Works by Myllyharju, Johanna

Results: 43

NMR Assignment of the N-terminal Domain a of the Glycoprotein Chaperone ERp57.

Published in:

Journal of Biomolecular NMR, 2005, v. 33, n. 2, p. 136, doi. 10.1007/s10858-005-2720-1

By:

Silvennoinen, Laura;
Koivunen, Peppi;
Myllyharju, Johanna;
Kilpeläinen, Ilkka;
Permi, Perttu

Publication type:

Article

Letter to the Editor: Assignment of 1H, 13C and 15N resonances of the a′ domain of ERp57.

Published in:

Journal of Biomolecular NMR, 2001, v. 20, n. 4, p. 385, doi. 10.1023/A:1011291316810

By:

Silvennoinen, Laura;
Karvonen, Päivi;
Koivunen, Peppi;
Myllyharju, Johanna;
Kivirikko, Kari;
Kilpeläinen, Ilkka

Publication type:

Article

Prolyl and lysyl hydroxylases in collagen synthesis.

Published in:

Experimental Dermatology, 2021, v. 30, n. 1, p. 38, doi. 10.1111/exd.14197

By:

Salo, Antti M.;
Myllyharju, Johanna

Publication type:

Article

Extracellular Matrix and Developing Growth Plate.

Published in:

Current Osteoporosis Reports, 2014, v. 12, n. 4, p. 439, doi. 10.1007/s11914-014-0232-1

By:

Myllyharju, Johanna

Publication type:

Article

Structural enzymology binding studies of the peptide‐substrate‐binding domain of human collagen prolyl 4‐hydroxylase (type‐II): High affinity peptides have a PxGP sequence motif.

Published in:

Protein Science: A Publication of the Protein Society, 2018, v. 27, n. 9, p. 1692, doi. 10.1002/pro.3450

By:

Murthy, Abhinandan V.;
Sulu, Ramita;
Koski, M. Kristian;
Tu, Hongmin;
Anantharajan, Jothi;
Sah‐Teli, Shiv K.;
Myllyharju, Johanna;
Wierenga, Rik K.

Publication type:

Article

Sandwich ELISA for quantitative detection of human collagen prolyl 4-hydroxylase.

Published in:

Microbial Cell Factories, 2010, v. 9, p. 48, doi. 10.1186/1475-2859-9-48

By:

Osmekhina, Ekaterina;
Neubauer, Antje;
Klinzing, Katharina;
Myllyharju, Johanna;
Neubauer, Peter

Publication type:

Article

Optimisation of substrate feeding in shake flask cultures of Pichia pastoris for recombinant protein production.

Published in:

2006

By:

Bollok, Monika;
Ruottinen, Maria;
Krause, Mirja;
Vasala, Antti;
Hämäläinen, Eija-Riitta;
Neubauer, Antje;
Myllyharju, Johanna;
Neubauer, Peter

Publication type:

Abstract

Hypoxia-inducible factor prolyl 4-hydroxylases: common and specific roles.

Published in:

Biological Chemistry, 2013, v. 394, n. 4, p. 435, doi. 10.1515/hsz-2012-0328

By:

Myllyharju, Johanna;
Koivunen, Peppi

Publication type:

Article

PHD1 regulates p53-mediated colorectal cancer chemoresistance.

Published in:

EMBO Molecular Medicine, 2015, v. 7, n. 10, p. 1350, doi. 10.15252/emmm.201505492

By:

Deschoemaeker, Sofie;
Di Conza, Giusy;
Lilla, Sergio;
Martín‐Pérez, Rosa;
Mennerich, Daniela;
Boon, Lise;
Hendrikx, Stefanie;
Maddocks, Oliver DK;
Marx, Christian;
Radhakrishnan, Praveen;
Prenen, Hans;
Schneider, Martin;
Myllyharju, Johanna;
Kietzmann, Thomas;
Vousden, Karen H;
Zanivan, Sara;
Mazzone, Massimiliano

Publication type:

Article

Effect of desferrioxamine and metals on the hydroxylases in the oxygen sensing pathway.

Published in:

FASEB Journal, 2005, v. 19, n. 10, p. 1308, doi. 10.1096/fj.04-3399fje

By:

Hirsilä, Maija;
Koivunen, Peppi;
Xu, Leon;
Seeley, Todd;
Kivirikko, Kari I.;
Myllyharju, Johanna

Publication type:

Article

Loss of Cln5 leads to altered Gad1 expression and deficits in interneuron development in mice.

