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PTEN, but not SHIP and SHIP2, suppresses the PI3K/Akt pathway and induces growth inhibition and apoptosis of myeloma cells.
- Published in:
- Oncogene, 2002, v. 21, n. 34, p. 5289, doi. 10.1038/sj.onc.1205650
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- Publication type:
- Article
Inhibition of Bcl-x<sub>L</sub> expression sensitizes normal human keratinocytes and epithelial cells to apoptotic stimuli.
- Published in:
- Oncogene, 1999, v. 18, n. 31, p. 4495, doi. 10.1038/sj.onc.1202836
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- Publication type:
- Article
Comparison of strategies targeting Raf-1 mRNA in ovarian cancer.
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- International Journal of Cancer, 2006, v. 118, n. 6, p. 1565, doi. 10.1002/ijc.21520
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- Publication type:
- Article
Antisense oligodeoxynucleotides for urokinase-plasminogen activator receptor have anti-invasive and anti-proliferative effects in vitro and inhibit spontaneous metastases of human melanoma in mice.
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- International Journal of Cancer, 2004, v. 110, n. 1, p. 125, doi. 10.1002/ijc.20077
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- Article
Bcl-X.
- Published in:
- International Journal of Cancer, 2002, v. 99, n. 1, p. 29, doi. 10.1002/ijc.10248
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- Publication type:
- Article
Inhibition of progression to androgen-independence by combined adjuvant treatment with antisense BCL-XL and antisense Bcl-2 oligonucleotides plus taxol after castration in the Shionogi tumor model.
- Published in:
- International Journal of Cancer, 2000, v. 86, n. 6, p. 855, doi. 10.1002/(SICI)1097-0215(20000615)86:6<855::AID-IJC15>3.0.CO;2-8
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- Article
Reduction in glucagon receptor expression by an antisense oligonucleotide ameliorates diabetic syndrome in db/db mice.
- Published in:
- 2004
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- Publication type:
- journal article
Protein tyrosine phosphatase 1B reduction regulates adiposity and expression of genes involved in lipogenesis.
- Published in:
- 2002
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- Publication type:
- journal article
Antisense Oligonucleotides Targeting Jagged 1 Reduce House Dust Mite-induced Goblet Cell Metaplasia in the Adult Murine Lung.
- Published in:
- American Journal of Respiratory Cell & Molecular Biology, 2020, v. 63, n. 1, p. 46, doi. 10.1165/rcmb.2019-0257OC
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- Publication type:
- Article
Nonsense-mediated RNA Decay Pathway Inhibition Restores Expression and Function of W1282X CFTR.
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- American Journal of Respiratory Cell & Molecular Biology, 2019, v. 61, n. 3, p. 290, doi. 10.1165/rcmb.2018-0316OC
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- Publication type:
- Article
Role for Cela1 in Postnatal Lung Remodeling and Alpha-1 Antitrypsin–Deficient Emphysema.
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- American Journal of Respiratory Cell & Molecular Biology, 2018, v. 59, n. 2, p. 167, doi. 10.1165/rcmb.2017-0361OC
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- Publication type:
- Article
Anti-Inflammatory Activity of Inhaled IL-4 Receptor-α Antisense Oligonucleotide in Mice.
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- American Journal of Respiratory Cell & Molecular Biology, 2007, v. 36, n. 3, p. 276, doi. 10.1165/rcmb.2005-0456OC
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- Publication type:
- Article
Anti-Inflammatory Activity of Inhaled IL-4 Receptor-a Antisense Oligonucleotide in Mice.
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- American Journal of Respiratory Cell & Molecular Biology, 2007, v. 36, n. 3, p. 1, doi. 10.1165/rcmb.2005-0456oc
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- Publication type:
- Article
In Vitro and In Vivo Inhibition of Interleukin (IL)-5-Mediated Eosinopoiesis by Murine IL-5Rα Antisense Oligonucleotide.
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- American Journal of Respiratory Cell & Molecular Biology, 2001, v. 24, n. 2, p. 116, doi. 10.1165/ajrcmb.24.2.4237
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- Publication type:
- Article
Raf-1 is the predominant Raf isoform that mediates growth factor-stimulated growth in ovarian cancer cells.
- Published in:
- Carcinogenesis, 2006, v. 27, n. 4, p. 729
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- Publication type:
- Article
Antisense oligonucleotide-mediated Dnm2 knockdown prevents and reverts myotubular myopathy in mice.
