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Potent acyl-CoA synthetase 10 inhibitors kill Plasmodium falciparum by disrupting triglyceride formation.
Published in:
Nature Communications, 2023, v. 14, n. 1, p. 1, doi. 10.1038/s41467-023-36921-2
By:
- Bopp, Selina;
- Pasaje, Charisse Flerida A.;
- Summers, Robert L.;
- Magistrado-Coxen, Pamela;
- Schindler, Kyra A.;
- Corpas-Lopez, Victoriano;
- Yeo, Tomas;
- Mok, Sachel;
- Dey, Sumanta;
- Smick, Sebastian;
- Nasamu, Armiyaw S.;
- Demas, Allison R.;
- Milne, Rachel;
- Wiedemar, Natalie;
- Corey, Victoria;
- Gomez-Lorenzo, Maria De Gracia;
- Franco, Virginia;
- Early, Angela M.;
- Lukens, Amanda K.;
- Milner, Danny
Publication type:
Article
Transcriptional profiling of growth perturbations of the human malaria parasite Plasmodium falciparum.
Published in:
Nature Biotechnology, 2010, v. 28, n. 1, p. 91, doi. 10.1038/nbt.1597
By:
- Hu, Guangan;
- Cabrera, Ana;
- Kono, Maya;
- Mok, Sachel;
- Chaal, Balbir K.;
- Haase, Silvia;
- Engelberg, Klemens;
- Cheemadan, Sabna;
- Spielmann, Tobias;
- Preiser, Peter R.;
- Gilberger, Tim-W.;
- Bozdech, Zbynek
Publication type:
Article
New insights into the Plasmodium vivax transcriptome using RNA-Seq.
Published in:
Scientific Reports, 2016, p. 20498, doi. 10.1038/srep20498
By:
- Zhu, Lei;
- Mok, Sachel;
- Imwong, Mallika;
- Jaidee, Anchalee;
- Russell, Bruce;
- Nosten, Francois;
- Day, Nicholas P.;
- White, Nicholas J.;
- Preiser, Peter R.;
- Bozdech, Zbynek
Publication type:
Article
Generation of a mutator parasite to drive resistome discovery in Plasmodium falciparum.
Published in:
Nature Communications, 2023, v. 14, n. 1, p. 1, doi. 10.1038/s41467-023-38774-1
By:
- Kümpornsin, Krittikorn;
- Kochakarn, Theerarat;
- Yeo, Tomas;
- Okombo, John;
- Luth, Madeline R.;
- Hoshizaki, Johanna;
- Rawat, Mukul;
- Pearson, Richard D.;
- Schindler, Kyra A.;
- Mok, Sachel;
- Park, Heekuk;
- Uhlemann, Anne-Catrin;
- Jana, Gouranga P.;
- Maity, Bikash C.;
- Laleu, Benoît;
- Chenu, Elodie;
- Duffy, James;
- Moliner Cubel, Sonia;
- Franco, Virginia;
- Gomez-Lorenzo, Maria G.
Publication type:
Article
Plasmodium falciparum K13 mutations in Africa and Asia impact artemisinin resistance and parasite fitness.
Published in:
eLife, 2021, p. 1, doi. 10.7554/eLife.66277
By:
- Stokes, Barbara H.;
- Dhingra, Satish K.;
- Rubiano, Kelly;
- Mok, Sachel;
- Straimer, Judith;
- Gnädig, Nina F.;
- Deni, Ioanna;
- Schindler, Kyra A.;
- Bath, Jade R.;
- Ward, Kurt E.;
- Striepen, Josefine;
- Yeo, Tomas;
- Ross, Leila S.;
- Legrand, Eric;
- Ariey, Frédéric;
- Cunningham, Clark H.;
- Souleymane, Issa M.;
- Gansané, Adama;
- Nzoumbou-Boko, Romaric;
- Ndayikunda, Claudette
Publication type:
Article
Structural polymorphism in the promoter of pfmrp2 confers P lasmodium falciparum tolerance to quinoline drugs.
