Works by Modesti, Mauro

Results: 34

Local delivery of recombinant vaccinia virus encoding for neu counteracts growth of mammary tumors more efficiently than systemic delivery in neu transgenic mice.

Published in:

Cancer Immunology, Immunotherapy, 2010, v. 59, n. 8, p. 1247, doi. 10.1007/s00262-010-0850-0

By:

Masuelli, Laura;
Marzocchella, Laura;
Focaccetti, Chiara;
Lista, Florigio;
Nardi, Alessandra;
Scardino, Antonio;
Mattei, Maurizio;
Turriziani, Mario;
Modesti, Mauro;
Forni, Guido;
Schlom, Jeffrey;
Modesti, Andrea;
Bei, Roberto

Publication type:

Article

A noncatalytic function of the ligation complex during nonhomologous end joining.

Published in:

Journal of Cell Biology, 2013, v. 200, n. 2, p. 173, doi. 10.1083/jcb.201203128

By:

Cottarel, Jessica;
Frit, Philippe;
Bombarde, Oriane;
Salles, Bernard;
Négrel, Aurélie;
Bernard, Stéphanie;
Jeggo, Penny A.;
Lieber, Michael R.;
Modesti, Mauro;
Calsou, Patrick

Publication type:

Article

Conformational changes in CLIP-i 70 regulate its binding to microtubules and dynactin localization.

Published in:

Journal of Cell Biology, 2004, v. 166, n. 7, p. 1003, doi. 10.1083/jcb.200402082

By:

Lansbergen, Gideon;
Komarova, Yulia;
Modesti, Mauro;
Wyman, Claire;
Hoogenraad, Casper C.;
Goodson, Holly V.;
Lemaare, Régis P.;
Drechsel, David N.;
Van Munster, Erik;
W. J. Gaddlla Jr., Theodorus;
Grosveld, Frank;
Galj Art, Niels;
Borisy, Gary G.;
Akhmanova, Anna

Publication type:

Article

Distinct pathways of homologous recombination controlled by the SWS1--SWSAP1--SPIDR complex.

Published in:

Nature Communications, 2021, v. 8, p. 1, doi. 10.1038/s41467-021-24205-6

By:

Prakash, Rohit;
Sandoval, Thomas;
Morati, Florian;
Zagelbaum, Jennifer A.;
Pei-Xin Lim;
White, Travis;
Taylor, Brett;
Wang, Raymond;
Desclos, Emilie C. B.;
Sullivan, Meghan R.;
Rein, Hayley L.;
Bernstein, Kara A.;
Krawczyk, Przemek M.;
Gautier, Jean;
Modesti, Mauro;
Vanoli, Fabio;
Jasin, Maria

Publication type:

Article

Two distinct conformational states define the interaction of human RAD51‐ATP with single‐stranded DNA.

Published in:

EMBO Journal, 2018, v. 37, n. 7, p. 1, doi. 10.15252/embj.201798162

By:

Brouwer, Ineke;
Moschetti, Tommaso;
Candelli, Andrea;
Garcin, Edwige B.;
Modesti, Mauro;
Pellegrini, Luca;
Wuite, Gijs J. L.;
Peterman, Erwin J. G.

Publication type:

Article

Bloom Syndrome Helicase Compresses Single‐Stranded DNA into Phase‐Separated Condensates.

Published in:

Angewandte Chemie International Edition, 2022, v. 61, n. 39, p. 1, doi. 10.1002/anie.202209463

By:

Wang, Teng;
Hu, Jiaojiao;
Li, Yanan;
Bi, Lulu;
Guo, Lijuan;
Jia, Xinshuo;
Zhang, Xia;
Li, Dan;
Hou, Xi‐Miao;
Modesti, Mauro;
Xi, Xu‐Guang;
Liu, Cong;
Sun, Bo

Publication type:

Article

Structure-Based Virtual Ligand Screening on the XRCC4/DNA Ligase IV Interface.

Published in:

Scientific Reports, 2016, p. 22878, doi. 10.1038/srep22878

By:

Menchon, Grégory;
Bombarde, Oriane;
Trivedi, Mansi;
Négrel, Aurélie;
Inard, Cyril;
Giudetti, Brigitte;
Baltas, Michel;
Milon, Alain;
Modesti, Mauro;
Czaplicki, Georges;
Calsou, Patrick

Publication type:

Article

ExoMeg1: a new exonuclease from metagenomic library.

