Works matching AU Molkentin, Jeffery D.

Results: 114

Persistent Increases in Ca2+ Influx through Cav1.2 Shortens Action Potential And Causes Ca2+ Overload-induced Afterdepolarizations and Arrhythmias.

Published in:

Basic Research in Cardiology, 2016, v. 111, n. 1, p. 1, doi. 10.1007/s00395-015-0523-4

By:

Xiaoying Zhang;
Xiaojie Ai;
Hiroyuki Nakayama;
Biyi Chen;
Harris, David M.;
Mingxin Tang;
Yuping Xie;
Szeto, Christopher;
Yingxin Li;
Ying Li;
Hongyu Zhang;
Eckhart, Andrea D.;
Koch, Walter J.;
Molkentin, Jeffery D.;
Xiongwen Chen

Publication type:

Article

Calcineurin and cardiac hypertrophy: Where have we been? Where are we going?

Published in:

Journal of Physiology, 2002, v. 541, n. 1, p. 1, doi. 10.1113/jphysiol.2002.017129

By:

Wilkins, Benjamin J.;
Molkentin, Jeffery D.

Publication type:

Article

An emerging consensus on cardiac regeneration.

Published in:

Nature Medicine, 2014, v. 20, n. 12, p. 1386, doi. 10.1038/nm.3764

By:

van Berlo, Jop H;
Molkentin, Jeffery D

Publication type:

Article

Sarcolipin is a newly identified regulator of muscle-based thermogenesis in mammals.

Published in:

Nature Medicine, 2012, v. 18, n. 12, p. 1857, doi. 10.1038/nm1212-1857b

By:

Bal, Naresh C;
Maurya, Santosh K;
Sopariwala, Danesh H;
Sahoo, Sanjaya K;
Gupta, Subash C;
Shaikh, Sana A;
Pant, Meghna;
Rowland, Leslie A;
Goonasekera, Sanjeewa A;
Molkentin, Jeffery D;
Periasamy, Muthu

Publication type:

Article

Sarcolipin is a newly identified regulator of muscle-based thermogenesis in mammals.

Published in:

Nature Medicine, 2012, v. 18, n. 10, p. 1575, doi. 10.1038/nm.2897

By:

Bal, Naresh C;
Maurya, Santosh K;
Sopariwala, Danesh H;
Sahoo, Sanjaya K;
Gupta, Subash C;
Shaikh, Sana A;
Pant, Meghna;
Rowland, Leslie A;
Goonasekera, Sanjeewa A;
Molkentin, Jeffery D;
Periasamy, Muthu

Publication type:

Article

CIB1 is a regulator of pathological cardiac hypertrophy.

Published in:

Nature Medicine, 2010, v. 16, n. 8, p. 872, doi. 10.1038/nm.2181

By:

Heineke, Joerg;
Auger-Messier, Mannix;
Correll, Robert N.;
Jian Xu;
Benard, Matthew J.;
Weiping Yuan;
Drexler, Helmut;
Parise, Leslie V.;
Molkentin, Jeffery D.

Publication type:

Article

Cyclophilin D deficiency attenuates mitochondrial and neuronal perturbation and ameliorates learning and memory in Alzheimer's disease.

Published in:

Nature Medicine, 2008, v. 14, n. 10, p. 1097, doi. 10.1038/nm.1868

By:

Heng Du;
Lan Guo;
Fang Fang;
Chen, Doris;
A Sosunov, Alexander;
M McKhann, Guy;
Yilin Yan;
Chunyu Wang;
Hong Zhang;
Molkentin, Jeffery D;
Gunn-Moore, Frank J;
Vonsattel, Jean Paul;
Arancio, Ottavio;
John Xi Chen;
Yan, Shi Du

Publication type:

Article

Genetic and pharmacologic inhibition of mitochondrial-dependent necrosis attenuates muscular dystrophy.

Published in:

Nature Medicine, 2008, v. 14, n. 4, p. 442, doi. 10.1038/nm1736

By:

Millay, Douglas P.;
Sargent, Michelle A.;
Osinska, Hanna;
Baines, Christopher P.;
Barton, Elisabeth R.;
Vuagniaux, Grégoire;
Sweeney, H. Lee;
Robbins, Jeffrey;
Molkentin, Jeffery D.

