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Polytherapy with a combination of three repurposed drugs (PXT3003) down-regulates Pmp22 overexpression and improves myelination, axonal and functional parameters in models of CMT1A neuropathy.
Published in:
Orphanet Journal of Rare Diseases, 2014, v. 9, n. 1, p. 282, doi. 10.1186/s13023-014-0201-x
By:
- Chumakov, Ilya;
- Milet, Aude;
- Cholet, Nathalie;
- Primas, Gwenaël;
- Boucard, Aurélie;
- Pereira, Yannick;
- Graudens, Esther;
- Mandel, Jonas;
- Laffaire, Julien;
- Foucquier, Julie;
- Glibert, Fabrice;
- Bertrand, Viviane;
- Nave, Klaus-Armin;
- Sereda, Michael W.;
- Vial, Emmanuel;
- Guedj, Mickaël;
- Hajj, Rodolphe;
- Nabirotchkin, Serguei;
- Cohen, Daniel
Publication type:
Article
Polytherapy with a combination of three repurposed drugs (PXT3003) down-regulates Pmp22 over-expression and improves myelination, axonal and functional parameters in models of CMT1A neuropathy.
Published in:
2014
By:
- Chumakov, Ilya;
- Milet, Aude;
- Cholet, Nathalie;
- Primas, Gwenaël;
- Boucard, Aurélie;
- Pereira, Yannick;
- Graudens, Esther;
- Mandel, Jonas;
- Laffaire, Julien;
- Foucquier, Julie;
- Glibert, Fabrice;
- Bertrand, Viviane;
- Nave, Klaus-Armin;
- Sereda, Michael W;
- Vial, Emmanuel;
- Guedj, Mickaël;
- Hajj, Rodolphe;
- Nabirotchkin, Serguei;
- Cohen, Daniel
Publication type:
Journal Article
P1‐061: DOUBLE‐BLIND ARGUMENT FOR A SYNERGISTIC THERAPEUTIC EFFECT OF A FIXED LOW‐DOSE COMBINATION OF ACAMPROSATE AND BACLOFEN IN ALZHEIMER'S DISEASE.
Published in:
Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2018, v. 14, p. P292, doi. 10.1016/j.jalz.2018.06.063
By:
- Orgogozo, Jean-Marc;
- Touchon, Jacques;
- Ousset, Pierre Jean;
- Pasquier, Florence;
- Guériot, Claude;
- Philippe, Robert;
- Auriacombe, Sophie;
- Hugon, Jacques;
- Schmidt, Peter;
- Bertrand, Viviane;
- Hajj, Rodolphe;
- Nabirotchkin, Serguei;
- Guedj, Mickaël;
- Goedkoop, Rene;
- Cohen, Daniel
Publication type:
Article
A COMBINATION OF ACAMPROSATE AND BACLOFEN (PXT864) SYNERGIZES WITH STANDARDS OF CARE FOR THE TREATMENT OF ALZHEIMER’S DISEASE.
Published in:
Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2017, v. 13, p. P948, doi. 10.1016/j.jalz.2017.06.1860
By:
- Cholet, Nathalie;
- Foucquier, Julie;
- Murphy, Niall;
- Guedj, Mickael;
- Nabirotchkin, Serguei;
- Hajj, Rodolphe;
- Cohen, Daniel
Publication type:
Article
Combination of acamprosate and baclofen as a promising therapeutic approach for Parkinson's disease.
Published in:
Scientific Reports, 2015, p. 16084, doi. 10.1038/srep16084
By:
- Hajj, Rodolphe;
- Milet, Aude;
- Toulorge, Damien;
- Cholet, Nathalie;
- Laffaire, Julien;
- Foucquier, Julie;
- Robelet, Sandra;
- Mitry, Richard;
- Guedj, Mickael;
- Nabirotchkin, Serguei;
- Chumakov, Ilya;
- Cohen, Daniel
Publication type:
Article
Combination of acamprosate and baclofen (PXT864) as a potential new therapy for amyotrophic lateral sclerosis.
Published in:
Journal of Neuroscience Research, 2020, v. 98, n. 12, p. 2435, doi. 10.1002/jnr.24714
By:
- Boussicault, Lydie;
- Laffaire, Julien;
- Schmitt, Peter;
- Rinaudo, Philippe;
- Callizot, Noëlle;
- Nabirotchkin, Serguei;
- Hajj, Rodolphe;
- Cohen, Daniel
Publication type:
Article
Synergistic PXT3003 therapy uncouples neuromuscular function from dysmyelination in male Charcot–Marie–Tooth disease type 1A (CMT1A) rats.
Published in:
Journal of Neuroscience Research, 2020, v. 98, n. 10, p. 1933, doi. 10.1002/jnr.24679
By:
- Prukop, Thomas;
- Wernick, Stephanie;
- Boussicault, Lydie;
- Ewers, David;
- Jäger, Karoline;
- Adam, Julia;
- Winter, Lorenz;
- Quintes, Susanne;
- Linhoff, Lisa;
- Barrantes‐Freer, Alonso;
- Bartl, Michael;
- Czesnik, Dirk;
- Zschüntzsch, Jana;
- Schmidt, Jens;
- Primas, Gwenaël;
- Laffaire, Julien;
- Rinaudo, Philippe;
- Brureau, Anthony;
- Nabirotchkin, Serguei;
- Schwab, Markus H.
Publication type:
Article
Early short-term PXT3003 combinational therapy delays disease onset in a transgenic rat model of Charcot-Marie-Tooth disease 1A (CMT1A).
Published in:
PLoS ONE, 2019, v. 14, n. 1, p. 1, doi. 10.1371/journal.pone.0209752
By:
- Prukop, Thomas;
- Stenzel, Jan;
- Wernick, Stephanie;
- Kungl, Theresa;
- Mroczek, Magdalena;
- Adam, Julia;
- Ewers, David;
- Nabirotchkin, Serguei;
- Nave, Klaus-Armin;
- Hajj, Rodolphe;
- Cohen, Daniel;
- Sereda, Michael W.
Publication type:
Article

Found: 8