Works matching AU Moutal, Aubin

Results: 40

Genetic editing of primary human dorsal root ganglion neurons using CRISPR-Cas9.

Published in:

Scientific Reports, 2025, v. 15, n. 1, p. 1, doi. 10.1038/s41598-025-91153-2

By:

Palomino, Seph M.;
Gabriel, Katherin A.;
Mwirigi, Juliet M.;
Cervantes, Anna;
Horton, Peter;
Funk, Geoffrey;
Moutal, Aubin;
Martin, Laurent F.;
Khanna, Rajesh;
Price, Theodore J.;
Patwardhan, Amol

Publication type:

Article

Membrane lipid nanodomains modulate HCN pacemaker channels in nociceptor DRG neurons.

Published in:

Nature Communications, 2024, v. 15, n. 1, p. 1, doi. 10.1038/s41467-024-54053-z

By:

Handlin, Lucas J.;
Macchi, Natalie L.;
Dumaire, Nicolas L. A.;
Salih, Lyuba;
Lessie, Erin N.;
McCommis, Kyle S.;
Moutal, Aubin;
Dai, Gucan

Publication type:

Article

Membrane lipid nanodomains modulate HCN pacemaker channels in nociceptor DRG neurons.

Published in:

Nature Communications, 2024, v. 15, n. 1, p. 1, doi. 10.1038/s41467-024-54053-z

By:

Handlin, Lucas J.;
Macchi, Natalie L.;
Dumaire, Nicolas L. A.;
Salih, Lyuba;
Lessie, Erin N.;
McCommis, Kyle S.;
Moutal, Aubin;
Dai, Gucan

Publication type:

Article

Restoration of Kv7 Channel-Mediated Inhibition Reduces Cued-Reinstatement of Cocaine Seeking.

Published in:

Journal of Neuroscience, 2018, v. 38, n. 17, p. 4212, doi. 10.1523/JNEUROSCI.2767-17.2018

By:

Parrilla-Carrero, Jeffrey;
Buchta, William C.;
Goswamee, Priyodarshan;
Culver, Oliver;
McKendrick, Greer;
Harlan, Benjamin;
Moutal, Aubin;
Penrod, Rachel;
Lauer, Abigail;
Ramakrishnan, Viswanathan;
Khanna, Rajesh;
Kalivas, Peter;
Riegel, Arthur C.

Publication type:

Article

Targeting a Potassium Channel/Syntaxin Interaction Ameliorates Cell Death in Ischemic Stroke.

Published in:

Journal of Neuroscience, 2017, v. 37, n. 23, p. 5648, doi. 10.1523/JNEUROSCI.3811-16.2017

By:

Chung-Yang Yeh;
Bulas, Ashlyn M.;
Moutal, Aubin;
Saloman, Jami L.;
Hartnett, Karen A.;
Anderson, Charles T.;
Tzounopoulos, Thanos;
Dandan Sun;
Khanna, Rajesh;
Aizenman, Elias

Publication type:

Article

The functionalized amino acid (S)-Lacosamide subverts CRMP2-mediated tubulin polymerization to prevent constitutive and activity-dependent increase in neurite outgrowth.

Published in:

Frontiers in Cellular Neuroscience, 2014, p. 1, doi. 10.3389/fncel.2014.00196

By:

Sarah M.^Wilson;
Aubin^Moutal;
Melemedjian, Ohannes K.;
Yuying Wang;
Weina Ju;
François-Moutal, Liberty;
Khanna, May;
Khanna, Rajesh

Publication type:

Article

The functionalized amino acid (S)-Lacosamide subverts CRMP2-mediated tubulin polymerization to prevent constitutive and activity-dependent increase in neurite outgrowth.

Published in:

Frontiers in Cellular Neuroscience, 2014, v. 8, p. 1, doi. 10.3389/fncel.2014.00196

By:

Wilson, Sarah M.;
Moutal, Aubin;
Melemedjian, Ohannes K.;
Yuying Wang;
Weina Ju;
Francois-Moutal, Liberty;
Khanna, May;
Khanna, Rajesh

Publication type:

Article

Heat shock protein Grp78/BiP/HspA5 binds directly to TDP-43 and mitigates toxicity associated with disease pathology.

Published in:

Scientific Reports, 2022, v. 12, n. 1, p. 1, doi. 10.1038/s41598-022-12191-8

By:

François-Moutal, Liberty;
Scott, David Donald;
Ambrose, Andrew J.;
Zerio, Christopher J.;
Rodriguez-Sanchez, Marina;
Dissanayake, Kumara;
May, Danielle G.;
Carlson, Jacob M.;
Barbieri, Edward;
Moutal, Aubin;
Roux, Kyle J.;
Shorter, James;
Khanna, Rajesh;
Barmada, Sami J.;
McGurk, Leeanne;
Khanna, May

Publication type:

Article

Non-SUMOylated CRMP2 decreases NaV1.7 currents via the endocytic proteins Numb, Nedd4-2 and Eps15.