Published in:

Human Molecular Genetics, 2019, v. 28, n. 19, p. 3309, doi. 10.1093/hmg/ddz165

By:

Singh, Yajuvinder;
Leinonen, Henri;
Fazaludeen, Feroze;
Jaronen, Merja;
Guest, Debbie;
Buckley, Noel;
Byts, Nadiya;
Oksa, Petra;
Jalkanen, Kari;
Iqbal, Imran;
Huuskonen, Mikko;
Savchenko, Ekaterina;
Keksa-Goldsteine, Velta;
Chew, Sweelin;
Myllyharju, Johanna;
Tanila, Heikki;
Ooi, Lezanne;
Koistinaho, Jari;
Kanninen, Katja M;
Malm, Tarja

Publication type:

Article

Wnt5a Deficiency Leads to Anomalies in Ureteric Tree Development, Tubular Epithelial Cell Organization and Basement Membrane Integrity Pointing to a Role in Kidney Collecting Duct Patterning.

Published in:

PLoS ONE, 2016, v. 11, n. 1, p. 1, doi. 10.1371/journal.pone.0147171

By:

Pietilä, Ilkka;
Prunskaite-Hyyryläinen, Renata;
Kaisto, Susanna;
Tika, Elisavet;
van Eerde, Albertien M.;
Salo, Antti M.;
Garma, Leonardo;
Miinalainen, Ilkka;
Feitz, Wout F.;
Bongers, Ernie M. H. F.;
Juffer, André;
Knoers, Nine V. A. M.;
Renkema, Kirsten Y.;
Myllyharju, Johanna;
Vainio, Seppo J.

Publication type:

Article

Improved production of human type II procollagen in the yeast Pichia pastoris in shake flasks by a wireless-controlled fed-batch system.

Published in:

BMC Biotechnology, 2008, v. 8, p. 1, doi. 10.1186/1472-6750-8-33

By:

Ruottinen, Maria;
Bollok, Monika;
Kögler, Martin;
Neubauer, Antje;
Krause, Mirja;
Hämäläinen, Eija-Riitta;
Myllyharju, Johanna;
Vasala, Antti;
Neubauer, Peter

Publication type:

Article

Notch Downregulation and Extramedullary Erythrocytosis in Hypoxia-Inducible Factor Prolyl 4-Hydroxylase 2-Deficient Mice.

Published in:

Molecular & Cellular Biology, 2017, v. 37, n. 2, p. 1, doi. 10.1128/MCB.00529-16

By:

Myllymäki, Mikko N. M.;
Määttä, Jenni;
Dimova, Elitsa Y.;
Izzi, Valerio;
Väisänen, Timo;
Myllyharju, Johanna;
Koivunen, Peppi;
Serpi, Raisa

Publication type:

Article

Metabolic characteristics of transmembrane prolyl 4-hydroxylase (P4H-TM) deficient mice.

Published in:

Pflügers Archiv: European Journal of Physiology, 2024, v. 476, n. 9, p. 1339, doi. 10.1007/s00424-024-02920-5

By:

Ala-Nisula, Tuulia;
Halmetoja, Riikka;
Leinonen, Henri;
Kurkela, Margareta;
Lipponen, Henna-Riikka;
Sakko, Samuli;
Karpale, Mikko;
Salo, Antti M.;
Sissala, Niina;
Röning, Tapio;
Raza, Ghulam S.;
Mäkelä, Kari A.;
Thevenot, Jérôme;
Herzig, Karl-Heinz;
Serpi, Raisa;
Myllyharju, Johanna;
Tanila, Heikki;
Koivunen, Peppi;
Dimova, Elitsa Y.

Publication type:

Article

Assembly of the elongated collagen prolyl 4-hydroxylase α2β2 heterotetramer around a central α2 dimer.

Published in:

Biochemical Journal, 2017, v. 474, n. 5, p. 751, doi. 10.1042/BCJ20161000

By:

Koski, M. Kristian;
Anantharajan, Jothi;
Kursula, Petri;
Dhavala, Prathusha;
Murthy, Abhinandan V.;
Bergmann, Ulrich;
Myllyharju, Johanna;
Wierenga, Rik K.

Publication type:

Article

Reduced Bone Mass in Collagen Prolyl 4‐Hydroxylase P4ha1+/−; P4ha2−/− Compound Mutant Mice.

