Works by Montecucco, Cesare

Results: 98

Botulinum neurotoxins: genetic, structural and mechanistic insights.

Published in:

Nature Reviews Microbiology, 2014, v. 12, n. 8, p. 535, doi. 10.1038/nrmicro3295

By:

Rossetto, Ornella;
Pirazzini, Marco;
Montecucco, Cesare

Publication type:

Article

The VacA toxin of Helicobacter pylori identifies a new intermediate filament-interacting protein.

Published in:

EMBO Journal, 2000, v. 19, n. 1, p. 48, doi. 10.1093/emboj/19.1.48

By:

de Bernard, Marina;
Moschioni, Monica;
Napolitani, Giorgio;
Rappuoli, Rino;
Montecucco, Cesare

Publication type:

Article

Formation of anion-selective channels in the cell plasma membrane by the toxin VacA of Helicobacter pylori is required for its biological activity.

Published in:

EMBO Journal, 1999, v. 18, n. 20, p. 5517, doi. 10.1093/emboj/18.20.5517

By:

Szabò, Ildikò;
Brutsche, Sandra;
Tombola, Francesco;
Moschioni, Monica;
Satin, Barbara;
Telford, John L.;
Rappuoli, Rino;
Montecucco, Cesare;
Papini, Emanuele;
Zoratti, Mario

Publication type:

Article

The small GTP binding protein rab7 is essential for cellular vacuolation induced by Helicobacter pylori cytotoxin.

Published in:

EMBO Journal, 1997, v. 16, n. 1, p. 15, doi. 10.1093/emboj/16.1.15

By:

Papini, Emanuele;
Satin, Barbara;
Bucci, Cecilia;
De Bernard, Marina;
Telford, John L.;
Manetti, Roberto;
Rappuoli, Rino;
Zerial, Marino;
Montecucco, Cesare

Publication type:

Article

Toxicology and pharmacology of botulinum and tetanus neurotoxins: an update.

Published in:

Archives of Toxicology, 2022, v. 96, n. 6, p. 1521, doi. 10.1007/s00204-022-03271-9

By:

Pirazzini, Marco;
Montecucco, Cesare;
Rossetto, Ornella

Publication type:

Article

Microbiology: Death of a chaperone.

Published in:

Nature, 2006, v. 443, n. 7111, p. 511, doi. 10.1038/443511a

By:

Montecucco, Cesare;
Molinari, Maurizio

Publication type:

Article

Hydrogen Peroxide Modulates the Timely Activation of Jun and Erk in Schwann Cells at the Injury Site and Is Required for Motor Axon Regeneration.

Published in:

Cells (2073-4409), 2025, v. 14, n. 9, p. 671, doi. 10.3390/cells14090671

By:

Negro, Samuele;
Baggio, Chiara;
Tonellato, Marika;
Stazi, Marco;
D'Este, Giorgia;
Megighian, Aram;
Montecucco, Cesare;
Rigoni, Michela

Publication type:

Article

An Agonist of the CXCR4 Receptor Strongly Promotes Regeneration of Degenerated Motor Axon Terminals.

Published in:

Cells (2073-4409), 2019, v. 8, n. 10, p. 1183, doi. 10.3390/cells8101183

By:

Negro, Samuele;
Zanetti, Giulia;
Mattarei, Andrea;
Valentini, Alice;
Megighian, Aram;
Tombesi, Giulia;
Zugno, Alessandro;
Dianin, Valentina;
Pirazzini, Marco;
Fillo, Silvia;
Lista, Florigio;
Rigoni, Michela;
Montecucco, Cesare

Publication type:

Article

The Helicobacter pylori neutrophil-activating protein is an iron-binding protein with dodecameric structure.

Published in:

Molecular Microbiology, 1999, v. 34, n. 2, p. 238, doi. 10.1046/j.1365-2958.1999.01584.x

By:

Tonello, Fiorella;
Dundon, William G;
Satin, Barbara;
Molinari, Maurizio;
Tognon, Giuseppe;
Grandi, Guido;
Del Giudice, Giuseppe;
Rappuoli, Rino;
Montecucco, Cesare

Publication type:

Article

Towards deciphering the Helicobacter pylori cytotoxin.

Published in:

Molecular Microbiology, 1999, v. 34, n. 2, p. 197, doi. 10.1046/j.1365-2958.1999.01592.x

By:

Reyrat, Jean-Marc;
Pelicic, Vladimir;
Papini, Emanuele;
Montecucco, Cesare;
Rappuoli, Rino;
Telford, John L

Publication type:

Article

Helicobacter pylori toxin VacA induces vacuole formation by acting in the cell cytosoi.

