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Modeling and simulation of bone mineral density response from a phase 2 study of ONO-5334, a new cathepsin K inhibitor, to support dose selection in osteoporosis.
- Published in:
- Journal of Clinical Pharmacology, 2014, v. 54, n. 8, p. 937, doi. 10.1002/jcph.279
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- Article
Population pharmacokinetic and pharmacodynamic modeling of different formulations of ONO-5334, cathepsin K inhibitor, in Caucasian and Japanese postmenopausal females.
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- Journal of Clinical Pharmacology, 2014, v. 54, n. 1, p. 23, doi. 10.1002/jcph.186
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- Article
Pharmacodynamic Effects on Biochemical Markers of Bone Turnover and Pharmacokinetics of the Cathepsin K Inhibitor, ONO-5334, in an Ascending Multiple-Dose, Phase 1 Study.
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- Journal of Clinical Pharmacology, 2012, v. 52, n. 3, p. 306, doi. 10.1177/0091270011399080
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- Article
Bone turnover markers and pharmacokinetics of a new sustained-release formulation of the cathepsin K inhibitor, ONO-5334, in healthy post-menopausal women.
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- Journal of Bone & Mineral Metabolism, 2015, v. 33, n. 1, p. 93, doi. 10.1007/s00774-013-0558-2
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- Article
The Effect of the Cathepsin K Inhibitor ONO-5334 on Trabecular and Cortical Bone in Postmenopausal Osteoporosis: The OCEAN Study.
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- Journal of Bone & Mineral Research, 2014, v. 29, n. 3, p. 629, doi. 10.1002/jbmr.2080
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- Article
Effect of ONO-5334 on Bone Mineral Density and Biochemical Markers of Bone Turnover in Postmenopausal Osteoporosis: 2-Year Results From the OCEAN Study.
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- Journal of Bone & Mineral Research, 2014, v. 29, n. 2, p. 458, doi. 10.1002/jbmr.2047
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- Article
Safety and efficacy of the cathepsin K inhibitor ONO-5334 in postmenopausal osteoporosis: The OCEAN study.
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- Journal of Bone & Mineral Research, 2011, v. 26, n. 6, p. 1303, doi. 10.1002/jbmr.341
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- Article
Serum and urine bone resorption markers and pharmacokinetics of the cathepsin K inhibitor ONO-5334 after ascending single doses in post menopausal women.
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- British Journal of Clinical Pharmacology, 2012, v. 74, n. 6, p. 959, doi. 10.1111/j.1365-2125.2012.04307.x
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- Article