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Glucocorticoid receptor triggers a reversible drug-tolerant dormancy state with acquired therapeutic vulnerabilities in lung cancer.
Published in:
Nature Communications, 2021, v. 12, n. 1, p. 1, doi. 10.1038/s41467-021-24537-3
By:
- Prekovic, Stefan;
- Schuurman, Karianne;
- Mayayo-Peralta, Isabel;
- Manjón, Anna G.;
- Buijs, Mark;
- Yavuz, Selçuk;
- Wellenstein, Max D.;
- Barrera, Alejandro;
- Monkhorst, Kim;
- Huber, Anne;
- Morris, Ben;
- Lieftink, Cor;
- Chalkiadakis, Theofilos;
- Alkan, Ferhat;
- Silva, Joana;
- Győrffy, Balázs;
- Hoekman, Liesbeth;
- van den Broek, Bram;
- Teunissen, Hans;
- Debets, Donna O.
Publication type:
Article
Blastic plasmacytoid dendritic cell neoplasm.
Published in:
British Journal of Haematology, 2014, v. 164, n. 6, p. 757, doi. 10.1111/bjh.12666
By:
- Roodbergen, Sofie L.;
- Hofland, Johannes;
- Lam, King H.;
- Dikrama, Petra K.;
- Broyl, Annemiek;
- Monkhorst, Kim
Publication type:
Article
Generation and characterization of an inducible transgenic model for studying mouse esophageal biology.
Published in:
BMC Developmental Biology, 2012, v. 12, n. 1, p. 18, doi. 10.1186/1471-213X-12-18
By:
- Roth, Sabrina;
- Franken, Patrick;
- Monkhorst, Kim;
- Kong a San, John;
- Fodde, Riccardo
Publication type:
Article
X chromosome choice occurs independently of asynchronous replication timing.
Published in:
Journal of Cell Biology, 2005, v. 168, n. 3, p. 365, doi. 10.1083/jcb.200405117
By:
- Gribnau, Joost;
- Luikenhuis, Sandra;
- Hochedlinger, Konrad;
- Monkhorst, Kim;
- Jaenisch, Rudolf
Publication type:
Article
The Probability to Initiate X Chromosome Inactivation Is Determined by the X to Autosomal Ratio and X Chromosome Specific Allelic Properties.
Published in:
PLoS ONE, 2009, v. 4, n. 5, p. 1, doi. 10.1371/journal.pone.0005616
By:
- Monkhorst, Kim;
- de Hoon, Bas;
- Jonkers, Iris;
- Achame, Eskeatnaf Mulugeta;
- Monkhorst, Wouter;
- Hoogerbrugge, Jos;
- Rentmeester, Eveline;
- Westerhoff, Hans V.;
- Grosveld, Frank;
- Grootegoed, J. Anton;
- Gribnau, Joost
Publication type:
Article
Cell-Free DNA at Diagnosis for Stage IV Non-Small Cell Lung Cancer: Costs, Time to Diagnosis and Clinical Relevance.
Published in:
Cancers, 2022, v. 14, n. 7, p. 1783, doi. 10.3390/cancers14071783
By:
- Koole, Simone N.;
- Vessies, Daan C. L.;
- Schuurbiers, Milou M. F.;
- Kramer, Astrid;
- Schouten, Robert D.;
- Degeling, Koen;
- Bosch, Linda J. W.;
- van den Heuvel, Michel M.;
- van Harten, Wim H.;
- van den Broek, Daan;
- Monkhorst, Kim;
- Retèl, Valesca P.
Publication type:
Article
Clinical Impact of Prospective Whole Genome Sequencing in Sarcoma Patients.
Published in:
Cancers, 2022, v. 14, n. 2, p. 436, doi. 10.3390/cancers14020436
By:
- Schipper, Luuk J.;
- Monkhorst, Kim;
- Samsom, Kris G.;
- Bosch, Linda J.W.;
- Snaebjornsson, Petur;
- van Boven, Hester;
- Roepman, Paul;
- van der Kolk, Lizet E.;
- van Houdt, Winan J.;
- van der Graaf, Winette T.A.;
- Meijer, Gerrit A.;
- Voest, Emile E.
Publication type:
Article
Identification of protein biomarkers for prediction of response to platinum‐based treatment regimens in patients with non‐small cell lung cancer.