Published in:

Molecular Microbiology, 1997, v. 26, n. 4, p. 665, doi. 10.1046/j.1365-2958.1997.5881952.x

By:

De Bernard, Marina;
Arico, Beatrice;
Papini, Emanuele;
Rizzuto, Rosario;
Grandi, Guido;
Rappuoli, Rino;
Montecucco, Cesare

Publication type:

Article

Similarities between the lethal factor of Bacillus anthracis and leukotriene A4 hydrolase.

Published in:

1995

By:

Ménard, Armelle;
Mock, Michèle;
Montecucco, Cesare

Publication type:

Letter

MP17, a fiber-specific intrinsic membrane protein from mammalian eye lens.

Published in:

Current Eye Research, 1988, v. 7, n. 2, p. 207, doi. 10.3109/02713688808995750

By:

Mulders, John W.M.;
Voorter, Christina E.M.;
Lamers, Cor;
de Haard-Hoekman, Willeke A.;
Montecucco, Cesare;
van de Ven, Wim J.M.;
Bloemendal, Hans;
de Jong, Wilfried W.

Publication type:

Article

Novel Small Molecule Inhibitors That Prevent the Neuroparalysis of Tetanus Neurotoxin.

Published in:

Pharmaceuticals (14248247), 2021, v. 14, n. 11, p. 1134, doi. 10.3390/ph14111134

By:

Zanetti, Giulia;
Mattarei, Andrea;
Lista, Florigio;
Rossetto, Ornella;
Montecucco, Cesare;
Pirazzini, Marco

Publication type:

Article

Envenomations by Bothrops and Crotalus Snakes Induce the Release of Mitochondrial Alarmins.

Published in:

PLoS Neglected Tropical Diseases, 2012, v. 6, n. 2, p. 1, doi. 10.1371/journal.pntd.0001526

By:

Zornetta, Irene;
Caccin, Paola;
Fernandez, Julián;
Lomonte, Bruno;
Gutierrez, José María;
Montecucco, Cesare

Publication type:

Article

Envenomations by Bothrops and Crotalus Snakes Induce the Release of Mitochondrial Alarmins.

Published in:

PLoS Neglected Tropical Diseases, 2012, v. 6, n. 2, p. 1, doi. 10.1371/journal.pntd.0001526

By:

Zornetta, Irene;
Caccin, Paola;
Fernandez, Julián;
Lomonte, Bruno;
Gutierrez, José María;
Montecucco, Cesare

Publication type:

Article

Crystal structure of antigen TpF1 from Treponema pallidum.

Published in:

Proteins, 2006, v. 62, n. 3, p. 827, doi. 10.1002/prot.20828

By:

Thumiger, Anton;
Polenghi, Alessandra;
Papinutto, Elena;
Battistutta, Roberto;
Montecucco, Cesare;
Zanotti, Giuseppe

Publication type:

Article

Structure and function of tetanus and botulinum neurotoxins.

Published in:

Quarterly Reviews of Biophysics, 1995, v. 28, n. 4, p. 423, doi. 10.1017/S0033583500003292

By:

Montecucco, Cesare;
Schiavo, Giampietro

Publication type:

Article

Transient Synaptic Silencing of Developing Striate Cortex Has Persistent Effects on Visual Function and Plasticity.

Published in:

Journal of Neuroscience, 2007, v. 27, n. 17, p. 4530, doi. 10.1523/JNEUROSCI.0772-07.2007

By:

Caleo, Matteo;
Restani, Laura;
Gianfranceschi, Laura;
Costantin, Laura;
Rossi, Chiara;
Rossetto, Ornella;
Montecucco, Cesare;
Maffei, Lamberto

Publication type:

Article

Antiepileptic Effects of Botulinum Neurotoxin E.

Published in:

Journal of Neuroscience, 2005, v. 25, n. 8, p. 1943, doi. 10.1523/JNEUROSCI.4402-04.2005

By:

Costantin, Laura;
Bozzi, Yuri;
Richichi, Cristina;
Viegi, Alessandro;
Antonucci, Flavia;
Funicello, Marcella;
Gobbi, Marco;
Mennini, Tiziana;
Rossetto, Ornella;
Montecucco, Cesare;
Maffei, Lamberto;
Vezzani, Annamaria;
Caleo, Matteo

Publication type:

Article

Muscle phospholipid hydrolysis by Bothrops asper Asp49 and Lys49 phospholipase A2 myotoxins - distinct mechanisms of action.

Published in:

FEBS Journal, 2013, v. 280, n. 16, p. 3878, doi. 10.1111/febs.12386

By:

Fernández, Julián;
Caccin, Paola;
Koster, Grielof;
Lomonte, Bruno;
Gutiérrez, José M.;
Montecucco, Cesare;
Postle, Anthony D.

