Works by Morimoto, Richard I.

Results: 58

Modulation of the Maladaptive Stress Response to Manage Diseases of Protein Folding.

Published in:

PLoS Biology, 2014, v. 12, n. 11, p. 1, doi. 10.1371/journal.pbio.1001998

By:

Roth, Daniela Martino;
Hutt, Darren M.;
Tong, Jiansong;
Bouchecareilh, Marion;
Wang, Ning;
Seeley, Theo;
Dekkers, Johanna F.;
Beekman, Jeffrey M.;
Garza, Dan;
Drew, Lawrence;
Masliah, Eliezer;
Morimoto, Richard I.;
Balch, William E.

Publication type:

Article

In vivo properties of the disaggregase function of J-proteins and Hsc70 in Caenorhabditis elegans stress and aging.

Published in:

Aging Cell, 2017, v. 16, n. 6, p. 1414, doi. 10.1111/acel.12686

By:

Kirstein, Janine;
Arnsburg, Kristin;
Scior, Annika;
Szlachcic, Anna;
Guilbride, D. Lys;
Morimoto, Richard I.;
Bukau, Bernd;
Nillegoda, Nadinath B.

Publication type:

Article

The nascent polypeptide-associated complex is a key regulator of proteostasis.

Published in:

EMBO Journal, 2013, v. 32, n. 10, p. 1451, doi. 10.1038/emboj.2013.87

By:

Kirstein‐Miles, Janine;
Scior, Annika;
Deuerling, Elke;
Morimoto, Richard I

Publication type:

Article

Metazoan Hsp70 machines use Hsp110 to power protein disaggregation.

Published in:

EMBO Journal, 2012, v. 31, n. 21, p. 4221, doi. 10.1038/emboj.2012.264

By:

Rampelt, Heike;
Kirstein-Miles, Janine;
Nillegoda, Nadinath B;
Chi, Kang;
Scholz, Sebastian R;
Morimoto, Richard I;
Bukau, Bernd

Publication type:

Article

Inefficient degradation of truncated polyglutamine proteins by the proteasome.

Published in:

EMBO Journal, 2004, v. 23, n. 21, p. 4307, doi. 10.1038/sj.emboj.7600426

By:

Holmberg, Carina I.;
Staniszewski, Kristine E.;
Mensah, Kwame N.;
Matouschek, Andreas;
Morimoto, Richard I.

Publication type:

Article

The life of proteins: the good, the mostly good and the ugly.

Published in:

2011

By:

Morimoto, Richard I;
Driessen, Arnold J M;
Hegde, Ramanujan S;
Langer, Thomas

Publication type:

Proceeding

Proteostasis and the Aging Proteome in Health and Disease.

Published in:

Journals of Gerontology Series A: Biological Sciences & Medical Sciences, 2014, v. 69, n. Suppl_1, p. S33, doi. 10.1093/gerona/glu049

By:

Morimoto, Richard I.;
Cuervo, Ana Maria

Publication type:

Article

Protein homeostasis and aging: taking care of proteins from the cradle to the grave.

Published in:

2009

By:

Morimoto RI;
Cuervo AM;
Morimoto, Richard I;
Cuervo, Ana M

Publication type:

journal article

In vivo binding of active heat shock transcription factor 1 to human chromosome 9 heterochromatin during stress.

Published in:

Journal of Cell Biology, 2002, v. 156, n. 5, p. 775, doi. 10.1083/jcb.200109018

By:

Jolly, Caroline;
Konecny, Lara;
Grady, Deborah L.;
Kutskova, Ylia A.;
Cotto, Jos&eacute J.;
Morimoto, Richard I.;
Vourc'h, Claire

Publication type:

Article

Dysregulation of the proteasome increases the toxicity of ALS-linked mutant SOD1.