Publication type:

Article

Evidence from a genetic fate-mapping study that stem cells refresh adult mammalian cardiomyocytes after injury.

Published in:

Nature Medicine, 2007, v. 13, n. 8, p. 970, doi. 10.1038/nm1618

By:

Hsieh, Patrick C. H.;
Segers, Vincent F. M.;
Davis, Michael E.;
MacGillivray, Catherine;
Gannon, Joseph;
Molkentin, Jeffery D.;
Robbins, Jeffrey;
Lee, Richard T.

Publication type:

Article

Locating heart failure.

Published in:

Nature Medicine, 2005, v. 11, n. 12, p. 1284, doi. 10.1038/nm1205-1284

By:

Molkentin, Jeffery D.

Publication type:

Article

Re-evaluating sarcoplasmic reticulum function in heart failure.

Published in:

Nature Medicine, 2000, v. 6, n. 9, p. 942, doi. 10.1038/79592

By:

Delling, Ulrike;
Sussman, Mark A.;
Molkentin, Jeffery D.

Publication type:

Article

Reply to Revisiting calcineurin and human heart failure.

Published in:

Nature Medicine, 2000, v. 6, n. 1, p. 3, doi. 10.1038/71511

By:

Lim, Hae W.;
Molkentin, Jeffery D.

Publication type:

Article

Calcineurin and human heart failure.

Published in:

Nature Medicine, 1999, v. 5, n. 3, p. 246, doi. 10.1038/6430

By:

Lim, Hae W.;
Molkentin, Jeffery D.

Publication type:

Article

Mutual antagonism between IP3RII and miRNA-133a regulates calcium signals and cardiac hypertrophy.

Published in:

Journal of Cell Biology, 2012, v. 199, n. 5, p. 783, doi. 10.1083/jcb.201111095

By:

Drawnel, Faye M.;
Wachten, Dagmar;
Molkentin, Jeffery D.;
Maillet, Marjorie;
Aronsen, Jan Magnus;
Swift, Fredrik;
Sjaastad, Ivar;
Ning Liu;
Catalucci, Daniele;
Mikoshiba, Katsuhiko;
Hisatsune, Chihiro;
Okkenhaug, Hanneke;
Andrews, Simon R.;
Bootman, Martin D.;
Roderick, H. Llewelyn

Publication type:

Article

Tinman/Nkx2-5 acts via miR-1 and upstream of Cdc42 to regulate heart function across species.

Published in:

Journal of Cell Biology, 2011, v. 193, n. 7, p. 1181, doi. 10.1083/jcb.201006114

By:

Li Qian;
Wythe, Joshua D.;
Jiandong Liu;
Cartry, Jerome;
Vogler, Georg;
Mohapatra, Bhagyalaxmi;
Otway, Robyn T.;
Yu Huang;
King, Isabelle N.;
Maillet, Marjorie;
Yi Zheng;
Crawley, Timothy;
Taghli-Lamallem, Ouarda;
Semsarian, Christopher;
Dunwoodie, Sally;
Winlaw, David;
Harvey, Richard P.;
Fatkin, Diane;
Towbin, Jeffrey A.;
Molkentin, Jeffery D.

Publication type:

Article

Modulation of chromatin position and gene expression by HDAC4 interaction with nucleoporins.

Published in:

Journal of Cell Biology, 2011, v. 193, n. 1, p. 21, doi. 10.1083/jcb.201101046

By:

Kehat, Izhak;
Accornero, Federica;
Aronow, Bruce J.;
Molkentin, Jeffery D.

Publication type:

Article

Calreticulin signal upstream of calcineurin and MEF2C in a critical Ca2+-dependent signaling cascade.

Published in:

Journal of Cell Biology, 2005, v. 170, n. 1, p. 37, doi. 10.1083/jcb.200412156

By:

Lynch, Jeffrey;
Guo, Lel;
Gelebart, Pascal;
Chilibeck, Kaari;
Jian Xu;
Molkentin, Jeffery D.;
Agellon, Luis B.;
Michalak, Marek

Publication type:

Article

Cardiomyocytes fuse with surrounding noncardiomyocytes and reenter the cell cycle.