Publication type:

Article

Determination of diphtheria toxin neutralizing antibody titers with a cell protein synthesis inhibition assay.

Published in:

Medical Microbiology & Immunology, 1991, v. 180, n. 1, p. 29, doi. 10.1007/BF00191698

By:

Padovan, Elisabetta;
Papini, Emanuele;
Rappuoli, Rino;
Montecucco, Cesare

Publication type:

Article

LIVING DANGEROUSLY: HOW HELICOBACTER PYLORI SURVIVES IN THE HUMAN STOMACH.

Published in:

Nature Reviews Molecular Cell Biology, 2001, v. 2, n. 6, p. 457, doi. 10.1038/35073084

By:

Montecucco, Cesare;
Rappuoli, Rino

Publication type:

Article

Agonists of melatonin receptors strongly promote the functional recovery from the neuroparalysis induced by neurotoxic snakes.

Published in:

PLoS Neglected Tropical Diseases, 2024, v. 18, n. 1, p. 1, doi. 10.1371/journal.pntd.0011825

By:

D'Este, Giorgia;
Fabris, Federico;
Stazi, Marco;
Baggio, Chiara;
Simonato, Morena;
Megighian, Aram;
Rigoni, Michela;
Negro, Samuele;
Montecucco, Cesare

Publication type:

Article

Detection of VAMP Proteolysis by Tetanus and Botulinum Neurotoxin Type B In Vivo with a Cleavage-Specific Antibody.

Published in:

International Journal of Molecular Sciences, 2022, v. 23, n. 8, p. 4355, doi. 10.3390/ijms23084355

By:

Fabris, Federico;
Šoštarić, Petra;
Matak, Ivica;
Binz, Thomas;
Toffan, Anna;
Simonato, Morena;
Montecucco, Cesare;
Pirazzini, Marco;
Rossetto, Ornella

Publication type:

Article

Latrotoxin-Induced Neuromuscular Junction Degeneration Reveals Urocortin 2 as a Critical Contributor to Motor Axon Terminal Regeneration.

Published in:

International Journal of Molecular Sciences, 2022, v. 23, n. 3, p. 1186, doi. 10.3390/ijms23031186

By:

D'Este, Giorgia;
Stazi, Marco;
Negro, Samuele;
Megighian, Aram;
Lista, Florigio;
Rossetto, Ornella;
Montecucco, Cesare;
Rigoni, Michela;
Pirazzini, Marco

Publication type:

Article

An Update on the Mechanism of Action of Tetanus and Botulinum Neurotoxins.

Published in:

Acta Chimica Slovenica, 2011, v. 58, n. 4, p. 702

By:

Rossetto, Ornella;
Pirazzini, Marco;
Bolognese, Paolo;
Rigoni, Michela;
Montecucco, Cesare

Publication type:

Article

Neurotoxic phospholipase A2: A proposed cause of equine grass sickness and other animal dysautonomias (multiple system neuropathies).

Published in:

Equine Veterinary Journal, 2025, v. 57, n. 1, p. 11, doi. 10.1111/evj.14442

By:

McGorum, Bruce;
Pirie, R. Scott;
Bano, Luca;
Davey, Tracey;
Harris, John;
Montecucco, Cesare

Publication type:

Article

Practical guidance for CD management involving treatment of botulinum toxin: a consensus statement.

Published in:

Journal of Neurology, 2015, v. 262, n. 10, p. 2201, doi. 10.1007/s00415-015-7703-x

By:

Albanese, Alberto;
Abbruzzese, Giovanni;
Dressler, Dirk;
Duzynski, Wojciech;
Khatkova, Svetlana;
Marti, Maria;
Mir, Pablo;
Montecucco, Cesare;
Moro, Elena;
Pinter, Michaela;
Relja, Maja;
Roze, Emmanuel;
Skogseid, Inger;
Timerbaeva, Sofiya;
Tzoulis, Charalampos

Publication type:

Article

Entering neurons: botulinum toxins and synaptic vesicle recycling.

Published in:

EMBO Reports, 2006, v. 7, n. 10, p. 995, doi. 10.1038/sj.embor.7400796

By:

Verderio, Claudia;
Rossetto, Ornella;
Grumelli, Carlotta;
Frassoni, Carolina;
Montecucco, Cesare;
Matteoli, Michela

Publication type:

Article

Potent inhibitors of anthrax lethal factor from green tea.