Published in:
Molecular Microbiology, 2014, v. 91, n. 5, p. 918, doi. 10.1111/mmi.12505
By:
- Mok, Sachel;
- Liong, Kek‐Yee;
- Lim, Eng‐How;
- Huang, Ximei;
- Zhu, Lei;
- Preiser, Peter Rainer;
- Bozdech, Zbynek
Publication type:
Article
The origins of malaria artemisinin resistance defined by a genetic and transcriptomic background.
Published in:
Nature Communications, 2018, v. 9, n. 1, p. 1, doi. 10.1038/s41467-018-07588-x
By:
- Lei Zhu;
- Tripathi, Jaishree;
- Rocamora, Frances Maureen;
- Miotto, Olivo;
- van der Pluijm, Rob;
- Voss, Till S.;
- Mok, Sachel;
- Kwiatkowski, Dominic P.;
- Nosten, François;
- Day, Nicholas P. J.;
- White, Nicholas J.;
- Dondorp, Arjen M.;
- Bozdech, Zbynek
Publication type:
Article
Oxidative stress and protein damage responses mediate artemisinin resistance in malaria parasites.
Published in:
PLoS Pathogens, 2018, v. 14, n. 3, p. 1, doi. 10.1371/journal.ppat.1006930
By:
- Rocamora, Frances;
- Zhu, Lei;
- Liong, Kek Yee;
- Dondorp, Arjen;
- Miotto, Olivo;
- Mok, Sachel;
- Bozdech, Zbynek
Publication type:
Article
Gene copy number variation in natural populations of <italic>Plasmodium falciparum</italic> in Eastern Africa.
Published in:
BMC Genomics, 2018, v. 19, n. 1, p. 1, doi. 10.1186/s12864-018-4689-7
By:
- Simam, Joan;
- Rono, Martin;
- Ngoi, Joyce;
- Nyonda, Mary;
- Mok, Sachel;
- Marsh, Kevin;
- Bozdech, Zbynek;
- Mackinnon, Margaret
Publication type:
Article
Dynamic Epigenetic Regulation of Gene Expression during the Life Cycle of Malaria Parasite Plasmodium falciparum.
Published in:
PLoS Pathogens, 2013, v. 9, n. 2, p. 1, doi. 10.1371/journal.ppat.1003170
By:
- Gupta, Archna P.;
- Wai Hoe Chin;
- Lei Zhu;
- Sachel Mok;
- Yen-Hoon Luah;
- Eng-How Lim;
- Zbynek Bozdech
Publication type:
Article
Comparative Transcriptional and Genomic Analysis of Plasmodium falciparum Field Isolates.
Published in:
PLoS Pathogens, 2009, v. 5, n. 10, p. 1, doi. 10.1371/journal.ppat.1000644
By:
- Mackinnon, Margaret J.;
- Jinguang Li;
- Sachel Mok;
- Kortok, Moses M.;
- Marsh, Kevin;
- Preiser, Peter R.;
- Bozdech, Zbynek
Publication type:
Article
Targeting the Cell Stress Response of Plasmodium falciparum to Overcome Artemisinin Resistance.
Published in:
PLoS Biology, 2015, v. 13, n. 4, p. 1, doi. 10.1371/journal.pbio.1002132
By:
- Dogovski, Con;
- Xie, Stanley C.;
- Burgio, Gaetan;
- Bridgford, Jess;
- Mok, Sachel;
- McCaw, James M.;
- Chotivanich, Kesinee;
- Kenny, Shannon;
- Gnädig, Nina;
- Straimer, Judith;
- Bozdech, Zbynek;
- Fidock, David A.;
- Simpson, Julie A.;
- Dondorp, Arjen M.;
- Foote, Simon;
- Klonis, Nectarios;
- Tilley, Leann
Publication type:
Article
Emerging Southeast Asian PfCRT mutations confer Plasmodium falciparum resistance to the first-line antimalarial piperaquine.
Published in:
Nature Communications, 2018, v. 9, n. 1, p. 1, doi. 10.1038/s41467-018-05652-0
By:
- Ross, Leila S.;
- Dhingra, Satish K.;
- Mok, Sachel;
- Yeo, Tomas;
- Wicht, Kathryn J.;
- Kümpornsin, Krittikorn;
- Takala-Harrison, Shannon;
- Witkowski, Benoit;
- Fairhurst, Rick M.;
- Ariey, Frederic;
- Menard, Didier;
- Fidock, David A.