Published in:

JBMR Plus, 2022, v. 6, n. 6, p. 1, doi. 10.1002/jbm4.10630

By:

Tolonen, Jussi‐Pekka;
Salo, Antti M;
Finnilä, Mikko;
Aro, Ellinoora;
Karjalainen, Emma;
Ronkainen, Veli‐Pekka;
Drushinin, Kati;
Merceron, Christophe;
Izzi, Valerio;
Schipani, Ernestina;
Myllyharju, Johanna

Publication type:

Article

A long hypoxia-inducible factor 3 isoform 2 is a transcription activator that regulates erythropoietin.

Published in:

Cellular & Molecular Life Sciences, 2020, v. 77, n. 18, p. 3627, doi. 10.1007/s00018-019-03387-9

By:

Tolonen, Jussi-Pekka;
Heikkilä, Minna;
Malinen, Marjo;
Lee, Hang-Mao;
Palvimo, Jorma J.;
Wei, Gong-Hong;
Myllyharju, Johanna

Publication type:

Article

Roles of the human hypoxia-inducible factor (HIF)-3α variants in the hypoxia response.

Published in:

Cellular & Molecular Life Sciences, 2011, v. 68, n. 23, p. 3885, doi. 10.1007/s00018-011-0679-5

By:

Heikkilä, Minna;
Pasanen, Annika;
Kivirikko, Kari;
Myllyharju, Johanna

Publication type:

Article

Extracellular matrix genes as hypoxia-inducible targets.

Published in:

Cell & Tissue Research, 2010, v. 339, n. 1, p. 19, doi. 10.1007/s00441-009-0841-7

By:

Myllyharju, Johanna;
Schipani, Ernestina

Publication type:

Article

Characterization of two carnation petal prolyl 4 hydroxylases.

Published in:

Physiologia Plantarum, 2010, v. 140, n. 2, p. 199, doi. 10.1111/j.1399-3054.2010.01390.x

By:

Vlad, Florina;
Tiainen, Päivi;
Owen, Carolyn;
Spano, Thodhoraq;
Daher, Firas Bou;
Oualid, Fatiha;
Senol, Namik Ozer;
Vlad, Daniela;
Myllyharju, Johanna;
Kalaitzis, Panagiotis

Publication type:

Article

High-level production of human type I collagen in the yeast Pichia pastoris.

Published in:

Yeast, 2001, v. 18, n. 9, p. 797, doi. 10.1002/yea.730

By:

Nokelainen, Minna;
Tu, Hongmin;
Vuorela, Annamari;
Notbohm, Holger;
Kivirikko, Kari I.;
Myllyharju, Johanna

Publication type:

Article

Identification of a novel proline-rich peptide-binding domain in prolyl 4-hydroxylase.

Published in:

EMBO Journal, 1999, v. 18, n. 2, p. 306, doi. 10.1093/emboj/18.2.306

By:

Myllyharju, Johanna;
Kivirikko, Kari I.

Publication type:

Article

Assembly of human prolyl 4-hydroxylase and type III collagen in the yeast Pichia pastoris: formation of a stable enzyme tetramer requires coexpression with collagen and assembly of a stable collagen requires coexpression with prolyl 4-hydroxylase.

Published in:

EMBO Journal, 1997, v. 16, n. 22, p. 6702, doi. 10.1093/emboj/16.22.6702

By:

Vuorela, Annamari;
Myllyharju, Johanna;
Nissi, Ritva;
Pihlajaniemi, Taina;
Kivirikko, Kari I.

Publication type:

Article

Characterization of the iron- and 2-oxoglutarate-binding sites of human prolyl 4-hydroxylase.

Published in:

EMBO Journal, 1997, v. 16, n. 6, p. 1173, doi. 10.1093/emboj/16.6.1173

By:

Myllyharju, Johanna;
Kivirikko, Kari I.

Publication type:

Article

Expression and Roles of Individual HIF Prolyl 4-Hydroxylase Isoenzymes in the Regulation of the Hypoxia Response Pathway along the Murine Gastrointestinal Epithelium.

Published in:

International Journal of Molecular Sciences, 2021, v. 22, n. 8, p. 4038, doi. 10.3390/ijms22084038

By:

Dengler, Franziska;
Sova, Sofia;
Salo, Antti M.;
Mäki, Joni M.;
Koivunen, Peppi;
Myllyharju, Johanna

Publication type:

Article

Structural basis of homo- and heterotrimerization of collagen I.

Published in:

Nature Communications, 2017, v. 8, n. 3, p. 14671, doi. 10.1038/ncomms14671

By:

Sharma, Urvashi;
Carrique, Loïc;
Vadon-Le Goff, Sandrine;
Mariano, Natacha;
Georges, Rainier-Numa;
Delolme, Frederic;
Koivunen, Peppi;
Myllyharju, Johanna;
Moali, Catherine;
Aghajari, Nushin;
Hulmes, David J. S.

