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Brain injections of glial cytoplasmic inclusions induce a multiple system atrophy-like pathology.
- Published in:
- 2022
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- Publication type:
- journal article
LRRK2 G2019S kinase activity triggers neurotoxic NSF aggregation.
- Published in:
- 2021
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- Publication type:
- journal article
Blockade of Nociceptin/Orphanin FQ Receptor Signaling in Rat Substantia Nigra Pars Reticulata Stimulates Nigrostriatal Dopaminergic Transmission and Motor Behavior.
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- Journal of Neuroscience, 2004, v. 24, n. 30, p. 6659, doi. 10.1523/JNEUROSCI.0987-04.2004
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- Publication type:
- Article
Pharmacological profiles of presynaptic nociceptin/orphanin FQ receptors modulating 5-hydroxytryptamine and noradrenaline release in the rat neocortex.
- Published in:
- 2003
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- Publication type:
- journal article
Direct and indirect inhibition by nociceptin/orphanin FQ on noradrenaline release from rodent cerebral cortex in vitro.
- Published in:
- 2002
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- Publication type:
- journal article
[Nphe[sup 1],Arg[sup 14],Lys[sup 15]]Nociceptin-NH[sub 2], a novel potent and selective antagonist of the nociceptin/orphanin FQ receptor.
- Published in:
- British Journal of Pharmacology, 2002, v. 136, n. 2, p. 303, doi. 10.1038/sj.bjp.0704706
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- Publication type:
- Article
Age-dependent dopamine transporter dysfunction and Serine129 phospho-α- synuclein overload in G2019S LRRK2 mice.
- Published in:
- Acta Neuropathologica Communications, 2017, v. 5, p. 1, doi. 10.1186/s40478-017-0426-8
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- Publication type:
- Article
Olanzapine, but not clozapine, increases glutamate release in the prefrontal cortex of freely moving mice by inhibiting D-aspartate oxidase activity.
- Published in:
- Scientific Reports, 2017, p. 46288, doi. 10.1038/srep46288
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- Publication type:
- Article
The Nociceptin/Orphanin FQ Receptor Antagonist J-113397 and L-DOPA Additively Attenuate Experimental Parkinsonism through Overinhibition of the Nigrothalamic Pathway.
- Published in:
- Journal of Neuroscience, 2007, v. 27, n. 6, p. 1297, doi. 10.1523/JNEUROSCI.4346-06.2007
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- Publication type:
- Article
Blockade of Nociceptin/Orphanin FQ Transmission Attenuates Symptoms and Neurodegeneration Associated with Parkinson's Disease.
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- Journal of Neuroscience, 2005, v. 25, n. 42, p. 9591, doi. 10.1523/JNEUROSCI.2546-05.2005
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- Publication type:
- Article
Nociceptin/Orphanin FQ Modulates Motor Behavior and Primary Motor Cortex Output Through Receptors Located in Substantia Nigra Reticulata.
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- Neuropsychopharmacology, 2009, v. 34, n. 2, p. 341, doi. 10.1038/npp.2008.56
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- Publication type:
- Article
Mechanisms underlying the impairment of hippocampal long-term potentiation and memory in experimental Parkinson’s disease.
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- Brain: A Journal of Neurology, 2012, v. 135, n. 6, p. 1884, doi. 10.1093/brain/aws101
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- Publication type:
- Article
Amantadine attenuates levodopa-induced dyskinesia in mice and rats preventing the accompanying rise in nigral GABA levels.
- Published in:
- Journal of Neurochemistry, 2011, v. 118, n. 6, p. 1043, doi. 10.1111/j.1471-4159.2011.07376.x
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- Publication type:
- Article
Further evidence for an involvement of nociceptin/orphanin FQ in the pathophysiology of Parkinson's disease: a behavioral and neurochemical study in reserpinized mice.
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- Journal of Neurochemistry, 2010, v. 115, n. 6, p. 1543, doi. 10.1111/j.1471-4159.2010.07061.x
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- Publication type:
- Article
Leucine-rich repeat kinase 2 controls protein kinase A activation state through phosphodiesterase 4.
- Published in:
- 2018
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- Publication type:
- journal article
Regulator of G‐Protein Signalling 4 (RGS4) negatively modulates nociceptin/orphanin FQ opioid receptor signalling: Implication for l‐Dopa‐induced dyskinesia.
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- British Journal of Pharmacology, 2023, v. 180, n. 7, p. 927, doi. 10.1111/bph.15730
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- Publication type:
- Article
6-Hydroxydopamine lesion and levodopa treatment modify the effect of buspirone in the substantia nigra pars reticulata.
- Published in:
- 2020
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- Publication type:
- journal article
Managing Parkinson's disease: moving ON with NOP.
