Works by Nachon, Florian

Results: 46
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    Multifunctional, Fluorene‐Based Modulator of Cholinergic and GABAergic Neurotransmission as a Novel Drug Candidate for Palliative Treatment of Alzheimer's Disease.

    Published in:
    Angewandte Chemie International Edition, 2025, v. 64, n. 6, p. 1, doi. 10.1002/anie.202420510
    By:
    • Panek, Dawid;
    • Pasieka, Anna;
    • Jończyk, Jakub;
    • Gawlińska, Milena;
    • Zaręba, Paula;
    • Siwek, Agata;
    • Wolak, Małgorzata;
    • Mordyl, Barbara;
    • Głuch‐Lutwin, Monika;
    • Latacz, Gniewomir;
    • Brazzolotto, Xavier;
    • Chantegreil, Fabien;
    • Nachon, Florian;
    • Zdarova Karasova, Jana;
    • Pejchal, Jaroslav;
    • Mzik, Martin;
    • Sestak, Vit;
    • Prchal, Lukas;
    • Odvarkova, Jitka;
    • Soukup, Ondrej
    Publication type:
    Article
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    Organophosphorus diisopropylfluorophosphate (DFP) intoxication in zebrafish larvae causes behavioral defects, neuronal hyperexcitation and neuronal death.

    Published in:
    Scientific Reports, 2020, v. 10, n. 1, p. N.PAG, doi. 10.1038/s41598-020-76056-8
    By:
    • Brenet, Alexandre;
    • Somkhit, Julie;
    • Hassan-Abdi, Rahma;
    • Yanicostas, Constantin;
    • Romain, Christiane;
    • Bar, Olivier;
    • Igert, Alexandre;
    • Saurat, Dominique;
    • Taudon, Nicolas;
    • Dal-Bo, Gregory;
    • Nachon, Florian;
    • Dupuis, Nina;
    • Soussi-Yanicostas, Nadia
    Publication type:
    Article
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    Development of versatile and potent monoquaternary reactivators of acetylcholinesterase.

    Published in:
    Archives of Toxicology, 2021, v. 95, n. 3, p. 985, doi. 10.1007/s00204-021-02981-w
    By:
    • Gorecki, Lukas;
    • Hepnarova, Vendula;
    • Karasova, Jana Zdarova;
    • Hrabinova, Martina;
    • Courageux, Charlotte;
    • Dias, José;
    • Kucera, Tomas;
    • Kobrlova, Tereza;
    • Muckova, Lubica;
    • Prchal, Lukas;
    • Malinak, David;
    • Jun, Daniel;
    • Musilek, Kamil;
    • Worek, Franz;
    • Nachon, Florian;
    • Soukup, Ondrej;
    • Korabecny, Jan
    Publication type:
    Article
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    Slow-binding inhibition of acetylcholinesterase by an alkylammonium derivative of 6-methyluracil: mechanism and possible advantages for myasthenia gravis treatment.

    Published in:
    Biochemical Journal, 2016, v. 473, n. 9, p. 1225, doi. 10.1042/BCJ20160084
    By:
    • Kharlamova, Alexandra D.;
    • Lushchekina, Sofya V.;
    • Petrov, Konstantin A.;
    • Kots, Ekaterina D.;
    • Nachon, Florian;
    • Villard-Wandhammer, Marielle;
    • Zueva, Irina V.;
    • Krejci, Eric;
    • Reznik, Vladimir S.;
    • Zobov, Vladimir V.;
    • Nikolsky, Evgeny E.;
    • Masson, Patrick
    Publication type:
    Article
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    Efficacy Assessment of an Uncharged Reactivator of NOP-Inhibited Acetylcholinesterase Based on Tetrahydroacridine Pyridine-Aldoxime Hybrid in Mouse Compared to Pralidoxime.

    Published in:
    Biomolecules (2218-273X), 2020, v. 10, n. 6, p. 858, doi. 10.3390/biom10060858
    By:
    • Calas, André-Guilhem;
    • Hanak, Anne-Sophie;
    • Jaffré, Nina;
    • Nervo, Aurélie;
    • Dias, José;
    • Rousseau, Catherine;
    • Courageux, Charlotte;
    • Brazzolotto, Xavier;
    • Villa, Pascal;
    • Obrecht, Adeline;
    • Goossens, Jean-François;
    • Landry, Christophe;
    • Hachani, Johan;
    • Gosselet, Fabien;
    • Dehouck, Marie-Pierre;
    • Yerri, Jagadeesh;
    • Kliachyna, Maria;
    • Baati, Rachid;
    • Nachon, Florian
    Publication type:
    Article
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    Multifunctional, Fluorene‐Based Modulator of Cholinergic and GABAergic Neurotransmission as a Novel Drug Candidate for Palliative Treatment of Alzheimer's Disease.