Publication type:

Article

HIF-P4H-2 inhibition enhances intestinal fructose metabolism and induces thermogenesis protecting against NAFLD.

Published in:

Journal of Molecular Medicine, 2020, v. 98, n. 5, p. 719, doi. 10.1007/s00109-020-01903-0

By:

Laitakari, Anna;
Tapio, Joona;
Mäkelä, Kari A.;
Herzig, Karl-Heinz;
Dengler, Franziska;
Gylling, Helena;
Walkinshaw, Gail;
Myllyharju, Johanna;
Dimova, Elitsa Y.;
Serpi, Raisa;
Koivunen, Peppi

Publication type:

Article

HIF-P4H-2 deficiency protects against skeletal muscle ischemia-reperfusion injury.

Published in:

Journal of Molecular Medicine, 2016, v. 94, n. 3, p. 301, doi. 10.1007/s00109-015-1349-0

By:

Karsikas, Sara;
Myllymäki, Mikko;
Heikkilä, Minna;
Sormunen, Raija;
Kivirikko, Kari;
Myllyharju, Johanna;
Serpi, Raisa;
Koivunen, Peppi

Publication type:

Article

Prolyl 4-hydroxylation regulates Argonaute 2 stability.

Published in:

Nature, 2008, v. 455, n. 7211, p. 421, doi. 10.1038/nature07186

By:

Qi, Hank H.;
Ongusaha, Pat P.;
Myllyharju, Johanna;
Dongmei Cheng;
Pakkanen, Outi;
Yujiang Shi;
Lee, Sam W.;
Junmin Peng;
Yang Shi

Publication type:

Article

P4HA1 mutations cause a unique congenital disorder of connective tissue involving tendon, bone, muscle and the eye.

Published in:

Human Molecular Genetics, 2017, v. 26, n. 12, p. 2207, doi. 10.1093/hmg/ddx110

By:

Yaqun Zou;
Donkervoort, Sandra;
Salo, Antti M.;
Foley, A. Reghan;
Barnes, Aileen M.;
Ying Hu;
Makareeva, Elena;
Leach, Meganne E.;
Mohassel, Payam;
Dastgir, Jahannaz;
Deardorff, Matthew A.;
Cohn, Ronald D.;
DiNonno, Wendy O.;
Malfait, Fransiska;
Lek, Monkol;
Leikin, Sergey;
Marini, Joan C.;
Myllyharju, Johanna;
Bönnemann, Carsten G.

Publication type:

Article

Lack of P4H-TM in mice results in age-related retinal and renal alterations.

Published in:

Human Molecular Genetics, 2016, v. 25, n. 17, p. 3810, doi. 10.1093/hmg/ddw228

By:

Leinonen, Henri;
Rossi, Maarit;
Salo, Antti M.;
Tiainen, Päaivi;
Hyväarinen, Jaana;
Pitkäanen, Marja;
Sormunen, Raija;
Miinalainen, Ilkka;
Chi Zhang;
Soininen, Raija;
Kivirikko, Kari I.;
Koskelainen, Ari;
Tanila, Heikki;
Myllyharju, Johanna;
Koivunen, Peppi

Publication type:

Article

Role of prolyl hydroxylation in the molecular interactions of collagens.

Published in:

Essays in Biochemistry, 2019, v. 63, n. 3, p. 325, doi. 10.1042/EBC20180053

By:

Rappu, Pekka;
Salo, Antti M.;
Myllyharju, Johanna;
Heino, Jyrki

Publication type:

Article

Activation of the hypoxia response protects mice from amyloid-β accumulation.

Published in:

Cellular & Molecular Life Sciences, 2022, v. 79, n. 8, p. 1, doi. 10.1007/s00018-022-04460-6

By:

Ollonen, Teemu;
Kurkela, Margareta;
Laitakari, Anna;
Sakko, Samuli;
Koivisto, Henna;
Myllyharju, Johanna;
Tanila, Heikki;
Serpi, Raisa;
Koivunen, Peppi

Publication type:

Article

Prolyl 4-hydroxylases, key enzymes in the synthesis of collagens and regulation of the response to hypoxia, and their roles as treatment targets.

Published in:

Annals of Medicine, 2008, v. 40, n. 6, p. 402, doi. 10.1080/07853890801986594

By:

Myllyharju, Johanna

Publication type:

Article

Collagens and collagen-related diseases.