- Published in:
- Nature Communications, 2017, v. 8, n. 6, p. 1, doi. 10.1038/ncomms15661
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- Publication type:
- Article
An oral antisense oligonucleotide for PCSK9 inhibition.
- Published in:
- Science Translational Medicine, 2021, v. 13, n. 593, p. 1, doi. 10.1126/scitranslmed.abe9117
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- Publication type:
- Article
Targeting KRAS-dependent tumors with AZD4785, a high-affinity therapeutic antisense oligonucleotide inhibitor of KRAS.
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- Science Translational Medicine, 2017, v. 9, n. 394, p. 1, doi. 10.1126/scitranslmed.aal5253
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- Publication type:
- Article
Platelet-localized FXI promotes a vascular coagulation-inflammatory circuit in arterial hypertension.
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- Science Translational Medicine, 2017, v. 9, n. 375, p. 1, doi. 10.1126/scitranslmed.aah4923
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- Publication type:
- Article
Transthyretin Antisense Oligonucleotides Lower Circulating RBP4 Levels and Improve Insulin Sensitivity in Obese Mice.
- Published in:
- Diabetes, 2015, v. 64, n. 5, p. 1603, doi. 10.2337/db14-0970
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- Publication type:
- Article
Reduction of JNK1 Expression Lowers Adiposity and Improves Insulin Sensitivity in Diet-Induced Obese Mice.
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- Diabetes, 2007, v. 56, p. A456
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- Publication type:
- Article
Antisense Reduction of mDIC Expression Lowers Body Weight and Improves Insulin Sensitivity in ob/ob Mice.
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- Diabetes, 2007, v. 56, p. A453
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- Publication type:
- Article
Short (12-Nucleotide) 2nd Generation Antisense Oligonucleotides Selectively Inhibit SGLT2 mRNA Expression Across Multiple Specie and Are Bioavailable Following Intrajejunal Administration.
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- Diabetes, 2007, v. 56, p. A144
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- Publication type:
- Article
Targeting foxo1 in mice using antisense oligonucleotide improves hepatic and peripheral insulin action.
- Published in:
- 2006
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- Publication type:
- journal article
Targeting Foxol in Mice Using Antisense Oligonucleotide Improves Hepatic and Peripheral Insulin Action.
- Published in:
- 2006
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- Publication type:
- Abstract
Reduction of hepatic and adipose tissue glucocorticoid receptor expression with antisense oligonucleotides improves hyperglycemia and hyperlipidemia in diabetic rodents without causing systemic glucocorticoid antagonism.
- Published in:
- 2005
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- Publication type:
- journal article
In Vitro and In Vivo Effects of SerpinA1 on the Modulation of Transthyretin Proteolysis.
- Published in:
- International Journal of Molecular Sciences, 2021, v. 22, n. 17, p. 9488, doi. 10.3390/ijms22179488
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- Publication type:
- Article
Bcl-xL Antisense Oligonucleotides Chemosensitize Human Glioblastoma Cells.
- Published in:
- Chemotherapy (0009-3157), 2002, v. 48, n. 4, p. 189, doi. 10.1159/000063873
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- Publication type:
- Article
Mcl-1 Antisense Therapy Chemosensitizes Human Melanoma in a SCID Mouse Xenotransplantation Model.
- Published in:
- Journal of Investigative Dermatology, 2003, v. 120, n. 6, p. 1081, doi. 10.1046/j.1523-1747.2003.12252.x
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- Publication type:
- Article
TMPRSS6 as a Therapeutic Target for Disorders of Erythropoiesis and Iron Homeostasis.
- Published in:
- Advances in Therapy, 2023, v. 40, n. 4, p. 1317, doi. 10.1007/s12325-022-02421-w
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- Article
Antisense transcripts are targets for activating small RNAs.
- Published in:
- Nature Structural & Molecular Biology, 2008, v. 15, n. 8, p. 842, doi. 10.1038/nsmb.1444
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- Article
Prediction of antisense oligonucleotide efficacy by in vitro methods.
- Published in:
- Nature Biotechnology, 1998, v. 16, n. 13, p. 1374, doi. 10.1038/4362
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- Publication type:
- Article
In vivo suppression of Bcl-X<sub>L</sub> expression facilitates chemotherapy-induced leukaemia cell death in a SCID/NOD-Hu model.
