Works by Molkentin, Jeffery D.

Results: 114

MCU-independent Ca2+ uptake mediates mitochondrial Ca2+ overload and necrotic cell death in a mouse model of Duchenne muscular dystrophy.

Published in:

Scientific Reports, 2024, v. 14, n. 1, p. 1, doi. 10.1038/s41598-024-57340-3

By:

Bround, Michael J.;
Abay, Eaman;
Huo, Jiuzhou;
Havens, Julian R.;
York, Allen J.;
Bers, Donald M.;
Molkentin, Jeffery D.

Publication type:

Article

Does Contractile Ca2+ Control Calcineurin-NFAT Signaling and Pathological Hypertrophy in Cardiac Myocytes?

Published in:

Science Signaling, 2008, v. 1, n. 25, p. 1, doi. 10.1126/scisignal.125pe31

By:

Houser, Steven R.;
Molkentin, Jeffery D.

Publication type:

Article

c-Jun N-terminal kinases (JNK) antagonize cardiac growth through cross-talk with calcineurin-NFAT signaling.

Published in:

EMBO Journal, 2003, v. 22, n. 19, p. 5079, doi. 10.1093/emboj/cdg474

By:

Liang, Qiangrong;
Bueno, Orlando F.;
Wilkins, Benjamin J.;
Chia-Yi Kuan;
Ying Xia;
Molkentin, Jeffery D.

Publication type:

Article

Requirement of transcription factor NFAT in developing atrial myocardium.

Published in:

Journal of Cell Biology, 2003, v. 161, n. 5, p. 861, doi. 10.1083/jcb.200301058

By:

Schubert, William;
Xiao Yong Yang;
Yang, Teddy T.C.;
Factor, Stephen M.;
Lisanti, Michael P.;
Molkentin, Jeffery D.;
Rincón, Mercedes;
Chi-Wing Chow

Publication type:

Article

Interaction between TAK1–TAB1–TAB2 and RCAN1–calcineurin defines a signalling nodal control point.

Published in:

Nature Cell Biology, 2009, v. 11, n. 2, p. 154, doi. 10.1038/ncb1823

By:

Liu, Qinghang;
Busby, Jennifer Caldwell;
Molkentin, Jeffery D.

Publication type:

Article

Voltage-dependent anion channels are dispensable for mitochondrial-dependent cell death.

Published in:

Nature Cell Biology, 2007, v. 9, n. 5, p. 550, doi. 10.1038/ncb1575

By:

Baines, Christopher P.;
Kaiser, Robert A.;
Sheiko, Tatiana;
Craigen, William J.;
Molkentin, Jeffery D.

Publication type:

Article

BEX1 is an RNA-dependent mediator of cardiomyopathy.

Published in:

Nature Communications, 2017, v. 8, n. 1, p. 1, doi. 10.1038/s41467-017-02005-1

By:

Accornero, Federica;
Schips, Tobias G.;
Petrosino, Jennifer M.;
Shan-Qing Gu;
Kanisicak, Onur;
van Berlo, Jop H.;
Molkentin, Jeffery D.

Publication type:

Article

Calcineurin A-β is required for hypertrophy but not matrix expansion in the diabetic kidney.

Published in:

Journal of Cellular & Molecular Medicine, 2011, v. 15, n. 2, p. 414, doi. 10.1111/j.1582-4934.2009.00910.x

By:

Reddy, Ramesh N.;
Knotts, Taylor L.;
Roberts, Brian R.;
Molkentin, Jeffery D.;
Price, S. Russ;
Gooch, Jennifer L.

Publication type:

Article

Calcium Sparklets Regulate Local and Global Calcium in Murine Arterial Smooth Muscle.

Published in:

FASEB Journal, 2007, v. 21, n. 6, p. A1241

By:

Amberg, Gregory C.;
Navedo, Manuel F.;
Nieves-Cintron, Madeline;
Molkentin, Jeffery D.;
Santana, Luis F.

Publication type:

Article

Calcineurin-dependent cardiomyopathy is activated by TRPC in the adult mouse heart.