Published in:

Annals of Medicine, 2001, v. 33, n. 1, p. 7, doi. 10.3109/07853890109002055

By:

Myllyharju, Johanna;
Kivirikko, Kari I

Publication type:

Article

Prolyl hydroxylase domain 2 reduction enhances skeletal muscle tissue regeneration after soft tissue trauma in mice.

Published in:

PLoS ONE, 2020, v. 15, n. 5, p. 1, doi. 10.1371/journal.pone.0233261

By:

Settelmeier, Stephan;
Schreiber, Timm;
Mäki, Joni;
Byts, Nadiya;
Koivunen, Peppi;
Myllyharju, Johanna;
Fandrey, Joachim;
Winning, Sandra

Publication type:

Article

Activation of Hypoxia Response in Endothelial Cells Contributes to Ischemic Cardioprotection.

Published in:

Molecular & Cellular Biology, 2013, v. 33, n. 16, p. 3321, doi. 10.1128/MCB.00432-13

By:

Kerkelä, Risto;
Karsikas, Sara;
Szabo, Zoltan;
Serpi, Raisa;
Magga, Johanna;
Gao, Erhe;
Alitalo, Kari;
Anisimov, Andrey;
Sormunen, Raija;
Pietilä, Ilkka;
Vainio, Laura;
Koch, Walter J.;
Kivirikko, Kari I.;
Myllyharju, Johanna;
Koivunen, Peppi

Publication type:

Article

Activation of Hypoxia Response in Endothelial Cells Contributes to Ischemic Cardioprotection.

Published in:

Molecular & Cellular Biology, 2013, v. 33, n. 15, p. 3321, doi. 10.1128/MCB.00432-13

By:

Kerkelä, Risto;
Karsikas, Sara;
Szabo, Zoltan;
Serpi, Raisa;
Magga, Johanna;
Gao, Erhe;
Alitalo, Kari;
Anisimov, Andrey;
Sormunen, Raija;
Pietilä, Ilkka;
Vainio, Laura;
Koch, Walter J.;
Kivirikko, Kari I.;
Myllyharju, Johanna;
Koivunen, Peppi

Publication type:

Article

The Ras Signaling Inhibitor LOX-PP Interacts with Hsp70 and c-Raf To Reduce Erk Activation and Transformed Phenotype of Breast Cancer Cells.

Published in:

Molecular & Cellular Biology, 2011, v. 31, n. 13, p. 12, doi. 10.1128/MCB.01148-10

By:

Sato, Seiichi;
Trackman, Philip C.;
Mäki, Joni M.;
Myllyharju, Johanna;
Kirsch, Kathrin H.;
Sonenshein, Gail E.

Publication type:

Article

Transmembrane Prolyl 4-Hydroxylase is a Novel Regulator of Calcium Signaling in Astrocytes.

Published in:

eNeuro, 2021, v. 8, n. 1, p. 1, doi. 10.1523/ENEURO.0253-20.2020

By:

Byts, Nadiya;
Sharma, Subodh;
Laurila, Jenny;
Paudel, Prodeep;
Miinalainen, Ilkka;
Ronkainen, Veli-Pekka;
Hinttala, Reetta;
Törnquist, Kid;
Koivunen, Peppi;
Myllyharju, Johanna

Publication type:

Article

Systemic long‐term inactivation of hypoxia‐inducible factor prolyl 4‐hydroxylase 2 ameliorates aging‐induced changes in mice without affecting their life span.

Published in:

FASEB Journal, 2020, v. 34, n. 4, p. 5590, doi. 10.1096/fj.201902331R

By:

Laitakari, Anna;
Huttunen, Riikka;
Kuvaja, Paula;
Hannuksela, Pauliina;
Szabo, Zoltan;
Heikkilä, Minna;
Kerkelä, Risto;
Myllyharju, Johanna;
Dimova, Elitsa Y.;
Serpi, Raisa;
Koivunen, Peppi

Publication type:

Article

HIF Prolyl 4-Hydroxylase-2 Inhibition Improves Glucose and Lipid Metabolism and Protects Against Obesity and Metabolic Dysfunction.

Published in:

Diabetes, 2014, v. 63, n. 10, p. 3324, doi. 10.2337/db14-0472

By:

Rahtu-Korpela, Lea;
Karsikas, Sara;
Hörkkö, Sohvi;
Blanco Sequeiros, Roberto;
Lammentausta, Eveliina;
Mäkelä, Kari A.;
Herzig, Karl-Heinz;
Walkinshaw, Gail;
Kivirikko, Kari I.;
Myllyharju, Johanna;
Serpi, Raisa;
Koivunen, Peppi

Publication type:

Article