Published in:

Scientific Reports, 2016, p. 19712, doi. 10.1038/srep19712

By:

Silva-Portela, Rita C. B.;
Carvalho, Fabíola M.;
Pereira, Carolina P. M.;
de Souza-Pinto, Nadja C.;
Modesti, Mauro;
Fuchs, Robert P.;
Agnez-Lima, Lucymara F.

Publication type:

Article

Probing Physical Properties of a DNA-Protein Complex Using Nanofluidic Channels.

Published in:

Small, 2014, v. 10, n. 5, p. 884, doi. 10.1002/smll.201302028

By:

Frykholm, Karolin;
Alizadehheidari, Mohammadreza;
Fritzsche, Joachim;
Wigenius, Jens;
Modesti, Mauro;
Persson, Fredrik;
Westerlund, Fredrik

Publication type:

Article

XRCC4/XLF Interaction Is Variably Required for DNA Repair and Is Not Required for Ligase IV Stimulation.

Published in:

Molecular & Cellular Biology, 2015, v. 35, n. 17, p. 3017, doi. 10.1128/MCB.01503-14

By:

Roy, Sunetra;
de Melo, Abinadabe J.;
Yao Xu;
Tadi, Satish K.;
Négrel, Aurélie;
Hendrickson, Eric;
Modesti, Mauro;
Meek, Katheryn

Publication type:

Article

Bloom Syndrome Helicase Compresses Single‐Stranded DNA into Phase‐Separated Condensates.

Published in:

Angewandte Chemie, 2022, v. 134, n. 39, p. 1, doi. 10.1002/ange.202209463

By:

Wang, Teng;
Hu, Jiaojiao;
Li, Yanan;
Bi, Lulu;
Guo, Lijuan;
Jia, Xinshuo;
Zhang, Xia;
Li, Dan;
Hou, Xi‐Miao;
Modesti, Mauro;
Xi, Xu‐Guang;
Liu, Cong;
Sun, Bo

Publication type:

Article

Single-molecule imaging reveals replication fork coupled formation of G-quadruplex structures hinders local replication stress signaling.

Published in:

Nature Communications, 2021, v. 12, n. 1, p. 1, doi. 10.1038/s41467-021-22830-9

By:

Lee, Wei Ting C.;
Yin, Yandong;
Morten, Michael J.;
Tonzi, Peter;
Gwo, Pam Pam;
Odermatt, Diana C.;
Modesti, Mauro;
Cantor, Sharon B.;
Gari, Kerstin;
Huang, Tony T.;
Rothenberg, Eli

Publication type:

Article

Sequential role of RAD51 paralog complexes in replication fork remodeling and restart.

Published in:

Nature Communications, 2020, v. 11, n. 1, p. 1, doi. 10.1038/s41467-020-17324-z

By:

Berti, Matteo;
Teloni, Federico;
Mijic, Sofija;
Ursich, Sebastian;
Fuchs, Jevgenij;
Palumbieri, Maria Dilia;
Krietsch, Jana;
Schmid, Jonas A.;
Garcin, Edwige B.;
Gon, Stéphanie;
Modesti, Mauro;
Altmeyer, Matthias;
Lopes, Massimo

Publication type:

Article

Single-molecule views on homologous recombination.

Published in:

Quarterly Reviews of Biophysics, 2013, v. 46, n. 4, p. 323, doi. 10.1017/S0033583513000073

By:

Candelli, Andrea;
Modesti, Mauro;
Peterman, Erwin J. G.;
Wuite, Gijs J. L.

Publication type:

Article

Metastasis to the Pancreas from Breast Cancer: Difficulties in Diagnosis and Controversies in Treatment.

Published in:

Breast Care, 2010, v. 5, n. 3, p. 170, doi. 10.1159/000314249

By:

Bonapasta, Stefano Amore;
Gregori, Matteo;
Lanza, Rosina;
Sangiorgi, Elena;
Menghi, Antonello;
Scarpini, Massimo;
Modesti, Mauro

Publication type:

Article

Crystal structure of the Xrcc4 DNA repair protein and implications for end joining.

Published in:

EMBO Journal, 2000, v. 19, n. 22, p. 5962, doi. 10.1093/emboj/19.22.5962

By:

Junop, Murray S.;
Modesti, Mauro;
Guarné, Alba;
Ghilrando, Rodolfo;
Gellert, Martin;
Wei Yang

Publication type:

Article

DNA binding of Xrcc4 protein is associated with V(D)J recombination but not with stimulation of DNA ligase IV activity.