Published in:

Genes to Cells, 2014, v. 19, n. 3, p. 209, doi. 10.1111/gtc.12125

By:

Kitamura, Akira;
Inada, Noriko;
Kubota, Hiroshi;
Matsumoto, Gen;
Kinjo, Masataka;
Morimoto, Richard I.;
Nagata, Kazuhiro

Publication type:

Article

Cytosolic chaperonin prevents polyglutamine toxicity with altering the aggregation state.

Published in:

Nature Cell Biology, 2006, v. 8, n. 10, p. 1163, doi. 10.1038/ncb1478

By:

Kitamura, Akira;
Kubota, Hiroshi;
Pack, Chan-Gi;
Matsumoto, Gen;
Hirayama, Shoshiro;
Takahashi, Yasuo;
Kimura, Hiroshi;
Kinjo, Masataka;
Morimoto, Richard I.;
Nagata, Kazuhiro

Publication type:

Article

Polyglutamine protein aggregates are dynamic.

Published in:

Nature Cell Biology, 2002, v. 4, n. 10, p. 826, doi. 10.1038/ncb863

By:

Kim, Soojin;
Nollen, Ellen A.A.;
Kitagawa, Kazunori;
Bindokas, Vytautas P.;
Morimoto, Richard I.

Publication type:

Article

Bag1?Hsp70 mediates a physiological stress signalling pathway that regulates Raf-1/ERK and cell growth.

Published in:

Nature Cell Biology, 2001, v. 3, n. 3, p. 276, doi. 10.1038/35060068

By:

Song, Jaewhan;
Takeda, Masahiro;
Morimoto, Richard I.

Publication type:

Article

Heat-shock protein 70 inhibits apoptosis by preventing recruitment of procaspase-9 to the Apaf-1 apoptosome.

Published in:

Nature Cell Biology, 2000, v. 2, n. 8, p. 469, doi. 10.1038/35019501

By:

Beere, Helen M.;
Wolf, Beni B.;
Cain, Kelvin;
Mosser, Dick D.;
Mahboubi, Artin;
Kuwana, Tomomi;
Tailor, Pankaj;
Morimoto, Richard I.;
Cohen, Gerald M.;
Green, Douglas R.

Publication type:

Article

Disease-Modifying Pathways in Neurodegeneration.

Published in:

Journal of Neuroscience, 2006, v. 26, n. 41, p. 10349, doi. 10.1523/JNEUROSCI.3829-06.2006

By:

Finkbeiner, Steven;
Cuervo, Ana Maria;
Morimoto, Richard I.;
Muchowski, Paul J.

Publication type:

Article

Polyglutamine Proteins at the Pathogenic Threshold Display Neuron-Specific Aggregation in a Pan-Neuronal Caenorhabditis elegans Model.

Published in:

Journal of Neuroscience, 2006, v. 26, n. 29, p. 21, doi. 10.1523/JNEUROSCI.0990-06.2006

By:

Brignull, Heather R.;
Moore, Finola E.;
Tang, Stephanie J.;
Morimoto, Richard I.

Publication type:

Article

Proteotoxic stress and ageing triggers the loss of redox homeostasis across cellular compartments.

Published in:

EMBO Journal, 2015, p. 2334, doi. 10.15252/embj.201591711

By:

Kirstein, Janine;
Daisuke Morito;
Taichi Kakihana;
Munechika Sugihara;
Minnen, Anita;
Hipp, Mark S.;
Nussbaum-Krammer, Carmen;
Kasturi, Prasad;
Hartl, F. Ulrich;
Kazuhiro Nagata;
Morimoto, Richard I.

Publication type:

Article

Proteotoxic stress and ageing triggers the loss of redox homeostasis across cellular compartments.

Published in:

EMBO Journal, 2015, v. 34, n. 18, p. 2334, doi. 10.15252/embj.201591711

By:

Kirstein, Janine;
Morito, Daisuke;
Kakihana, Taichi;
Sugihara, Munechika;
Minnen, Anita;
Hipp, Mark S;
Nussbaum‐Krammer, Carmen;
Kasturi, Prasad;
Hartl, F Ulrich;
Nagata, Kazuhiro;
Morimoto, Richard I

Publication type:

Article

Malfolded Protein Structure and Proteostasis in Lung Diseases.