- Published in:
- 2020
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- Publication type:
- journal article
Anti-Parkinsonian and anti-dyskinetic profiles of two novel potent and selective nociceptin/orphanin FQ receptor agonists.
- Published in:
- 2018
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- Publication type:
- journal article
Translation Imaging in Parkinson's Disease: Focus on Neuroinflammation.
- Published in:
- Frontiers in Aging Neuroscience, 2020, v. 12, p. 1, doi. 10.3389/fnagi.2020.00152
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- Publication type:
- Article
Pharmacological antagonism of kainate receptor rescues dysfunction and loss of dopamine neurons in a mouse model of human parkin-induced toxicity.
- Published in:
- Cell Death & Disease, 2020, v. 11, n. 11, p. 1, doi. 10.1038/s41419-020-03172-8
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- Publication type:
- Article
Dopamine D2 receptor-mediated neuroprotection in a G2019S Lrrk2 genetic model of Parkinson’s disease.
- Published in:
- Cell Death & Disease, 2018, v. 9, n. 2, p. 1, doi. 10.1038/s41419-017-0221-2
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- Publication type:
- Article
Evidence for a striatal NMDA receptor modulation of nigral glutamate release. A dual probe microdialysis study in the awake freely moving rat.
- Published in:
- European Journal of Neuroscience, 1998, v. 10, n. 5, p. 1716, doi. 10.1046/j.1460-9568.1998.00176.x
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- Publication type:
- Article
Modeling Parkinson’s disease in LRRK2 mice: focus on synaptic dysfunction and the autophagylysosomal pathway.
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- Biochemical Society Transactions, 2022, v. 50, n. 1, p. 621, doi. 10.1042/BST20211288
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- Publication type:
- Article
Dopamine Transporter, PhosphoSerine129 α-Synuclein and α-Synuclein Levels in Aged LRRK2 G2019S Knock-In and Knock-Out Mice.
- Published in:
- Biomedicines, 2022, v. 10, n. 4, p. 881, doi. 10.3390/biomedicines10040881
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- Publication type:
- Article
Early Dysfunction of Substantia Nigra Dopamine Neurons in the ParkinQ311X Mouse.
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- Biomedicines, 2021, v. 9, n. 5, p. 514, doi. 10.3390/biomedicines9050514
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- Publication type:
- Article
Sinapic Acid Protects SH-SY5Y Human Neuroblastoma Cells against 6-Hydroxydopamine-Induced Neurotoxicity.
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- Biomedicines, 2021, v. 9, n. 3, p. 295, doi. 10.3390/biomedicines9030295
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- Publication type:
- Article
Dopamine D3 Receptor Plasticity in Parkinson's Disease and L-DOPA-Induced Dyskinesia.
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- Biomedicines, 2021, v. 9, n. 3, p. 314, doi. 10.3390/biomedicines9030314
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- Publication type:
- Article
Oral Administration of Probiotic Bifidobacterium breve Improves Facilitation of Hippocampal Memory Extinction via Restoration of Aberrant Higher Induction of Neuropsin in an MPTP-Induced Mouse Model of Parkinson's Disease.
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- Biomedicines, 2021, v. 9, n. 2, p. 167, doi. 10.3390/biomedicines9020167
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- Publication type:
- Article
L-dopa-induced dyskinesia: beyond an excessive dopamine tone in the striatum.
- Published in:
- Scientific Reports, 2014, p. 1, doi. 10.1038/srep03730
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- Publication type:
- Article
Mind the Gap: LRRK2 Phenotypes in the Clinic vs. in Patient Cells.
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- Cells (2073-4409), 2021, v. 10, n. 5, p. 981, doi. 10.3390/cells10050981
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- Publication type:
- Article
A LRRK2 GTP Binding Inhibitor, 68, Reduces LPS-Induced Signaling Events and TNF-α Release in Human Lymphoblasts.
- Published in:
- Cells (2073-4409), 2021, v. 10, n. 2, p. 480, doi. 10.3390/cells10020480
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- Publication type:
- Article
LRRK2 Modulates the Exocyst Complex Assembly by Interacting with Sec8.
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- Cells (2073-4409), 2021, v. 10, n. 2, p. 203, doi. 10.3390/cells10020203
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- Publication type:
- Article
Pharmacological profile of nociceptin/orphanin FQ receptors regulating 5-hydroxytryptamine release in the mouse neocortex.
- Published in:
- European Journal of Neuroscience, 2004, v. 19, n. 5, p. 1317, doi. 10.1111/j.1460-9568.2004.03220.x
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- Publication type:
- Article
Differential responsiveness of rat striatal nerve endings to the mitochondrial toxin 3-nitropropionic acid: implications for Huntington's disease.
