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O4-03-02: The gamma secretase inhibitor MK-0752 acutely and significantly reduces CSF Abeta40 concentrations in humans
Published in:
2006
By:
- Rosen, Laura B.;
- Stone, Julie A.;
- Plump, Andrew;
- Yuan, Jinyu;
- Harrison, Tim;
- Flynn, Mary;
- Dallob, Aimee;
- Matthews, Catherine;
- Stevenson, Donna;
- Schmidt, Dennis;
- Palmieri, Theresa;
- Leibowitz, Mark;
- Jhee, Stanford;
- Ereshefsky, Larry;
- Salomon, Ronald;
- Winchell, Greg;
- Shearman, Mark S.;
- Murphy, M. Gail;
- Gottesdiener, Keith M.
Publication type:
Abstract
O4-03-02: The gamma secretase inhibitor MK-0752 acutely and significantly reduces CSF Abeta40 concentrations in humans
Published in:
2006
By:
- Rosen, Laura B.;
- Stone, Julie A.;
- Plump, Andrew;
- Yuan, Jinyu;
- Harrison, Tim;
- Flynn, Mary;
- Dallob, Aimee;
- Matthews, Catherine;
- Stevenson, Donna;
- Schmidt, Dennis;
- Palmieri, Theresa;
- Leibowitz, Mark;
- Jhee, Stanford;
- Ereshefsky, Larry;
- Salomon, Ronald;
- Winchell, Greg;
- Shearman, Mark S.;
- Murphy, M. Gail;
- Gottesdiener, Keith M.
Publication type:
Abstract
Pharmacokinetic assessment of an oral enalapril suspension for use in children.
Published in:
Biopharmaceutics & Drug Disposition, 2000, v. 21, n. 9, p. 339, doi. 10.1002/bdd.241
By:
- Rippley, Ronda K.;
- Connor, John;
- Boyle, Janet;
- Bradstreet, Thomas E;
- Hand, Elizabeth;
- Lo, Man-Wai;
- Murphy, M. Gail
Publication type:
Article
Effects of the neurokinin<sub>1</sub> receptor antagonist aprepitant on the pharmacokinetics of dexamethasone and methylprednisolone<sup>*</sup>.
Published in:
Clinical Pharmacology & Therapeutics, 2003, v. 74, n. 1, p. 17, doi. 10.1016/S0009-9236(03)00066-3
By:
- McCrea, Jacqueline B.;
- Majumdar, Anup K.;
- Goldberg, Michael R.;
- Iwamoto, Marian;
- Gargano, Cynthia;
- Panebianco, Deborah L.;
- Hesney, Michael;
- Lines, Christopher R.;
- Petty, Kevin J.;
- Deutsch, Paul J.;
- Murphy, M. Gail;
- Gottesdiener, Keith M.;
- Goldwater, D. Ronald;
- Blum, Robert A.
Publication type:
Article
The gastrin-receptor antagonist L-365,260 inhibits stimulated acid secretion in humans.
Published in:
Clinical Pharmacology & Therapeutics, 1993, v. 54, n. 5, p. 533, doi. 10.1038/clpt.1993.185
By:
- Murphy, M Gail;
- Sytnik, Bozena;
- Kovacs, Thomas O G;
- Mertz, Howard;
- Ewanik, Daria;
- Shingo, Sumiko;
- Lin, Juinn H;
- Gertz, Barry J;
- Walsh, John H
Publication type:
Article
Transcutaneous theophylline collection in preterm infants.
Published in:
Clinical Pharmacology & Therapeutics, 1990, v. 47, n. 4, p. 427, doi. 10.1038/clpt.1990.53
By:
- Murphy, M Gail;
- Peck, Carl C;
- Conner, Dale P;
- Zamani, Kaveh;
- Merenstein, Gerald B;
- Rodden, Donna
Publication type:
Article
Characterizing the PK/ PD relationship for inhibition of capsaicin-induced dermal vasodilatation by MK-3207, an oral calcitonin gene related peptide receptor antagonist.
Published in:
British Journal of Clinical Pharmacology, 2015, v. 79, n. 5, p. 831, doi. 10.1111/bcp.12547
By:
- Li, Chi‐Chung;
- Vermeersch, Steve;
- Denney, William S.;
- Kennedy, William P.;
- Palcza, John;
- Gipson, Adrianna;
- Han, Tae H.;
- Blanchard, Rebecca;
- De Lepeleire, Inge;
- Depré, Marleen;
- Murphy, M. Gail;
- Van Dyck, Kristien;
- Hoon, Jan N.
