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Heat shock inhibits caspase-1 activity while also preventing its inflammasome-mediated activation by anthrax lethal toxin.
Published in:
Cellular Microbiology, 2008, v. 10, n. 12, p. 2434, doi. 10.1111/j.1462-5822.2008.01220.x
By:
- Levin, Tera C.;
- Wickliffe, Katherine E.;
- Leppla, Stephen H.;
- Moayeri, Mahtab
Publication type:
Article
Killing of macrophages by anthrax lethal toxin: involvement of the N-end rule pathway.
Published in:
Cellular Microbiology, 2008, v. 10, n. 6, p. 1352, doi. 10.1111/j.1462-5822.2008.01131.x
By:
- Wickliffe, Katherine E.;
- Leppla, Stephen H.;
- Moayeri, Mahtab
Publication type:
Article
Anthrax lethal toxin-induced inflammasome formation and caspase-1 activation are late events dependent on ion fluxes and the proteasome.
Published in:
Cellular Microbiology, 2008, v. 10, n. 2, p. 332, doi. 10.1111/j.1462-5822.2007.01044.x
By:
- Wickliffe, Katherine E.;
- Leppla, Stephen H.;
- Moayeri, Mahtab
Publication type:
Article
In vivo characterization of an Hfq protein encoded by the Bacillus anthracis virulence plasmid pXO1.
Published in:
BMC Microbiology, 2017, v. 17, p. 1, doi. 10.1186/s12866-017-0973-y
By:
- Keefer, Andrea B.;
- Asare, Eugenia K.;
- Pomerantsev, Andrei P.;
- Moayeri, Mahtab;
- Martens, Craig;
- Porcella, Stephen F.;
- Gottesman, Susan;
- Leppla, Stephen H.;
- Vrentas, Catherine E.
Publication type:
Article
Mycobacterium tuberculosis Induces Irg1 in Murine Macrophages by a Pathway Involving Both TLR-2 and STING/IFNAR Signaling and Requiring Bacterial Phagocytosis.
Published in:
Frontiers in Cellular & Infection Microbiology, 2022, v. 12, p. 1, doi. 10.3389/fcimb.2022.862582
By:
- Bomfim, Caio C. B.;
- Fisher, Logan;
- Amaral, Eduardo P.;
- Mittereder, Lara;
- McCann, Katelyn;
- Correa, André A. S.;
- Namasivayam, Sivaranjani;
- Swamydas, Muthulekha;
- Moayeri, Mahtab;
- Weiss, Jonathan M.;
- Chari, Raj;
- McVicar, Daniel W.;
- Costa, Diego L.;
- D'Império Lima, Maria R.;
- Sher, Alan
Publication type:
Article
Sublethal Doses of Bacillus anthracis Lethal Toxin Inhibit Inflammation with Lipopolysaccharide and Escherichia coli Challenge but Have Opposite Effects on Survival.
Published in:
Journal of Infectious Diseases, 2006, v. 193, n. 6, p. 829, doi. 10.1086/500468
By:
- Xizhong Cui;
- Yan Li;
- Xuemei Li;
- Michael Haley;
- Moayeri, Mahtab;
- Fitz, Yvonne;
- Leppla, Stephen H.;
- Eichacker, Peter Q.
Publication type:
Article
Efficient Neutralization of Anthrax Toxin by Chimpanzee Monoclonal Antibodies against Protective Antigen.
Published in:
Journal of Infectious Diseases, 2006, v. 193, n. 5, p. 625, doi. 10.1086/500148
By:
- Zhaochun Chen;
- Moayeri, Mahtab;
- Yi-Hua Zhou;
- Leppla, Stephen;
- Emerson, Suzanne;
- Sebrell, Andrew;
- Yu, Fujuan;
- Svitel, Juraj;
- Schuck, Peter;
- St. Claire, Marisa;
- Purcell, Robert
Publication type:
Article
Late Treatment with a Protective Antigen--Directed Monoclonal Antibody Improves Hemodynamic Function and Survival in a Lethal Toxin--Infused Rat Model of Anthrax Sepsis.
Published in:
Journal of Infectious Diseases, 2005, v. 191, n. 3, p. 422, doi. 10.1086/427189
By:
- Xizhong Cui;
- Yan Li;
- Moayeri, Mahtab;
- Choi, Gil H.;
- Subramanian, G. M.;
- Xuemei Li;
- Haley, Michael;
- Fitz, Yvonne;
- Jing Feng;
- Banks, Steven M.;
- Leppla, Stephen H.;
- Eichacker, Peter Q.
Publication type:
Article
Anthrax Edema Factor Toxicity Is Strongly Mediated by the N-end Rule.