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- European Journal of Neuroscience, 2003, v. 18, n. 4, p. 759, doi. 10.1046/j.1460-9568.2003.02806.x
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- Publication type:
- Article
LRRK2 kinase activity regulates synaptic vesicle trafficking and neurotransmitter release through modulation of LRRK2 macro-molecular complex.
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- Frontiers in Molecular Neuroscience, 2014, v. 7, p. 1, doi. 10.3389/fnmol.2014.00049
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- Publication type:
- Article
Stimulation of delta opioid receptors located in substantia nigra reticulata but not globus pallidus or striatum restores motor activity in 6-hydroxydopamine lesioned rats: new insights into the role of delta receptors in parkinsonism.
- Published in:
- Journal of Neurochemistry, 2008, v. 107, n. 6, p. 1647, doi. 10.1111/j.1471-4159.2008.05727.x
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- Publication type:
- Article
The novel nociceptin/orphanin FQ receptor antagonist Trap-101 alleviates experimental parkinsonism through inhibition of the nigro-thalamic pathway: positive interaction withL-DOPA.
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- Journal of Neurochemistry, 2008, v. 107, n. 6, p. 1683, doi. 10.1111/j.1471-4159.2008.05735.x
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- Publication type:
- Article
Differential effect of NR2A and NR2B subunit selective NMDA receptor antagonists on striato-pallidal neurons: relationship to motor response in the 6-hydroxydopamine model of parkinsonism.
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- Journal of Neurochemistry, 2008, v. 106, n. 2, p. 957, doi. 10.1111/j.1471-4159.2008.05439.x
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- Publication type:
- Article
NR2A and NR2B subunit containing NMDA receptors differentially regulate striatal output pathways.
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- Journal of Neurochemistry, 2007, v. 103, n. 6, p. 2200, doi. 10.1111/j.1471-4159.2007.04966.x
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- Publication type:
- Article
Antagonism of metabotropic glutamate receptor type 5 attenuatesl-DOPA-induced dyskinesia and its molecular and neurochemical correlates in a rat model of Parkinson’s disease.
- Published in:
- Journal of Neurochemistry, 2007, v. 101, n. 2, p. 483, doi. 10.1111/j.1471-4159.2007.04456.x
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- Publication type:
- Article
Striatal glutamate release evokedin vivoby NMDA is dependent upon ongoing neuronal activity in the substantia nigra, endogenous striatal substance P and dopamine.
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- Journal of Neurochemistry, 2005, v. 93, n. 1, p. 195, doi. 10.1111/j.1471-4159.2005.03015.x
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- Publication type:
- Article
Blockade of nociceptin/orphanin FQ transmission in rat substantia nigra reverses haloperidol-induced akinesia and normalizes nigral glutamate release.
- Published in:
- Journal of Neurochemistry, 2004, v. 91, n. 6, p. 1501, doi. 10.1111/j.1471-4159.2004.02843.x
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- Publication type:
- Article
Plasticity of glutamatergic control of striatal acetylcholine release in experimental parkinsonism: opposite changes at group-II metabotropic and NMDA receptors.
- Published in:
- Journal of Neurochemistry, 2003, v. 84, n. 4, p. 792, doi. 10.1046/j.1471-4159.2003.01569.x
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- Publication type:
- Article
Somatostatin Release in the Hippocampus in the Kindling Model of Epilepsy.
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- Journal of Neurochemistry, 2000, v. 74, n. 6, p. 2497, doi. 10.1046/j.1471-4159.2000.0742497.x
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- Publication type:
- Article
Nociceptin/Orphanin FQ Inhibits the Survival and Axon Growth of Midbrain Dopaminergic Neurons Through a p38-MAPK Dependent Mechanism.
- Published in:
- Molecular Neurobiology, 2016, v. 53, n. 10, p. 7284, doi. 10.1007/s12035-015-9611-6
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- Publication type:
- Article
Eltoprazine prevents levodopa-induced dyskinesias by reducing striatal glutamate and direct pathway activity.
- Published in:
- 2015
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- Publication type:
- journal article
L-DOPA impairs proteasome activity in parkinsonism through D1 dopamine receptor.
- Published in:
- Movement Disorders, 2012, v. 27, n. 6, p. 706, doi. 10.1002/mds.24961
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- Publication type:
- Article
Brain Interstitial Nociceptin/Orphanin FQ Levels are Elevated in Parkinson's Disease.
- Published in:
- Movement Disorders, 2010, v. 25, n. 11, p. 1723, doi. 10.1002/mds.23271
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- Publication type:
- Article
Differential involvement of Ras-GRF1 and Ras-GRF2 in L-DOPA-induced dyskinesia.
- Published in:
- Annals of Clinical & Translational Neurology, 2015, v. 2, n. 6, p. 662, doi. 10.1002/acn3.202
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- Publication type:
- Article