Published in:

Journal of Cell Biology, 2004, v. 167, n. 2, p. 351, doi. 10.1083/jcb.200312111

By:

Matsuura, Katsuhisa;
Wada, Hiroshi;
Nagai, Toshio;
Iijima, Yoshihiro;
Minamino, Tohru;
Sano, Masanori;
Akazawa, Hiroshi;
Molkentin, Jeffery D.;
Kasanuki, Hiroshi;
Komuro, Issei

Publication type:

Article

Depletion of skeletal muscle satellite cells attenuates pathology in muscular dystrophy.

Published in:

Nature Communications, 2022, v. 13, n. 1, p. 1, doi. 10.1038/s41467-022-30619-7

By:

Boyer, Justin G.;
Huo, Jiuzhou;
Han, Sarah;
Havens, Julian R.;
Prasad, Vikram;
Lin, Brian L.;
Kass, David A.;
Song, Taejeong;
Sadayappan, Sakthivel;
Khairallah, Ramzi J.;
Ward, Christopher W.;
Molkentin, Jeffery D.

Publication type:

Article

RhoA signaling in cardiomyocytes protects against stress-induced heart failure but facilitates cardiac fibrosis.

Published in:

Science Signaling, 2014, v. 7, n. 348, p. 1, doi. 10.1126/scisignal.2005262

By:

Lauriol, Jessica;
Keith, Kimberly;
Jaffré, Fabrice;
Couvillon, Anthony;
Saci, Abdel;
Goonasekera, Sanjeewa A.;
McCarthy, Jason R.;
Kessinger, Chase W.;
Jianxun Wang;
Qingen Ke;
Kang, Peter M.;
Molkentin, Jeffery D.;
Carpenter, Christopher;
Kontaridis, Maria I.

Publication type:

Article

Necroptosis Interfaces with MOMP and the MPTP in Mediating Cell Death.

Published in:

PLoS ONE, 2015, v. 10, n. 6, p. 1, doi. 10.1371/journal.pone.0130520

By:

Karch, Jason;
Kanisicak, Onur;
Brody, Matthew J.;
Sargent, Michelle A.;
Michael, Demetria M.;
Molkentin, Jeffery D.

Publication type:

Article

Parsing the Roles of the Transcription Factors GATA-4 and GATA-6 in the Adult Cardiac Hypertrophic Response.

Published in:

PLoS ONE, 2013, v. 8, n. 12, p. 1, doi. 10.1371/journal.pone.0084591

By:

van Berlo, Jop H.;
Aronow, Bruce J.;
Molkentin, Jeffery D.

Publication type:

Article

Apoptosis Repressor with a CARD Domain (ARC) Restrains Bax-Mediated Pathogenesis in Dystrophic Skeletal Muscle.

Published in:

PLoS ONE, 2013, v. 8, n. 12, p. 1, doi. 10.1371/journal.pone.0082053

By:

Davis, Jennifer;
Kwong, Jennifer Q.;
Kitsis, Richard N.;
Molkentin, Jeffery D.

Publication type:

Article

Postnatal Ablation of Foxm1 from Cardiomyocytes Causes Late Onset Cardiac Hypertrophy and Fibrosis without Exacerbating Pressure Overload-Induced Cardiac Remodeling.

Published in:

PLoS ONE, 2012, v. 7, n. 11, p. 1, doi. 10.1371/journal.pone.0048713

By:

Bolte, Craig;
Yufang Zhang;
York, Allen;
Kalin, Tanya V.;
Schultz, Jo El J.;
Molkentin, Jeffery D.;
Kalinichenko, Vladimir V.

Publication type:

Article

Proteasome functional insufficiency activates the calcineurin–NFAT pathway in cardiomyocytes and promotes maladaptive remodelling of stressed mouse hearts.

Published in:

Cardiovascular Research, 2010, v. 88, n. 3, p. 424, doi. 10.1093/cvr/cvq217

By:

Mingxin Tang;
Jie Li;
Wei Huang;
Huabo Su;
Qiangrong Liang;
Zongwen Tian;
Horak, Kathleen M.;
Molkentin, Jeffery D.;
Xuejun Wang

Publication type:

Article

Phosphodiesterase 5 inhibition blocks pressure overload-induced cardiac hypertrophy independent of the calcineurin pathway.

