Works by Moechars, Diederik

Results: 23

Time course of tinnitus development following noise exposure in mice.

Published in:

Journal of Neuroscience Research, 2012, v. 90, n. 7, p. 1480, doi. 10.1002/jnr.22827

By:

Turner, Jeremy;
Larsen, Deb;
Hughes, Larry;
Moechars, Diederik;
Shore, Susan

Publication type:

Article

Comparison of New Tau PET-Tracer Candidates With [18F]T808 and [18F]T807.

Published in:

Molecular Imaging, 2016, v. 15, p. 1, doi. 10.1177/1536012115624920

By:

Declercq, Lieven;
Celen, Sofie;
Lecina, Joan;
Ahamed, Muneer;
Tousseyn, Thomas;
Moechars, Diederik;
Alcazar, Jesus;
Ariza, Manuela;
Fierens, Katleen;
Bottelbergs, Astrid;
Mariën, Jonas;
Vandenberghe, Rik;
Andres, Ignacio Jose;
Van Laere, Koen;
Verbruggen, Alfons;
Bormans, Guy

Publication type:

Article

Targeted degradation of a‐synuclein via the AdPROM system prevents PFF‐induced a‐synuclein aggregation.

Published in:

Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2024, v. 20, n. S6, p. 1, doi. 10.1002/alz.088682

By:

Carton, Bill;
Gelders, Géraldine;
Kocaturk, Nur;
Roth, Sascha;
Macartney, Thomas;
Van Elsen, Joke;
De Muynck, Louis;
Buist, Arjan;
Moechars, Diederik;
Sapkota, Gopal

Publication type:

Article

A family‐based genetic study identifies mutations in TLR9 impairing receptor activation: A role for innate immunity in AD pathogenesis: Developing topics.

Published in:

Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2020, v. 16, n. 11, p. 1, doi. 10.1002/alz.047212

By:

Cacace, Rita;
Hoogmartens, Julie;
Hens, Elisabeth;
Buist, Arjan;
Cras, Patrick;
Sieben, Anne;
Vandenberghe, Rik;
Engelborghs, Sebastiaan;
De Deyn, Peter Paul;
Martin, Jean‐Jacques;
Moechars, Diederik;
Van Broeckhoven, Christine

Publication type:

Article

P2‐372: IMAGING ALZHEIMER'S TAU PATHOLOGY IN HUMANS: [18F]JNJ‐067—A PHASE 0 EXPLORATORY STUDY IN HEALTHY VOLUNTEERS AND SUBJECTS WITH PROBABLE ALZHEIMER'S DISEASE.

Published in:

Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2018, v. 14, p. P838, doi. 10.1016/j.jalz.2018.06.1063

By:

Kolb, Hartmuth C.;
Moechars, Diederik;
Rombouts, Frederik;
Schmidt, Mark E.;
Szardenings, Anna Katrin;
Timmers, Maarten;
Barret, Olivier;
Madonia, Jennifer;
Marek, Kenneth;
Sandiego, Christine

Publication type:

Article

PRE-CLINICAL CHARACTERIZATION OF THE NOVEL TAU PET LIGAND [18F]-JNJ'067.

Published in:

Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2017, v. 13, p. P1069, doi. 10.1016/j.jalz.2017.06.1531

By:

Kolb, Hartmuth C.;
Bottelbergs, Astrid;
Moechars, Diederik;
Declercq, Lieven;
Bormans, Guy;
Rombouts, Frederik

Publication type:

Article

IDENTIFICATION OF NOVEL TARGETS FOR INHIBITING PRION-LIKE SEEDING AND PROPAGATION OF TAU PATHOLOGY IN VITRO AND IN VIVO.

Published in:

Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2017, v. 13, p. P1270, doi. 10.1016/j.jalz.2017.06.1901

By:

Dewachter, Ilse;
Stancu, Ilie-Cosmin;
Vanoosthuyse, Alexandre;
Buist, Arjan;
Vasconcelos, Bruno;
Wang, Peng;
Kienlen-Campard, Pascal;
Octave, Jean-Noël;
Moechars, Diederik

Publication type:

Article

MOLECULAR MECHANISMS OF ABETA-INDUCED TAU-PATHOLOGY: ANALYSIS OF CROSS-SEEDING OF ABETA AND TAU AND ITS ROLE IN PRION-LIKE PROPAGATION OF TAU-PATHOLOGY IN VITRO AND IN VIVO.

