Works by Mosedale, Merrie

Results: 13

Bioprinted liver provides early insight into the role of Kupffer cells in TGF-β1 and methotrexate-induced fibrogenesis.

Published in:

PLoS ONE, 2019, v. 14, n. 01, p. 1, doi. 10.1371/journal.pone.0208958

By:

Norona, Leah M.;
Nguyen, Deborah G.;
Gerber, David A.;
Presnell, Sharon C.;
Mosedale, Merrie;
Watkins, Paul B.

Publication type:

Article

Subtoxic Alterations in Hepatocyte-Derived Exosomes: An Early Step in Drug-Induced Liver Injury?

Published in:

Toxicological Sciences, 2016, v. 151, n. 2, p. 365, doi. 10.1093/toxsci/kfw047

By:

Holman, Natalie S.;
Mosedale, Merrie;
Wolf, Kristina K.;
LeCluyse, Edward L.;
Watkins, Paul B.

Publication type:

Article

A Systems Biology Approach Utilizing a Mouse Diversity Panel Identifies Genetic Differences Influencing Isoniazid-Induced Microvesicular Steatosis.

Published in:

Toxicological Sciences, 2014, v. 140, n. 2, p. 481, doi. 10.1093/toxsci/kfu094

By:

Church, Rachel J.;
Wu, Hong;
Mosedale, Merrie;
Sumner, Susan J.;
Pathmasiri, Wimal;
Kurtz, Catherine L.;
Pletcher, Mathew T.;
Eaddy, John S.;
Pandher, Karamjeet;
Singer, Monica;
Batheja, Ameesha;
Watkins, Paul B.;
Adkins, Karissa;
Harrill, Alison H.

Publication type:

Article

Tolvaptan safety in autosomal-dominant polycystic kidney disease; a focus on idiosyncratic drug-induced liver injury liabilities.

Published in:

Toxicological Sciences, 2025, v. 203, n. 1, p. 11, doi. 10.1093/toxsci/kfae142

By:

Hammond, Sean;
Meng, Xiaoli;
Barber, Jane;
Mosedale, Merrie;
Chadwick, Amy;
Watkins, Paul B;
Naisbitt, Dean J

Publication type:

Article

Shedding Light on Drug-Induced Liver Injury: Activation of T Cells From Drug Naive Human Donors With Tolvaptan and a Hydroxybutyric Acid Metabolite.

Published in:

Toxicological Sciences, 2021, v. 179, n. 1, p. 95, doi. 10.1093/toxsci/kfaa157

By:

Hammond, Sean;
Gibson, Andrew;
Jaruthamsophon, Kanoot;
Roth, Sharin;
Mosedale, Merrie;
Naisbitt, Dean J

Publication type:

Article

Identification of Candidate Risk Factor Genes for Human Idelalisib Toxicity Using a Collaborative Cross Approach.

Published in:

Toxicological Sciences, 2019, v. 172, n. 2, p. 265, doi. 10.1093/toxsci/kfz199

By:

Mosedale, Merrie;
Cai, Yanwei;
Eaddy, John Scott;
Corty, Robert W;
Nautiyal, Manisha;
Watkins, Paul B;
Valdar, William

Publication type:

Article

Hepatocyte-Derived Exosomes Promote Liver Immune Tolerance: Possible Implications for Idiosyncratic Drug-Induced Liver Injury.

Published in:

Toxicological Sciences, 2019, v. 170, n. 2, p. 499, doi. 10.1093/toxsci/kfz112

By:

Holman, Natalie S;
Church, Rachel J;
Nautiyal, Manisha;
Rose, Kelly A;
Thacker, Sarah E;
Otieno, Monicah A;
Wolf, Kristina K;
LeCluyse, Edward;
Watkins, Paul B;
Mosedale, Merrie

Publication type:

Article

Quantitative Systems Toxicology Analysis of In Vitro Mechanistic Assays Reveals Importance of Bile Acid Accumulation and Mitochondrial Dysfunction in TAK-875-Induced Liver Injury.

Published in:

Toxicological Sciences, 2019, v. 167, n. 2, p. 458, doi. 10.1093/toxsci/kfy253

By:

Longo, Diane M;
Woodhead, Jeffrey L;
Walker, Paul;
Herédi-Szabó, Krisztina;
Mogyorósi, Károly;
Wolenski, Francis S;
Dragan, Yvonne P;
Mosedale, Merrie;
Siler, Scott Q;
Watkins, Paul B;
Howell, Brett A

Publication type:

Article

Optimized Methods to Explore the Mechanistic and Biomarker Potential of Hepatocyte-Derived Exosomes in Drug-Induced Liver Injury.

Published in:

Toxicological Sciences, 2018, v. 163, n. 1, p. 92, doi. 10.1093/toxsci/kfy015

By:

Thacker, Sarah E;
Nautiyal, Manisha;
Otieno, Monicah A;
Watkins, Paul B;
Mosedale, Merrie

Publication type:

Article

Transient Changes in Hepatic Physiology That Alter Bilirubin and Bile Acid Transport May Explain Elevations in Liver Chemistries Observed in Clinical Trials of GGF2 (Cimaglermin Alfa).

Published in:

Toxicological Sciences, 2018, v. 161, n. 2, p. 401, doi. 10.1093/toxsci/kfx222

By:

Mosedale, Merrie;
Button, Donald;
Jackson, Jonathan P;
Freeman, Kimberly M;
Brouwer, Kenneth R;
Caggiano, Anthony O;
Eisen, Andrew;
Iaci, Jennifer F;
Parry, Tom J;
Stanulis, Ric

Publication type:

Article

miR-122 Release in Exosomes Precedes Overt Tolvaptan-Induced Necrosis in a Primary Human Hepatocyte Micropatterned Coculture Model.

Published in:

Toxicological Sciences, 2018, v. 161, n. 1, p. 149, doi. 10.1093/toxsci/kfx206

By:

Mosedale, Merrie;
Eaddy, J Scott;
Trask, O Joseph;
Holman, Natalie S;
Wolf, Kristina K;
LeCluyse, Edward;
Ware, Brenton R;
Khetani, Salman R;
Lu, Jingtao;
Brock, William J

Publication type:

Article

Candidate Risk Factors and Mechanisms for Tolvaptan-Induced Liver Injury Are Identified Using a Collaborative Cross Approach.

Published in:

Toxicological Sciences, 2017, v. 156, n. 2, p. 438, doi. 10.1093/toxsci/kfw269

By:

Mosedale, Merrie;
Yunjung Kim;
Brock, William J.;
Roth, Sharin E.;
Wiltshire, Tim;
Eaddy, J. Scott;
Keele, Gregory R.;
Corty, Robert W.;
Yuying Xie;
Valdar, William;
Watkins, Paul B.

Publication type:

Article

Application of a Mechanistic Model to Evaluate Putative Mechanisms of Tolvaptan Drug-Induced Liver Injury and Identify Patient Susceptibility Factors.

Published in:

Toxicological Sciences, 2017, v. 155, n. 1, p. 61, doi. 10.1093/toxsci/kfw193

By:

Woodhead, Jeffrey L.;
Brock, William J.;
Roth, Sharin E.;
Shoaf, Susan E.;
Brouwer, Kim L. R.;
Church, Rachel;
Grammatopoulos, Tom N.;
Stiles, Linsey;
Siler, Scott Q.;
Howell, Brett A.;
Mosedale, Merrie;
Watkins, Paul B.;
Shoda, Lisl K. M.

Publication type:

Article