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A journey into the regulatory secrets of the de novo purine nucleotide biosynthesis.
- Published in:
- Frontiers in Pharmacology, 2024, p. 1, doi. 10.3389/fphar.2024.1329011
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- Article
Identification of novel leishmanicidal molecules by virtual and biochemical screenings targeting Leishmania eukaryotic initiation factor 4A.
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- PLoS Neglected Tropical Diseases, 2018, v. 12, n. 1, p. 1, doi. 10.1371/journal.pntd.0006160
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- Article
Mycobacterium tuberculosis Thymidine Monophosphate Kinase Inhibitors: Biological Evaluation and Conformational Analysis of 2'- and 3'-Modified Thymidine Analogues.
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- European Journal of Organic Chemistry, 2003, v. 2003, n. 15, p. 2911, doi. 10.1002/ejoc.200300177
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- Article
A real‐time cell‐binding assay reveals dynamic features of STxB–Gb3 cointernalization and STxB‐mediated cargo delivery into cancer cells.
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- FEBS Letters, 2020, v. 594, n. 15, p. 2406, doi. 10.1002/1873-3468.13847
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Insight into the role of the Bateman domain at the molecular and physiological levels through engineered IMP dehydrogenases.
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- Protein Science: A Publication of the Protein Society, 2023, v. 32, n. 8, p. 1, doi. 10.1002/pro.4703
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- Article
Interaction network among de novo purine nucleotide biosynthesis enzymes in Escherichia coli.
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- FEBS Journal, 2023, v. 290, n. 12, p. 3165, doi. 10.1111/febs.16746
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Structural basis for the allosteric inhibition of UMP kinase from Gram‐positive bacteria, a promising antibacterial target.
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- FEBS Journal, 2022, v. 289, n. 16, p. 4869, doi. 10.1111/febs.16393
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Discovery of Bis-Imidazoline Derivatives as New CXCR4 Ligands.
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- Molecules, 2023, v. 28, n. 3, p. 1156, doi. 10.3390/molecules28031156
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- Article
1-(1-Arylethylpiperidin-4-yl)thymine Analogs as Antimycobacterial TMPK Inhibitors.
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- Molecules, 2020, v. 25, n. 12, p. 2805, doi. 10.3390/molecules25122805
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Novel Antiviral Molecules against Ebola Virus Infection.
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- International Journal of Molecular Sciences, 2023, v. 24, n. 19, p. 14791, doi. 10.3390/ijms241914791
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- Article
Inhibition of Pyrimidine Biosynthesis Pathway Suppresses Viral Growth through Innate Immunity.
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- PLoS Pathogens, 2013, v. 9, n. 10, p. 1, doi. 10.1371/journal.ppat.1003678
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- Article
Tetrahydro-2-furanyl-2,4(1 H,3H)-pyrimidinedione Derivatives as Novel Antibacterial Compounds against Mycobacterium.
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- International Journal of Mycobacteriology, 2017, v. 6, n. 1, p. 61, doi. 10.4103/2212-5531.201893
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- Article
The crystal structure of Mycobacterium tuberculosis adenylate kinase in complex with two molecules of ADP and Mg<sup>2+</sup> supports an associative mechanism for phosphoryl transfer.
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- Protein Science: A Publication of the Protein Society, 2006, v. 15, n. 6, p. 1489, doi. 10.1110/ps.062163406
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- Article
Thymidylate kinase of Mycobacterium tuberculosis: A chimera sharing properties common to eukaryotic and bacterial enzymes.
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- Protein Science: A Publication of the Protein Society, 2001, v. 10, n. 6, p. 1195, doi. 10.1110/ps.45701
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- Article
High Content Analysis of Primary Macrophages Hosting Proliferating Leishmania Amastigotes: Application to Anti-leishmanial Drug Discovery.
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- PLoS Neglected Tropical Diseases, 2013, v. 7, n. 4, p. 1, doi. 10.1371/journal.pntd.0002154
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- Article
High Content Analysis of Primary Macrophages Hosting Proliferating Leishmania Amastigotes: Application to Anti-leishmanial Drug Discovery.
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- PLoS Neglected Tropical Diseases, 2013, v. 7, n. 4, p. 1, doi. 10.1371/journal.pntd.0002154
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- Article
Activation de la réponse innée antivirale par des inhibiteurs de la biosynthèse des pyrimidines Les surprises d'un criblage phénotypique.
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- Médecine Sciences, 2015, v. 31, n. 1, p. 98, doi. 10.1051/medsci/20153101019
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- Article
Synergy of the antibiotic colistin with echinocandin antifungals in Candida species.