Published in:

Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2016, v. 12, p. P385, doi. 10.1016/j.jalz.2016.06.722

By:

Vasconcelos, Bruno;
Stancu, Ilie-Cosmin;
Buist, Arjan;
Bird, Matthew;
Wang, Peng;
Vanoosthuyse, Alexandre;
Van Kolen, Kristof;
Verheyen, An;
Kienlen-Campard, Pascal;
Octave, Jean-Noël;
Baatsen, Peter;
Moechars, Diederik;
Dewachter, Ilse

Publication type:

Article

IDENTIFICATION AND VALIDATION OF TAU-MODIFIERS, IDENTIFIED BY UNBIASED GENOME WIDE APPROACHES, USING AAV-BASED APPROACHES IN TAU TRANSGENIC MICE.

Published in:

Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2016, v. 12, p. P845, doi. 10.1016/j.jalz.2016.06.1730

By:

Wang, Peng;
Stancu, Ilie-Cosmin;
Vasconcelos, Bruno;
Bird, Matthew;
Vanoosthuyse, Alexandre;
Moechars, Diederik;
Dewachter, Ilse

Publication type:

Article

Does leucine-rich repeat Kinase 2 mediate alpha-synuclein seeding via its role in endocytosis?

Published in:

Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2014, v. 10, p. P792, doi. 10.1016/j.jalz.2014.05.1539

By:

Delbroek, Lore;
Van Kolen, Kristof;
Arranz, Amaia;
Daneels, Guy;
Mandemakers, Wim;
Calafate, Sara;
Moechars, Diederik

Publication type:

Article

Genetic complexity in the BIN1 locus

Published in:

2012

By:

Mounier, Anaïs;
Hansmannel, Franck;
Chapuis, Julien;
Gistelinck, Marc;
Van Cauwenberghe, Caroline;
Grenier-Bolay, Benjamin;
Van Broeckhoven, Christine;
Amouyel, Philippe;
Moechars, Diederik;
Dermaut, Bart;
Lambert, Jean-Charles

Publication type:

Abstract

Identification of proteins that form complexes with tau in mouse brain

Published in:

2010

By:

Moechars, Diederik;
Winderickx, Joris;
Fischer, Frank;
Jundt, Melanie;
Mercken, Marc;
Bantscheff, Marcus;
Rowley, Adele;
Van Leuven, Fred;
Karran, Eric;
Drewes, Gerard;
Joberty, Gerard

Publication type:

Abstract

Preclinical Evaluation of 18F-JNJ64349311, a Novel PET Tracer for Tau Imaging.

Published in:

Journal of Nuclear Medicine, 2017, v. 58, n. 6, p. 975, doi. 10.2967/jnumed.116.185199

By:

Declercq, Lieven;
Rombouts, Frederik;
Koole, Michel;
Fierens, Katleen;
Mariën, Jonas;
Langlois, Xavier;
Andrés, José Ignacio;
Schmidt, Mark;
Macdonald, Gregor;
Moechars, Diederik;
Vanduffel, Wim;
Tousseyn, Thomas;
Vandenberghe, Rik;
Van Laere, Koen;
Verbruggen, Alfons;
Bormans, Guy

Publication type:

Article

Clinical evaluation of [18F] JNJ-64326067, a novel candidate PET tracer for the detection of tau pathology in Alzheimer's disease.

Published in:

European Journal of Nuclear Medicine & Molecular Imaging, 2020, v. 47, n. 13, p. 3176, doi. 10.1007/s00259-020-04880-1

By:

Schmidt, Mark E.;
Janssens, Luc;
Moechars, Diederik;
Rombouts, Frederik J. R.;
Timmers, Maarten;
Barret, Olivier;
Constantinescu, Cristian C.;
Madonia, Jennifer;
Russell, David S.;
Sandiego, Christine M.;
Kolb, Hartmuth

Publication type:

Article

Vesicular Glutamate Transporter VGLUT1 Has a Role in Hippocampal Long-Term Potentiation and Spatial Reversal Learning.

Published in:

Cerebral Cortex, 2010, v. 20, n. 3, p. 684, doi. 10.1093/cercor/bhp133

By:

Balschun, Detlef;
Moechars, Diederik;
Callaerts-Vegh, Zsuzsanna;
Vermaercke, Ben;
Van Acker, Nathalie;
Andries, Luc;
D'Hooge, Rudi

Publication type:

Article

Bexarotene treatment does not clear β-Amyloid in an AD mouse model and Beagle dogs.