Published in:

Cardiovascular Research, 2009, v. 81, n. 2, p. 301

By:

Steven Hsu;
Takahiro Nagayama;
Norimichi Koitabashi;
Manling Zhang;
Liye Zhou;
Djahida Bedja;
Kathleen L. Gabrielson;
Jeffery D. Molkentin;
David A. Kass;
Eiki Takimoto

Publication type:

Article

Calcineurin regulates NFAT-dependent iNOS expression and protection of cardiomyocytes: Co-operation with Src tyrosine kinase

Published in:

Cardiovascular Research, 2006, v. 71, n. 4, p. 672, doi. 10.1016/j.cardiores.2006.05.026

By:

Obasanjo-Blackshire, Kofo;
Mesquita, Rui;
Jabr, Rita I.;
Molkentin, Jeffery D.;
Hart, Stephen L.;
Marber, Michael S.;
Xia, Yang;
Heads, Richard J.

Publication type:

Article

Calcineurin–NFAT signaling regulates the cardiac hypertrophic response in coordination with the MAPKs

Published in:

Cardiovascular Research, 2004, v. 63, n. 3, p. 467, doi. 10.1016/j.cardiores.2004.01.021

By:

Molkentin, Jeffery D.

Publication type:

Article

Overexpression of calcineurin in mouse causes sudden cardiac death associated with decreased density of K+ channels

Published in:

Cardiovascular Research, 2003, v. 57, n. 2, p. 320, doi. 10.1016/S0008-6363(02)00661-2

By:

Dong, Deli;
Duan, Yanjun;
Guo, Jiqing;
Roach, Dan E.;
Swirp, Shauni L.;
Wang, Li;
Lees-Miller, J.P.;
Sheldon, R.S.;
Molkentin, Jeffery D.;
Duff, Henry J.

Publication type:

Article

Cardiac function and electrical remodeling of the calcineurin-overexpressed transgenic mouse

Published in:

Cardiovascular Research, 2002, v. 54, n. 1, p. 117, doi. 10.1016/S0008-6363(02)00241-9

By:

Petrashevskaya, Natalia N.;
Bodi, Ilona;
Rubio, Marta;
Molkentin, Jeffery D.;
Schwartz, Arnold

Publication type:

Article

Enhanced myocyte contractility and Ca2+ handling in a calcineurin transgenic model of heart failure

Published in:

Cardiovascular Research, 2002, v. 54, n. 1, p. 105, doi. 10.1016/S0008-6363(02)00230-4

By:

Chu, Guoxiang;
Carr, Andrew N.;
Young, Karen B.;
Lester, J. William;
Yatani, Atsuko;
Sanbe, Atsushi;
Colbert, Melissa C.;
Schwartz, Steven M.;
Frank, Konrad F.;
Lampe, Paul D.;
Robbins, Jeffrey;
Molkentin, Jeffery D.;
Kranias, Evangelia G.

Publication type:

Article

Calcineurin and hypertrophic heart disease: novel insights and remaining questions

Published in:

Cardiovascular Research, 2002, v. 53, n. 4, p. 806, doi. 10.1016/S0008-6363(01)00493-X

By:

Bueno, Orlando F.;
van Rooij, Eva;
Molkentin, Jeffery D.;
Doevendans, Pieter A.;
De Windt, Leon J.

Publication type:

Article

Hypertrophic defect unmasked by calcineurin expression in asymptomatic tropomodulin overexpressing transgenic mice.

Published in:

Cardiovascular Research, 2000, v. 46, n. 1, p. 90, doi. 10.1016/S0008-6363(99)00422-8

By:

Sussman, Mark A.;
Welch, Sara;
Walker, Angela;
Klevitsky, Raisa;
Hewett, Timothy E.;
Witt, Sandra A.;
Kimball, Thomas R.;
Price, Robert;
Lim, Hae W.;
Molkentin, Jeffery D.

Publication type:

Article

Calcium Sparklets Regulate Local and Global Calcium in Murine Arterial Smooth Muscle.