Published in:
Molecular Oncology, 2024, v. 18, n. 6, p. 1417, doi. 10.1002/1878-0261.13555
By:
- Böttger, Franziska;
- Radonic, Teodora;
- Bahce, Idris;
- Monkhorst, Kim;
- Piersma, Sander R.;
- Pham, Thang V.;
- Dingemans, Anne‐Marie C.;
- Hillen, Lisa M.;
- Santarpia, Mariacarmela;
- Giovannetti, Elisa;
- Smit, Egbert F.;
- Burgers, Sjaak A.;
- Jimenez, Connie R.
Publication type:
Article
Combining variant detection and fragment length analysis improves detection of minimal residual disease in postsurgery circulating tumour DNA of stage II-IIIA NSCLC patients.
Published in:
Molecular Oncology, 2022, v. 16, n. 14, p. 2719, doi. 10.1002/1878-0261.13267
By:
- Vessies, Daan C. L.;
- Schuurbiers, Milou M. F.;
- van der Noort, Vincent;
- Schouten, Irene;
- Linders, Theodora C.;
- Lanfermeijer, Mirthe;
- Ramkisoensing, Kalpana L.;
- Hartemink, Koen J.;
- Monkhorst, Kim;
- van den Heuvel, Michel M.;
- van den Broek, Daan
Publication type:
Article
An Automated Correction Algorithm (ALPACA) for ddPCR Data Using Adaptive Limit of Blank and Correction of False Positive Events Improves Specificity of Mutation Detection.
Published in:
Clinical Chemistry, 2021, v. 67, n. 7, p. 959, doi. 10.1093/clinchem/hvab040
By:
- Vessies, Daan C. L.;
- Linders, Theodora C.;
- Lanfermeijer, Mirthe;
- Ramkisoensing, Kalpana L.;
- van der Noort, Vincent;
- Schouten, Robert D.;
- Meijer, Gerrit A.;
- van den Heuvel, Michel M.;
- Monkhorst, Kim;
- den Broek, Daan van
Publication type:
Article
Importance of tumour volume and histology in trimodality treatment of patients with Stage IIIA non-small cell lung cancer—results from a retrospective analysis.
Published in:
Interactive Cardiovascular & Thoracic Surgery, 2022, v. 34, n. 4, p. 566, doi. 10.1093/icvts/ivab291
By:
- Joosten, Pieter J M;
- Dickhoff, Chris;
- van der Noort, Vincent;
- Smeekens, Maarten;
- Numan, Rachel C;
- Klomp, Houke M;
- Diessen, Judi N A van;
- Belderbos, Jose S A;
- Smit, Egbert F;
- Monkhorst, Kim;
- Oosterhuis, Jan W A;
- Heuvel, Michel M van den;
- Dahele, Max;
- Hartemink, Koen J
Publication type:
Article
Head-to-head comparison of composite and individual biomarkers to predict clinical benefit to PD-1 blockade in non-small cell lung cancer.
Published in:
PLoS ONE, 2024, v. 19, n. 7, p. 1, doi. 10.1371/journal.pone.0293707
By:
- Hummelink, Karlijn;
- van der Noort, Vincent;
- Muller, Mirte;
- Schouten, Robert D.;
- van den Heuvel, Michel M.;
- Thommen, Daniela S.;
- Smit, Egbert F.;
- Meijer, Gerrit A.;
- Monkhorst, Kim
Publication type:
Article
Phase 1 study of the pan-HER inhibitor dacomitinib plus the MEK1/2 inhibitor PD-0325901 in patients with KRAS-mutation-positive colorectal, non-small-cell lung and pancreatic cancer.
Published in:
2020
By:
- van Geel, Robin M. J. M.;
- van Brummelen, Emilie M. J.;
- Eskens, Ferry A. L. M.;
- Huijberts, Sanne C. F. A.;
- de Vos, Filip Y. F. L.;
- Lolkema, Martijn P. J. K.;
- Devriese, Lot A.;
- Opdam, Frans L.;
- Marchetti, Serena;
- Steeghs, Neeltje;
- Monkhorst, Kim;
- Thijssen, Bas;
- Rosing, Hilde;
- Huitema, Alwin D. R.;
- Beijnen, Jos H.;
- Bernards, René;
- Schellens, Jan H. M.
Publication type:
journal article
Trastuzumab and paclitaxel in patients with EGFR mutated NSCLC that express HER2 after progression on EGFR TKI treatment.