Published in:

FASEB Journal, 2006, v. 20, n. 10, p. 1660, doi. 10.1096/fj.05-5560com

By:

Nakayama, Hiroyuki;
Wilkin, Benjamin J.;
Bodi, Ilona;
Molkentin, Jeffery D.

Publication type:

Article

Temporal activation of c‐Jun N‐terminal kinase in adult transgenic heart via cre‐loxP‐mediated DNA recombination.

Published in:

FASEB Journal, 2003, v. 17, n. 6, p. 749, doi. 10.1096/fj.02-0438fje

By:

Petrich, Brian G.;
Molkentin, Jeffery D.;
Wang, Yibin

Publication type:

Article

Regulation of angiogenesis by a non-canonical Wnt-Flt1 pathway in myeloid cells.

Published in:

Nature, 2011, v. 474, n. 7352, p. 511, doi. 10.1038/nature10085

By:

Stefater III, James A.;
Lewkowich, Ian;
Rao, Sujata;
Mariggi, Giovanni;
Carpenter, April C.;
Burr, Adam R.;
Fan, Jieqing;
Ajima, Rieko;
Molkentin, Jeffery D.;
Williams, Bart O.;
Wills-Karp, Marsha;
Pollard, Jeffrey W.;
Yamaguchi, Terry;
Ferrara, Napoleone;
Gerhardt, Holger;
Lang, Richard A.

Publication type:

Article

Molecular basis of physiological heart growth: fundamental concepts and new players.

Published in:

Nature Reviews Molecular Cell Biology, 2013, v. 14, n. 1, p. 38, doi. 10.1038/nrm3495

By:

Maillet, Marjorie;
van Berlo, Jop H.;
Molkentin, Jeffery D.

Publication type:

Article

Regulation of cardiac hypertrophy by intracellular signalling pathways.

Published in:

Nature Reviews Molecular Cell Biology, 2006, v. 7, n. 8, p. 589, doi. 10.1038/nrm1983

By:

Heineke, Joerg;
Molkentin, Jeffery D.

Publication type:

Article

Nemo-Like Kinase (NLK) Is a Pathological Signaling Effector in the Mouse Heart.

Published in:

PLoS ONE, 2016, v. 11, n. 10, p. 1, doi. 10.1371/journal.pone.0164897

By:

Liu, Ruijie;
Khalil, Hadi;
Lin, Suh-Chin J.;
Sargent, Michelle A.;
York, Allen J.;
Molkentin, Jeffery D.

Publication type:

Article

The EYA3 tyrosine phosphatase activity promotes pulmonary vascular remodeling in pulmonary arterial hypertension.

Published in:

Nature Communications, 2019, v. 10, n. 1, p. N.PAG, doi. 10.1038/s41467-019-12226-1

By:

Wang, Yuhua;
Pandey, Ram Naresh;
York, Allen J.;
Mallela, Jaya;
Nichols, William C.;
Hu, Yueh-Chiang;
Molkentin, Jeffery D.;
Wikenheiser-Brokamp, Kathryn A.;
Hegde, Rashmi S.

Publication type:

Article

Thrombospondin-3 augments injury-induced cardiomyopathy by intracellular integrin inhibition and sarcolemmal instability.

Published in:

Nature Communications, 2019, v. 10, n. 1, p. 1, doi. 10.1038/s41467-018-08026-8

By:

Schips, Tobias G.;
Vanhoutte, Davy;
Vo, Alexander;
Correll, Robert N.;
Brody, Matthew J.;
Khalil, Hadi;
Karch, Jason;
Tjondrokoesoemo, Andoria;
Sargent, Michelle A.;
Maillet, Marjorie;
Ross, Robert S.;
Molkentin, Jeffery D.

Publication type:

Article

An emerging consensus on cardiac regeneration.

Published in:

Nature Medicine, 2014, v. 20, n. 12, p. 1386, doi. 10.1038/nm.3764

By:

van Berlo, Jop H;
Molkentin, Jeffery D

Publication type:

Article

Sarcolipin is a newly identified regulator of muscle-based thermogenesis in mammals.

