Works by Mladenov, Emil

Results: 36

Low CDK Activity and Enhanced Degradation by APC/C CDH1 Abolishes CtIP Activity and Alt-EJ in Quiescent Cells.

Published in:

Cells (2073-4409), 2023, v. 12, n. 11, p. 1530, doi. 10.3390/cells12111530

By:

Li, Fanghua;
Mladenov, Emil;
Sun, Yanjie;
Soni, Aashish;
Stuschke, Martin;
Timmermann, Beate;
Iliakis, George

Publication type:

Article

The p38/MK2 Pathway Functions as Chk1-Backup Downstream of ATM/ATR in G 2 -Checkpoint Activation in Cells Exposed to Ionizing Radiation.

Published in:

Cells (2073-4409), 2023, v. 12, n. 10, p. 1387, doi. 10.3390/cells12101387

By:

Luo, Daxian;
Mladenov, Emil;
Soni, Aashish;
Stuschke, Martin;
Iliakis, George

Publication type:

Article

Increased Resection at DSBs in G 2 -Phase Is a Unique Phenotype Associated with DNA-PKcs Defects That Is Not Shared by Other Factors of c-NHEJ.

Published in:

Cells (2073-4409), 2022, v. 11, n. 13, p. N.PAG, doi. 10.3390/cells11132099

By:

Xiao, Huaping;
Li, Fanghua;
Mladenov, Emil;
Soni, Aashish;
Mladenova, Veronika;
Pan, Bing;
Dueva, Rositsa;
Stuschke, Martin;
Timmermann, Beate;
Iliakis, George

Publication type:

Article

Shift in G 1 -Checkpoint from ATM-Alone to a Cooperative ATM Plus ATR Regulation with Increasing Dose of Radiation.

Published in:

Cells (2073-4409), 2022, v. 11, n. 1, p. 63, doi. 10.3390/cells11010063

By:

Li, Fanghua;
Mladenov, Emil;
Dueva, Rositsa;
Stuschke, Martin;
Timmermann, Beate;
Iliakis, George

Publication type:

Article

Functional redundancy between DNA ligases I and III in DNA replication in vertebrate cells.

Published in:

Nucleic Acids Research, 2012, v. 40, n. 6, p. 2599, doi. 10.1093/nar/gkr1024

By:

Arakawa, Hiroshi;
Bednar, Theresa;
Wang, Minli;
Paul, Katja;
Mladenov, Emil;
Bencsik-Theilen, Alena A.;
Iliakis, George

Publication type:

Article

FTO levels affect RNA modification and the transcriptome.

Published in:

European Journal of Human Genetics, 2013, v. 21, n. 3, p. 317, doi. 10.1038/ejhg.2012.168

By:

Berulava, Tea;
Ziehe, Matthias;
Klein-Hitpass, Ludger;
Mladenov, Emil;
Thomale, Jürgen;
Rüther, Ulrich;
Horsthemke, Bernhard

Publication type:

Article

Cell Cycle–Dependent Association of Rad51 with the Nuclear Matrix.

Published in:

DNA & Cell Biology, 2007, v. 26, n. 1, p. 36, doi. 10.1089/dna.2006.0503

By:

Mladenov, Emil;
Tsaneva, Irina;
Anachkova, Boyka

Publication type:

Article

Strong Shift to ATR-Dependent Regulation of the G 2 -Checkpoint after Exposure to High-LET Radiation.

Published in:

Life (2075-1729), 2021, v. 11, n. 6, p. 560, doi. 10.3390/life11060560

By:

Mladenova, Veronika;
Mladenov, Emil;
Scholz, Michael;
Stuschke, Martin;
Iliakis, George

Publication type:

Article

New Facets of DNA Double Strand Break Repair: Radiation Dose as Key Determinant of HR versus c-NHEJ Engagement.

Published in:

International Journal of Molecular Sciences, 2023, v. 24, n. 19, p. 14956, doi. 10.3390/ijms241914956

By:

Mladenov, Emil;
Mladenova, Veronika;
Stuschke, Martin;
Iliakis, George

Publication type:

Article

PTEN Loss Enhances Error-Prone DSB Processing and Tumor Cell Radiosensitivity by Suppressing RAD51 Expression and Homologous Recombination.

