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A small-molecule inhibitor of the NLRP3 inflammasome for the treatment of inflammatory diseases.
Published in:
Nature Medicine, 2015, v. 21, n. 3, p. 248, doi. 10.1038/nm.3806
By:
- Coll, Rebecca C;
- Robertson, Avril A B;
- Chae, Jae Jin;
- Higgins, Sarah C;
- Muñoz-Planillo, Raúl;
- Inserra, Marco C;
- Vetter, Irina;
- Dungan, Lara S;
- Monks, Brian G;
- Stutz, Andrea;
- Croker, Daniel E;
- Butler, Mark S;
- Haneklaus, Moritz;
- Sutton, Caroline E;
- Núñez, Gabriel;
- Latz, Eicke;
- Kastner, Daniel L;
- Mills, Kingston H G;
- Masters, Seth L;
- Schroder, Kate
Publication type:
Article
iGLuc: a luciferase-based inflammasome and protease activity reporter.
Published in:
Nature Methods, 2013, v. 10, n. 2, p. 147, doi. 10.1038/nmeth.2327
By:
- Bartok, Eva;
- Bauernfeind, Franz;
- Khaminets, Maria G;
- Jakobs, Christopher;
- Monks, Brian;
- Fitzgerald, Katherine A;
- Latz, Eicke;
- Hornung, Veit
Publication type:
Article
The adaptor ASC has extracellular and 'prionoid' activities that propagate inflammation.
Published in:
Nature Immunology, 2014, v. 15, n. 8, p. 727, doi. 10.1038/ni.2913
By:
- Franklin, Bernardo S;
- Bossaller, Lukas;
- De Nardo, Dominic;
- Ratter, Jacqueline M;
- Stutz, Andrea;
- Engels, Gudrun;
- Brenker, Christoph;
- Nordhoff, Mark;
- Mirandola, Sandra R;
- Al-Amoudi, Ashraf;
- Mangan, Matthew S;
- Zimmer, Sebastian;
- Monks, Brian G;
- Fricke, Martin;
- Schmidt, Reinhold E;
- Espevik, Terje;
- Jones, Bernadette;
- Jarnicki, Andrew G;
- Hansbro, Philip M;
- Busto, Patricia
Publication type:
Article
The AIM2 inflammasome is essential for host defense against cytosolic bacteria and DNA viruses.
Published in:
Nature Immunology, 2010, v. 11, n. 5, p. 395, doi. 10.1038/ni.1864
By:
- Rathinam, Vijay A K;
- Jiang, Zhaozhao;
- Waggoner, Stephen N;
- Sharma, Shruti;
- Cole, Leah E;
- Waggoner, Lisa;
- Vanaja, Sivapriya Kailasan;
- Monks, Brian G;
- Ganesan, Sandhya;
- Latz, Eicke;
- Hornung, Veit;
- Vogel, Stefanie N;
- Szomolanyi-Tsuda, Eva;
- Fitzgerald, Katherine A
Publication type:
Article
The NALP3 inflammasome is involved in the innate immune response to amyloid-β.
Published in:
Nature Immunology, 2008, v. 9, n. 8, p. 857, doi. 10.1038/ni.1636
By:
- Halle, Annett;
- Hornung, Veit;
- Petzold, Gabor C;
- Stewart, Cameron R;
- Monks, Brian G;
- Reinheckel, Thomas;
- Fitzgerald, Katherine A;
- Latz, Eicke;
- Moore, Kathryn J;
- Golenbock, Douglas T
Publication type:
Article
Corrigendum: Ligand-induced conformational changes allosterically activate Toll-like receptor 9.
Published in:
Nature Immunology, 2007, v. 8, n. 11, p. 1266, doi. 10.1038/ni1107-1266c
By:
- Latz, Eicke;
- Verma, Anjali;
- Visintin, Alberto;
- Gong, Mei;
- Sirois, Cherilyn M;
- Klein, Dionne C G;
- Monks, Brian G;
- McKnight, C James;
- Lamphier, Marc S;
- Duprex, W Paul;
- Espevik, Terje;
- Golenbock, Douglas T
Publication type:
Article
Ligand-induced conformational changes allosterically activate Toll-like receptor 9.
Published in:
Nature Immunology, 2007, v. 8, n. 7, p. 772, doi. 10.1038/ni1479
By:
- Latz, Eicke;
- Verma, Anjali;
- Visintin, Alberto;
- Gong, Mei;
- Sirois, Cherilyn M;
- Klein, Dionne C G;
- Monks, Brian G;
- McKnight, C James;
- Lamphier, Marc S;
- Duprex, W Paul;
- Espevik, Terje;
- Golenbock, Douglas T
Publication type:
Article
TLR9 signals after translocating from the ER to CpG DNA in the lysosome.
Published in:
Nature Immunology, 2004, v. 5, n. 2, p. 190, doi. 10.1038/ni1028
By:
- Latz, Eicke;
- Schoenemeyer, Annett;
- Visintin, Alberto;
- Fitzgerald, Katherine A.;
- Monks, Brian G.;
- Knetter, Catherine F.;
- Lien, Egil;
- Nilsen, Nadra J.;
- Espevik, Terje;
- Golenbock, Douglas T.
Publication type:
Article
Chemical genetics reveals a kinase-independent role for protein kinase R in pyroptosis.
Published in:
Nature Chemical Biology, 2013, v. 9, n. 7, p. 466, doi. 10.1038/nchembio-0613-466a
By:
- Hett, Erik C;
- Slater, Louise H;
- Mark, Kevin G;
- Kawate, Tomohiko;
- Monks, Brian G;
- Stutz, Andrea;
- Latz, Eicke;
- Hung, Deborah T
Publication type:
Article
Chemical genetics reveals a kinase-independent role for protein kinase R in pyroptosis.
Published in:
Nature Chemical Biology, 2013, v. 9, n. 6, p. 398, doi. 10.1038/nchembio.1236
By:
- Hett, Erik C;
- Slater, Louise H;
- Mark, Kevin G;
- Kawate, Tomohiko;
- Monks, Brian G;
- Stutz, Andrea;
- Latz, Eicke;
- Hung, Deborah T
Publication type:
Article
Surface presentation of LPS is sufficient for initiation of signaling events.
Published in:
Innate Immunity, 1999, v. 5, n. 4, p. 244, doi. 10.1177/09680519990050040301
By:
- Ingalls, Robin R.;
- Monks, Brian G.;
- Golenbock, Douglas T.
Publication type:
Article

Found: 11