Published in:

FASEB Journal, 2007, v. 21, n. 6, p. A1241

By:

Amberg, Gregory C.;
Navedo, Manuel F.;
Nieves-Cintron, Madeline;
Molkentin, Jeffery D.;
Santana, Luis F.

Publication type:

Article

Calcineurin-dependent cardiomyopathy is activated by TRPC in the adult mouse heart.

Published in:

FASEB Journal, 2006, v. 20, n. 10, p. 1660, doi. 10.1096/fj.05-5560com

By:

Nakayama, Hiroyuki;
Wilkin, Benjamin J.;
Bodi, Ilona;
Molkentin, Jeffery D.

Publication type:

Article

Temporal activation of c‐Jun N‐terminal kinase in adult transgenic heart via cre‐loxP‐mediated DNA recombination.

Published in:

FASEB Journal, 2003, v. 17, n. 6, p. 749, doi. 10.1096/fj.02-0438fje

By:

Petrich, Brian G.;
Molkentin, Jeffery D.;
Wang, Yibin

Publication type:

Article

Genetic overexpression of Serpina3n attenuates muscular dystrophy in mice.

Published in:

Human Molecular Genetics, 2016, v. 25, n. 6, p. 1192, doi. 10.1093/hmg/ddw005

By:

Tjondrokoesoemo, Andoria;
Schips, Tobias;
Kanisicak, Onur;
Sargent, Michelle A.;
Molkentin, Jeffery D.

Publication type:

Article

Excess SMAD signaling contributes to heart and muscle dysfunction in muscular dystrophy.

Published in:

Human Molecular Genetics, 2014, v. 23, n. 25, p. 6722, doi. 10.1093/hmg/ddu390

By:

Goldstein, Jeffery A.;
Bogdanovich, Sasha;
Beiriger, Anastasia;
Wren, Lisa M.;
Rossi, Ann E.;
Gao, Quan Q.;
Gardner, Brandon B.;
Earley, Judy U.;
Molkentin, Jeffery D.;
McNally, Elizabeth M.

Publication type:

Article

Myofiber-specific inhibition of TGFβ signaling protects skeletal muscle from injury and dystrophic disease in mice.

Published in:

Human Molecular Genetics, 2014, v. 23, n. 25, p. 6903, doi. 10.1093/hmg/ddu413

By:

Accornero, Federica;
Kanisicak, Onur;
Tjondrokoesoemo, Andoria;
Attia, Aria C.;
McNally, Elizabeth M.;
Molkentin, Jeffery D.

Publication type:

Article

P38α MAPK underlies muscular dystrophy and myofiber death through a Bax-dependent mechanism.

Published in:

Human Molecular Genetics, 2014, v. 23, n. 20, p. 5452, doi. 10.1093/hmg/ddu270

By:

Wissing, Erin R.;
Boyer, Justin G.;
Kwong, Jennifer Q.;
Sargent, Michelle A.;
Karch, Jason;
McNally, Elizabeth M.;
Otsu, Kinya;
Molkentin, Jeffery D.

Publication type:

Article

Enhanced Ca2+ influx from STIM1–Orai1 induces muscle pathology in mouse models of muscular dystrophy.

Published in:

Human Molecular Genetics, 2014, v. 23, n. 14, p. 3706, doi. 10.1093/hmg/ddu079

By:

Goonasekera, Sanjeewa A.;
Davis, Jennifer;
Kwong, Jennifer Q.;
Accornero, Federica;
Wei-LaPierre, Lan;
Sargent, Michelle A.;
Dirksen, Robert T.;
Molkentin, Jeffery D.

Publication type:

Article

A high-throughput screening identifies ZNF418 as a novel regulator of the ubiquitin-proteasome system and autophagy-lysosomal pathway.

Published in:

Autophagy, 2021, v. 17, n. 10, p. 3124, doi. 10.1080/15548627.2020.1856493

By:

Singh, Sonia R;
Meyer-Jens, Moritz;
Alizoti, Erda;
Bacon, W Clark;
Davis, Gregory;
Osinska, Hanna;
Gulick, James;
Reischmann-Düsener, Silke;
Orthey, Ellen;
McLendon, Patrick M;
Molkentin, Jeffery D;
Schlossarek, Saskia;
Robbins, Jeffrey;
Carrier, Lucie

Publication type:

Article

Overexpression of Latent TGFβ Binding Protein 4 in Muscle Ameliorates Muscular Dystrophy through Myostatin and TGFβ.