Published in:

American Journal of Respiratory & Critical Care Medicine, 2014, v. 189, n. 1, p. 96, doi. 10.1164/rccm.201306-1164WS

By:

Balch, William E.;
Sznajder, Jacob I.;
Budinger, Scott;
Cuervo, Ana Maria;
Laposky, Aaron D.;
Finley, Daniel;
Benjamin, Ivor J.;
Barreiro, Esther;
Morimoto, Richard I.;
Postow, Lisa;
Weissman, Allan M.;
Gail, Dorothy;
Banks-Schlegel, Susan;
Croxton, Thomas;
Gan, Weiniu

Publication type:

Article

Natural genetic variation determines susceptibility to aggregation or toxicity in a C. elegans model for polyglutamine disease.

Published in:

BMC Biology, 2013, v. 11, n. 1, p. 1, doi. 10.1186/1741-7007-11-100

By:

Gidalevitz, Tali;
Ning Wang;
Deravaj, Tanuja;
Alexander-Floyd, Jasmine;
Morimoto, Richard I.

Publication type:

Article

Macro-level Modeling of the Response of C. elegans Reproduction to Chronic Heat Stress.

Published in:

PLoS Computational Biology, 2012, v. 8, n. 1, p. 1, doi. 10.1371/journal.pcbi.1002338

By:

McMullen, Patrick D.;
Aprison, Erin Z.;
Winter, Peter B.;
Amaral, Luis A. N.;
Morimoto, Richard I.;
Ruvinsky, Ilya

Publication type:

Article

A simple mass-action model for the eukaryotic heat shock response and its mathematical validation.

Published in:

Natural Computing, 2011, v. 10, n. 1, p. 595, doi. 10.1007/s11047-010-9216-y

By:

Petre, Ion;
Mizera, Andrzej;
Hyder, Claire L.;
Meinander, Annika;
Mikhailov, Andrey;
Morimoto, Richard I.;
Sistonen, Lea;
Eriksson, John E.;
Back, Ralph-Johan

Publication type:

Article

Hetero-oligomerization of TDP-43 carboxy-terminal fragments with cellular proteins contributes to proteotoxicity.

Published in:

Communications Biology, 2024, v. 7, n. 1, p. 1, doi. 10.1038/s42003-024-06410-3

By:

Kitamura, Akira;
Fujimoto, Ai;
Kawashima, Rei;
Lyu, Yidan;
Sasaki, Kotetsu;
Hamada, Yuta;
Moriya, Kanami;
Kurata, Ayumi;
Takahashi, Kazuho;
Brielmann, Reneé;
Bott, Laura C.;
Morimoto, Richard I.;
Kinjo, Masataka

Publication type:

Article

Heat shock factors: integrators of cell stress, development and lifespan.

Published in:

Nature Reviews Molecular Cell Biology, 2010, v. 11, n. 8, p. 545, doi. 10.1038/nrm2938

By:

Åkerfelt, Malin;
Morimoto, Richard I.;
Sistonen, Lea

Publication type:

Article

Caenorhabditis elegans as a model system to study intercompartmental proteostasis: Interrelation of mitochondrial function, longevity, and neurodegenerative diseases.

Published in:

Developmental Dynamics, 2010, v. 239, n. 5, p. 1529, doi. 10.1002/dvdy.22292

By:

Kirstein-Miles, Janine;
Morimoto, Richard I.

Publication type:

Article

Caenorhabditis elegans OSR-1 Regulates Behavioral and Physiological Responses to Hyperosmotic Environments.