Published in:

Nature Medicine, 2012, v. 18, n. 12, p. 1857, doi. 10.1038/nm1212-1857b

By:

Bal, Naresh C;
Maurya, Santosh K;
Sopariwala, Danesh H;
Sahoo, Sanjaya K;
Gupta, Subash C;
Shaikh, Sana A;
Pant, Meghna;
Rowland, Leslie A;
Goonasekera, Sanjeewa A;
Molkentin, Jeffery D;
Periasamy, Muthu

Publication type:

Article

Sarcolipin is a newly identified regulator of muscle-based thermogenesis in mammals.

Published in:

Nature Medicine, 2012, v. 18, n. 10, p. 1575, doi. 10.1038/nm.2897

By:

Bal, Naresh C;
Maurya, Santosh K;
Sopariwala, Danesh H;
Sahoo, Sanjaya K;
Gupta, Subash C;
Shaikh, Sana A;
Pant, Meghna;
Rowland, Leslie A;
Goonasekera, Sanjeewa A;
Molkentin, Jeffery D;
Periasamy, Muthu

Publication type:

Article

CIB1 is a regulator of pathological cardiac hypertrophy.

Published in:

Nature Medicine, 2010, v. 16, n. 8, p. 872, doi. 10.1038/nm.2181

By:

Heineke, Joerg;
Auger-Messier, Mannix;
Correll, Robert N.;
Jian Xu;
Benard, Matthew J.;
Weiping Yuan;
Drexler, Helmut;
Parise, Leslie V.;
Molkentin, Jeffery D.

Publication type:

Article

Cyclophilin D deficiency attenuates mitochondrial and neuronal perturbation and ameliorates learning and memory in Alzheimer's disease.

Published in:

Nature Medicine, 2008, v. 14, n. 10, p. 1097, doi. 10.1038/nm.1868

By:

Heng Du;
Lan Guo;
Fang Fang;
Chen, Doris;
A Sosunov, Alexander;
M McKhann, Guy;
Yilin Yan;
Chunyu Wang;
Hong Zhang;
Molkentin, Jeffery D;
Gunn-Moore, Frank J;
Vonsattel, Jean Paul;
Arancio, Ottavio;
John Xi Chen;
Yan, Shi Du

Publication type:

Article

Genetic and pharmacologic inhibition of mitochondrial-dependent necrosis attenuates muscular dystrophy.

Published in:

Nature Medicine, 2008, v. 14, n. 4, p. 442, doi. 10.1038/nm1736

By:

Millay, Douglas P.;
Sargent, Michelle A.;
Osinska, Hanna;
Baines, Christopher P.;
Barton, Elisabeth R.;
Vuagniaux, Grégoire;
Sweeney, H. Lee;
Robbins, Jeffrey;
Molkentin, Jeffery D.

Publication type:

Article

Evidence from a genetic fate-mapping study that stem cells refresh adult mammalian cardiomyocytes after injury.

Published in:

Nature Medicine, 2007, v. 13, n. 8, p. 970, doi. 10.1038/nm1618

By:

Hsieh, Patrick C. H.;
Segers, Vincent F. M.;
Davis, Michael E.;
MacGillivray, Catherine;
Gannon, Joseph;
Molkentin, Jeffery D.;
Robbins, Jeffrey;
Lee, Richard T.

Publication type:

Article

Locating heart failure.

Published in:

Nature Medicine, 2005, v. 11, n. 12, p. 1284, doi. 10.1038/nm1205-1284

By:

Molkentin, Jeffery D.

Publication type:

Article

Re-evaluating sarcoplasmic reticulum function in heart failure.

Published in:

Nature Medicine, 2000, v. 6, n. 9, p. 942, doi. 10.1038/79592

By:

Delling, Ulrike;
Sussman, Mark A.;
Molkentin, Jeffery D.

Publication type:

Article

Analysis of the transcriptional activity of endogenous NFAT5 in primary cells using transgenic NFAT-luciferase reporter mice.

Published in:

BMC Molecular Biology, 2008, v. 9, p. 1, doi. 10.1186/1471-2199-9-13

By:

Morancho, Beatriz;
Minguillón, Jordi;
Molkentin, Jeffery D.;
López-Rodríguez, Cristina;
Aramburu, Jose

Publication type:

Article

Defective Flux of Thrombospondin-4 through the Secretory Pathway Impairs Cardiomyocyte Membrane Stability and Causes Cardiomyopathy.

