Works by Mugundu, Ganesh M.

Results: 15

Longitudinal Circulating Tumor DNA Modeling to Predict Disease Progression in First‐Line Mutant Epidermal Growth Factor Receptor Non‐Small Cell Lung Cancer.

Published in:

Clinical Pharmacology & Therapeutics, 2024, v. 115, n. 2, p. 349, doi. 10.1002/cpt.3113

By:

Johnson, Martin;
Serra Traynor, Carlos;
Vishwanathan, Karthick;
Overend, Philip;
Hartmaier, Ryan;
Markovets, Aleksandra;
Chmielecki, Juliann;
Mugundu, Ganesh M.;
Barrett, J. Carl;
Tomkinson, Helen;
Ramalingam, Suresh S.

Publication type:

Article

Phase I study to assess the effect of adavosertib (AZD1775) on the pharmacokinetics of substrates of CYP1A2, CYP2C19, and CYP3A in patients with advanced solid tumors.

Published in:

Cancer Chemotherapy & Pharmacology, 2023, v. 92, n. 3, p. 193, doi. 10.1007/s00280-023-04554-3

By:

Någård, Mats;
Ah-See, Mei-Lin;
Strauss, James;
Wise-Draper, Trisha;
Safran, Howard P.;
Nadeau, Laura;
Edenfield, William J.;
Lewis, Lionel D.;
Ottesen, Lone H.;
Li, Yan;
Mugundu, Ganesh M.

Publication type:

Article

Adavosertib (AZD1775) does not prolong the QTc interval in patients with advanced solid tumors: a phase I open-label study.

Published in:

Cancer Chemotherapy & Pharmacology, 2023, v. 92, n. 2, p. 141, doi. 10.1007/s00280-023-04555-2

By:

Någård, Mats;
Ah-See, Mei-Lin;
Strauss, James;
Wise-Draper, Trisha;
Safran, Howard P.;
Nadeau, Laura;
Edenfield, William J.;
Lewis, Lionel D.;
Rekić, Dinko;
Dota, Corina;
Ottesen, Lone H.;
Li, Yan;
Mugundu, Ganesh M.

Publication type:

Article

Open-Label, Multicenter, Phase I Study to Assess Safety and Tolerability of Adavosertib Plus Durvalumab in Patients with Advanced Solid Tumors: Adavosertib Plus Durvalumab for Solid Tumors: A Phase I Study: M.R. Patel et al.

Published in:

Targeted Oncology, 2025, v. 20, n. 1, p. 127, doi. 10.1007/s11523-024-01110-8

By:

Patel, Manish R.;
Falchook, Gerald S.;
Wang, Judy S.;
Imedio, Esteban Rodrigo;
Kumar, Sanjeev;
Miah, Kowser;
Mugundu, Ganesh M.;
Jones, Suzanne F.;
Spigel, David R.;
Hamilton, Erika P.

Publication type:

Article

Adavosertib in Combination with Olaparib in Patients with Refractory Solid Tumors: An Open-Label, Dose-Finding, and Dose-Expansion Phase Ib Trial.

Published in:

Targeted Oncology, 2024, v. 19, n. 6, p. 879, doi. 10.1007/s11523-024-01102-8

By:

Hamilton, Erika P.;
Falchook, Gerald S.;
Wang, Judy S.;
Fu, Siqing;
Oza, Amit M.;
Imedio, Esteban Rodrigo;
Kumar, Sanjeev;
Ottesen, Lone;
Mugundu, Ganesh M.;
de Bruin, Elza C.;
O'Connor, Mark J.;
Jones, Suzanne F.;
Spigel, David R.;
Li, Bob T.

Publication type:

Article

Safety, Pharmacokinetics, and Clinical Activity of Adavosertib in Combination with Chemotherapy in Asian Patients with Advanced Solid Tumors: Phase Ib Study.

Published in:

2020

By:

Kato, Hidenori;
de Souza, Paul;
Kim, Sang-We;
Lickliter, Jason D.;
Naito, Yoichi;
Park, Keunchil;
Kumar, Sanjeev;
Mugundu, Ganesh M.;
Bang, Yung-Jue

Publication type:

journal article

Quantification of human hepatocyte cytochrome P450 enzymes and transporters induced by HIV protease inhibitors using newly validated LC-MS/MS cocktail assays and RT-PCR.