Published in:

EMBO Journal, 1999, v. 18, n. 7, p. 2008, doi. 10.1093/emboj/18.7.2008

By:

Modesti, Mauro;
Hesse, Joanne E.;
Gellert, Martin

Publication type:

Article

The SMC-like RecN protein is at the crossroads of several genotoxic stress responses in Escherichia coli.

Published in:

Frontiers in Microbiology, 2023, p. 1, doi. 10.3389/fmicb.2023.1146496

By:

Camus, Adrien;
Espinosa, Elena;
Baras, Pénélope Zapater;
Singh, Parul;
Quenech’Du, Nicole;
Vickridge, Elise;
Modesti, Mauro;
Barre, François Xavier;
Espéli, Olivier

Publication type:

Article

Lig3-dependent rescue of mouse viability and DNA double-strand break repair by catalytically inactive Lig4.

Published in:

Nucleic Acids Research, 2025, v. 53, n. 2, p. 1, doi. 10.1093/nar/gkae1216

By:

Medina-Suárez, David;
Han, Li;
O'Reilly, Sandra;
Liu, Jiali;
Wei, Chao;
Brenière, Manon;
Goff, Noah J;
Chen, Chen;
Modesti, Mauro;
Meek, Katheryn;
Harrington, Bonnie;
Yu, Kefei

Publication type:

Article

Catalytically inactive DNA ligase IV promotes DNA repair in living cells.

Published in:

Nucleic Acids Research, 2022, v. 50, n. 19, p. 11058, doi. 10.1093/nar/gkac913

By:

Goff, Noah J;
Brenière, Manon;
Buehl, Christopher J;
de Melo, Abinadabe J;
Huskova, Hana;
Ochi, Takashi;
Blundell, Tom L;
Mao, Weifeng;
Yu, Kefei;
Modesti, Mauro;
Meek, Katheryn

Publication type:

Article

Dynamics of Ku and bacterial non-homologous end-joining characterized using single DNA molecule analysis.

Published in:

Nucleic Acids Research, 2021, v. 49, n. 5, p. 2629, doi. 10.1093/nar/gkab083

By:

Öz, Robin;
Wang, Jing L;
Guerois, Raphael;
Goyal, Gaurav;
KK, Sriram;
Ropars, Virginie;
Sharma, Rajhans;
Koca, Firat;
Charbonnier, Jean-Baptiste;
Modesti, Mauro;
Strick, Terence R;
Westerlund, Fredrik

Publication type:

Article

Counting RAD51 proteins disassembling from nucleoprotein filaments under tension.

Published in:

2009

By:

van Mameren, Joost;
Modesti, Mauro;
Kanaar, Roland;
Wyman, Claire;
Peterman, Erwin J. G.;
Wuite, Gijs J. L.

Publication type:

Letter

Rad52 and Ku bind to different DNA structures produced early in double‐strand break repair.

Published in:

Nucleic Acids Research, 2003, v. 31, n. 18, p. 5229, doi. 10.1093/nar/gkg729

By:

Ristic, Dejan;
Modesti, Mauro;
Kanaar, Roland;
Wyman, Claire

Publication type:

Article

DNA-binding and strand-annealing activities of human Mre11: implications for its roles in DNA double-strand break repair pathways.

Published in:

Nucleic Acids Research, 2001, v. 29, n. 6, p. 1317, doi. 10.1093/nar/29.6.1317

By:

de Jager, Martijn;
Dronkert, Mies L. G.;
Modesti, Mauro;
Beerens, Cecile E. M. T.;
Kanaar, Roland;
van Gent, Dik C.

Publication type:

Article

EXTRACELLULAR MATRIX REMODELLING IN A MURINE MAMMARY ADENOCARCINOMA TRANSFECTED WITH THE INTERFERON-ALPHA1 GENE.

Published in:

Journal of Pathology, 1997, v. 181, n. 1, p. 116, doi. 10.1002/(SICI)1096-9896(199701)181:1<116::AID-PATH116>3.0.CO;2-X

By:

SCARPA, SUSANNA;
GIUFFRIDA, ANNA;
PALUMBO, CAMILLA;
VASATURO, FORTUNATA;
SIGNORELLI, PAOLA;
FORNI, GUIDO;
MODESTI, MAURO;
FERRANTINI, MARIA;
BELARDELLI, FILIPPO;
MUSIANI, PIERO;
MODESTI, ANDREA

Publication type:

Article

Differential Requirements for the RAD51 Paralogs in Genome Repair and Maintenance in Human Cells.