Published in:

Genetics, 2004, v. 167, n. 1, p. 161, doi. 10.1534/genetics.167.1.161

By:

Solomon, Aharon;
Bandhakavi, Sricharan;
Jabbar, Sean;
Shah, Rena;
Beitel, Greg J.;
Morimoto, Richard I.

Publication type:

Article

Serotonergic signalling suppresses ataxin 3 aggregation and neurotoxicity in animal models of Machado-Joseph disease.

Published in:

2015

By:

Teixeira-Castro, Andreia;
Jalles, Ana;
Esteves, Sofia;
Soosung Kang;
da Silva Santos, Liliana;
Silva-Fernandes, Anabela;
Neto, Mário F.;
Brielmann, Renée M.;
Bessa, Carlos;
Duarte-Silva, Sara;
Miranda, Adriana;
Oliveira, Stéphanie;
Neves-Carvalho, Andreia;
Bessa, João;
Summavielle, Teresa;
Silverman, Richard B.;
Oliveira, Pedro;
Morimoto, Richard I.;
Maciel, Patrícia;
Kang, Soosung

Publication type:

journal article

Crucial HSP70 co-chaperone complex unlocks metazoan protein disaggregation.

Published in:

Nature, 2015, v. 524, n. 7564, p. 247, doi. 10.1038/nature14884

By:

Nillegoda, Nadinath B.;
Kirstein, Janine;
Szlachcic, Anna;
Berynskyy, Mykhaylo;
Stank, Antonia;
Stengel, Florian;
Arnsburg, Kristin;
Gao, Xuechao;
Scior, Annika;
Aebersold, Ruedi;
Guilbride, D. Lys;
Wade, Rebecca C.;
Morimoto, Richard I.;
Mayer, Matthias P.;
Bukau, Bernd

Publication type:

Article

Role of the heat shock response and molecular chaperones in oncogenesis and cell death.

Published in:

2000

By:

Jolly, Caroline;
Morimoto, Richard I.;
Jolly, C;
Morimoto, R I

Publication type:

journal article

Small subclass of rat olfactory neurons with specific bulbar projections is reactive with monoclonal antibodies to the HSP70 heat shock protein.

Published in:

Journal of Comparative Neurology, 1994, v. 348, n. 1, p. 150, doi. 10.1002/cne.903480109

By:

Carr, Virginia McMillan;
Murphy, Shawn P.;
Morimoto, Richard I.;
Farbman, Albert I.

Publication type:

Article

Role of the Heat-Shock Response in the Life and Death of Proteins.

Published in:

Annals of the New York Academy of Sciences, 1998, v. 851, n. 1, p. 99, doi. 10.1111/j.1749-6632.1998.tb08982.x

By:

MATHEW, ANU;
MORIMOTO, RICHARD I.

Publication type:

Article

Reply to “Far away from the lamppost”.

Published in:

2018

By:

Stoeger, Thomas;
Gerlach, Martin;
Morimoto, Richard I.;
Amaral, Luís A. Nunes

Publication type:

Letter to the Editor

Large-scale investigation of the reasons why potentially important genes are ignored.

Published in:

PLoS Biology, 2018, v. 16, n. 9, p. 1, doi. 10.1371/journal.pbio.2006643

By:

Stoeger, Thomas;
Nunes Amaral, Luís A.;
Gerlach, Martin;
Morimoto, Richard I.

Publication type:

Article

Structural properties and neuronal toxicity of amyotrophic lateral sclerosis-associated Cu/Zn superoxide dismutase 1 aggregates.

Published in:

Journal of Cell Biology, 2005, v. 171, n. 1, p. 75, doi. 10.1083/jcb.200504050

By:

Matsumoto, Gen;
Stojanovic, Aleksandar;
Holmberg, Carina I.;
Kim, Soojin;
Morimoto, Richard I.

Publication type:

Article

Phosphorylation of serine 230 promotes inducible transcriptional activity of heat shock factor 1.