Published in:

Molecular Brain, 2021, v. 14, n. 1, p. 1, doi. 10.1186/s13041-020-00714-1

By:

Gomez, Kimberly;
Ran, Dongzhi;
Madura, Cynthia L.;
Moutal, Aubin;
Khanna, Rajesh

Publication type:

Article

Differential expression of Cdk5-phosphorylated CRMP2 following a spared nerve injury.

Published in:

Molecular Brain, 2020, v. 13, n. 1, p. 1, doi. 10.1186/s13041-020-00633-1

By:

Moutal, Aubin;
Ji, Yingshi;
Bellampalli, Shreya Sai;
Khanna, Rajesh

Publication type:

Article

1-O-Acetylgeopyxin A, a derivative of a fungal metabolite, blocks tetrodotoxin-sensitive voltage-gated sodium, calcium channels and neuronal excitability which correlates with inhibition of neuropathic pain.

Published in:

Molecular Brain, 2020, v. 13, n. 1, p. 1, doi. 10.1186/s13041-020-00616-2

By:

Zhou, Yuan;
Cai, Song;
Gomez, Kimberly;
Wijeratne, E. M. Kithsiri;
Ji, Yingshi;
Bellampalli, Shreya S.;
Luo, Shizhen;
Moutal, Aubin;
Gunatilaka, A. A. Leslie;
Khanna, Rajesh

Publication type:

Article

The natural product argentatin C attenuates postoperative pain via inhibition of voltage‐gated sodium and T‐type voltage‐gated calcium channels.

Published in:

British Journal of Pharmacology, 2023, v. 180, n. 9, p. 1267, doi. 10.1111/bph.15974

By:

Duran, Paz;
Loya‐López, Santiago;
Ran, Dongzhi;
Tang, Cheng;
Calderon‐Rivera, Aida;
Gomez, Kimberly;
Stratton, Harrison J.;
Huang, Sun;
Xu, Ya‐ming;
Wijeratne, E. M. Kithsiri;
Perez‐Miller, Samantha;
Shan, Zhiming;
Cai, Song;
Gabrielsen, Anna T.;
Dorame, Angie;
Masterson, Kyleigh A.;
Alsbiei, Omar;
Madura, Cynthia L.;
Luo, Guoqin;
Moutal, Aubin

Publication type:

Article

Homology-guided mutational analysis reveals the functional requirements for antinociceptive specificity of collapsin response mediator protein 2-derived peptides.

Published in:

2018

By:

Moutal, Aubin;
Li, Wennan;
Wang, Yue;
Ju, Weina;
Luo, Shizhen;
Cai, Song;
François‐Moutal, Liberty;
Perez‐Miller, Samantha;
Hu, Jackie;
Dustrude, Erik T.;
Vanderah, Todd W.;
Gokhale, Vijay;
Khanna, May;
Khanna, Rajesh;
François-Moutal, Liberty;
Perez-Miller, Samantha

Publication type:

journal article

The Effects of Repeated Morphine Treatment on the Endogenous Cannabinoid System in the Ventral Tegmental Area.

Published in:

Frontiers in Pharmacology, 2021, v. 11, p. N.PAG, doi. 10.3389/fphar.2021.632757

By:

Zhang, Hong;
Lipinski, Austin A.;
Liktor-Busa, Erika;
Smith, Angela F.;
Moutal, Aubin;
Khanna, Rajesh;
Langlais, Paul R.;
Largent-Milnes, Tally M.;
Vanderah, Todd W.

Publication type:

Article

TNF-α mediated upregulation of NaV1.7 currents in rat dorsal root ganglion neurons is independent of CRMP2 SUMOylation.

Published in:

Molecular Brain, 2019, v. 12, n. 1, p. 1, doi. 10.1186/s13041-019-0538-0

By:

de Macedo, Flávio Henrique Pequeno;
Aires, Rosária Dias;
Fonseca, Esdras Guedes;
Ferreira, Renata Cristina Mendes;
Machado, Daniel Portela Dias;
Chen, Lina;
Zhang, Fang-Xiong;
Souza, Ivana A.;
Lemos, Virgínia Soares;
Romero, Thiago Roberto Lima;
Moutal, Aubin;
Khanna, Rajesh;
Zamponi, Gerald W.;
Cruz, Jader S.

