Works by Molden, Espen

Results: 104

Improved Prediction of CYP2D6 Catalyzed Drug Metabolism by Taking Variant Substrate Specificities and Novel Polymorphic Haplotypes into Account.

Published in:

Clinical Pharmacology & Therapeutics, 2025, v. 118, n. 1, p. 218, doi. 10.1002/cpt.3680

By:

Johansson, Inger;
Xanthopoulou, Emmanouella M.;
Zhou, Yitian;
Sanchez‐Spitman, Anabel;
van der Lee, Maaike;
Wollmann, Birgit M.;
Størset, Elisabet;
Swen, Jesse J.;
Guchelaar, Henk‐Jan;
Molden, Espen;
Jukic, Marin M.;
Ingelman‐Sundberg, Magnus

Publication type:

Article

Correlation Between Clozapine and CRP Levels in Relation to Smoking Status.

Published in:

Acta Psychiatrica Scandinavica, 2025, v. 152, n. 1, p. 69, doi. 10.1111/acps.13801

By:

Smith, Robert Løvsletten;
Andreassen, Ole A.;
Kane, John M.;
Schoretsanitis, Georgios;
Molden, Espen

Publication type:

Article

Therapeutic drug monitoring, liquid biopsies or pharmacogenomics for prediction of human drug metabolism and response.

Published in:

British Journal of Clinical Pharmacology, 2025, v. 91, n. 6, p. 1569, doi. 10.1111/bcp.16048

By:

Ingelman‐Sundberg, Magnus;
Molden, Espen

Publication type:

Article

Effect of metoprolol exposure following myocardial infarction on future cardiovascular events: a Mendelian randomization study.

Published in:

European Journal of Clinical Pharmacology, 2025, v. 81, n. 4, p. 551, doi. 10.1007/s00228-025-03806-w

By:

Bruun, Lina Dorthea;
Andersen, Geir Øystein;
Kringen, Marianne Kristiansen;
Myhre, Peder Langeland;
Halvorsen, Sigrun;
Hansen, Charlotte Holst;
Molden, Espen;
Øie, Erik

Publication type:

Article

Impact of CYP2D62, CYP2D635, rs5758550, and related haplotypes on risperidone clearance in vivo.

Published in:

European Journal of Clinical Pharmacology, 2024, v. 80, n. 10, p. 1531, doi. 10.1007/s00228-024-03721-6

By:

Størset, Elisabet;
Bråten, Line Skute;
Ingelman-Sundberg, Magnus;
Johansson, Inger;
Molden, Espen;
Kringen, Marianne Kristiansen

Publication type:

Article

Dose-dependent effect of lamotrigine on quetiapine serum concentration in patients using instant release tablets.

Published in:

European Journal of Clinical Pharmacology, 2024, v. 80, n. 6, p. 839, doi. 10.1007/s00228-024-03655-z

By:

Hole, Kristine;
Lorentsen, Silje K;
Nordby, Karoline L;
Slettvik, Marie;
Sørum, Ida TG;
Molden, Espen;
Haslemo, Tore

Publication type:

Article

Age of onset for increased dose-adjusted serum concentrations of antidepressants and association with sex and genotype: An observational study of 34,777 individuals.

Published in:

European Journal of Clinical Pharmacology, 2024, v. 80, n. 3, p. 435, doi. 10.1007/s00228-023-03611-3

By:

Tveit, Kristine;
Hermann, Monica;
Nilsen, Roy M.;
Wallerstedt, Susanna M.;
Rongve, Arvid;
Molden, Espen;
Hole, Kristine

Publication type:

Article

Prediction of CYP2D6 poor metabolizers by measurements of solanidine and metabolites—a study in 839 patients with known CYP2D6 genotype.

Published in:

European Journal of Clinical Pharmacology, 2023, v. 79, n. 4, p. 523, doi. 10.1007/s00228-023-03462-y

By:

Wollmann, Birgit M.;
Størset, Elisabet;
Kringen, Marianne Kristiansen;
Molden, Espen;
Smith, Robert L.

Publication type:

Article

Response to: "Utility of endogenous 4β-hydroxycholesterol as a biomarker to assess cytochrome P 450 3A (CYP3A) activity: not quite ready for prime time".

Published in:

2022

By:

Kvitne, Kine Eide;
Hole, Kristine;
Molden, Espen;
Robertsen, Ida

Publication type:

Letter

Co-prescription of metoprolol and CYP2D6-inhibiting antidepressants before and after implementation of an optimized drug interaction database in Norway.