Published in:

EMBO Journal, 2001, v. 20, n. 14, p. 3800, doi. 10.1093/emboj/20.14.3800

By:

Holmberg, Carina I.;
Hietakangas, Ville;
Mikhailov, Andrey;
Rantanen, Jouni O.;
Kallio, Marko;
Meinander, Annika;
Hellman, Jukka;
Morrice, Nick;
MacKintosh, Carol;
Morimoto, Richard I.;
Eriksson, John E.;
Sistonen, Lea

Publication type:

Article

Phosphorylation of serine 230 promotes inducible transcriptional activity of heat shock factor 1.

Published in:

EMBO Journal, 2001, v. 20, n. 14, p. 3800, doi. 10.1093/emboj/20.14.3800

By:

Holmberg, Carina I.;
Hietakangas, Ville;
Mikhailov, Andrey;
Rantanen, Jouni O.;
Kallio, Marko;
Meinander, Annika;
Hellman, Jukka;
Morrice, Nick;
MacKintosh, Carol;
Morimoto, Richard I.;
Eriksson, John E.;
Sistonen, Lea

Publication type:

Article

Reversible inhibition of Hsp70 chaperone function by Scythe and Reaper.

Published in:

EMBO Journal, 2001, v. 20, n. 5, p. 1033, doi. 10.1093/emboj/20.5.1033

By:

Thress, Kenneth;
Song, Jaewhan;
Morimoto, Richard I.;
Kornbluth, Sally

Publication type:

Article

BAG-1, a negative regulator of Hsp70 chaperone activity, uncouples nucleotide hydrolysis from substrate release.

Published in:

EMBO Journal, 1998, v. 17, n. 23, p. 6871, doi. 10.1093/emboj/17.23.6871

By:

Bimston, David;
Song, Jaewhan;
Winchester, David;
Takayama, Shinichi;
Reed, John C.;
Morimoto, Richard I.

Publication type:

Article

Disruption of the HSF3 gene results in the severe reduction of heat shock gene expression and loss of thermotolerance.

Published in:

EMBO Journal, 1998, v. 17, n. 6, p. 1750, doi. 10.1093/emboj/17.6.1750

By:

Tanabe, Masako;
Kawazoe, Yoshinori;
Takeda, Shunichi;
Morimoto, Richard I.;
Nagata, Kazuhiro;
Nakai, Akira

Publication type:

Article

BAG-1 modulates the chaperone activity of Hsp70/Hsc70.

Published in:

EMBO Journal, 1997, v. 16, n. 16, p. 4887, doi. 10.1093/emboj/16.16.4887

By:

Takayama, Shinichi;
Bimston, David M.;
Matsuzawa, Shu-ichi;
Freeman, Brian C.;
Aime-Sempe, Christine;
Zhihua Xie;
Morimoto, Richard I.;
Reed, John C.

Publication type:

Article

ERdj8 governs the size of autophagosomes during the formation process.

Published in:

Journal of Cell Biology, 2020, v. 219, n. 8, p. 1, doi. 10.1083/jcb.201903127

By:

Yo-hei Yamamoto;
Ayano Kasai;
Hiroko Omori;
Tomoe Takino;
Munechika Sugihara;
Tetsuo Umemoto;
Maho Hamasaki;
Tomohisa Hatta;
Tohru Natsume;
Morimoto, Richard I.;
Ritsuko Arai;
Satoshi Waguri;
Miyuki Sato;
Ken Sato;
Shoshana Bar-Nun;
Tamotsu Yoshimori;
Takeshi Noda;
Kazuhiro Nagata

Publication type:

Article

Shaping proteostasis at the cellular, tissue, and organismal level.

Published in:

Journal of Cell Biology, 2017, v. 216, n. 5, p. 1231, doi. 10.1083/jcb.201612111

By:

Sala, Ambre J.;
Bott, Laura C.;
Morimoto, Richard I.

Publication type:

Article

A metastable subproteome underlies inclusion formation in muscle proteinopathies.