Published in:

International Journal of Molecular Sciences, 2022, v. 23, n. 21, p. 12876, doi. 10.3390/ijms232112876

By:

Pei, Xile;
Mladenov, Emil;
Soni, Aashish;
Li, Fanghua;
Stuschke, Martin;
Iliakis, George

Publication type:

Article

Increased Gene Targeting in Hyper-Recombinogenic LymphoBlastoid Cell Lines Leaves Unchanged DSB Processing by Homologous Recombination.

Published in:

International Journal of Molecular Sciences, 2022, v. 23, n. 16, p. 9180, doi. 10.3390/ijms23169180

By:

Mladenov, Emil;
Paul-Konietzko, Katja;
Mladenova, Veronika;
Stuschke, Martin;
Iliakis, George

Publication type:

Article

Disruption of Chromatin Dynamics by Hypotonic Stress Suppresses HR and Shifts DSB Processing to Error-Prone SSA.

Published in:

International Journal of Molecular Sciences, 2021, v. 22, n. 20, p. 10957, doi. 10.3390/ijms222010957

By:

Krieger, Lisa Marie;
Mladenov, Emil;
Soni, Aashish;
Demond, Marilen;
Stuschke, Martin;
Iliakis, George

Publication type:

Article

Conformational transitions of proteins engaged in DNA double-strand break repair, analysed by tryptophan fluorescence emission and FRET.

Published in:

Biochemical Journal, 2012, v. 443, n. 3, p. 701, doi. 10.1042/BJ20112151

By:

STANKOVA, Katia;
IVANOVA, Katia;
MLADENOV, Emil;
ROSIDI, Bustanur;
SHARMA, Aparna;
BOTEVA, Rayna;
ILIAKIS, George

Publication type:

Article

Repair of DNA interstrand crosslinks may take place at the nuclear matrix.

Published in:

Journal of Cellular Biochemistry, 2005, v. 96, n. 1, p. 126, doi. 10.1002/jcb.20518

By:

Boyko Atanassov;
Anastas Gospodinov;
Ivaylo Stoimenov;
Emil Mladenov;
George Russev;
Irina Tsaneva;
Boyka Anachkova

Publication type:

Article

DNA-PKcs and ATM epistatically suppress DNA end resection and hyperactivation of ATR-dependent G<sub>2</sub>-checkpoint in S-phase irradiated cells.

Published in:

Scientific Reports, 2019, v. 9, n. 1, p. N.PAG, doi. 10.1038/s41598-019-51071-6

By:

Mladenov, Emil;
Fan, Xiaoxiang;
Paul-Konietzko, Katja;
Soni, Aashish;
Iliakis, George

Publication type:

Article

Radiation-dose-dependent functional synergisms between ATM, ATR and DNA-PKcs in checkpoint control and resection in G<sub>2</sub>-phase.

Published in:

Scientific Reports, 2019, v. 9, n. 1, p. N.PAG, doi. 10.1038/s41598-019-44771-6

By:

Mladenov, Emil;
Fan, Xiaoxiang;
Dueva, Rositsa;
Soni, Aashish;
Iliakis, George

Publication type:

Article

Necessities in the Processing of DNA Double Strand Breaks and Their Effects on Genomic Instability and Cancer.

Published in:

Cancers, 2019, v. 11, n. 11, p. 1671, doi. 10.3390/cancers11111671

By:

Iliakis, George;
Mladenov, Emil;
Mladenova, Veronika

Publication type:

Article

NGS Detects Extensive Genomic Alterations in Survivors of Irradiated Normal Human Fibroblast Cells.

Published in:

Radiation Research, 2025, v. 203, n. 1, p. 37, doi. 10.1667/RADE-24-00094.1

By:

Soni, Aashish;
Beisser, Daniela;
Mladenov, Emil;
Höller, Matthias;
Wohlers, Inken;
Nikolov, Vladimir;
Magin, Simon;
Mussfeldt, Tamara;
Klein-Hitpass, Ludger;
Cornforth, Michael N.;
Loucas, Bradford D.;
Rahmann, Sven;
Iliakis, George

Publication type:

Article

Selective vulnerability of ARID1A deficient colon cancer cells to combined radiation and ATR-inhibitor therapy.