Published in:
PLoS ONE, 2013, v. 8, n. 8, p. 1, doi. 10.1371/journal.pone.0074474
By:
- Leysath, Clinton E.;
- Phillips, Damilola D.;
- Crown, Devorah;
- Fattah, Rasem J.;
- Moayeri, Mahtab;
- Leppla, Stephen H.
Publication type:
Article
Anthrax Lethal Toxin Downregulates Claudin-5 Expression in Human Endothelial Tight Junctions.
Published in:
PLoS ONE, 2013, v. 8, n. 4, p. 1, doi. 10.1371/journal.pone.0062576
By:
- D’Agnillo, Felice;
- Williams, Matthew C.;
- Moayeri, Mahtab;
- Warfel, Jason M.
Publication type:
Article
Anthrax Lethal Factor Cleaves Mouse Nlrp1b in Both Toxin-Sensitive and Toxin-Resistant Macrophages.
Published in:
PLoS ONE, 2012, v. 7, n. 11, p. 1, doi. 10.1371/journal.pone.0049741
By:
- Hellmich, Kristina A.;
- Levinsohn, Jonathan L.;
- Fattah, Rasem;
- Newman, Zachary L.;
- Maier, Nolan;
- Sastalla, Inka;
- Liu, Shihui;
- Leppla, Stephen H.;
- Moayeri, Mahtab
Publication type:
Article
Role of N-Terminal Amino Acids in the Potency of Anthrax Lethal Factor.
Published in:
PLoS ONE, 2008, v. 3, n. 9, p. 1, doi. 10.1371/journal.pone.0003130
By:
- Gupta, Pradeep K.;
- Moayeri, Mahtab;
- Crown, Devorah;
- Fattah, Rasem J.;
- Leppla, Stephen H.
Publication type:
Article
Bacillus anthracis Edema and Lethal Toxin Have Different Hemodynamic Effects but Function Together to Worsen Shock and Outcome in a Rat Model.
Published in:
Journal of Infectious Diseases, 2007, v. 195, n. 4, p. 572, doi. 10.1086/510856
By:
- Xizhong Cui;
- Yan Li;
- Xuemei Li;
- Laird, Michael W.;
- Subramanian, Mani;
- Moayeri, Mahtab;
- Leppla, Stephen H.;
- Fitz, Yvonne;
- Junwu Su;
- Sherer, Kevin;
- Eichacker, Peter Q.
Publication type:
Article
Novel Repression of the Glucocorticoid Receptor by Anthrax Lethal Toxin.
Published in:
Annals of the New York Academy of Sciences, 2004, v. 1024, n. 1, p. 9, doi. 10.1196/annals.1321.003
By:
- WEBSTER, JEANETTE I.;
- MOAYERI, MAHTAB;
- STERNBERG, ESTHER M.
Publication type:
Article
Lipoprotein biosynthesis by prolipoprotein diacylglyceryl transferase is required for efficient spore germination and full virulence of Bacillus anthracis.
Published in:
Molecular Microbiology, 2012, v. 83, n. 1, p. 96, doi. 10.1111/j.1365-2958.2011.07915.x
By:
- Okugawa, Shu;
- Moayeri, Mahtab;
- Pomerantsev, Andrei P.;
- Sastalla, Inka;
- Crown, Devorah;
- Gupta, Pradeep K.;
- Leppla, Stephen H.
Publication type:
Article
A Review of the Efficacy of FDA-Approved B. anthracis Anti-Toxin Agents When Combined with Antibiotic or Hemodynamic Support in Infection- or Toxin-Challenged Preclinical Models.
Published in:
Toxins, 2021, v. 13, n. 1, p. 53, doi. 10.3390/toxins13010053
By:
- Couse, Zoe;
- Cui, Xizhong;
- Li, Yan;
- Moayeri, Mahtab;
- Leppla, Stephen;
- Eichacker, Peter Q.
Publication type:
Article
Inflammasome Sensor NLRP1 Controls Rat Macrophage Susceptibility to <i>Toxoplasma gondii</i>.
Published in:
PLoS Pathogens, 2014, v. 10, n. 3, p. 1, doi. 10.1371/journal.ppat.1003927
By:
- Cirelli, Kimberly M.;
- Gorfu, Gezahegn;
- Hassan, Musa A.;
- Printz, Morton;
- Crown, Devorah;
- Leppla, Stephen H.;
- Grigg, Michael E.;
- Saeij, Jeroen P. J.;
- Moayeri, Mahtab
Publication type:
Article
Anthrax Lethal Factor Cleavage of Nlrp1 Is Required for Activation of the Inflammasome.