Published in:

Molecular & Cellular Biology, 2018, v. 38, n. 14, p. 1, doi. 10.1128/MCB.00114-18

By:

Brody, Matthew J.;
Vanhoutte, Davy;
Schips, Tobias G.;
Boyer, Justin G.;
Bakshi, Chinmay V.;
Sargent, Michelle A.;
York, Allen J.;
Molkentin, Jeffery D.

Publication type:

Article

Dissection of Thrombospondin-4 Domains Involved in Intracellular Adaptive Endoplasmic Reticulum Stress-Responsive Signaling.

Published in:

Molecular & Cellular Biology, 2015, v. 35, n. 24, p. 2, doi. 10.1128/MCB.00607-15

By:

Brody, Matthew J.;
Schips, Tobias G.;
Vanhoutte, Davy;
Kanisicak, Onur;
Karch, Jason;
Maliken, Bryan D.;
Blair, N. Scott;
Sargent, Michelle A.;
Prasad, Vikram;
Molkentin, Jeffery D.

Publication type:

Article

Genetic Analysis of Connective Tissue Growth Factor as an Effector of Transforming Growth Factor β Signaling and Cardiac Remodeling.

Published in:

Molecular & Cellular Biology, 2015, v. 35, n. 12, p. 2154, doi. 10.1128/MCB.00199-15

By:

Accornero, Federica;
van Berlo, Jop H.;
Correll, Robert N.;
Elrod, John W.;
Sargent, Michelle A.;
York, Allen;
Rabinowitz, Joseph E.;
Leask, Andrew;
Molkentin, Jeffery D.

Publication type:

Article

Na+ Dysregulation Coupled with Ca2+ Entry through NCX1 Promotes Muscular Dystrophy in Mice.

Published in:

Molecular & Cellular Biology, 2014, v. 34, n. 11, p. 1991, doi. 10.1128/MCB.00339-14

By:

Burr, Adam R.;
Millay, Douglas P.;
Goonasekera, Sanjeewa A.;
Ki Ho Park;
Sargent, Michelle A.;
Collins, James;
Altamirano, Francisco;
Philipson, Kenneth D.;
Allen, Paul D.;
Jianjie Ma;
López, José Rafael;
Molkentin, Jeffery D.

Publication type:

Article

c-kit+ cells minimally contribute cardiomyocytes to the heart.

Published in:

Nature, 2014, v. 509, n. 7500, p. 337, doi. 10.1038/nature13309

By:

van Berlo, Jop H.;
Kanisicak, Onur;
Maillet, Marjorie;
Vagnozzi, Ronald J.;
Karch, Jason;
Lin, Suh-Chin J.;
Middleton, Ryan C.;
Marbán, Eduardo;
Molkentin, Jeffery D.

Publication type:

Article

TGFBI functions similar to periostin but is uniquely dispensable during cardiac injury.

Published in:

PLoS ONE, 2017, v. 12, n. 7, p. 1, doi. 10.1371/journal.pone.0181945

By:

Schwanekamp, Jennifer A.;
Lorts, Angela;
Sargent, Michelle A.;
York, Allen J.;
Grimes, Kelly M.;
Fischesser, Demetria M.;
Gokey, Jason J.;
Whitsett, Jeffrey A.;
Conway, Simon J.;
Molkentin, Jeffery D.

Publication type:

Article

Caveolae-localized L-type Ca2+ channels do not contribute to function or hypertrophic signalling in the mouse heart.

Published in:

Cardiovascular Research, 2017, v. 113, n. 7, p. 749, doi. 10.1093/cvr/cvx046

By:

Correll, Robert N.;
Makarewich, Catherine A.;
Hongyu Zhang;
Chen Zhang;
Sargent, Michelle A.;
York, Allen J.;
Berretta, Remus M.;
Xiongwen Chen;
Houser, Steven R.;
Molkentin, Jeffery D.