Published in:

EMBO Reports, 2004, v. 5, n. 4, p. 418, doi. 10.1038/sj.embor.7400118

By:

Dell'Aica, Isabella;
Donà, Massimo;
Tonello, Fiorella;
Piris, Alejandro;
Mock, Michèle;
Montecucco, Cesare;
Garbisa, Spiridione

Publication type:

Article

Traffic of Botulinum Toxins A and E in Excitatory and Inhibitory Neurons.

Published in:

Traffic, 2007, v. 8, n. 2, p. 142, doi. 10.1111/j.1600-0854.2006.00520.x

By:

Verderio, Claudia;
Grumelli, Carlotta;
Raiteri, Luca;
Coco, Silvia;
Paluzzi, Silvio;
Caccin, Paola;
Rossetto, Ornella;
Bonanno, Giambattista;
Montecucco, Cesare;
Matteoli, Michela

Publication type:

Article

Peroxynitrite and Nitric Oxide Donors Induce Neuronal Apoptosis by Eliciting Autocrine Excitotoxicity.

Published in:

European Journal of Neuroscience, 1997, v. 9, n. 7, p. 1488, doi. 10.1111/j.1460-9568.1997.tb01503.x

By:

Leist, Marcel;
Fava, Eugenio;
Montecucco, Cesare;
Nicotera, Pierluigi

Publication type:

Article

The concerted action of the Helicobacter pylori cytotoxin VacA and of the v-ATPase proton pump induces swelling of isolated endosomes.

Published in:

Cellular Microbiology, 2007, v. 9, n. 6, p. 1481, doi. 10.1111/j.1462-5822.2006.00886.x

By:

Genisset, Christophe;
Puhar, Andrea;
Calore, Federica;
de Bernard, Marina;
Dell'Antone, Paolo;
Montecucco, Cesare

Publication type:

Article

Anthrax toxins inhibit immune cell chemotaxis by perturbing chemokine receptor signalling.

Published in:

Cellular Microbiology, 2007, v. 9, n. 4, p. 924, doi. 10.1111/j.1462-5822.2006.00840.x

By:

Rossi Paccani, Silvia;
Tonello, Fiorella;
Patrussi, Laura;
Capitani, Nagaja;
Simonato, Morena;
Montecucco, Cesare;
Baldari, Cosima T.

Publication type:

Article

TheHelicobacter pyloriVacA cytotoxin activates RBL-2H3 cells by inducing cytosolic calcium oscillations.

Published in:

Cellular Microbiology, 2005, v. 7, n. 2, p. 191, doi. 10.1111/j.1462-5822.2004.00446.x

By:

de Bernard, Marina;
Cappon, Andrea;
Pancotto, Laura;
Ruggiero, Paolo;
Rivera, Juan;
Del Giudice, Giuseppe;
Montecucco, Cesare

Publication type:

Article

The Vibrio cholerae haemolysin anion channel is required for cell vacuolation and death.

Published in:

Cellular Microbiology, 2002, v. 4, n. 7, p. 397, doi. 10.1046/j.1462-5822.2002.00199.x

By:

Moschioni, Monica;
Tombola, Francesco;
Bernard, Marina de;
Coelho, Ana;
Zitzer, Alexander;
Zoratti, Mario;
Montecucco, Cesare

Publication type:

Article

CXCL12α/ SDF-1 from perisynaptic Schwann cells promotes regeneration of injured motor axon terminals.

Published in:

EMBO Molecular Medicine, 2017, v. 9, n. 8, p. 1000, doi. 10.15252/emmm.201607257

By:

Negro, Samuele;
Lessi, Francesca;
Duregotti, Elisa;
Aretini, Paolo;
La Ferla, Marco;
Franceschi, Sara;
Menicagli, Michele;
Bergamin, Elisanna;
Radice, Egle;
Thelen, Marcus;
Megighian, Aram;
Pirazzini, Marco;
Mazzanti, Chiara M;
Rigoni, Michela;
Montecucco, Cesare

Publication type:

Article

Extra-pineal melatonin in perisynaptic Schwann cell–muscle fiber cross talk at the regenerating neuromuscular junction.

Published in:

Neural Regeneration Research, 2026, v. 21, n. 1, p. 300, doi. 10.4103/NRR.NRR-D-24-01136

By:

Negro, Samuele;
Montecucco, Cesare;
Rigoni, Michela

Publication type:

Article

Neutralisation of specific surface carboxylates speeds up translocation of botulinum neurotoxin type B enzymatic domain.