Published in:
British Journal of Cancer, 2018, v. 119, n. 5, p. 558, doi. 10.1038/s41416-018-0194-7
By:
- de Langen, Adrianus J.;
- Jebbink, M.;
- Hashemi, Sayed M. S.;
- Kuiper, Justine L.;
- de Bruin-Visser, J.;
- Monkhorst, Kim;
- Thunnissen, Erik;
- Smit, Egbert F.
Publication type:
Article
Trastuzumab and paclitaxel in patients with EGFR mutated NSCLC that express HER2 after progression on EGFR TKI treatment.
Published in:
2018
By:
- de Langen, Adrianus J;
- Jebbink, M;
- Hashemi, Sayed M S;
- Kuiper, Justine L;
- de Bruin-Visser, J;
- Monkhorst, Kim;
- Thunnissen, Erik;
- Smit, Egbert F
Publication type:
journal article
Phase I study of lapatinib plus trametinib in patients with KRAS-mutant colorectal, non-small cell lung, and pancreatic cancer.
Published in:
2020
By:
- Huijberts, Sanne C. F. A.;
- van Geel, Robin M. J. M.;
- van Brummelen, Emilie M. J.;
- Opdam, Frans L.;
- Marchetti, Serena;
- Steeghs, Neeltje;
- Pulleman, Saskia;
- Thijssen, Bas;
- Rosing, Hilde;
- Monkhorst, Kim;
- Huitema, Alwin D. R.;
- Beijnen, Jos H.;
- Bernards, René;
- Schellens, Jan H. M.
Publication type:
journal article
Study protocol: Whole genome sequencing Implementation in standard Diagnostics for Every cancer patient (WIDE).
Published in:
BMC Medical Genomics, 2020, v. 13, n. 1, p. N.PAG, doi. 10.1186/s12920-020-00814-w
By:
- Samsom, Kris G.;
- Bosch, Linda J. W.;
- Schipper, Luuk J.;
- Roepman, Paul;
- de Bruijn, Ewart;
- Hoes, Louisa R.;
- Riethorst, Immy;
- Schoenmaker, Lieke;
- van der Kolk, Lizet E.;
- Retèl, Valesca P.;
- Frederix, Geert W. J.;
- Buffart, Tineke E.;
- van der Hoeven, Jacobus J. M.;
- Voest, Emile E.;
- Cuppen, Edwin;
- Monkhorst, Kim;
- Meijer, Gerrit A.
Publication type:
Article
A review on genetic alterations in CNS metastases related to breast cancer treatment. Is there a role for liquid biopsies in CSF?
Published in:
Journal of Neuro-Oncology, 2023, v. 162, n. 1, p. 1, doi. 10.1007/s11060-023-04261-2
By:
- Wessels, Peter H.;
- Boelens, Mirjam C.;
- Monkhorst, Kim;
- Sonke, Gabe S.;
- van den Broek, Daan;
- Brandsma, Dieta
Publication type:
Article
Multicenter Comparison of Molecular Tumor Boards in The Netherlands: Definition, Composition, Methods, and Targeted Therapy Recommendations.
Published in:
Oncologist, 2021, v. 26, n. 8, p. e1347, doi. 10.1002/onco.13580
By:
- Koopman, Bart;
- Groen, Harry J.M.;
- Ligtenberg, Marjolijn J.L.;
- Grünberg, Katrien;
- Monkhorst, Kim;
- de Langen, Adrianus J.;
- Boelens, Mirjam C.;
- Paats, Marthe S.;
- von der Thüsen, Jan H.;
- Dinjens, Winand N.M.;
- Solleveld, Nienke;
- van Wezel, Tom;
- Gelderblom, Hans;
- Hendriks, Lizza E.;
- Speel, Ernst‐Jan M.;
- Theunissen, Tom E.;
- Kroeze, Leonie I.;
- Mehra, Niven;
- Piet, Berber;
- van der Wekken, Anthonie J.
Publication type:
Article
Phase I Study of Afatinib and Selumetinib in Patients with KRAS‐Mutated Colorectal, Non‐Small Cell Lung, and Pancreatic Cancer.