Publication type:

Article

Inositol 1,4,5-trisphosphate-mediated sarcoplasmic reticulum-mitochondrial crosstalk influences adenosine triphosphate production via mitochondrial Ca2+ uptake through the mitochondrial ryanodine receptor in cardiacmyocytes.

Published in:

Cardiovascular Research, 2016, v. 112, n. 1, p. 491, doi. 10.1093/cvr/cvw185

By:

Seidlmayer, Lea K.;
Kuhn, Johannes;
Berbner, Annette;
Arias-Loza, Paula-Anahi;
Williams, Tatjana;
Kaspar, Mathias;
Czolbe, Martin;
Kwong, Jennifer Q.;
Molkentin, Jeffery D.;
Heinze, Katrin Gertrud;
Dedkova, Elena N.;
Ritter, Oliver

Publication type:

Article

Proteasome functional insufficiency activates the calcineurin–NFAT pathway in cardiomyocytes and promotes maladaptive remodelling of stressed mouse hearts.

Published in:

Cardiovascular Research, 2010, v. 88, n. 3, p. 424, doi. 10.1093/cvr/cvq217

By:

Mingxin Tang;
Jie Li;
Wei Huang;
Huabo Su;
Qiangrong Liang;
Zongwen Tian;
Horak, Kathleen M.;
Molkentin, Jeffery D.;
Xuejun Wang

Publication type:

Article

Phosphodiesterase 5 inhibition blocks pressure overload-induced cardiac hypertrophy independent of the calcineurin pathway.

Published in:

Cardiovascular Research, 2009, v. 81, n. 2, p. 301

By:

Steven Hsu;
Takahiro Nagayama;
Norimichi Koitabashi;
Manling Zhang;
Liye Zhou;
Djahida Bedja;
Kathleen L. Gabrielson;
Jeffery D. Molkentin;
David A. Kass;
Eiki Takimoto

Publication type:

Article

Calcineurin regulates NFAT-dependent iNOS expression and protection of cardiomyocytes: Co-operation with Src tyrosine kinase

Published in:

Cardiovascular Research, 2006, v. 71, n. 4, p. 672, doi. 10.1016/j.cardiores.2006.05.026

By:

Obasanjo-Blackshire, Kofo;
Mesquita, Rui;
Jabr, Rita I.;
Molkentin, Jeffery D.;
Hart, Stephen L.;
Marber, Michael S.;
Xia, Yang;
Heads, Richard J.

Publication type:

Article

Calcineurin–NFAT signaling regulates the cardiac hypertrophic response in coordination with the MAPKs

Published in:

Cardiovascular Research, 2004, v. 63, n. 3, p. 467, doi. 10.1016/j.cardiores.2004.01.021

By:

Molkentin, Jeffery D.

Publication type:

Article

Overexpression of calcineurin in mouse causes sudden cardiac death associated with decreased density of K+ channels

Published in:

Cardiovascular Research, 2003, v. 57, n. 2, p. 320, doi. 10.1016/S0008-6363(02)00661-2

By:

Dong, Deli;
Duan, Yanjun;
Guo, Jiqing;
Roach, Dan E.;
Swirp, Shauni L.;
Wang, Li;
Lees-Miller, J.P.;
Sheldon, R.S.;
Molkentin, Jeffery D.;
Duff, Henry J.

Publication type:

Article

Cardiac function and electrical remodeling of the calcineurin-overexpressed transgenic mouse

Published in:

Cardiovascular Research, 2002, v. 54, n. 1, p. 117, doi. 10.1016/S0008-6363(02)00241-9

By:

Petrashevskaya, Natalia N.;
Bodi, Ilona;
Rubio, Marta;
Molkentin, Jeffery D.;
Schwartz, Arnold

Publication type:

Article

Enhanced myocyte contractility and Ca2+ handling in a calcineurin transgenic model of heart failure

Published in:

Cardiovascular Research, 2002, v. 54, n. 1, p. 105, doi. 10.1016/S0008-6363(02)00230-4

By:

Chu, Guoxiang;
Carr, Andrew N.;
Young, Karen B.;
Lester, J. William;
Yatani, Atsuko;
Sanbe, Atsushi;
Colbert, Melissa C.;
Schwartz, Steven M.;
Frank, Konrad F.;
Lampe, Paul D.;
Robbins, Jeffrey;
Molkentin, Jeffery D.;
Kranias, Evangelia G.