Published in:

2013

By:

Tesseur, Ina;
Lo, Adrian;
Roberfroid, Anouk;
Dietvorst, Sofie;
Van Broeck, Bianca;
Borgers, Marianne;
Gijsen, Harrie;
Moechars, Diederik;
Mercken, Marc;
Kemp, John;
D'Hooge, Rudi;
De Strooper, Bart

Publication type:

Abstract

Tau association with synaptic vesicles causes presynaptic dysfunction.

Published in:

Nature Communications, 2017, v. 8, n. 5, p. 15295, doi. 10.1038/ncomms15295

By:

Zhou, Lujia;
McInnes, Joseph;
Wierda, Keimpe;
Holt, Matthew;
Herrmann, Abigail G.;
Jackson, Rosemary J.;
Wang, Yu-Chun;
Swerts, Jef;
Beyens, Jelle;
Miskiewicz, Katarzyna;
Vilain, Sven;
Dewachter, Ilse;
Moechars, Diederik;
De Strooper, Bart;
Spires-Jones, Tara L.;
De Wit, Joris;
Verstreken, Patrik

Publication type:

Article

Dissecting the role of sodium currents in visceral sensory neurons in a model of chronic hyperexcitability using Nav1.8 and Nav1.9 null mice.

Published in:

Journal of Physiology, 2006, v. 576, n. 1, p. 257, doi. 10.1113/jphysiol.2006.113597

By:

Hillsley, Kirk;
Jia-Hui Lin;
Stanisz, Andre;
Grundy, David;
Aerssens, Jeroen;
Peeters, Pieter J.;
Moechars, Diederik;
Coulie, Bernard;
Stead, Ronald H.

Publication type:

Article

Tau interactome mapping based identification of Otub1 as Tau deubiquitinase involved in accumulation of pathological Tau forms in vitro and in vivo.

Published in:

Acta Neuropathologica, 2017, v. 133, n. 5, p. 731, doi. 10.1007/s00401-016-1663-9

By:

Wang, Peng;
Joberty, Gerard;
Buist, Arjan;
Vanoosthuyse, Alexandre;
Stancu, Ilie-Cosmin;
Vasconcelos, Bruno;
Pierrot, Nathalie;
Faelth-Savitski, Maria;
Kienlen-Campard, Pascal;
Octave, Jean-Noël;
Bantscheff, Marcus;
Drewes, Gerard;
Moechars, Diederik;
Dewachter, Ilse

Publication type:

Article

Heterotypic seeding of Tau fibrillization by pre-aggregated Abeta provides potent seeds for prion-like seeding and propagation of Tau-pathology in vivo.

Published in:

Acta Neuropathologica, 2016, v. 131, n. 4, p. 549, doi. 10.1007/s00401-015-1525-x

By:

Vasconcelos, Bruno;
Stancu, Ilie-Cosmin;
Buist, Arjan;
Bird, Matthew;
Wang, Peng;
Vanoosthuyse, Alexandre;
Kolen, Kristof;
Verheyen, An;
Kienlen-Campard, Pascal;
Octave, Jean-Noël;
Baatsen, Peter;
Moechars, Diederik;
Dewachter, Ilse

Publication type:

Article

Templated misfolding of Tau by prion-like seeding along neuronal connections impairs neuronal network function and associated behavioral outcomes in Tau transgenic mice.

Published in:

Acta Neuropathologica, 2015, v. 129, n. 6, p. 875, doi. 10.1007/s00401-015-1413-4

By:

Stancu, Ilie-Cosmin;
Vasconcelos, Bruno;
Ris, Laurence;
Wang, Peng;
Villers, Agnès;
Peeraer, Eve;
Buist, Arjan;
Terwel, Dick;
Baatsen, Peter;
Oyelami, Tutu;
Pierrot, Nathalie;
Casteels, Cindy;
Bormans, Guy;
Kienlen-Campard, Pascal;
Octave, Jean-Nöel;
Moechars, Diederik;
Dewachter, Ilse

Publication type:

Article

The 3-O sulfation of heparan sulfate proteoglycans contributes to the cellular internalization of tau aggregates.