Published in:
PLoS Pathogens, 2012, v. 8, n. 3, p. 1, doi. 10.1371/journal.ppat.1002638
By:
- Levinsohn, Jonathan L.;
- Newman, Zachary L.;
- Hellmich, Kristina A.;
- Fattah, Rasem;
- Getz, Matthew A.;
- Liu, Shihui;
- Sastalla, Inka;
- Leppla, Stephen H.;
- Moayeri, Mahtab
Publication type:
Article
Inflammasome Sensor Nlrp1b-Dependent Resistance to Anthrax Is Mediated by Caspase-1, IL-1 Signaling and Neutrophil Recruitment.
Published in:
PLoS Pathogens, 2010, v. 6, n. 12, p. 1, doi. 10.1371/journal.ppat.1001222
By:
- Moayeri, Mahtab;
- Crown, Devorah;
- Newman, Zachary L.;
- Okugawa, Shu;
- Eckhaus, Michael;
- Cataisson, Christophe;
- Shihui Liu;
- Sastalla, Inka;
- Leppla, Stephen H.
Publication type:
Article
Susceptibility to Anthrax Lethal Toxin-Induced Rat Death Is Controlled by a Single Chromosome 10 Locus That Includes rNlrp1.
Published in:
PLoS Pathogens, 2010, v. 6, n. 5, p. 1, doi. 10.1371/journal.ppat.1000906
By:
- Newman, Zachary L.;
- Printz, Morton P.;
- Shihui Liu;
- Crown, Devorah;
- Breen, Laura;
- Miller-Randolph, Sharmina;
- Flodman, Pamela;
- Leppla, Stephen H.;
- Moayeri, Mahtab
Publication type:
Article
The Heart Is an Early Target of Anthrax Lethal Toxin in Mice: A Protective Role for Neuronal Nitric Oxide Synthase (nNOS).
Published in:
PLoS Pathogens, 2009, v. 5, n. 5, p. 1, doi. 10.1371/journal.ppat.1000456
By:
- Moayeri, Mahtab;
- Crown, Devorah;
- Dorward, David W.;
- Gardner, Don;
- Ward, Jerrold M.;
- Yan Li;
- Xizhong Cui;
- Eichacker, Peter;
- Leppla, Stephen H.
Publication type:
Article
A Bivalent Anthrax-Plague Vaccine That Can Protect against Two Tier-1 Bioterror Pathogens, Bacillus anthracis and Yersinia pestis.
Published in:
Frontiers in Immunology, 2017, p. 1, doi. 10.3389/fimmu.2017.00687
By:
- Pan Tao;
- Mahalingam, Marthandan;
- Jingen Zhu;
- Moayeri, Mahtab;
- Kirtley, Michelle L.;
- Fitts, Eric C.;
- Andersson, Jourdan A.;
- Lawrence, William S.;
- Leppla, Stephen H.;
- Chopra, Ashok K.;
- Rao, Venigalla B.
Publication type:
Article
Monoclonal Antibody Therapies against Anthrax.
Published in:
Toxins, 2011, v. 3, n. 8, p. 1004, doi. 10.3390/toxins3081004
By:
- Zhaochun Chen;
- Moayeri, Mahtab;
- Purcell, Robert
Publication type:
Article
Frontline Science: Anthrax lethal toxin‐induced, NLRP1‐mediated IL‐1β release is a neutrophil and PAD4‐dependent event.
Published in:
Journal of Leukocyte Biology, 2020, v. 108, n. 3, p. 773, doi. 10.1002/JLB.4HI0320-028R
By:
- Greaney, Allison J.;
- Portley, Makayla K.;
- O'Mard, Danielle;
- Crown, Devorah;
- Maier, Nolan K.;
- Mendenhall, Megan A.;
- Mayer‐Barber, Katrin D.;
- Leppla, Stephen H.;
- Moayeri, Mahtab
Publication type:
Article
Anthrax edema toxin disrupts distinct steps in Rab11-dependent junctional transport.
Published in:
PLoS Pathogens, 2017, v. 13, n. 9, p. 1, doi. 10.1371/journal.ppat.1006603
By:
- Guichard, Annabel;
- Jain, Prashant;
- Schwartz, Ruth;
- Chin, Stephen;
- Zhu, Lin;
- Cruz-Moreno, Beatriz;
- Bier, Ethan;
- Moayeri, Mahtab;
- Leppla, Stephen H.;
- Liu, Janet Z.;
- Hollands, Andrew;
- Aguilar, Bernice;
- Nizet, Victor
Publication type:
Article
Key tissue targets responsible for anthrax-toxin-induced lethality.