Publication type:
Article
The potent calcitonin gene-related peptide receptor antagonist, telcagepant, does not affect nitroglycerin-induced vasodilation in healthy men.
Published in:
British Journal of Clinical Pharmacology, 2011, v. 71, n. 5, p. 708, doi. 10.1111/j.1365-2125.2010.03869.x
By:
- Van der Schueren, Bart J.;
- Blanchard, Rebecca;
- Murphy, M. Gail;
- Palcza, John;
- De Lepeleire, Inge;
- Van Hecken, Anne;
- Depré, Marleen;
- de Hoon, Jan N.
Publication type:
Article
Inhibition of capsaicin-induced increase in dermal blood flow by the oral CGRP receptor antagonist, telcagepant (MK-0974).
Published in:
British Journal of Clinical Pharmacology, 2010, v. 69, n. 1, p. 15, doi. 10.1111/j.1365-2125.2009.03543.x
By:
- Sinclair, Simon R.;
- Kane, Stefanie A.;
- Van der Schueren, Bart J.;
- Alan Xiao;
- Willson, Kenneth J.;
- Boyle, Janet;
- de Lepeleire, Inge;
- Yang Xu;
- Hickey, Lisa;
- Denney, William S.;
- Chi-Chung Li;
- Palcza, John;
- Vanmolkot, Floris H. M.;
- Depré, Marleen;
- Van Hecken, Anne;
- Murphy, M. Gail;
- Ho, Tony W.;
- de Hoon, Jay N.
Publication type:
Article
Tolerability, pharmacokinetics and night-time effects on postural sway and critical flicker fusion of gaboxadol and zolpidem in elderly subjects.
Published in:
British Journal of Clinical Pharmacology, 2009, v. 67, n. 2, p. 180, doi. 10.1111/j.1365-2125.2008.03331.x
By:
- Boyle, Julia;
- Danjou, Philippe;
- Alexander, Robert;
- Calder, Nicole;
- Gargano, Cynthia;
- Agrawal, Nancy;
- Fu, Irong;
- McCrea, Jacqueline B.;
- Murphy, M. Gail
Publication type:
Article
Effect of Aprepitant 40 mg on Cytochrome P-450 2C9 Activity: A Randomized, Double-Blind, Placebo-Controlled, Parallel-Group Study in Healthy Young Adults.
Published in:
Journal of Applied Research, 2009, v. 9, n. 4, p. 123
By:
- Ngo, Phung L.;
- Shadle, Craig R.;
- Murphy, M. Gail;
- Jin, Bo;
- Panebianco, Deborah L.;
- Evans, Judith K.;
- Valentine, Jack L.;
- Blum, Robert A.
Publication type:
Article
Aprepitant when added to a standard antiemetic regimen consisting of ondansetron and dexamethasone does not affect vinorelbine pharmacokinetics in cancer patients.
Published in:
Cancer Chemotherapy & Pharmacology, 2007, v. 59, n. 3, p. 407, doi. 10.1007/s00280-006-0359-6
By:
- Loos, Walter J.;
- de Wit, Ronald;
- Freedman, Steven J.;
- Van Dyck, Kristien;
- Gambale, Jay J.;
- Li, Susie;
- Murphy, Gail M.;
- van Noort, Connie;
- de Bruijn, Peter;
- Verweij, Jaap
Publication type:
Article
Lack of effect of aprepitant on the pharmacokinetics of docetaxel in cancer patients.
Published in:
Cancer Chemotherapy & Pharmacology, 2005, v. 55, n. 6, p. 609, doi. 10.1007/s00280-004-0946-3
By:
- Nygren, Peter;
- Hande, Kenneth;
- Petty, Kevin J.;
- Fedgchin, Margaret;
- van Dyck, Kristien;
- Majumdar, Anup;
- Panebianco, Debbie;
- Smet, Marina;
- Ahmed, Tuli;
- Murphy, M. Gail;
- Gottesdiener, Keith;
- Cocquyt, Veronique;
- vanBelle, Simon
Publication type:
Article
Pharmacokinetics of famotidine in infants.
