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In Vitro and In Vivo Pharmacological Comparison of Mu‐Opioid Receptor Activity of the Kratom (Mitragyna speciosa) Alkaloid Mitragynine and its Metabolite 7‐Hydroxymitragynine.
Published in:
Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2021, v. 17, p. 1, doi. 10.1002/alz.058605
By:
- Calvache, Maria P Guerrero;
- Obeng, Samuel;
- Leon, Francisco;
- Gamez‐Jimenez, Lea R;
- Patel, Avi;
- Ho, Nicholas P;
- Crowley, Morgan L;
- Pallares, Victoria;
- Mottinelli, Marco;
- McCurdy, Christopher R;
- McMahon, Lance R;
- Hiranita, Takato
Publication type:
Article
N‐Phenyl‐1,2,3,4‐tetrahydroisoquinoline: An Alternative Scaffold for the Design of 17β‐Hydroxysteroid Dehydrogenase 1 Inhibitors.
Published in:
ChemMedChem, 2021, v. 16, n. 1, p. 259, doi. 10.1002/cmdc.202000762
By:
- Mottinelli, Marco;
- Sinreih, Maša;
- Rižner, Tea L.;
- Leese, Mathew P.;
- Potter, Barry V. L.
Publication type:
Article
Metabolism of Speciociliatine, an Overlooked Kratom Alkaloid for its Potential Pharmacological Effects.
Published in:
AAPS Journal, 2022, v. 24, n. 5, p. 1, doi. 10.1208/s12248-022-00736-8
By:
- Kamble, Shyam H.;
- Berthold, Erin C.;
- Kanumuri, Siva Rama Raju;
- King, Tamara I.;
- Kuntz, Michelle A.;
- León, Francisco;
- Mottinelli, Marco;
- McMahon, Lance R.;
- McCurdy, Christopher R.;
- Sharma, Abhisheak
Publication type:
Article
Characterization of CM-398, a Novel Selective Sigma-2 Receptor Ligand, as a Potential Therapeutic for Neuropathic Pain.
Published in:
Molecules, 2022, v. 27, n. 11, p. 3617, doi. 10.3390/molecules27113617
By:
- Wilson, Lisa L.;
- Alleyne, Amy R.;
- Eans, Shainnel O.;
- Cirino, Thomas J.;
- Stacy, Heather M.;
- Mottinelli, Marco;
- Intagliata, Sebastiano;
- McCurdy, Christopher R.;
- McLaughlin, Jay P.
Publication type:
Article
Mitragynine Reverses Paclitaxel Chemotherapy‐Induced Peripheral Neuropathy and is Mediated via Opioid Receptor Involvement.
Published in:
FASEB Journal, 2022, v. 36, p. N.PAG, doi. 10.1096/fasebj.2022.36.S1.0R851
By:
- Ortiz, Yuma;
- Mottinelli, Marco;
- McCurdy, Christopher;
- McMahon, Lance;
- Wilkerson, Jenny
Publication type:
Article
Probing the Activity of Mitragyna Speciosa (Kratom) Alkaloids at Serotonin G Protein‐Coupled Receptors.
Published in:
FASEB Journal, 2022, v. 36, p. N.PAG, doi. 10.1096/fasebj.2022.36.S1.R2407
By:
- Chen, Yiming;
- McCurdy, Christopher;
- Mottinelli, Marco;
- Canal, Clinton
Publication type:
Article
Effects of Mitragynine and its Active Metabolites on the Reinforcing Effects of Remifentanil and Cocaine in Rats Self‐Administering Remifentanil.
Published in:
FASEB Journal, 2022, v. 36, p. N.PAG, doi. 10.1096/fasebj.2022.36.S1.R5776
By:
- Hiranita, Takato;
- Zuarth Gonzalez, Julio;
- Patel, Rohan C.;
- Mazpule‐Carrigan, Christian C.;
- Martins Rocha, Joelma;
- Gamez Jimenez, Lea R.;
- Ho, Nicholas P.;
- Patel, Avi;
- Obeng, Samuel;
- Leon, Francisco;
- Mottinelli, Marco;
- Mukhopadhyay, Sushobhan;
- McCurdy, Christopher R.;
- McMahon, Lance R.
Publication type:
Article
Serotonin 5‐HT<sub>1A</sub> Receptor Activity of Kratom Alkaloids Mitragynine, Paynantheine, and Speciogynine.