Published in:

European Journal of Clinical Pharmacology, 2022, v. 78, n. 10, p. 1623, doi. 10.1007/s00228-022-03364-5

By:

Gedde-Dahl, Ane;
Spigset, Olav;
Molden, Espen

Publication type:

Article

Correlations between 4β-hydroxycholesterol and hepatic and intestinal CYP3A4: protein expression, microsomal ex vivo activity, and in vivo activity in patients with a wide body weight range.

Published in:

European Journal of Clinical Pharmacology, 2022, v. 78, n. 8, p. 1289, doi. 10.1007/s00228-022-03336-9

By:

Eide Kvitne, Kine;
Hole, Kristine;
Krogstad, Veronica;
Wollmann, Birgit Malene;
Wegler, Christine;
Johnson, Line K.;
Hertel, Jens K.;
Artursson, Per;
Karlsson, Cecilia;
Andersson, Shalini;
Andersson, Tommy B.;
Sandbu, Rune;
Hjelmesæth, Jøran;
Skovlund, Eva;
Christensen, Hege;
Jansson-Löfmark, Rasmus;
Åsberg, Anders;
Molden, Espen;
Robertsen, Ida

Publication type:

Article

Impact of age and gender on paliperidone exposure in patients after administration of long-acting injectable formulations—an observational study using blood samples from 1223 patients.

Published in:

European Journal of Clinical Pharmacology, 2021, v. 77, n. 8, p. 1201, doi. 10.1007/s00228-021-03114-z

By:

Tveito, Marit;
Høiseth, Gudrun;
Haslemo, Tore;
Molden, Espen;
Smith, Robert Løvsletten

Publication type:

Article

Impact of age and CYP2D6 genotype on exposure of zuclopenthixol in patients using long-acting injectable versus oral formulation—an observational study including 2044 patients.

Published in:

European Journal of Clinical Pharmacology, 2021, v. 77, n. 2, p. 215, doi. 10.1007/s00228-020-03002-y

By:

Tveito, Marit;
Smith, Robert Løvsletten;
Molden, Espen;
Høiseth, Gudrun

Publication type:

Article

Impact of genotype-predicted CYP2D6 metabolism on clinical effects and tolerability of metoprolol in patients after myocardial infarction – a prospective observational study.

Published in:

European Journal of Clinical Pharmacology, 2020, v. 76, n. 5, p. 673, doi. 10.1007/s00228-020-02832-0

By:

Anstensrud, Anne Kristine;
Molden, Espen;
Haug, Hans Jørgen;
Qazi, Rehman;
Muriq, Hysen;
Fosshaug, Linn E.;
Spigset, Olav;
Øie, Erik

Publication type:

Article

Impact of age and CYP2D6 genetics on exposure of aripiprazole and dehydroaripiprazole in patients using long-acting injectable versus oral formulation: relevance of poor and intermediate metabolizer status.

Published in:

European Journal of Clinical Pharmacology, 2020, v. 76, n. 1, p. 41, doi. 10.1007/s00228-019-02768-0

By:

Tveito, Marit;
Molden, Espen;
Høiseth, Gudrun;
Correll, Christoph U.;
Smith, Robert Løvsletten

Publication type:

Article

Impact of age on serum concentrations of venlafaxine and escitalopram in different CYP2D6 and CYP2C19 genotype subgroups.

Published in:

European Journal of Clinical Pharmacology, 2014, v. 70, n. 8, p. 933, doi. 10.1007/s00228-014-1696-8

By:

Waade, Ragnhild;
Hermann, Monica;
Moe, Hanne;
Molden, Espen

Publication type:

Article

CYP2C19 genetics in fatal carisoprodol intoxications.

Published in:

European Journal of Clinical Pharmacology, 2012, v. 68, n. 11, p. 1561, doi. 10.1007/s00228-012-1278-6

By:

Høiseth, Gudrun;
Majid, Umair;
Mørland, Jørg;
Bramness, Jørgen;
Molden, Espen

Publication type:

Article

Increased frequency of CYP2C9 variant alleles and homozygous VKORC1*2B carriers in warfarin-treated patients with excessive INR response.

Published in:

European Journal of Clinical Pharmacology, 2010, v. 66, n. 5, p. 525, doi. 10.1007/s00228-010-0813-6

By:

Molden, Espen;
Okkenhaug, Cecilie;
Ekker Solberg, Erik

Publication type:

Article

Impact of age on serum concentrations of venlafaxine and escitalopram in different CYP2D6 and CYP2C19 genotype subgroups.

Published in:

2008

By:

Waade, Ragnhild;
Hermann, Monica;
Moe, Hanne;
Molden, Espen

Publication type:

Journal Article

Impact of the CYP2D6 genotype on steady-state serum concentrations of aripiprazole and dehydroaripiprazole.