Publication type:

Article

Calcineurin and hypertrophic heart disease: novel insights and remaining questions

Published in:

Cardiovascular Research, 2002, v. 53, n. 4, p. 806, doi. 10.1016/S0008-6363(01)00493-X

By:

Bueno, Orlando F.;
van Rooij, Eva;
Molkentin, Jeffery D.;
Doevendans, Pieter A.;
De Windt, Leon J.

Publication type:

Article

Hypertrophic defect unmasked by calcineurin expression in asymptomatic tropomodulin overexpressing transgenic mice.

Published in:

Cardiovascular Research, 2000, v. 46, n. 1, p. 90, doi. 10.1016/S0008-6363(99)00422-8

By:

Sussman, Mark A.;
Welch, Sara;
Walker, Angela;
Klevitsky, Raisa;
Hewett, Timothy E.;
Witt, Sandra A.;
Kimball, Thomas R.;
Price, Robert;
Lim, Hae W.;
Molkentin, Jeffery D.

Publication type:

Article

Reply to Revisiting calcineurin and human heart failure.

Published in:

Nature Medicine, 2000, v. 6, n. 1, p. 3, doi. 10.1038/71511

By:

Lim, Hae W.;
Molkentin, Jeffery D.

Publication type:

Article

Calcineurin and human heart failure.

Published in:

Nature Medicine, 1999, v. 5, n. 3, p. 246, doi. 10.1038/6430

By:

Lim, Hae W.;
Molkentin, Jeffery D.

Publication type:

Article

Mutual antagonism between IP3RII and miRNA-133a regulates calcium signals and cardiac hypertrophy.

Published in:

Journal of Cell Biology, 2012, v. 199, n. 5, p. 783, doi. 10.1083/jcb.201111095

By:

Drawnel, Faye M.;
Wachten, Dagmar;
Molkentin, Jeffery D.;
Maillet, Marjorie;
Aronsen, Jan Magnus;
Swift, Fredrik;
Sjaastad, Ivar;
Ning Liu;
Catalucci, Daniele;
Mikoshiba, Katsuhiko;
Hisatsune, Chihiro;
Okkenhaug, Hanneke;
Andrews, Simon R.;
Bootman, Martin D.;
Roderick, H. Llewelyn

Publication type:

Article

Tinman/Nkx2-5 acts via miR-1 and upstream of Cdc42 to regulate heart function across species.

Published in:

Journal of Cell Biology, 2011, v. 193, n. 7, p. 1181, doi. 10.1083/jcb.201006114

By:

Li Qian;
Wythe, Joshua D.;
Jiandong Liu;
Cartry, Jerome;
Vogler, Georg;
Mohapatra, Bhagyalaxmi;
Otway, Robyn T.;
Yu Huang;
King, Isabelle N.;
Maillet, Marjorie;
Yi Zheng;
Crawley, Timothy;
Taghli-Lamallem, Ouarda;
Semsarian, Christopher;
Dunwoodie, Sally;
Winlaw, David;
Harvey, Richard P.;
Fatkin, Diane;
Towbin, Jeffrey A.;
Molkentin, Jeffery D.

Publication type:

Article

Modulation of chromatin position and gene expression by HDAC4 interaction with nucleoporins.

Published in:

Journal of Cell Biology, 2011, v. 193, n. 1, p. 21, doi. 10.1083/jcb.201101046

By:

Kehat, Izhak;
Accornero, Federica;
Aronow, Bruce J.;
Molkentin, Jeffery D.

Publication type:

Article

Calreticulin signal upstream of calcineurin and MEF2C in a critical Ca2+-dependent signaling cascade.

Published in:

Journal of Cell Biology, 2005, v. 170, n. 1, p. 37, doi. 10.1083/jcb.200412156

By:

Lynch, Jeffrey;
Guo, Lel;
Gelebart, Pascal;
Chilibeck, Kaari;
Jian Xu;
Molkentin, Jeffery D.;
Agellon, Luis B.;
Michalak, Marek

Publication type:

Article