Publication type:
Article
The antimalarial MMV688533 provides potential for single-dose cures with a high barrier to Plasmodium falciparum parasite resistance.
Published in:
Science Translational Medicine, 2021, v. 13, n. 603, p. 1, doi. 10.1126/scitranslmed.abg6013
By:
- Murithi, James M.;
- Pascal, Cécile;
- Bath, Jade;
- Boulenc, Xavier;
- Gnädig, Nina F.;
- Pasaje, Charisse Flerida A.;
- Rubiano, Kelly;
- Yeo, Tomas;
- Mok, Sachel;
- Klieber, Sylvie;
- Desert, Paul;
- Jiménez-Díaz, María Belén;
- Marfurt, Jutta;
- Rouillier, Mélanie;
- Cherkaoui-Rbati, Mohammed H.;
- Gobeau, Nathalie;
- Wittlin, Sergio;
- Uhlemann, Anne-Catrin;
- Price, Ric N.;
- Wirjanata, Grennady
Publication type:
Article
Mutant PfCRT Can Mediate Piperaquine Resistance in African Plasmodium falciparum With Reduced Fitness and Increased Susceptibility to Other Antimalarials.
Published in:
2022
By:
- Wicht, Kathryn J;
- Small-Saunders, Jennifer L;
- Hagenah, Laura M;
- Mok, Sachel;
- Fidock, David A
Publication type:
journal article
Plasmodium knowlesi gene expression differs in ex vivo compared to in vitro blood-stage cultures.
Published in:
Malaria Journal, 2015, v. 14, n. 1, p. 1, doi. 10.1186/s12936-015-0612-8
By:
- Lapp, Stacey A.;
- Mok, Sachel;
- Lei Zhu;
- Hao Wu;
- Preiser, Peter R.;
- Bozdech, Zybnek;
- Galinski, Mary R.
Publication type:
Article
Insights into the intracellular localization, protein associations and artemisinin resistance properties of Plasmodium falciparum K13.
Published in:
PLoS Pathogens, 2020, v. 16, n. 4, p. 1, doi. 10.1371/journal.ppat.1008482
By:
- Gnädig, Nina F.;
- Stokes, Barbara H.;
- Edwards, Rachel L.;
- Kalantarov, Gavreel F.;
- Heimsch, Kim C.;
- Kuderjavy, Michal;
- Crane, Audrey;
- Lee, Marcus C. S.;
- Straimer, Judith;
- Becker, Katja;
- Trakht, Ilya N.;
- Odom John, Audrey R.;
- Mok, Sachel;
- Fidock, David A.
Publication type:
Article
Short tandem repeat polymorphism in the promoter region of cyclophilin 19B drives its transcriptional upregulation and contributes to drug resistance in the malaria parasite Plasmodium falciparum.
Published in:
PLoS Pathogens, 2023, v. 18, n. 1, p. 1, doi. 10.1371/journal.ppat.1011118
By:
- Kucharski, Michal;
- Wirjanata, Grennady;
- Nayak, Sourav;
- Boentoro, Josephine;
- Dziekan, Jerzy Michal;
- Assisi, Christina;
- van der Pluijm, Rob W.;
- Miotto, Olivo;
- Mok, Sachel;
- Dondorp, Arjen M.;
- Bozdech, Zbynek
Publication type:
Article
Piperaquine-resistant PfCRT mutations differentially impact drug transport, hemoglobin catabolism and parasite physiology in Plasmodium falciparum asexual blood stages.
Published in:
PLoS Pathogens, 2022, v. 18, n. 10, p. 1, doi. 10.1371/journal.ppat.1010926
By:
- Okombo, John;
- Mok, Sachel;
- Qahash, Tarrick;
- Yeo, Tomas;
- Bath, Jade;
- Orchard, Lindsey M.;
- Owens, Edward;
- Koo, Imhoi;
- Albert, Istvan;
- Llinás, Manuel;
- Fidock, David A.
Publication type:
Article

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