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"Getting the Dose Right"—Revisiting the Topic With Focus on Biologic Agents.
- Published in:
- Clinical Pharmacology & Therapeutics, 2024, v. 116, n. 3, p. 613, doi. 10.1002/cpt.3285
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- Article
Comparative Analysis of Posiphen Pharmacokinetics across Different Species—Similar Absorption and Metabolism in Mouse, Rat, Dog and Human.
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- Biomolecules (2218-273X), 2024, v. 14, n. 5, p. 582, doi. 10.3390/biom14050582
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- Article
Development of a Weight-Band Dosing Approach for Vosoritide in Children with Achondroplasia Using a Population Pharmacokinetic Model.
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- Clinical Pharmacokinetics, 2024, v. 63, n. 5, p. 707, doi. 10.1007/s40262-024-01371-6
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- Article
Application of a Precision‐Dosing Model to a Real‐World Cohort of Patients on Infliximab Maintenance Therapy: Drug Usage and Cost Analysis.
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- Journal of Clinical Pharmacology, 2024, v. 64, n. 4, p. 399, doi. 10.1002/jcph.2384
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- Article
Tumor growth inhibition modeling in patients with second line biliary tract cancer and first line non‐small cell lung cancer based on bintrafusp alfa trials.
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- CPT: Pharmacometrics & Systems Pharmacology, 2024, v. 13, n. 1, p. 143, doi. 10.1002/psp4.13068
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- Article
Personalized Dosing of Infliximab in Patients With Inflammatory Bowel Disease Using a Bayesian Approach: A Next Step in Therapeutic Drug Monitoring.
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- Journal of Clinical Pharmacology, 2023, v. 63, n. 4, p. 480, doi. 10.1002/jcph.2189
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- Article
Effect of Pevonedistat, an Investigational NEDD8‐Activating Enzyme Inhibitor, on the QTc Interval in Patients With Advanced Solid Tumors.
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- Clinical Pharmacology in Drug Development, 2023, v. 12, n. 3, p. 257, doi. 10.1002/cpdd.1194
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- Article
Model Informed Precision Dosing Tool Forecasts Trough Infliximab and Associates with Disease Status and Tumor Necrosis Factor-Alpha Levels of Inflammatory Bowel Diseases.
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- Journal of Clinical Medicine, 2022, v. 11, n. 12, p. 3316, doi. 10.3390/jcm11123316
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- Article
Population Pharmacokinetics and Exposure‐Safety Relationships of Alisertib in Children and Adolescents With Advanced Malignancies.
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- Journal of Clinical Pharmacology, 2022, v. 62, n. 2, p. 206, doi. 10.1002/jcph.1958
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- Article
Limited Systemic Exposure with Topical Glycopyrronium Tosylate in Primary Axillary Hyperhidrosis.
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- Clinical Pharmacokinetics, 2021, v. 60, n. 5, p. 665, doi. 10.1007/s40262-020-00975-y
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- Article
Approaches to handling missing or "problematic" pharmacology data: Pharmacokinetics.
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- CPT: Pharmacometrics & Systems Pharmacology, 2021, v. 10, n. 4, p. 291, doi. 10.1002/psp4.12611
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- Article
Correction to: Optimization of infliximab therapy in inflammatory bowel disease using a dashboard approach—an Indian experience.
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- European Journal of Clinical Pharmacology, 2021, v. 77, n. 2, p. 273, doi. 10.1007/s00228-020-02989-8
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- Article
Increased Induction Infliximab Clearance Predicts Early Antidrug Antibody Detection.
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- Journal of Clinical Pharmacology, 2021, v. 61, n. 2, p. 224, doi. 10.1002/jcph.1732
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- Article
Optimization of infliximab therapy in inflammatory bowel disease using a dashboard approach—an Indian experience.
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- European Journal of Clinical Pharmacology, 2021, v. 77, n. 1, p. 55, doi. 10.1007/s00228-020-02975-0
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- Article
Population Pharmacokinetics of Brentuximab Vedotin in Adult and Pediatric Patients With Relapsed/Refractory Hematologic Malignancies: Model‐Informed Hypothesis Generation for Pediatric Dosing Regimens.
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- Journal of Clinical Pharmacology, 2020, v. 60, n. 12, p. 1585, doi. 10.1002/jcph.1682
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- Article
Development and Implementation of Electronic Health Record–Integrated Model‐Informed Clinical Decision Support Tools for the Precision Dosing of Drugs.