Published in:

FEBS Letters, 2013, v. 587, n. 23, p. 3831, doi. 10.1016/j.febslet.2013.10.010

By:

Pirazzini, Marco;
Henke, Tina;
Rossetto, Ornella;
Mahrhold, Stefan;
Krez, Nadja;
Rummel, Andreas;
Montecucco, Cesare;
Binz, Thomas

Publication type:

Article

The thioredoxin reductase-thioredoxin system is involved in the entry of tetanus and botulinum neurotoxins in the cytosol of nerve terminals

Published in:

FEBS Letters, 2013, v. 587, n. 2, p. 150, doi. 10.1016/j.febslet.2012.11.007

By:

Pirazzini, Marco;
Bordin, Fulvio;
Rossetto, Ornella;
Shone, Clifford C.;
Binz, Thomas;
Montecucco, Cesare

Publication type:

Article

Electric dipole reorientation in the interaction of botulinum neurotoxins with neuronal membranes

Published in:

FEBS Letters, 2009, v. 583, n. 14, p. 2321, doi. 10.1016/j.febslet.2009.06.046

By:

Fogolari, Federico;
Tosatto, Silvio C.E.;
Muraro, Lucia;
Montecucco, Cesare

Publication type:

Article

Reversible skeletal neuromuscular paralysis induced by different lysophospholipids

Published in:

FEBS Letters, 2006, v. 580, n. 27, p. 6317, doi. 10.1016/j.febslet.2006.10.039

By:

Caccin, Paola;
Rigoni, Michela;
Bisceglie, Alessandra;
Rossetto, Ornella;
Montecucco, Cesare

Publication type:

Article

VAMP/synaptobrevin cleavage by tetanus and botulinum neurotoxins is strongly enhanced by acidic liposomes

Published in:

FEBS Letters, 2003, v. 542, n. 1-3, p. 132, doi. 10.1016/S0014-5793(03)00365-X

By:

Caccin, Paola;
Rossetto, Ornella;
Rigoni, Michela;
Johnson, Eric;
Schiavo, Giampietro;
Montecucco, Cesare

Publication type:

Article

The crystal structure of CagS from the Helicobacter pylori pathogenicity island.

Published in:

Proteins, 2007, v. 69, n. 2, p. 440, doi. 10.1002/prot.21576

By:

Cendron, Laura;
Tasca, Elisabetta;
Seraglio, Tommaso;
Seydel, Anke;
Angelini, Alessandro;
Battistutta, Roberto;
Montecucco, Cesare;
Zanotti, Giuseppe

Publication type:

Article

Tetanus and tetanus neurotoxin: From peripheral uptake to central nervous tissue targets.

Published in:

Journal of Neurochemistry, 2021, v. 158, n. 6, p. 1244, doi. 10.1111/jnc.15330

By:

Megighian, Aram;
Pirazzini, Marco;
Fabris, Federico;
Rossetto, Ornella;
Montecucco, Cesare

Publication type:

Article

Animal models for studying motor axon terminal paralysis and recovery.

Published in:

Journal of Neurochemistry, 2017, v. 142, p. 122, doi. 10.1111/jnc.13956

By:

Rigoni, Michela;
Montecucco, Cesare

Publication type:

Article

The Apoptogenic Toxin AIP56 Is a Metalloprotease A-B Toxin that Cleaves NF-κb P65.

Published in:

PLoS Pathogens, 2013, v. 9, n. 2, p. 1, doi. 10.1371/journal.ppat.1003128

By:

Silva, Daniela S.;
Pereira, Liliana M. G.;
Moreira, Ana R.;
Ferreira-da-Silva, Frederico;
Brito, Rui M.;
Faria, Tiago Q.;
Zornetta, Irene;
Montecucco, Cesare;
Oliveira, Pedro;
Azevedo, Jorge E.;
Pereira, Pedro J. B.;
Macedo-Ribeiro, Sandra;
do Vale, Ana;
dos Santos, Nuno M. S.

Publication type:

Article

The Adenylate Cyclase Toxins of Bacillus anthracis and Bordetella pertussis Promote Th2 Cell Development by Shaping T Cell Antigen Receptor Signaling.

Published in:

PLoS Pathogens, 2009, v. 5, n. 3, p. 1, doi. 10.1371/journal.ppat.1000325

By:

Paccani, Silvia Rossi;
Benagiano, Marisa;
Capitani, Nagaja;
Zornetta, Irene;
Ladant, Daniel;
Montecucco, Cesare;
D'Elios, Mario M.;
Baldari, Cosima T.

Publication type:

Article

Different types of botulinum toxin in humans.

Published in:

Movement Disorders, 2004, v. 19, p. S53, doi. 10.1002/mds.20010

By:

Roberto Eleopra;
Valeria Tugnoli;
Rocco Quatrale;
Ornella Rossetto;
Cesare Montecucco

Publication type:

Article