Published in:

PLoS Genetics, 2019, v. 15, n. 10, p. 1, doi. 10.1371/journal.pgen.1008355

By:

Garcin, Edwige B.;
Gon, Stéphanie;
Sullivan, Meghan R.;
Brunette, Gregory J.;
Cian, Anne De;
Concordet, Jean-Paul;
Giovannangeli, Carine;
Dirks, Wilhelm G.;
Eberth, Sonja;
Bernstein, Kara A.;
Prakash, Rohit;
Jasin, Maria;
Modesti, Mauro

Publication type:

Article

Mutational phospho-mimicry reveals a regulatory role for the XRCC4 and XLF C-terminal tails in modulating DNA bridging during classical non-homologous end joining.

Published in:

eLife, 2017, p. 1, doi. 10.7554/eLife.22900

By:

Normanno, Davide;
Négrel, Aurélie;
de Melo, Abinadabe J.;
Betzi, Stéphane;
Meek, Katheryn;
Modesti, Mauro

Publication type:

Article

N-terminal constraint activates the catalytic subunit of the DNA-dependent protein kinase in the absence of DNA or Ku.

Published in:

Nucleic Acids Research, 2012, v. 40, n. 7, p. 2964, doi. 10.1093/nar/gkr1211

By:

Meek, Katheryn;
Lees-Miller, Susan P.;
Modesti, Mauro

Publication type:

Article

XRCC4's interaction with XLF is required for coding (but not signal) end joining.

Published in:

Nucleic Acids Research, 2012, v. 40, n. 4, p. 1684, doi. 10.1093/nar/gkr1315

By:

Roy, Sunetra;
Andres, Sara N.;
Vergnes, Alexandra;
Neal, Jessica A.;
Xu, Yao;
Yu, Yaping;
Lees-Miller, Susan P.;
Junop, Murray;
Modesti, Mauro;
Meek, Katheryn

Publication type:

Article

A human XRCC4–XLF complex bridges DNA.

Published in:

Nucleic Acids Research, 2012, v. 40, n. 4, p. 1868, doi. 10.1093/nar/gks022

By:

Andres, Sara N.;
Vergnes, Alexandra;
Ristic, Dejan;
Wyman, Claire;
Modesti, Mauro;
Junop, Murray

Publication type:

Article

Real-time assembly and disassembly of human RAD51 filaments on individual DNA molecules.

Published in:

Nucleic Acids Research, 2007, v. 35, n. 17, p. 5646, doi. 10.1093/nar/gkm629

By:

van der Heijden, Thijn;
Seidel, Ralf;
Modesti, Mauro;
Kanaar, Roland;
Wyman, Claire;
Dekker, Cees

Publication type:

Article

Domain swapping between FEN-1 and XPG defines regions in XPG that mediate nucleotide excision repair activity and substrate specificity.

Published in:

Nucleic Acids Research, 2007, v. 35, n. 9, p. 3053, doi. 10.1093/nar/gkm092

By:

Hohl, Marcel;
Dunand-Sauthier, Isabelle;
Staresincic, Lidija;
Jaquier-Gubler, Pascale;
Thorel, Fabrizio;
Modesti, Mauro;
Clarkson, Stuart G.;
Schärer, Orlando D.

Publication type:

Article

Human Rad51 filaments on double- and single-stranded DNA: correlating regular and irregular forms with recombination function.

Published in:

Nucleic Acids Research, 2005, v. 33, n. 10, p. 3292, doi. 10.1093/nar/gki640

By:

Ristic, Dejan;
Modesti, Mauro;
van der Heijden, Thijn;
van Noort, John;
Dekker, Cees;
Kanaar, Roland;
Wyman, Claire

Publication type:

Article

The structure-specific endonuclease Mus81–Eme1 promotes conversion of interstrand DNA crosslinks into double-strands breaks.

Published in:

EMBO Journal, 2006, v. 25, n. 20, p. 4921, doi. 10.1038/sj.emboj.7601344

By:

Hanada, Katsuhiro;
Budzowska, Magda;
Modesti, Mauro;
Maas, Alex;
Wyman, Claire;
Essers, Jeroen;
Kanaar, Roland

Publication type:

Article