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- Journal of Antimicrobial Chemotherapy (JAC), 2013, v. 68, n. 6, p. 1285, doi. 10.1093/jac/dks538
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- Article
Replication of Equine arteritis virus is efficiently suppressed by purine and pyrimidine biosynthesis inhibitors.
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- Scientific Reports, 2020, v. 10, n. 1, p. 1, doi. 10.1038/s41598-020-66944-4
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AutomiG, a Biosensor to Detect Alterations in miRNA Biogenesis and in Small RNA Silencing Guided by Perfect Target Complementarity.
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- PLoS ONE, 2013, v. 8, n. 9, p. 1, doi. 10.1371/journal.pone.0074296
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Exploring Acyclic Nucleoside Analogues as Inhibitors of Mycobacterium tuberculosis Thymidylate Kinase.
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- ChemMedChem, 2008, v. 3, n. 7, p. 1083, doi. 10.1002/cmdc.200800060
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Synthesis and Biological Evaluation of Bicyclic Nucleosides as Inhibitors of M. tuberculosis Thymidylate Kinase.
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- ChemMedChem, 2006, v. 1, n. 10, p. 1081, doi. 10.1002/cmdc.200600028
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- Article
Unique GMP-binding site in Mycobacterium tuberculosis guanosine monophosphate kinase.
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- Proteins, 2006, v. 62, n. 2, p. 489, doi. 10.1002/prot.20662
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Structural and functional consequences of single amino acid substitutions in the pyrimidine base binding pocket of Escherichia coli CMP kinase.
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- FEBS Journal, 2007, v. 274, n. 13, p. 3363, doi. 10.1111/j.1742-4658.2007.05870.x
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Letter to the Editor: 1H, 13C and 15N resonance assignment and secondary structure of Mycobacterium tuberculosis adenylate kinase.
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- Journal of Biomolecular NMR, 2001, v. 19, n. 1, p. 89, doi. 10.1023/A:1008392515781
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- Article
SARS-CoV-2 Nsp3 unique domain SUD interacts with guanine quadruplexes and G4-ligands inhibit this interaction.
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- Nucleic Acids Research, 2021, v. 49, n. 13, p. 7695, doi. 10.1093/nar/gkab571
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Structural and functional characterization of the Mycobacterium tuberculosis uridine monophosphate kinase: insights into the allosteric regulation†.
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- Nucleic Acids Research, 2011, v. 39, n. 8, p. 3458, doi. 10.1093/nar/gkq1250
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A new subfamily of short bacterial adenylate kinases with the Mycobacterium tuberculosis enzyme as a model: A predictive and experimental study.
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- Proteins, 1999, v. 36, n. 2, p. 238, doi. 10.1002/(SICI)1097-0134(19990801)36:2<238::AID-PROT9>3.0.CO;2-K
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- Article
Comparative Study of Purine and Pyrimidine Nucleoside Analogues Acting on the Thymidylate Kinases of Mycobacterium tuberculosis and of Humans.
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- ChemBioChem, 2003, v. 4, n. 8, p. 742, doi. 10.1002/cbic.200300608
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- Article
Nucleoside Analogues as Inhibitors of Thymidylate Kinases: Possible Therapeutic Applications.
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- ChemBioChem, 2002, v. 3, n. 1, p. 108, doi. 10.1002/1439-7633(20020104)3:1<108::AID-CBIC108>3.0.CO;2-B
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An equine iPSC-based phenotypic screening platform identifies pro- and anti-viral molecules against West Nile virus.
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- Veterinary Research, 2024, v. 55, n. 1, p. 1, doi. 10.1186/s13567-024-01290-1
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Synthesis and Evaluation of 6-Aza-2′-deoxyuridine Monophosphate Analogs as Inhibitors of Thymidylate Synthases, and as Substrates or Inhibitors of Thymidine Monophosphate Kinase in Mycobacterium tuberculosis.
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- Chemistry & Biodiversity, 2012, v. 9, n. 3, p. 536, doi. 10.1002/cbdv.201100285
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Correction: Two Classes of Bacterial IMPDHs according to Their Quaternary Structures and Catalytic Properties.
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- PLoS ONE, 2015, v. 10, n. 4, p. 1, doi. 10.1371/journal.pone.0125884
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Two Classes of Bacterial IMPDHs according to Their Quaternary Structures and Catalytic Properties.
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- PLoS ONE, 2015, v. 10, n. 2, p. 1, doi. 10.1371/journal.pone.0116578
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Synthesis and evaluation of original bioisosteres of bacterial type IIA topoisomerases inhibitors.
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- Canadian Journal of Chemistry, 2016, v. 94, n. 3, p. 240, doi. 10.1139/cjc-2015-0475
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- Article