Published in:

European Journal of Clinical Pharmacology, 2007, v. 63, n. 12, p. 1147, doi. 10.1007/s00228-007-0373-6

By:

Hendset, Magnhild;
Hermann, Monica;
Lunde, Hilde;
Refsum, Helge;
Molden, Espen

Publication type:

Article

The effect of variable cigarette consumption on the interaction with clozapine and olanzapine.

Published in:

European Journal of Clinical Pharmacology, 2006, v. 62, n. 12, p. 1049, doi. 10.1007/s00228-006-0209-9

By:

Haslemo, Tore;
Eikeseth, Per Hankon;
Tanum, Lars;
Molden, Espen;
Refsum, Helge

Publication type:

Article

Co-prescription ofcytochrome<sub>P450</sub> 2D6/3A4 inhibitor-substrate pairs in clinical practice. A retrospective analysis of data from Norwegian primary pharmacies.

Published in:

European Journal of Clinical Pharmacology, 2005, v. 61, n. 2, p. 119, doi. 10.1007/s00228-004-0877-2

By:

Molden, Espen;
Garcia, Beate H.;
Braathen, Pia;
Eggen, Anne E.

Publication type:

Article

Pharmacogenetic Variants and Plasma Concentrations of Antiseizure Drugs: A Systematic Review and Meta-Analysis.

Published in:

JAMA Network Open, 2024, v. 7, n. 8, p. e2425593, doi. 10.1001/jamanetworkopen.2024.25593

By:

Milosavljević, Filip;
Manojlović, Marina;
Matković, Lena;
Molden, Espen;
Ingelman-Sundberg, Magnus;
Leucht, Stefan;
Jukić, Marin M.

Publication type:

Article

Association Between CYP2D6 Genotypes and Serum Concentrations of Mirtazapine and Mianserin.

Published in:

Basic & Clinical Pharmacology & Toxicology, 2025, v. 136, n. 4, p. 1, doi. 10.1111/bcpt.70013

By:

Hole, Kristine;
Molden, Espen

Publication type:

Article

Effect of CYP2D6 genotype on duloxetine serum concentration.

Published in:

Basic & Clinical Pharmacology & Toxicology, 2024, v. 134, n. 1, p. 186, doi. 10.1111/bcpt.13954

By:

Hole, Kristine;
Gangsø, Sofie;
Jensstuen, Åsa Tonette;
Ormøy, Hanne Holte;
Paulsen, Maren;
Molden, Espen;
Haslemo, Tore

Publication type:

Article

Fatal liver failure after therapeutic doses of paracetamol in a patient with Duchenne muscular dystrophy and atypical pharmacogenetic profile of drug‐metabolizing enzymes.

Published in:

Basic & Clinical Pharmacology & Toxicology, 2020, v. 127, n. 1, p. 47, doi. 10.1111/bcpt.13389

By:

Lao, Yvonne Elisabeth;
Molden, Espen;
Kringen, Marianne Kristiansen;
Annexstad, Ellen Johanne;
Sæverud, Håvard Andreassen;
Jacobsen, Dag;
Hovda, Knut Erik

Publication type:

Article

Impact of Ageing on Serum Concentrations of Risperidone and Its Active Metabolite in Patients with Known CYP2D6 Genotype.

Published in:

Basic & Clinical Pharmacology & Toxicology, 2016, v. 119, n. 5, p. 470, doi. 10.1111/bcpt.12614

By:

Molden, Espen;
Waade, Ragnhild Birkeland;
Hoff, Maren;
Haslemo, Tore

Publication type:

Article

Effect of Clinical Geriatric Assessments and Collaborative Medication Reviews by Geriatrician and Family Physician for Improving Health-Related Quality of Life in Home-Dwelling Older Patients Receiving Polypharmacy: A Cluster Randomized Clinical Trial.

Published in:

2020

By:

Romskaug, Rita;
Skovlund, Eva;
Straand, Jørund;
Molden, Espen;
Kersten, Hege;
Pitkala, Kaisu H.;
Lundqvist, Christofer;
Wyller, Torgeir B.

Publication type:

journal article

Genome-wide association analysis of treatment resistant schizophrenia for variant discovery and polygenic assessment.

Published in:

Human Genomics, 2024, v. 18, n. 1, p. 1, doi. 10.1186/s40246-024-00673-x

By:

Lenk, Hasan Çağın;
Koch, Elise;
O'Connell, Kevin S.;
Smith, Robert Løvsletten;
Akkouh, Ibrahim A.;
Djurovic, Srdjan;
Andreassen, Ole A.;
Molden, Espen

Publication type:

Article

Correlation Between Serum Concentrations of N-Desmethylclozapine and Granulocyte Levels in Patients with Schizophrenia: A Retrospective Observational Study.