Published in:

PLoS Genetics, 2016, v. 12, n. 5, p. 1, doi. 10.1371/journal.pgen.1006019

By:

Lamar, Kay-Marie;
Bogdanovich, Sasha;
Gardner, Brandon B.;
Gao, Quan Q.;
Miller, Tamari;
Earley, Judy U.;
Hadhazy, Michele;
Vo, Andy H.;
Wren, Lisa;
Molkentin, Jeffery D.;
McNally, Elizabeth M.

Publication type:

Article

Signaling effectors underlying pathologic growth and remodeling of the heart.

Published in:

Journal of Clinical Investigation, 2013, v. 123, n. 1, p. 37, doi. 10.1172/JCI62839

By:

Van Berlo, Jop H.;
Maillet, Marjorie;
Molkentin, Jeffery D.

Publication type:

Article

Decreased cardiac L-type Ca2+ channel activity induces hypertrophy and heart failure in mice.

Published in:

Journal of Clinical Investigation, 2012, v. 122, n. 1, p. 280, doi. 10.1172/JCI58227

By:

Goonasekera, Sanjeewa A.;
Hammer, Karin;
Auger-Messier, Mannix;
Bodi, Ilona;
Xiongwen Chen;
Hongyu Zhang;
Reiken, Steven;
Elrod, John W.;
Correll, Robert N.;
York, Allen J.;
Sargent, Michelle A.;
Hofmann, Franz;
Moosmang, Sven;
Marks, Andrew R.;
Houser, Steven R.;
Bers, Donald M.;
Molkentin, Jeffery D.

Publication type:

Article

RhoA protects the mouse heart against ischemia/reperfusion injury.

Published in:

2011

By:

Sunny Yang Xiang;
Vanhoutte, Davy;
Del Re, Dominic P.;
Purcell, Nicole H.;
Haiyun Ling;
Banerjee, Indroneal;
Bossuyt, Julie;
Lang, Richard A.;
Yi Zheng;
Matkovich, Scot J.;
Miyamoto, Shigeki;
Molkentin, Jeffery D.;
Dorn II, Gerald W.;
Brown, Joan Heller;
Xiang, Sunny Yang;
Ling, Haiyun;
Zheng, Yi;
Dorn, Gerald W 2nd

Publication type:

journal article

Mitigation of muscular dystrophy in mice by SERCA overexpression in skeletal muscle.

Published in:

2011

By:

Goonasekera, Sanjeewa A.;
Lam, Chi K.;
Millay, Douglas P.;
Sargent, Michelle A.;
Hajjar, Roger J.;
Kranias, Evangelia G.;
Molkentin, Jeffery D.

Publication type:

journal article

Cyclophilin D controls mitochondrial pore-dependent Ca(2+) exchange, metabolic flexibility, and propensity for heart failure in mice.

Published in:

2010

By:

Elrod, John W.;
Wong, Renee;
Mishra, Shikha;
Vagnozzi, Ronald J.;
Sakthievel, Bhuvana;
Goonasekera, Sanjeewa A.;
Karch, Jason;
Gabel, Scott;
Farber, John;
Force, Thomas;
Brown, Joan Heller;
Murphy, Elizabeth;
Molkentin, Jeffery D.

Publication type:

journal article

alpha1G-dependent T-type Ca2+ current antagonizes cardiac hypertrophy through a NOS3-dependent mechanism in mice.

Published in:

2009

By:

Nakayama, Hiroyuki;
Bodi, Ilona;
Correll, Robert N.;
Xiongwen Chen;
Lorenz, John;
Houser, Steven R.;
Robbins, Jeffrey;
Schwartz, Arnold;
Molkentin, Jeffery D.;
Chen, Xiongwen

Publication type:

journal article

Cdc42 is an antihypertrophic molecular switch in the mouse heart.

Published in:

2009

By:

Maillet, Marjorie;
Lynch, Jeffrey M.;
Sanna, Bastiano;
York, Allen J.;
Yi Zheng;
Molkentin, Jeffery D.;
Zheng, Yi

Publication type:

journal article