Published in:
Nature, 2013, v. 501, n. 7465, p. 63, doi. 10.1038/nature12510
By:
- Liu, Shihui;
- Zhang, Yi;
- Moayeri, Mahtab;
- Liu, Jie;
- Crown, Devorah;
- Fattah, Rasem J.;
- Wein, Alexander N.;
- Yu, Zu-Xi;
- Finkel, Toren;
- Leppla, Stephen H.
Publication type:
Article
Rapid induction of inflammatory lipid mediators by the inflammasome in vivo.
Published in:
Nature, 2012, v. 490, n. 7418, p. 107, doi. 10.1038/nature11351
By:
- von Moltke, Jakob;
- Trinidad, Norver J.;
- Moayeri, Mahtab;
- Kintzer, Alexander F.;
- Wang, Samantha B.;
- van Rooijen, Nico;
- Brown, Charles R.;
- Krantz, Bryan A.;
- Leppla, Stephen H.;
- Gronert, Karsten;
- Vance, Russell E.
Publication type:
Article
Anthrax immune globulin improves hemodynamics and survival during B. anthracis toxin-induced shock in canines receiving titrated fluid and vasopressor support.
Published in:
Intensive Care Medicine Experimental, 2017, v. 5, n. 1, p. 1, doi. 10.1186/s40635-017-0159-9
By:
- Suffredini, Dante;
- Cui, Xizhong;
- Jaswal, Dharmvir;
- Remy, Kenneth;
- Li, Yan;
- Sun, Junfeng;
- Solomon, Steven;
- Fitz, Yvonne;
- Moayeri, Mahtab;
- Leppla, Stephen;
- Eichacker, Peter
Publication type:
Article
Raxibacumab augments hemodynamic support and improves outcomes during shock with B. anthracis edema toxin alone or together with lethal toxin in canines.
Published in:
Intensive Care Medicine Experimental, 2015, v. 3, n. 1, p. 1, doi. 10.1186/s40635-015-0043-4
By:
- Remy, Kenneth;
- Cui, Xizhong;
- Li, Yan;
- Sun, Junfeng;
- Solomon, Steven;
- Fitz, Yvonne;
- Barochia, Amisha;
- Al-Hamad, Mariam;
- Moayeri, Mahtab;
- Leppla, Stephen;
- Eichacker, Peter
Publication type:
Article
Spatial localization of bacteria controls coagulation of human blood by 'quorum acting'.
Published in:
Nature Chemical Biology, 2008, v. 4, n. 12, p. 742, doi. 10.1038/nchembio.124
By:
- Kastrup, Christian J.;
- Boedicker, James Q.;
- Pomerantsev, Andrei P.;
- Moayeri, Mahtab;
- Bian, Yao;
- Pompano, Rebecca R.;
- Kline, Timothy R.;
- Sylvestre, Patricia;
- Shen, Feng;
- Leppla, Stephen H.;
- Tang, Wei-Jen;
- Ismagilov, Rustem F.
Publication type:
Article
Transcriptional analysis of the three Nlrp1 paralogs in mice.
Published in:
BMC Genomics, 2013, v. 14, n. 1, p. 1, doi. 10.1186/1471-2164-14-188
By:
- Sastalla, Inka;
- Crown, Devorah;
- Masters, Seth L.;
- McKenzie, Andrew;
- Leppla, Stephen H.;
- Moayeri, Mahtab
Publication type:
Article
S9.6-based hybrid capture immunoassay for pathogen detection.
Published in:
Scientific Reports, 2023, v. 13, n. 1, p. 1, doi. 10.1038/s41598-023-49881-w
By:
- Bothra, Ankur;
- Perry, Megan L.;
- Wei, Elena;
- Moayeri, Mahtab;
- Ma, Qian;
- Biamonte, Marco A.;
- Siirin, Marina;
- Leppla, Stephen H.
Publication type:
Article
Bacterial Exotoxins and the Inflammasome.
Published in:
Frontiers in Immunology, 2015, v. 6, p. 1, doi. 10.3389/fimmu.2015.00570
By:
- Greaney, Allison J.;
- Leppla, Stephen H.;
- Moayeri, Mahtab;
- Lenz, Laurel L.;
- Shin, Sunny;
- Boyaka, Prosper N.
Publication type:
Article
Characterization of the NLRP1 inflammasome response in bovine species.
Published in:
Innate Immunity, 2020, v. 26, n. 4, p. 301, doi. 10.1177/1753425919886649
By:
- Vrentas, Catherine E;
- Boggiatto, Paola M;
- Olsen, Steven C;
- Leppla, Stephen H;
- Moayeri, Mahtab
Publication type:
Article

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