Published in:

2017

By:

Smith, Robert;
Haslemo, Tore;
Andreassen, Ole;
Eliasson, Erik;
Dahl, Marja-Liisa;
Spigset, Olav;
Molden, Espen;
Smith, Robert L;
Andreassen, Ole A

Publication type:

journal article

En jente i tidlig skolealder uten effekt av opioider ved generell anestesi.

Published in:

Journal of the Norwegian Medical Association / Tidsskrift for Den Norske Laegeforening, 2019, v. 139, n. 7, p. 621

By:

OLSEN, THOMAS CHR. RISOM;
RASMUSSEN, ANDERS R.;
KRINGEN, MARIANNE K.;
MOLDEN, ESPEN

Publication type:

Article

Hvem bør få klopidogrel etter hjerneslag?

Published in:

Journal of the Norwegian Medical Association / Tidsskrift for Den Norske Laegeforening, 2018, v. 138, n. 9, p. 806

By:

IHLE-HANSEN, HÅKON;
HAGBERG, GURI;
MOLDEN, ESPEN;
MYRSTAD, MARIUS

Publication type:

Article

Serumkonsentra-sjonsmålinger av DOAK-legemidler.

Published in:

Journal of the Norwegian Medical Association / Tidsskrift for Den Norske Laegeforening, 2018, v. 138, n. 7, p. 620

By:

DYRKORN, ROAR;
LUNDGAARD, HALVOR;
STOKES, CHARLOTTE LORENTZE;
MOLDEN, ESPEN;
SPIGSET, OLAV

Publication type:

Article

Hvis du skal gjøre det, gjør det riktig!

Published in:

Journal of the Norwegian Medical Association / Tidsskrift for Den Norske Laegeforening, 2017, v. 137, n. 12/13, p. 854

By:

SOLBERG, DAG KRISTEN;
REFSUM, HELGE;
MOLDEN, ESPEN

Publication type:

Article

Tryggere behandling med serumkonsentrasjonsmåling av de nye antikoagulasjonsmidlene?

Published in:

Journal of the Norwegian Medical Association / Tidsskrift for Den Norske Laegeforening, 2016, v. 136, n. 18, p. 1556, doi. 10.4045/tidsskr.16.0255

By:

Lundgaard, Halvor;
Dyrkorn, Roar;
Lorentze Stokes, Charlotte;
Molden, Espen;
Spigset, Olav

Publication type:

Article

Genetisk betinget variasjon i bioaktivering av tamoksifen og klopidogrel.

Published in:

Journal of the Norwegian Medical Association / Tidsskrift for Den Norske Laegeforening, 2016, v. 136, n. 5, p. 434, doi. 10.4045/tidsskr.15.0555

By:

Solhaug, Vigdis;
Molden, Espen

Publication type:

Article

Genetic Association Between Schizophrenia and Cortical Brain Surface Area and Thickness.

Published in:

2021

By:

Cheng, Weiqiu;
Frei, Oleksandr;
van der Meer, Dennis;
Wang, Yunpeng;
O'Connell, Kevin S.;
Chu, Yunhan;
Bahrami, Shahram;
Shadrin, Alexey A.;
Alnæs, Dag;
Hindley, Guy F. L.;
Lin, Aihua;
Karadag, Naz;
Fan, Chun-Chieh;
Westlye, Lars T.;
Kaufmann, Tobias;
Molden, Espen;
Dale, Anders M.;
Djurovic, Srdjan;
Smeland, Olav B.;
Andreassen, Ole A.

Publication type:

journal article

Association of CYP2C19 and CYP2D6 Poor and Intermediate Metabolizer Status With Antidepressant and Antipsychotic Exposure: A Systematic Review and Meta-analysis.

Published in:

2021

By:

Milosavljević, Filip;
Bukvić, Nikola;
Pavlović, Zorana;
Miljević, Čedo;
Pešić, Vesna;
Molden, Espen;
Ingelman-Sundberg, Magnus;
Leucht, Stefan;
Jukić, Marin M.;
Milosavljevic, Filip;
Bukvic, Nikola;
Pavlovic, Zorana;
Miljevic, Cedo;
Pešic, Vesna;
Jukic, Marin M

Publication type:

journal article

Therapeutic Reference Range for Aripiprazole in Schizophrenia Revised: a Systematic Review and Metaanalysis.