Published in:

BMC Molecular & Cell Biology, 2022, v. 23, n. 1, p. 1, doi. 10.1186/s12860-022-00462-1

By:

Ferreira, Andreia;
Royaux, Ines;
Liu, Jian;
Wang, Zhangjie;
Su, Guowei;
Moechars, Diederik;
Callewaert, Nico;
De Muynck, Louis

Publication type:

Article

Vesicular Glutamate Transporter VGLUT2 Expression Levels Control Quantal Size and Neuropathic Pain.

Published in:

Journal of Neuroscience, 2006, v. 26, n. 46, p. 10, doi. 10.1523/JNEUROSCI.2556-06.2006

By:

Moechars, Diederik;
Weston, Matthew C.;
Leo, Sandra;
Callaerts-Vegh, Zsuzsanna;
Goris, Ilse;
Daneels, Guy;
Buist, A.;
Cik, M.;
Van der Spek, P.;
Kass, Stefan;
Meert, Theo;
D'Hooge, Rudi;
Rosenmund, Christian;
Hampson, R. Mark

Publication type:

Article

Works by Moechars, Diederik

Time course of tinnitus development following noise exposure in mice.

Comparison of New Tau PET-Tracer Candidates With [<sup>18</sup>F]T808 and [<sup>18</sup>F]T807.

Targeted degradation of a‐synuclein via the AdPROM system prevents PFF‐induced a‐synuclein aggregation.

A family‐based genetic study identifies mutations in TLR9 impairing receptor activation: A role for innate immunity in AD pathogenesis: Developing topics.

P2‐372: IMAGING ALZHEIMER'S TAU PATHOLOGY IN HUMANS: [18F]JNJ‐067—A PHASE 0 EXPLORATORY STUDY IN HEALTHY VOLUNTEERS AND SUBJECTS WITH PROBABLE ALZHEIMER'S DISEASE.

PRE-CLINICAL CHARACTERIZATION OF THE NOVEL TAU PET LIGAND [18F]-JNJ'067.

IDENTIFICATION OF NOVEL TARGETS FOR INHIBITING PRION-LIKE SEEDING AND PROPAGATION OF TAU PATHOLOGY IN VITRO AND IN VIVO.

MOLECULAR MECHANISMS OF ABETA-INDUCED TAU-PATHOLOGY: ANALYSIS OF CROSS-SEEDING OF ABETA AND TAU AND ITS ROLE IN PRION-LIKE PROPAGATION OF TAU-PATHOLOGY IN VITRO AND IN VIVO.

IDENTIFICATION AND VALIDATION OF TAU-MODIFIERS, IDENTIFIED BY UNBIASED GENOME WIDE APPROACHES, USING AAV-BASED APPROACHES IN TAU TRANSGENIC MICE.

Does leucine-rich repeat Kinase 2 mediate alpha-synuclein seeding via its role in endocytosis?

Genetic complexity in the BIN1 locus

Identification of proteins that form complexes with tau in mouse brain

Preclinical Evaluation of <sup>18</sup>F-JNJ64349311, a Novel PET Tracer for Tau Imaging.

Clinical evaluation of [18F] JNJ-64326067, a novel candidate PET tracer for the detection of tau pathology in Alzheimer's disease.

Vesicular Glutamate Transporter VGLUT1 Has a Role in Hippocampal Long-Term Potentiation and Spatial Reversal Learning.

Bexarotene treatment does not clear β-Amyloid in an AD mouse model and Beagle dogs.

Tau association with synaptic vesicles causes presynaptic dysfunction.

Dissecting the role of sodium currents in visceral sensory neurons in a model of chronic hyperexcitability using Na<sub>v</sub>1.8 and Na<sub>v</sub>1.9 null mice.

Tau interactome mapping based identification of Otub1 as Tau deubiquitinase involved in accumulation of pathological Tau forms in vitro and in vivo.

Heterotypic seeding of Tau fibrillization by pre-aggregated Abeta provides potent seeds for prion-like seeding and propagation of Tau-pathology in vivo.

Templated misfolding of Tau by prion-like seeding along neuronal connections impairs neuronal network function and associated behavioral outcomes in Tau transgenic mice.

The 3-O sulfation of heparan sulfate proteoglycans contributes to the cellular internalization of tau aggregates.

Vesicular Glutamate Transporter VGLUT2 Expression Levels Control Quantal Size and Neuropathic Pain.