Published in:
FASEB Journal, 2021, v. 35, p. N.PAG, doi. 10.1096/fasebj.2021.35.S1.04764
By:
- Obeng, Samuel;
- León, Francisco;
- Patel, Avi;
- Restrepo, Luis;
- Gamez‐Jimenez, Lea;
- Zuarth Gonzalez, Julio;
- Pallares, Victoria;
- Mottinelli, Marco;
- Lopera‐Londoño, Carolina;
- McCurdy, Christopher;
- McMahon, Lance;
- Hiranita, Takato
Publication type:
Article
Pharmacological Characterization of Mitragynine: Antinociception, Respiratory Depression, Self‐Administration, Drug Discrimination, Tolerance, and withdrawal in Rats.
Published in:
FASEB Journal, 2021, v. 35, p. N.PAG, doi. 10.1096/fasebj.2021.35.S1.02725
By:
- Hiranita, Takato;
- Zuarth Gonzalez, Julio;
- Patel, Avi;
- Restrepo, Luis;
- Mazpule‐Carrigan, Christian;
- Leon, Francisco;
- Mottinelli, Marco;
- Gamez Jimenez, Lea;
- Ho, Nicholas;
- Patel, Rohan;
- Obeng, Samuel;
- McCurdy, Christopher;
- McMahon, Lance
Publication type:
Article
Mitragynine Attenuates the Development of Tolerance to and Withdrawal from Morphine in Rats.
Published in:
FASEB Journal, 2021, v. 35, p. N.PAG, doi. 10.1096/fasebj.2021.35.S1.05506
By:
- Zuarth Gonzalez, Julio;
- Patel, Avi;
- Patel, Rohan;
- Patel, Megan;
- Gamez Jimenez, Lea;
- Ho, Nicholas;
- Leon, Francisco;
- Mottinelli, Marco;
- McCurdy, Christopher;
- McMahon, Lance;
- Hiranita, Takato
Publication type:
Article
Assessment of Contribution of 7‐Hydroxymitragynine and Mitragynine Pseudoindoxyl to the MU‐Opioid Activity of Mitragynine.
Published in:
FASEB Journal, 2021, v. 35, p. N.PAG, doi. 10.1096/fasebj.2021.35.S1.05475
By:
- Crowley, Morgan;
- Obeng, Samuel;
- Patel, Avi;
- Gamez‐Jimenez, Lea;
- Restrepo, Luis;
- Ho, Nicholas;
- Alvarez, Manuel;
- Thadisetti, Amsha;
- Kern, Elizabeth;
- Pallares, Victoria;
- Leon, Francisco;
- Mottinelli, Marco;
- Zuarth Gonzalez, Julio;
- McCurdy, Christopher;
- McMahon, Lance;
- Hiranita, Takato
Publication type:
Article
The Lofexidine‐Like Discriminative Effects of the Primary Kratom Alkaloid Mitragynine in Rats.
Published in:
FASEB Journal, 2021, v. 35, p. N.PAG, doi. 10.1096/fasebj.2021.35.S1.04912
By:
- Patel, Avi;
- Obeng, Samuel;
- Gamez‐Jimenez, Lea;
- Ho, Nicholas;
- Alvarez, Manuel;
- Thadisetti, Amsha;
- Kern, Elizabeth;
- León, Francisco;
- Mottinelli, Marco;
- Gonzalez, Julio;
- McCurdy, Christopher;
- McMahon, Lance;
- Hiranita, Takato
Publication type:
Article
Highly Specific Sigma Receptor Ligands Exhibit Anti-Viral Properties in SARS-CoV-2 Infected Cells.
Published in:
Pathogens, 2021, v. 10, n. 11, p. 1514, doi. 10.3390/pathogens10111514
By:
- Ostrov, David A.;
- Bluhm, Andrew P.;
- Li, Danmeng;
- Khan, Juveriya Qamar;
- Rohamare, Megha;
- Rajamanickam, Karthic;
- K. Bhanumathy, Kalpana;
- Lew, Jocelyne;
- Falzarano, Darryl;
- Vizeacoumar, Franco J.;
- Wilson, Joyce A.;
- Mottinelli, Marco;
- Kanumuri, Siva Rama Raju;
- Sharma, Abhisheak;
- McCurdy, Christopher R.;
- Norris, Michael H.
Publication type:
Article
Characterization of Sigma 1 Receptor Antagonist CM-304 and Its Analog, AZ-66: Novel Therapeutics Against Allodynia and Induced Pain.
Published in:
Frontiers in Pharmacology, 2019, p. N.PAG, doi. 10.3389/fphar.2019.00678
By:
- Cirino, Thomas J.;
- Eans, Shainnel O.;
- Medina, Jessica M.;
- Wilson, Lisa L.;
- Mottinelli, Marco;
- Intagliata, Sebastiano;
- McCurdy, Christopher R.;
- McLaughlin, Jay P.
Publication type:
Article

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