Published in:
Oncologist, 2021, v. 26, n. 4, p. 290, doi. 10.1002/onco.13631
By:
- Brummelen, Emilie M.J.;
- Huijberts, Sanne;
- Herpen, Carla;
- Desar, Ingrid;
- Opdam, Frans;
- Geel, Robin;
- Marchetti, Serena;
- Steeghs, Neeltje;
- Monkhorst, Kim;
- Thijssen, Bas;
- Rosing, Hilde;
- Huitema, Alwin;
- Beijnen, Jos;
- Bernards, Rene;
- Schellens, Jan
Publication type:
Article
Absence of PD-L1 expression on tumor cells in the context of an activated immune infiltrate may indicate impaired IFNγ signaling in non-small cell lung cancer.
Published in:
PLoS ONE, 2019, v. 14, n. 5, p. 1, doi. 10.1371/journal.pone.0216864
By:
- Theelen, Willemijn S. M. E.;
- Kuilman, Thomas;
- Schulze, Katja;
- Zou, Wei;
- Krijgsman, Oscar;
- Peters, Dennis D. G. C.;
- Cornelissen, Sten;
- Monkhorst, Kim;
- Sarma, Pranamee;
- Sumiyoshi, Teiko;
- Amler, Lukas C.;
- Willems, Stefan M.;
- Blaauwgeers, Johannes L. G.;
- van Noesel, Carel J. M.;
- Peeper, Daniel S.;
- van den Heuvel, Michel M.;
- Kowanetz, Marcin
Publication type:
Article
Formalin fixation for optimal concordance of programmed death‐ligand 1 immunostaining between cytologic and histologic specimens from patients with non–small cell lung cancer.
Published in:
Cancer Cytopathology, 2021, v. 129, n. 4, p. 304, doi. 10.1002/cncy.22383
By:
- Koomen, Bregje M.;
- Starre‐Gaal, Jose;
- Vonk, Judith M.;
- Thüsen, Jan H.;
- Meij, Jacqueline J. C.;
- Monkhorst, Kim;
- Willems, Stefan M.;
- Timens, Wim;
- 't Hart, Nils A.
Publication type:
Article
A phase 2 trial combining afatinib with cetuximab in patients with EGFR exon 20 insertion–positive non–small cell lung cancer.
Published in:
Cancer (0008543X), 2024, v. 130, n. 5, p. 683, doi. 10.1002/cncr.35090
By:
- van Veggel, Bianca A. M. H.;
- van der Wekken, Anthonie J.;
- Paats, Marthe S.;
- Hendriks, Lizza E. L.;
- Hashemi, Sayed M. S.;
- Daletzakis, Antonios;
- van den Broek, Daan;
- Bosch, Linda J. W.;
- Monkhorst, Kim;
- Smit, Egbert F.;
- de Langen, Adrianus J.
Publication type:
Article
Implementation of Novel Molecular Biomarkers for Non-small Cell Lung Cancer in the Netherlands: How to Deal With Increasing Complexity.
Published in:
Frontiers in Oncology, 2020, v. 9, p. 1, doi. 10.3389/fonc.2019.01521
By:
- van den Broek, Daan;
- Hiltermann, T. Jeroen N.;
- Biesma, Bonne;
- Dinjens, Winand N. M.;
- 't Hart, Nils A.;
- Hinrichs, John W. J.;
- Leers, Mathie P. G.;
- Monkhorst, Kim;
- van Oosterhout, Matthijs;
- Scharnhorst, Volkher;
- Schuuring, Ed;
- Speel, Ernst-Jan M.;
- van den Heuvel, Michel M.;
- van Schaik, Ron H. N.;
- von der Thüsen, Jan;
- Willems, Stefan M.;
- de Visser, Leonie;
- Ligtenberg, Marjolijn J. L.
Publication type:
Article
Implementation of Novel Molecular Biomarkers for Non-small Cell Lung Cancer in the Netherlands: How to Deal With Increasing Complexity.
Published in:
Frontiers in Oncology, 2020, v. 10, p. 1, doi. 10.3389/fonc.2019.01521
By:
- van den Broek, Daan;
- Hiltermann, T. Jeroen N.;
- Biesma, Bonne;
- Dinjens, Winand N. M.;
- 't Hart, Nils A.;
- Hinrichs, John W. J.;
- Leers, Mathie P. G.;
- Monkhorst, Kim;
- van Oosterhout, Matthijs;
- Scharnhorst, Volkher;
- Schuuring, Ed;
- Speel, Ernst-Jan M.;
- van den Heuvel, Michel M.;
- van Schaik, Ron H. N.;
- von der Thüsen, Jan;
- Willems, Stefan M.;
- de Visser, Leonie;
- Ligtenberg, Marjolijn J. L.
Publication type:
Article

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