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- Clinical Pharmacology & Therapeutics, 2020, v. 107, n. 1, p. 129, doi. 10.1002/cpt.1679
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- Article
Population Pharmacokinetic Modeling of Mogamulizumab in Adults With Cutaneous T‐Cell Lymphoma or Adult T‐Cell Lymphoma.
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- Journal of Clinical Pharmacology, 2020, v. 60, n. 1, p. 58, doi. 10.1002/jcph.1564
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- Article
Population Pharmacokinetic Modeling and Exposure–Response Assessment for the Antibody‐Drug Conjugate Brentuximab Vedotin in Hodgkin's Lymphoma in the Phase III ECHELON‐1 Study.
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- Clinical Pharmacology & Therapeutics, 2019, v. 106, n. 6, p. 1268, doi. 10.1002/cpt.1530
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- Article
Population pharmacokinetics of pevonedistat alone or in combination with standard of care in patients with solid tumours or haematological malignancies.
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- British Journal of Clinical Pharmacology, 2019, v. 85, n. 11, p. 2568, doi. 10.1111/bcp.14078
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- Article
Pharmacokinetic and Pharmacodynamic Effects of Oral CXA‐10, a Nitro Fatty Acid, After Single and Multiple Ascending Doses in Healthy and Obese Subjects.
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- CTS: Clinical & Translational Science, 2019, v. 12, n. 6, p. 667, doi. 10.1111/cts.12672
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- Article
Individualized Dosing of Therapeutic Monoclonal Antibodies—a Changing Treatment Paradigm?
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- AAPS Journal, 2018, v. 20, n. 6, p. 1, doi. 10.1208/s12248-018-0257-y
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- Article
Population PK and Exposure–Response Relationships for the Antibody–Drug Conjugate Brentuximab Vedotin in CTCL Patients in the Phase III ALCANZA Study.
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- Clinical Pharmacology & Therapeutics, 2018, v. 104, n. 5, p. 989, doi. 10.1002/cpt.1037
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- Article
Pharmacokinetic‐Pharmacodynamic Model of Neutropenia in Patients With Myeloma Receiving High‐Dose Melphalan for Autologous Stem Cell Transplant.
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- CPT: Pharmacometrics & Systems Pharmacology, 2018, v. 7, n. 11, p. 748, doi. 10.1002/psp4.12345
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Dashboards for Therapeutic Monoclonal Antibodies: Learning and Confirming.
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- AAPS Journal, 2018, v. 20, n. 4, p. 1, doi. 10.1208/s12248-018-0237-2
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- Article
Exposure–response characterization of tofacitinib efficacy in moderate to severe ulcerative colitis: Results from a dose‐ranging phase 2 trial.
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- British Journal of Clinical Pharmacology, 2018, v. 84, n. 6, p. 1136, doi. 10.1111/bcp.13523
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- Article
Prediction of Individual Serum Infliximab Concentrations in Inflammatory Bowel Disease by a Bayesian Dashboard System.
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- Journal of Clinical Pharmacology, 2018, v. 58, n. 6, p. 790, doi. 10.1002/jcph.1069
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- Article
Accelerated Clearance of Infliximab is Associated With Treatment Failure in Patients With Corticosteroid-Refractory Acute Ulcerative Colitis.
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- Journal of Crohn's & Colitis, 2018, v. 12, n. 6, p. 662, doi. 10.1093/ecco-jcc/jjy028
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- Article
Effect of alisertib, an investigational aurora a kinase inhibitor on the QTc interval in patients with advanced malignancies.
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- Investigational New Drugs, 2018, v. 36, n. 2, p. 240, doi. 10.1007/s10637-017-0498-0
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- Article
Global population pharmacokinetics of the investigational Aurora A kinase inhibitor alisertib in cancer patients: rationale for lower dosage in Asia.
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- British Journal of Clinical Pharmacology, 2018, v. 84, n. 1, p. 35, doi. 10.1111/bcp.13430
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- Article
Accounting for Pharmacokinetic Variability of Certolizumab Pegol in Patients with Crohn's Disease.
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- 2017
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- journal article
Critical Considerations in Anticancer Drug Development and Dosing Strategies: The Past, Present, and Future.
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- Journal of Clinical Pharmacology, 2017, v. 57, p. S116, doi. 10.1002/jcph.983
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- Article
Population Pharmacokinetic Analysis of Bortezomib in Pediatric Leukemia Patients: Model-Based Support for Body Surface Area-Based Dosing Over the 2- to 16-Year Age Range.
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- Journal of Clinical Pharmacology, 2017, v. 57, n. 9, p. 1183, doi. 10.1002/jcph.906
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- Article
Efficacy, safety and population pharmacokinetics of sapropterin in PKU patients <4 years: results from the SPARK open-label, multicentre, randomized phase IIIb trial.