Published in:

Psychopharmacology, 2022, v. 239, n. 11, p. 3377, doi. 10.1007/s00213-022-06233-2

By:

Hart, Xenia M.;
Hiemke, Christoph;
Eichentopf, Luzie;
Lense, Xenija M.;
Clement, Hans Willi;
Conca, Andreas;
Faltraco, Frank;
Florio, Vincenzo;
Grüner, Jessica;
Havemann-Reinecke, Ursula;
Molden, Espen;
Paulzen, Michael;
Schoretsanitis, Georgios;
Riemer, Thomas G.;
Gründer, Gerhard

Publication type:

Article

Effect of teaching and checklist implementation on accuracy of medication history recording at hospital admission.

Published in:

2016

By:

Lea, Marianne;
Barstad, Ingeborg;
Mathiesen, Liv;
Mowe, Morten;
Molden, Espen

Publication type:

journal article

Individual variability in clinical effect and tolerability of opioid analgesics – Importance of drug interactions and pharmacogenetics.

Published in:

Scandinavian Journal of Pain, 2017, v. 17, n. 1, p. 193, doi. 10.1016/j.sjpain.2017.09.009

By:

Solhaug, Vigdis;
Molden, Espen

Publication type:

Article

Simvastatin-Associated Rhabdomyolysis After Coadministration of Macrolide Antibiotics in Two Patients.

Published in:

Pharmacotherapy, 2007, v. 27, n. 4, p. 603, doi. 10.1592/phco.27.4.603

By:

Molden, Espen;
Andersson, Kirsti Svendsen

Publication type:

Article

Cognitive Effects of Reducing Anticholinergic Drug Burden in a Frail Elderly Population: A Randomized Controlled Trial.

Published in:

Journals of Gerontology Series A: Biological Sciences & Medical Sciences, 2013, v. 68, n. 3, p. 271, doi. 10.1093/gerona/gls176

By:

Kersten, Hege;
Molden, Espen;
Tolo, Inga Kristin;
Skovlund, Eva;
Engedal, Knut;
Wyller, Torgeir Bruun

Publication type:

Article

Correction: Selective serotonin reuptake inhibitors and venlafaxine in pregnancy: Changes in drug disposition.

Published in:

2018

By:

Westin, Andreas Austgulen;
Brekke, Malin;
Molden, Espen;
Skogvoll, Eirik;
Spigset, Olav

Publication type:

Correction Notice

Selective serotonin reuptake inhibitors and venlafaxine in pregnancy: Changes in drug disposition.

Published in:

PLoS ONE, 2017, v. 12, n. 7, p. 1, doi. 10.1371/journal.pone.0181082

By:

Westin, Andreas Austgulen;
Brekke, Malin;
Molden, Espen;
Skogvoll, Eirik;
Spigset, Olav

Publication type:

Article

Therapeutic drug monitoring of clozapine in adults with schizophrenia: a review of challenges and strategies.

Published in:

Expert Opinion on Drug Metabolism & Toxicology, 2021, v. 17, n. 10, p. 1211, doi. 10.1080/17425255.2021.1974400

By:

Molden, Espen

Publication type:

Article

Statin medication in patients treated with antiepileptic drugs in Norway.

Published in:

Pharmacoepidemiology & Drug Safety, 2012, v. 21, n. 8, p. 881, doi. 10.1002/pds.3287

By:

Gedde-Dahl, Ane;
Devold, Helene M.;
Molden, Espen

Publication type:

Article

CYP2D6 is involved in O-demethylation of diltiazem: An in vitro study with transfected human liver cells.

Published in:

European Journal of Clinical Pharmacology, 2000, v. 56, n. 8, p. 575, doi. 10.1007/s002280000182

By:

Molden, Espen;
Åsberg, Anders;
Christensen, Hege

Publication type:

Article

Use of Antidepressants in Older People during a 10-Year Period: An Observational Study on Prescribed Doses and Serum Levels.

Published in:

Drugs & Aging, 2020, v. 37, n. 9, p. 691, doi. 10.1007/s40266-020-00784-9

By:

Tveit, Kristine;
Hermann, Monica;
Waade, Ragnhild Birkeland;
Nilsen, Roy Miodini;
Wallerstedt, Susanna M.;
Molden, Espen

Publication type:

Article

Prescribed Doses of CYP2D6-Metabolized Drugs and Hemodynamic Responses in Relation to CYP2D6 Genotype Among Older Patients Exposed to Polypharmacy.

Published in:

Drugs & Aging, 2020, v. 37, n. 6, p. 425, doi. 10.1007/s40266-020-00763-0

By:

Romskaug, Rita;
Wyller, Torgeir Bruun;
Straand, Jørund;
Kersten, Hege;
Molden, Espen

Publication type:

Article