Published in:

Acta Neuropathologica Communications, 2019, v. 7, n. 1, p. N.PAG, doi. 10.1186/s40478-019-0853-9

By:

Ciryam, Prajwal;
Antalek, Matthew;
Cid, Fernando;
Tartaglia, Gian Gaetano;
Dobson, Christopher M.;
Guettsches, Anne-Katrin;
Eggers, Britta;
Vorgerd, Matthias;
Marcus, Katrin;
Kley, Rudolf A.;
Morimoto, Richard I.;
Vendruscolo, Michele;
Weihl, Conrad C.

Publication type:

Article

A network approach to discerning the identities of C. elegans in a free moving population.

Published in:

Scientific Reports, 2016, p. 34859, doi. 10.1038/srep34859

By:

Winter, Peter B.;
Brielmann, Renee M.;
Timkovich, Nicholas P.;
Navarro, Helio T.;
Teixeira-Castro, Andreia;
Morimoto, Richard I.;
Amaral, Luis A. N.

Publication type:

Article

Neuron-specific proteotoxicity of mutant ataxin-3 in C. elegans: rescue by the DAF-16 and HSF-1 pathways.

Published in:

Human Molecular Genetics, 2011, v. 20, n. 15, p. 2996, doi. 10.1093/hmg/ddr203

By:

Teixeira-Castro, Andreia;
Ailion, Michael;
Jalles, Ana;
Brignull, Heather R.;
Vilaça, João L.;
Dias, Nuno;
Rodrigues, Pedro;
Oliveira, João F.;
Neves-Carvalho, Andreia;
Morimoto, Richard I.;
Maciel, Patrícia

Publication type:

Article

Hsp27 overexpression in the R6/2 mouse model of Huntington's disease: chronic neurodegeneration does not induce Hsp27 activation.

Published in:

Human Molecular Genetics, 2007, v. 16, n. 9, p. 1078, doi. 10.1093/hmg/ddm057

By:

Zourlidou, Alexandra;
Gidalevitz, Tali;
Kristiansen, Mark;
Landles, Christian;
Woodman, Ben;
Wells, Dominic J.;
Latchman, David S.;
de Belleroche, Jackie;
Tabrizi, Sarah J.;
Morimoto, Richard I.;
Bates, Gillian P.

Publication type:

Article

Odorants as cell-type specific activators of a heat shock response in the rat olfactory mucosa.

Published in:

Journal of Comparative Neurology, 2001, v. 432, n. 4, p. 425, doi. 10.1002/cne.1112

By:

Carr, Virginian McMillan;
Menco, Bert Ph.M.;
Yankova, Maya P.;
Morimoto, Richard I.;
Farbman, Albert I.

Publication type:

Article

Development and further characterization of a small subclass of rat olfactory receptor neurons that shows immunoreactivity for the HSP70 heat shock protein.

Published in:

Journal of Comparative Neurology, 1999, v. 404, n. 3, p. 375, doi. 10.1002/(SICI)1096-9861(19990215)404:3<375::AID-CNE7>3.0.CO;2-8

By:

McMillan Carr, Virginia;
Morimoto, Richard I.;
Farbman, Albert I.

Publication type:

Article

Neuronal Reprograming of Protein Homeostasis by Calcium-Dependent Regulation of the Heat Shock Response.

Published in:

PLoS Genetics, 2013, v. 9, n. 8, p. 1, doi. 10.1371/journal.pgen.1003711

By:

Silva, M. Catarina;
Amaral, Margarida D.;
Morimoto, Richard I.

Publication type:

Article

Identification of a Tissue-Selective Heat Shock Response Regulatory Network.

Published in:

PLoS Genetics, 2013, v. 9, n. 4, p. 1, doi. 10.1371/journal.pgen.1003466

By:

Guisbert, Eric;
Czyz, Daniel M.;
Richter, Klaus;
McMullen, Patrick D.;
Morimoto, Richard I.

Publication type:

Article