- Published in:
- British Journal of Haematology, 2001, v. 112, n. 3, p. 706, doi. 10.1046/j.1365-2141.2001.02603.x
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- Publication type:
- Article
Navigating the Future of Cardiovascular Drug Development-Leveraging Novel Approaches to Drive Innovation and Drug Discovery: Summary of Findings from the Novel Cardiovascular Therapeutics Conference.
- Published in:
- Cardiovascular Drugs & Therapy, 2017, v. 31, n. 4, p. 445, doi. 10.1007/s10557-017-6739-9
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- Publication type:
- Article
Antisense suppression of the nonsense mediated decay factor Upf3b as a potential treatment for diseases caused by nonsense mutations.
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- Genome Biology, 2018, v. 19, p. 1, doi. 10.1186/s13059-017-1386-9
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- Publication type:
- Article
Peripheral Reduction of FGFR4 with Antisense Oligonucleotides Increases Metabolic Rate and Lowers Adiposity in Diet-Induced Obese Mice.
- Published in:
- PLoS ONE, 2013, v. 8, n. 7, p. 1, doi. 10.1371/journal.pone.0066923
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- Article
Genomic Analysis of wig-1 Pathways.
- Published in:
- PLoS ONE, 2012, v. 7, n. 2, p. 1, doi. 10.1371/journal.pone.0029429
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- Publication type:
- Article
Nicotinamide N-methyltransferase knockdown protects against diet-induced obesity.
- Published in:
- Nature, 2014, v. 508, n. 7495, p. 258, doi. 10.1038/nature13198
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- Publication type:
- Article
Antisense therapy for cancer.
- Published in:
- Nature Reviews Cancer, 2005, v. 5, n. 6, p. 468, doi. 10.1038/nrc1631
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- Publication type:
- Article
CFTR mRNAs with nonsense codons are degraded by the SMG6-mediated endonucleolytic decay pathway.
- Published in:
- Nature Communications, 2022, v. 13, n. 1, p. 1, doi. 10.1038/s41467-022-29935-9
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- Publication type:
- Article
Evaluation of the Antihemostatic and Antithrombotic Effects of Lowering Coagulation Factor VII Levels in a Non-human Primate.
- Published in:
- Cellular & Molecular Bioengineering, 2020, v. 13, n. 3, p. 179, doi. 10.1007/s12195-020-00613-4
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- Publication type:
- Article
Platelet-localized FXI promotes a glycoprotein Ibα dependent feedback loop in arterial hypertension and vascular inflammation.
- Published in:
- Artery Research, 2015, v. 12, p. 4, doi. 10.1016/j.artres.2015.10.201
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- Publication type:
- Article
Antisense oligonucleotide treatment ameliorates alpha-1 antitrypsin--related liver disease in mice.
- Published in:
- Journal of Clinical Investigation, 2014, v. 124, n. 1, p. 251, doi. 10.1172/JCI67968
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- Publication type:
- Article
Reducing TMPRSS6 ameliorates hemochromatosis and β-thalassemia in mice.
- Published in:
- Journal of Clinical Investigation, 2013, v. 123, n. 4, p. 1531, doi. 10.1172/JCI66969
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- Publication type:
- Article
Inhibition of protein kinase Cepsilon prevents hepatic insulin resistance in nonalcoholic fatty liver disease.
- Published in:
- 2007
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- Publication type:
- journal article
Antisense oligonucleotide therapy for neurodegenerative disease.
- Published in:
- 2006
- By:
- Publication type:
- journal article
Critical role of stearoyl-CoA desaturase-1 (SCD1) in the onset of diet-induced hepatic insulin resistance.
- Published in:
- 2006
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- Publication type:
- journal article
Reversal of diet-induced hepatic steatosis and hepatic insulin resistance by antisense oligonucleotide inhibitors of acetyl-CoA carboxylases 1 and 2.
- Published in:
- 2006
- By:
- Publication type:
- journal article
Severe impairment in liver insulin signaling fails to alter hepatic insulin action in conscious mice.
- Published in:
- 2005
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- Publication type:
- journal article
Role of resistin in diet-induced hepatic insulin resistance.
- Published in:
- Journal of Clinical Investigation, 2004, v. 114, n. 2, p. 232, doi. 10.1172/JCI200421270
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- Publication type:
- Article