    Published in:
    Angewandte Chemie, 2025, v. 137, n. 6, p. 1, doi. 10.1002/ange.202420510
    By:
    • Panek, Dawid;
    • Pasieka, Anna;
    • Jończyk, Jakub;
    • Gawlińska, Milena;
    • Zaręba, Paula;
    • Siwek, Agata;
    • Wolak, Małgorzata;
    • Mordyl, Barbara;
    • Głuch‐Lutwin, Monika;
    • Latacz, Gniewomir;
    • Brazzolotto, Xavier;
    • Chantegreil, Fabien;
    • Nachon, Florian;
    • Zdarova Karasova, Jana;
    • Pejchal, Jaroslav;
    • Mzik, Martin;
    • Sestak, Vit;
    • Prchal, Lukas;
    • Odvarkova, Jitka;
    • Soukup, Ondrej
    Publication type:
    Article
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    Development of an in-vivo active reversible butyrylcholinesterase inhibitor.

    Published in:
    Scientific Reports, 2016, p. 39495, doi. 10.1038/srep39495
    By:
    • Košak, Urban;
    • Brus, Boris;
    • Knez, Damijan;
    • Šink, Roman;
    • Žakelj, Simon;
    • Trontelj, Jurij;
    • Pišlar, Anja;
    • Šlenc, Jasna;
    • Gobec, Martina;
    • Živin, Marko;
    • Tratnjek, Larisa;
    • Perše, Martina;
    • Sałat, Kinga;
    • Podkowa, Adrian;
    • Filipek, Barbara;
    • Nachon, Florian;
    • Brazzolotto, Xavier;
    • Więckowska, Anna;
    • Malawska, Barbara;
    • Stojan, Jure
    Publication type:
    Article
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    Chemoselective Hydrogenation of 6‐Alkynyl‐3‐fluoro‐2‐pyridinaldoximes: Access to First‐in‐Class 6‐Alkyl‐3‐Fluoro‐2‐pyridinaldoxime Scaffolds as New Reactivators of Sarin‐Inhibited Human Acetylcholinesterase with Increased Blood–Brain Barrier Permeability

    Published in:
    Chemistry - A European Journal, 2020, v. 26, n. 65, p. 15035, doi. 10.1002/chem.202002012
    By:
    • Yerri, Jagadeesh;
    • Dias, José;
    • Nimmakayala, Mallikajurna Reddy;
    • Razafindrainibe, Franck;
    • Courageux, Charlotte;
    • Gastellier, Anne‐Julie;
    • Jegoux, Johanne;
    • Coisne, Caroline;
    • Landry, Christophe;
    • Gosselet, Fabien;
    • Hachani, Johan;
    • Goossens, Jean‐François;
    • Dehouck, Marie‐Pierre;
    • Nachon, Florian;
    • Baati, Rachid
    Publication type:
    Article
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    Potent 3‐Hydroxy‐2‐Pyridine Aldoxime Reactivators of Organophosphate‐Inhibited Cholinesterases with Predicted Blood–Brain Barrier Penetration.

    Published in:
    Chemistry - A European Journal, 2018, v. 24, n. 38, p. 9675, doi. 10.1002/chem.201801394
    By:
    • Zorbaz, Tamara;
    • Braïki, Anissa;
    • Maraković, Nikola;
    • Renou, Julien;
    • de la Mora, Eugenio;
    • Maček Hrvat, Nikolina;
    • Katalinić, Maja;
    • Silman, Israel;
    • Sussman, Joel L.;
    • Mercey, Guillaume;
    • Gomez, Catherine;
    • Mougeot, Romain;
    • Pérez, Belén;
    • Baati, Rachid;
    • Nachon, Florian;
    • Weik, Martin;
    • Jean, Ludovic;
    • Kovarik, Zrinka;
    • Renard, Pierre‐Yves
    Publication type:
    Article
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