Publication type:

Article

Nociceptors are functionally male or female: from mouse to monkey to man.

Published in:

Brain: A Journal of Neurology, 2024, v. 147, n. 12, p. 4280, doi. 10.1093/brain/awae179

By:

Stratton, Harrison;
Lee, Grace;
Dolatyari, Mahdi;
Ghetti, Andre;
Cotta, Tamara;
Mitchell, Stefanie;
Yue, Xu;
Ibrahim, Mohab;
Dumaire, Nicolas;
Salih, Lyuba;
Moutal, Aubin;
François-Moutal, Liberty;
Martin, Laurent;
Navratilova, Edita;
Porreca, Frank

Publication type:

Article

Chronic pain recruits hypothalamic dynorphin/kappa opioid receptor signalling to promote wakefulness and vigilance.

Published in:

Brain: A Journal of Neurology, 2023, v. 146, n. 3, p. 1186, doi. 10.1093/brain/awac153

By:

Ito, Hisakatsu;
Navratilova, Edita;
Vagnerova, Barbora;
Watanabe, Moe;
Kopruszinski, Carol;
Souza, Luiz H Moreira de;
Yue, Xu;
Ikegami, Daigo;
Moutal, Aubin;
Patwardhan, Amol;
Khanna, Rajesh;
Yamazaki, Mitsuaki;
Guerrero, Miguel;
Rosen, Hugh;
Roberts, Ed;
Neugebauer, Volker;
Dodick, David W;
Porreca, Frank

Publication type:

Article

Dysregulation of serum prolactin links the hypothalamus with female nociceptors to promote migraine.

Published in:

2022

By:

Watanabe, Moe;
Kopruszinski, Caroline M;
Moutal, Aubin;
Ikegami, Daigo;
Khanna, Rajesh;
Chen, Yanxia;
Ross, Sarah;
Mackenzie, Kimberly;
Stratton, Jennifer;
Dodick, David W;
Navratilova, Edita;
Porreca, Frank

Publication type:

journal article

Editorial: Complementary/Alternative Therapies for Epilepsy and Related Psychiatric Comorbidities.

Published in:

Frontiers in Neuroscience, 2022, v. 16, p. 1, doi. 10.3389/fnins.2022.947644

By:

Xu, Zhenghao;
Wang, Yi;
Moutal, Aubin

Publication type:

Article

Dynamic CRMP2 Regulation of CaV2.2 in the Prefrontal Cortex Contributes to the Reinstatement of Cocaine Seeking.

Published in:

Molecular Neurobiology, 2020, v. 57, n. 1, p. 346, doi. 10.1007/s12035-019-01711-9

By:

Buchta, William C.;
Moutal, Aubin;
Hines, Bethany;
Garcia-Keller, Constanza;
Smith, Alexander C. W.;
Kalivas, Peter;
Khanna, Rajesh;
Riegel, Arthur C.

Publication type:

Article

Dysregulation of CRMP2 Post-Translational Modifications Drive Its Pathological Functions.

Published in:

Molecular Neurobiology, 2019, v. 56, n. 10, p. 6736, doi. 10.1007/s12035-019-1568-4

By:

Moutal, Aubin;
White, Katherine A.;
Chefdeville, Aude;
Laufmann, Rachel N.;
Vitiello, Peter F.;
Feinstein, Douglas;
Weimer, Jill M.;
Khanna, Rajesh

Publication type:

Article

Phosphorylated CRMP2 Regulates Spinal Nociceptive Neurotransmission.

Published in:

Molecular Neurobiology, 2019, v. 56, n. 7, p. 5241, doi. 10.1007/s12035-018-1445-6

By:

Yu, Jie;
Moutal, Aubin;
Dorame, Angie;
Bellampalli, Shreya S.;
Chefdeville, Aude;
Kanazawa, Iori;
Pham, Nancy Y. N.;
Park, Ki Duk;
Weimer, Jill M.;
Khanna, Rajesh

Publication type:

Article

CRMP2 Phosphorylation Drives Glioblastoma Cell Proliferation.

Published in:

Molecular Neurobiology, 2018, v. 55, n. 5, p. 4403, doi. 10.1007/s12035-017-0653-9

By:

Moutal, Aubin;
Villa, Lex Salas;
Yeon, Seul Ki;
Householder, Kyle T.;
Park, Ki Duk;
Sirianni, Rachael W.;
Khanna, Rajesh

Publication type:

Article

Sensitization of Ion Channels Contributes to Central and Peripheral Dysfunction in Neurofibromatosis Type 1.