Published in:
2005
By:
- Wenning, Larissa A.;
- Murphy, M. Gail;
- James, Laura P.;
- Blumer, Jeffrey L.;
- Marshall, James D.;
- Baier, John;
- Scheimann, Ann O.;
- Panebianco, Deborah L.;
- Zhong, Ling;
- Eisenhandler, Roy;
- Yeh, Kuang C.;
- Kearns, Gregory L.
Publication type:
journal article
Early-stage comparative effectiveness: Randomized controlled trial with histamine inverse agonist MK-7288 in excessive daytime sleepiness patients.
Published in:
Journal of Clinical Pharmacology, 2013, v. 53, n. 12, p. 1294, doi. 10.1002/jcph.182
By:
- Sun, Hong;
- MacLeod, Catherine;
- Mostoller, Kate;
- Mahon, Chantal;
- Han, Lingling;
- Renger, John J.;
- Ma, Junshui;
- Brown, Kevin R.;
- Schulz, Valerie;
- Kay, Gary G.;
- Herring, W. Joseph;
- Lines, Christopher;
- Rosen, Laura B.;
- Murphy, M. Gail;
- Wagner, John A.
Publication type:
Article
Single- and Multiple-Dose Pharmacokinetics and Tolerability of Telcagepant, an Oral Calcitonin Gene-Related Peptide Receptor Antagonist, in Adults.
Published in:
Journal of Clinical Pharmacology, 2010, v. 50, n. 12, p. 1367, doi. 10.1177/0091270010361741
By:
- Han, Tae H.;
- Blanchard, Rebecca L.;
- Palcza, John;
- McCrea, Jacqueline B.;
- Laethem, Tine;
- Willson, Kenneth;
- Yang Xu;
- Ermlich, Susan;
- Boyle, Janet;
- Lines, Christopher;
- Gutierrez, Maria;
- Van Bortel, Luc;
- Xiao, Alan J.;
- Sinclair, Simon;
- Hickey, Lisa;
- Panebianco, Deborah;
- Murphy, M. Gail
Publication type:
Article
Lack of Effect of Aprepitant on Hydrodolasetron Pharmacokinetics in CYP2D6 Extensive and Poor Metabolizers.
Published in:
Journal of Clinical Pharmacology, 2006, v. 46, n. 7, p. 792, doi. 10.1177/0091270006288954
By:
- Li, Susie Xiujiang;
- Pequignot, Edward;
- Panebianco, Deborah;
- Lupinacci, Paul;
- Majumdar, Anup;
- Rosen, Laura;
- Ahmed, Tuli;
- Royalty, Jane E.;
- Rushmore, Thomas H.;
- Murphy, M. Gail;
- Petty, Kevin J.
Publication type:
Article
Lack of Effect of Aprepitant on Digoxin Pharmacokinetics in Healthy Subjects.
Published in:
Journal of Clinical Pharmacology, 2003, v. 43, n. 8, p. 912, doi. 10.1177/0091270003256113
By:
- Feuring, Martin;
- Lee, Yih;
- Orlowski, Laura H.;
- Michiels, Nicole;
- Smet, Marina De;
- Majumdar, Anup K.;
- Petty, Kevin J.;
- Goldberg, Michael R.;
- Murphy, M. Gail;
- Gottesdiener, Keith M.;
- Hesney, Michael;
- Brackett, L. Ellen;
- Wehling, Martin
Publication type:
Article
Human Pharmacokinetics and Tolerability of L-365,260, a Novel Cholecystokinin-B Antagonist.
Published in:
1996
By:
- Grasing, Kenneth;
- Murphy, M. Gail;
- Lin, Juinn;
- Swigar, Mary;
- Freedholm, Debra;
- Clarke, Laura;
- Zhang, Ji;
- Wolkowitz, Owen M.;
- Weingartner, Herbert;
- Putnam, Karen;
- Seibold, James R.
Publication type:
Other
Effect of Telcagepant on Spontaneous Ischemia in Cardiovascular Patients in a Randomized Study.
Published in:
Headache: The Journal of Head & Face Pain, 2011, v. 51, n. 6, p. 954, doi. 10.1111/j.1526-4610.2011.01901.x
By:
- Behm, Martin O.;
- Blanchard, Rebecca L.;
- Murphy, M. Gail;
- Palcza, John S.;
- Harris, Dawn E.;
- Butterfield, Kristin L.;
- Smith, William B.;
- Preston, Richard A.;
- Chodakewitz, Jeffrey A.;
- Krucoff, Mitchell W.
Publication type:
Article

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