Nakaya, Tadashi;
Michikawa, Makoto;
Suzuki, Toshiharu

Publication type:

Article

p3-Alc peptides produced by covariant processing of Alcadein and APP implicate γ-secretase dysfunction in sporadic Alzheimer's disease

Published in:

2009

By:

Hata, Saori;
Maeda, Masahiro;
Nishimura, Masaki;
Levey, Allan;
Chung, Kathryn A.;
Montine, Thomas;
Fagan, Anne;
Goate, Alison;
Bateman, Randall;
Holtzman, David M.;
Nakaya, Tadashi;
Gandy, Sam;
Suzuki, Toshiharu

Publication type:

Abstract

Amyloidogenic metabolism of human APP in X11-like deficient mice brain

Published in:

2009

By:

Kondo, Maho;
Sakuma, Megumi;
Saito, Yuhki;
Nakaya, Tadashi;
Maeda, Masahiro;
Suzuki, Toshiharu

Publication type:

Abstract

Exclusion of phosporylated APP CTFs from membrane region rich in active γ-secretase

Published in:

2009

By:

Matsushima, Takahide;
Nakaya, Tadashi;
Suzuki, Toshiharu

Publication type:

Abstract

Aberrant localization of amyloid precursor protein in X11 and X11L- deficient mice brain

Published in:

2009

By:

Saito, Yuhki;
Nakaya, Tadashi;
Suzuki, Toshiharu

Publication type:

Abstract

P4-237: Nuclear translocation of FE65 regulated by APP in cells with osmotic stress

Published in:

2008

By:

Nakaya, Tadashi;
Suzuki, Toshiharu

Publication type:

Abstract

P3-072: Analysis of β-Alc; Alcadein processing yields fragment homologous to APP P3 peptide

Published in:

2008

By:

Hata, Saori;
Araki, Yoichi;
Urakami, Katsuya;
Akatsu, Hiroyasu;
Nishimura, Masaki;
Gandy, Sam;
Nakaya, Tadashi;
Suzuki, Toshiharu

Publication type:

Abstract

P1-453: APP metabolism in brain of Thr668 residue mutant mice

Published in:

2008

By:

Matsushima, Takahide;
Suzuki, Toshiharu;
Nakaya, Tadashi

Publication type:

Abstract

P1-384: Analysis of Alcadein metabolic fragments in brain

Published in:

2008

By:

Araseki, Masahiko;
Hata, Saori;
Nakaya, Tadashi;
Gandy, Sam;
Martins, Ralph N.;
Suzuki, Toshiharu

Publication type:

Abstract

P1-391: Intracellular dynamics of Alcadein family molecules and their metabolites in neuronal cells and tissues

Published in:

2008

By:

Gotoh, Naoya;
Urano, Satomi;
Maruta, Chiaki;
Nakaya, Tadashi;
Suzuki, Toshiharu;
Yamamoto, Tohru

Publication type:

Abstract

P1-022: Inhibitory mechanism of amyloidgenic APP metabolism by X11 and X11L in brain

Published in:

2008

By:

Saito, Yuhki;
Nakaya, Tadashi;
Suzuki, Toshiharu

Publication type:

Abstract

O4-06-07: Involvement of the prostaglandin E2 receptors, EP2 and EP4, in the production of amyloid-β peptides both in vitro and in vivo

Published in:

2008

By:

Hoshino, Tatsuya;
Nakaya, Tadashi;
Sugimoto, Yukihiko;
Araki, Wataru;
Narumiya, Shuh;
Suzuki, Toshiharu;
Mizushima, Tohru

Publication type:

Abstract

P4-029: Inhibition of amyloid-B production by endoplasmic reticulum chaperones

Published in:

2006

By:

Hoshino, Tatsuya;
Nakaya, Tadashi;
Suzuki, Toshiharu;
Mizushima, Tohru

Publication type:

Abstract

P4-025: Characterization of primary secretase-like cleavages of alcadein

Published in:

2006

By:

Fujishige, Sayaka;
Yamamoto, Kazuo;
Suenaga, Naoko;
Seiki, Motoharu;
Saftig, Paul;
Hartmann, Dieter;
Nakaya, Tadashi;
Gandy, Sam;
Suzuki, Toshiharu

Publication type:

Abstract

P4-020: β-Alc, metabolic products of alcadein, as a novel diagnostic marker in CSF of Alzheimer’s disease

Published in:

2006

By:

Hata, Saori;
Araki, Yoichi;
Akatsu, Hiroyasu;
Urakami, Katsuya;
Nishimura, Masaki;
Nakaya, Tadashi;
Suzuki, Toshiharu

Publication type:

Abstract

P4-015: Hyperosmotic stress enhances the interaction between APP and X11L

Published in:

2006

By:

Sakuma, Megumi;
Taru, Hidenori;
Tanaka, Emi;
Nakaya, Tadashi;
Suzuki, Toshiharu

Publication type:

Abstract

P2-010: Analysis of X11/X11L gene deficient mice

Published in:

2006

By:

Saito, Yuhki;
Zhu, Gang;
Sano, Yoshitake;
Okada, Motohiro;
Nakaya, Tadashi;
Kaneko, Sunao;
Itohara, Shigeyoshi;
Suzuki, Toshiharu