Published in:

Molecular Neurobiology, 2017, v. 54, n. 5, p. 3342, doi. 10.1007/s12035-016-9907-1

By:

Moutal, Aubin;
Dustrude, Erik;
Khanna, Rajesh

Publication type:

Article

( S)-Lacosamide Binding to Collapsin Response Mediator Protein 2 (CRMP2) Regulates CaV2.2 Activity by Subverting Its Phosphorylation by Cdk5.

Published in:

Molecular Neurobiology, 2016, v. 53, n. 3, p. 1959, doi. 10.1007/s12035-015-9141-2

By:

Moutal, Aubin;
François-Moutal, Liberty;
Perez-Miller, Samantha;
Cottier, Karissa;
Chew, Lindsey;
Yeon, Seul;
Dai, Jixun;
Park, Ki;
Khanna, May;
Khanna, Rajesh

Publication type:

Article

Heat shock protein Grp78/BiP/HspA5 binds directly to TDP-43 and mitigates toxicity associated with disease pathology.

Published in:

Scientific Reports, 2022, v. 12, n. 1, p. 1, doi. 10.1038/s41598-022-12191-8

By:

François-Moutal, Liberty;
Scott, David Donald;
Ambrose, Andrew J.;
Zerio, Christopher J.;
Rodriguez-Sanchez, Marina;
Dissanayake, Kumara;
May, Danielle G.;
Carlson, Jacob M.;
Barbieri, Edward;
Moutal, Aubin;
Roux, Kyle J.;
Shorter, James;
Khanna, Rajesh;
Barmada, Sami J.;
McGurk, Leeanne;
Khanna, May

Publication type:

Article

Selective targeting of NaV1.7 via inhibition of the CRMP2-Ubc9 interaction reduces pain in rodents.

Published in:

Science Translational Medicine, 2021, v. 13, n. 619, p. 1, doi. 10.1126/scitranslmed.abh1314

By:

Cai, Song;
Moutal, Aubin;
Yu, Jie;
Chew, Lindsey A.;
Isensee, Jörg;
Chawla, Reena;
Gomez, Kimberly;
Luo, Shizhen;
Zhou, Yuan;
Chefdeville, Aude;
Madura, Cynthia;
Perez-Miller, Samantha;
Bellampalli, Shreya Sai;
Dorame, Angie;
Scott, David D.;
François-Moutal, Liberty;
Shan, Zhiming;
Woodward, Taylor;
Gokhale, Vijay;
Hohmann, Andrea G.

Publication type:

Article

The prolactin receptor long isoform regulates nociceptor sensitization and opioid-induced hyperalgesia selectively in females.

Published in:

Science Translational Medicine, 2020, v. 12, n. 529, p. 1, doi. 10.1126/scitranslmed.aay7550

By:

Chen, Yanxia;
Moutal, Aubin;
Navratilova, Edita;
Kopruszinski, Caroline;
Yue, Xu;
Ikegami, Megumi;
Chow, Michele;
Kanazawa, Iori;
Bellampalli, Shreya Sai;
Xie, Jennifer;
Patwardhan, Amol;
Rice, Kenner;
Fields, Howard;
Akopian, Armen;
Neugebauer, Volker;
Dodick, David;
Khanna, Rajesh;
Porreca, Frank

Publication type:

Article

Neuronal CRMP2 phosphorylation inhibition by the flavonoid, naringenin, contributes to the reversal of spinal sensitization and arthritic pain improvement.

Published in:

Arthritis Research & Therapy, 2022, v. 24, n. 1, p. 1, doi. 10.1186/s13075-022-02975-8

By:

Jiang, Yue-Peng;
Wang, Song;
Lai, Wei-Dong;
Wu, Xue-Qing;
Jin, Yan;
Xu, Zheng-Hao;
Moutal, Aubin;
Khanna, Rajesh;
Park, Ki Duk;
Shan, Zhi-Ming;
Wen, Cheng-Ping;
Yu, Jie

Publication type:

Article

Differential neuroprotective potential of CRMP2 peptide aptamers conjugated to cationic, hydrophobic, and amphipathic cell penetrating peptides.

Published in:

Frontiers in Cellular Neuroscience, 2015, v. 8/9, p. 1, doi. 10.3389/fncel.2014.00471

By:

Moutal, Aubin;
François-Moutal, Liberty;
Brittain, Joel M.;
Khanna, May;
Khanna, Rajesh

Publication type:

Article

Neuronal Conditional Knockout of Collapsin Response Mediator Protein 2 Ameliorates Disease Severity in a Mouse Model of Multiple Sclerosis.