Published in:

Biopharmaceutics & Drug Disposition, 2012, v. 33, n. 4, p. 207, doi. 10.1002/bdd.1788

By:

Liu, Li;
Mugundu, Ganesh M.;
Kirby, Brian J.;
Samineni, Divya;
Desai, Pankaj B.;
Unadkat, Jashvant D.

Publication type:

Article

A phase Ib study of adavosertib, a selective Wee1 inhibitor, in patients with locally advanced or metastatic solid tumors.

Published in:

Investigational New Drugs, 2023, v. 41, n. 3, p. 493, doi. 10.1007/s10637-023-01371-6

By:

Falchook, Gerald S;
Sachdev, Jasgit;
Imedio, Esteban Rodrigo;
Kumar, Sanjeev;
Mugundu, Ganesh M;
Jenkins, Suzanne;
Chmielecki, Juliann;
Jones, Suzanne;
Spigel, David R;
Johnson, Melissa

Publication type:

Article

Mechanistic Evaluation of Anti‐CD19 CAR‐T Cell Therapy Repurposed in Systemic Lupus Erythematosus Using a Quantitative Systems Pharmacology Model.

Published in:

CTS: Clinical & Translational Science, 2025, v. 18, n. 2, p. 1, doi. 10.1111/cts.70146

By:

Park, Hyunseo;
Mugundu, Ganesh M.;
Singh, Aman P.

Publication type:

Article

Translational PK–PD model for in vivo CAR‐T‐cell therapy delivered using CAR mRNA‐loaded polymeric nanoparticle vector.

Published in:

CTS: Clinical & Translational Science, 2024, v. 17, n. 12, p. 1, doi. 10.1111/cts.70101

By:

Kim, Se Jin;
Mugundu, Ganesh M.;
Singh, Aman P.

Publication type:

Article

The pharmacokinetics of acyl, des-acyl, and total ghrelin in healthy human subjects.

Published in:

European Journal of Endocrinology, 2013, v. 168, n. 6, p. 821, doi. 10.1530/EJE-13-0072

By:

Tong, Jenny;
Dave, Nimita;
Mugundu, Ganesh M.;
Davis, Harold W.;
Gaylinn, Bruce D.;
Thorner, Michael O.;
Tschöp, Matthias H.;
D'Alessio, David;
Desai, Pankaj B.

Publication type:

Article

Quantitative pharmacology of dual‐targeted bicistronic CAR‐T‐cell therapy using multiscale mechanistic modeling.

Published in:

CPT: Pharmacometrics & Systems Pharmacology, 2025, v. 14, n. 2, p. 229, doi. 10.1002/psp4.13259

By:

Su, Mei‐Chi;
Dey, Agnish;
Maddah, Erfan;
Mugundu, Ganesh M.;
Singh, Aman P.

Publication type:

Article

Development of a multiscale mechanistic modeling framework integrating differential cellular kinetics of CAR T‐cell subsets and immunophenotypes in cancer patients.

Published in:

CPT: Pharmacometrics & Systems Pharmacology, 2023, v. 12, n. 9, p. 1285, doi. 10.1002/psp4.13009

By:

Salem, Ahmed M.;
Mugundu, Ganesh M.;
Singh, Aman P.

Publication type:

Article

Population Pharmacokinetic Modeling of Adavosertib (AZD1775) in Patients with Solid Tumors.

Published in:

Journal of Clinical Pharmacology, 2024, v. 64, n. 11, p. 1419, doi. 10.1002/jcph.2492

By:

Johnson, Martin;
Kaschek, Daniel;
Ghiorghiu, Dana;
Lanke, Shankar;
Miah, Kowser;
Schmidt, Henning;
Mugundu, Ganesh M.

Publication type:

Article

Association between immune-mediated adverse events and efficacy in metastatic non-small-cell lung cancer patients treated with durvalumab and tremelimumab.

Published in:

Frontiers in Immunology, 2022, v. 13, p. 1, doi. 10.3389/fimmu.2022.1026964

By:

Dey, Agnish;
Austin, Matthew;
Kluger, Harriet M.;
Trunova, Nataliya;
Mann, Helen;
Shire, Norah;
Morgan, Claire;
Diansong Zhou;
Mugundu, Ganesh M.

Publication type:

Article