Publication type:

Abstract

P1-409: Nuclear translocation of FE65

Published in:

2006

By:

Nakaya, Tadashi;
Suzuki, Toshiharu

Publication type:

Abstract

P1-376: The analysis of Alcadein α isoform function in vesicular transport

Published in:

2006

By:

Kawano, Takanori;
Araki, Yoichi;
Nakaya, Tadashi;
Matsuno, Kenji;
Suzuki, Toshiharu

Publication type:

Abstract

P1-060: APP metabolism in the brain of X11-like null mutant mouse

Published in:

2006

By:

Suzuki, Toshiharu;
Sano, Yoshitake;
Itohara, Shigeyoshi;
Nakaya, Tadashi

Publication type:

Abstract

P4-029: Inhibition of amyloid-B production by endoplasmic reticulum chaperones

Published in:

2006

By:

Hoshino, Tatsuya;
Nakaya, Tadashi;
Suzuki, Toshiharu;
Mizushima, Tohru

Publication type:

Abstract

P4-025: Characterization of primary secretase-like cleavages of alcadein

Published in:

2006

By:

Fujishige, Sayaka;
Yamamoto, Kazuo;
Suenaga, Naoko;
Seiki, Motoharu;
Saftig, Paul;
Hartmann, Dieter;
Nakaya, Tadashi;
Gandy, Sam;
Suzuki, Toshiharu

Publication type:

Abstract

P4-020: β-Alc, metabolic products of alcadein, as a novel diagnostic marker in CSF of Alzheimer’s disease

Published in:

2006

By:

Hata, Saori;
Araki, Yoichi;
Akatsu, Hiroyasu;
Urakami, Katsuya;
Nishimura, Masaki;
Nakaya, Tadashi;
Suzuki, Toshiharu

Publication type:

Abstract

P4-015: Hyperosmotic stress enhances the interaction between APP and X11L

Published in:

2006

By:

Sakuma, Megumi;
Taru, Hidenori;
Tanaka, Emi;
Nakaya, Tadashi;
Suzuki, Toshiharu

Publication type:

Abstract

P2-010: Analysis of X11/X11L gene deficient mice

Published in:

2006

By:

Saito, Yuhki;
Zhu, Gang;
Sano, Yoshitake;
Okada, Motohiro;
Nakaya, Tadashi;
Kaneko, Sunao;
Itohara, Shigeyoshi;
Suzuki, Toshiharu

Publication type:

Abstract

P1-409: Nuclear translocation of FE65

Published in:

2006

By:

Nakaya, Tadashi;
Suzuki, Toshiharu

Publication type:

Abstract

P1-376: The analysis of Alcadein α isoform function in vesicular transport

Published in:

2006

By:

Kawano, Takanori;
Araki, Yoichi;
Nakaya, Tadashi;
Matsuno, Kenji;
Suzuki, Toshiharu

Publication type:

Abstract

P1-060: APP metabolism in the brain of X11-like null mutant mouse

Published in:

2006

By:

Suzuki, Toshiharu;
Sano, Yoshitake;
Itohara, Shigeyoshi;
Nakaya, Tadashi

Publication type:

Abstract

Facilitation of brain mitochondrial activity by 5-aminolevulinic acid in a mouse model of Alzheimer's disease.

Published in:

Nutritional Neuroscience, 2017, v. 20, n. 9, p. 538, doi. 10.1080/1028415X.2016.1199114

By:

Omori, Chiori;
Motodate, Rika;
Shiraki, Yuzuha;
Chiba, Kyoko;
Sobu, Yuriko;
Kimura, Ayano;
Nakaya, Tadashi;
Kondo, Hikaru;
Kurumiya, Satoshi;
Tanaka, Toru;
Yamamoto, Kazuo;
Nakajima, Motowo;
Suzuki, Toshiharu;
Hata, Saori

Publication type:

Article

Enhanced amyloid-β generation by γ-secretase complex in DRM microdomains with reduced cholesterol levels.

Published in:

Human Molecular Genetics, 2020, v. 29, n. 3, p. 382, doi. 10.1093/hmg/ddz297

By:

Hata, Saori;
Hu, Anqi;
Piao, Yi;
Nakaya, Tadashi;
Taru, Hidenori;
Morishima-Kawashima, Maho;
Murayama, Shigeo;
Nishimura, Masaki;
Suzuki, Toshiharu

Publication type:

Article

Evaluating the role of the FUS/TLS-related gene EWSR1 in amyotrophic lateral sclerosis.

Published in:

Human Molecular Genetics, 2012, v. 21, n. 13, p. 2899, doi. 10.1093/hmg/dds116

By:

Couthouis, Julien;
Hart, Michael P.;
Erion, Renske;
King, Oliver D.;
Diaz, Zamia;
Nakaya, Tadashi;
Ibrahim, Fadia;
Kim, Hyung-Jun;
Mojsilovic-Petrovic, Jelena;
Panossian, Saarene;
Kim, Cecilia E.;
Frackelton, Edward C.;
Solski, Jennifer A.;
Williams, Kelly L.;
Clay-Falcone, Dana;
Elman, Lauren;
McCluskey, Leo;
Greene, Robert;
Hakonarson, Hakon;
Kalb, Robert G.

Publication type:

Article