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- 2017
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- Publication type:
- journal article
A Randomized Study Evaluating Oral Fusidic Acid (CEM-102) in Combination With Oral Rifampin Compared With Standard-of-Care Antibiotics for Treatment of Prosthetic Joint Infections: A Newly Identified Drug-Drug Interaction.
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- Clinical Infectious Diseases, 2016, v. 63, n. 12, p. 1599, doi. 10.1093/cid/ciw665
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- Article
Lack of effect of smoking status on axitinib pharmacokinetics in patients with non-small-cell lung cancer.
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- 2016
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- Publication type:
- journal article
Using Population Pharmacokinetic and Pharmacodynamic Analyses of Entecavir in Pediatric Subjects to Simplify Dosing Recommendations.
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- 2016
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- Publication type:
- journal article
Assessment of hemoglobin responsiveness to epoetin alfa in patients on hemodialysis using a population pharmacokinetic pharmacodynamic model.
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- Journal of Clinical Pharmacology, 2015, v. 55, n. 10, p. 1157, doi. 10.1002/jcph.527
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- Article
The Pharmacokinetics of Biologics: A Primer.
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- Digestive Diseases, 2015, v. 33, p. 61, doi. 10.1159/000437077
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- Article
Helicobacter pylori treatment in children: Defining a dose for rabeprazole as a part of a triple therapy regimen.
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- Journal of Clinical Pharmacology, 2015, v. 55, n. 5, p. 592, doi. 10.1002/jcph.457
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- Article
Dashboard systems: Pharmacokinetic/pharmacodynamic mediated dose optimization for monoclonal antibodies.
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- Journal of Clinical Pharmacology, 2015, v. 55, p. S51, doi. 10.1002/jcph.370
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- Article
Dose Selection for the Investigational Anticancer Agent Alisertib (MLN8237): Pharmacokinetics, Pharmacodynamics, and Exposure-Safety Relationships.
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- Journal of Clinical Pharmacology, 2015, v. 55, n. 3, p. 336, doi. 10.1002/jcph.410
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- Article
New tools and approaches for improved management of inflammatory bowel diseases.
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- Journal of Crohn's & Colitis, 2014, v. 8, n. 10, p. 1246, doi. 10.1016/j.crohns.2014.02.026
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- Article
Population pharmacokinetics of azithromycin and chloroquine in healthy adults and paediatric malaria subjects following oral administration of fixed-dose azithromycin and chloroquine combination tablets.
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- Malaria Journal, 2014, v. 13, n. 1, p. 1, doi. 10.1186/1475-2875-13-36
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- Article
Romiplostim dose-response in patients with myelodysplastic syndromes.
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- British Journal of Clinical Pharmacology, 2013, v. 75, n. 6, p. 1445, doi. 10.1111/bcp.12041
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- Article
Population pharmacokinetic analysis of sorafenib in patients with solid tumours.
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- British Journal of Clinical Pharmacology, 2011, v. 72, n. 2, p. 294, doi. 10.1111/j.1365-2125.2011.03963.x
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- Article
Dose Proportionality of Once-Daily Trazodone Extended-Release Caplets Under Fasting Conditions.
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- Journal of Clinical Pharmacology, 2010, v. 50, n. 12, p. 1438, doi. 10.1177/0091270009360979
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- Article
Population Pharmacokinetic-Pharmacodynamic Modeling of Biological Agents: When Modeling Meets Reality.
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- Journal of Clinical Pharmacology, 2010, v. 50, n. 9, p. 91S, doi. 10.1177/0091270010376965
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- Article
Pharmacokinetics and Pharmacodynamics of Monoclonal Antibodies: Concepts and Lessons for Drug Development.
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- BioDrugs, 2010, v. 24, n. 1, p. 23, doi. 10.2165/11530560-000000000-00000
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- Article
Population pharmacokinetic analysis of carboxyhaemoglobin concentrations in adult cigarette smokers.
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- British Journal of Clinical Pharmacology, 2008, v. 65, n. 1, p. 30, doi. 10.1111/j.1365-2125.2007.02974.x
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- Article
Pralatrexate, a novel class of antifol with high affinity for the reduced folate carrier-type 1, produces marked complete and durable remissions in a diversity of chemotherapy refractory cases of T-cell lymphoma.
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- British Journal of Haematology, 2007, v. 139, n. 3, p. 425, doi. 10.1111/j.1365-2141.2007.06658.x
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- Article