Published in:

ASN Neuro, 2019, v. 11, p. N.PAG, doi. 10.1177/1759091419892090

By:

Moutal, Aubin;
Kalinin, Sergey;
Kowal, Kathy;
Marangoni, Natalia;
Dupree, Jeffrey;
Lin, Shao Xia;
Lis, Kinga;
Lisi, Lucia;
Hensley, Kenneth;
Khanna, Rajesh;
Feinstein, Douglas L.

Publication type:

Article

Cortical kappa opioid receptors integrate negative affect and sleep disturbance.

Published in:

Translational Psychiatry, 2024, v. 14, n. 1, p. 1, doi. 10.1038/s41398-024-03123-3

By:

Lillo Vizin, Robson C.;
Ito, Hisakatsu;
Kopruszinski, Caroline M.;
Ikegami, Megumi;
Ikegami, Daigo;
Yue, Xu;
Navratilova, Edita;
Moutal, Aubin;
Cowen, Stephen L.;
Porreca, Frank

Publication type:

Article

A male-specific mechanism of meningeal nociceptor sensitization promoting migraine headache.

Published in:

Cephalalgia, 2024, v. 44, n. 9, p. 1, doi. 10.1177/03331024241281493

By:

Kopruszinski, Caroline M.;
Lee, Grace;
Martin, Laurent K.;
Barber, Kara R.;
Moutal, Aubin;
Dodick, David W.;
Navratilova, Edita;
Porreca, Frank

Publication type:

Article

A prolactin-dependent sexually dimorphic mechanism of migraine chronification.

Published in:

Cephalalgia, 2022, v. 42, n. 3, p. 197, doi. 10.1177/03331024211039813

By:

Ikegami, Daigo;
Navratilova, Edita;
Yue, Xu;
Moutal, Aubin;
Kopruszinski, Caroline M;
Khanna, Rajesh;
Patwardhan, Amol;
Dodick, David W;
Porreca, Frank

Publication type:

Article

Comparison of quinazoline and benzoylpyrazoline chemotypes targeting the CaVα-β interaction as antagonists of the N-type CaV2.2 channel.

Published in:

Channels (19336950), 2021, v. 15, n. 1, p. 128, doi. 10.1080/19336950.2020.1863595

By:

Ran, Dongzhi;
Gomez, Kimberly;
Moutal, Aubin;
Patek, Marcel;
Perez-Miller, Samantha;
Khanna, Rajesh

Publication type:

Article

Evaluation of edonerpic maleate as a CRMP2 inhibitor for pain relief.

Published in:

Channels (19336950), 2019, v. 13, n. 1, p. 498, doi. 10.1080/19336950.2019.1684608

By:

Moutal, Aubin;
Shan, Zhiming;
Miranda, Victor G.;
François-Moutal, Liberty;
Madura, Cynthia L.;
Khanna, May;
Khanna, Rajesh

Publication type:

Article

Activity of T-type calcium channels is independent of CRMP2 in sensory neurons.

Published in:

Channels (19336950), 2019, v. 13, n. 1, p. 147, doi. 10.1080/19336950.2019.1608129

By:

Cai, Song;
Shan, Zhiming;
Zhang, Zhongjun;
Moutal, Aubin;
Khanna, Rajesh

Publication type:

Article

CRMP2 is necessary for Neurofibromatosis type 1 related pain.

Published in:

Channels (19336950), 2018, v. 12, n. 1, p. 47, doi. 10.1080/19336950.2017.1370524

By:

Moutal, Aubin;
Cai, Song;
Luo, Shizhen;
Voisin, Raphaëlle;
Khanna, Rajesh

Publication type:

Article

A single structurally conserved SUMOylation site in CRMP2 controls NaV1.7 function.

Published in:

Channels (19336950), 2017, v. 11, n. 4, p. 316, doi. 10.1080/19336950.2017.1299838

By:

Dustrude, Erik Thomas;
Perez-Miller, Samantha;
François-Moutal, Liberty;
Moutal, Aubin;
Khanna, May;
Khanna, Rajesh

Publication type:

Article

Transcriptional regulation of CRMP5 controls neurite outgrowth through Sox5.

Published in:

Cellular & Molecular Life Sciences, 2018, v. 75, n. 1, p. 67, doi. 10.1007/s00018-017-2634-6

By:

Naudet, Nicolas;
Moutal, Aubin;
Vu, Hong Nhung;
Chounlamountri, Naura;
Watrin, Chantal;
Cavagna, Sylvie;
Malleval, Céline;
Benetollo, Claire;
Bardel, Claire;
Dronne, Marie-Aimée;
Honnorat, Jérôme;
Meissirel, Claire;
Besançon, Roger

Publication type:

Article