Published in:

Frontiers in Oncology, 2022, v. 12, p. 1, doi. 10.3389/fonc.2022.999626

By:

Shan Xu;
Sak, Ali;
Niedermaier, Ben;
Erol, Yasin Bahadir;
Groneberg, Michael;
Mladenov, Emil;
Ming Wei Kang;
Iliakis, George;
Stuschke, Martin

Publication type:

Article

DNA double-strand break repair as determinant of cellular radiosensitivity to killing and target in radiation therapy.

Published in:

Frontiers in Oncology, 2013, v. 3, p. 1, doi. 10.3389/fonc.2013.00113

By:

Mladenov, Emil;
Magin, Simon;
Soni, Aashish;
Iliakis, George

Publication type:

Article

DNA Double-Strand Break Repair as determinant of cellular radiosensitivity to killing and target in radiation therapy.

Published in:

Frontiers in Oncology, 2013, p. 1, doi. 10.3389/fonc.2013.00113

By:

Mladenov, Emil;
Magin, Simon;
Soni, Aashish;
Iliakis, George

Publication type:

Article

Strong suppression of gene conversion with increasing DNA double-strand break load delimited by 53BP1 and RAD52.

Published in:

Nucleic Acids Research, 2020, v. 48, n. 4, p. 1905, doi. 10.1093/nar/gkz1167

By:

Mladenov, Emil;
Staudt, Christian;
Soni, Aashish;
Murmann-Konda, Tamara;
Siemann-Loekes, Maria;
Iliakis, George

Publication type:

Article

Chromosome thripsis by DNA double strand break clusters causes enhanced cell lethality, chromosomal translocations and 53BP1-recruitment.

Published in:

Nucleic Acids Research, 2016, v. 44, n. 16, p. 7673, doi. 10.1093/nar/gkw487

By:

Schipler, Agnes;
Mladenova, Veronika;
Soni, Aashish;
Nikolov, Vladimir;
Saha, Janapriya;
Mladenov, Emil;
Iliakis, George

Publication type:

Article

Intercellular communication of DNA damage and oxidative status underpin bystander effects.

Published in:

International Journal of Radiation Biology, 2018, v. 94, n. 8, p. 719, doi. 10.1080/09553002.2018.1434323

By:

Mladenov, Emil;
Li, Fanghua;
Zhang, Lihua;
Klammer, Holger;
Iliakis, George

Publication type:

Article

BMN673 Is a PARP Inhibitor with Unique Radiosensitizing Properties: Mechanisms and Potential in Radiation Therapy.

Published in:

Cancers, 2022, v. 14, n. 22, p. 5619, doi. 10.3390/cancers14225619

By:

Soni, Aashish;
Lin, Xixi;
Mladenov, Emil;
Mladenova, Veronika;
Stuschke, Martin;
Iliakis, George

Publication type:

Article

DEFINED BIOLOGICAL MODELS OF HIGH-LET RADIATION LESIONS.

Published in:

Radiation Protection Dosimetry, 2019, v. 183, n. 1/2, p. 60, doi. 10.1093/rpd/ncy248

By:

Iliakis, George;
Mladenova, Veronika;
Sharif, Mortoga;
Chaudhary, Shipra;
Mavragani, Ifigeneia V;
Soni, Aashish;
Saha, Janapriya;
Schipler, Agnes;
Mladenov, Emil

Publication type:

Article

Novel Biological Approaches for Testing the Contributions of Single DSBs and DSB Clusters to the Biological effects of High LeT Radiation.

Published in:

Frontiers in Oncology, 2016, p. 1, doi. 10.3389/fonc.2016.00163

By:

Mladenova, Veronika;
Mladenov, Emil;
Iliakis, George

Publication type:

Article

Sub-nuclear localization of Rad51 in response to DNA damage.

Published in:

Genes to Cells, 2006, v. 11, n. 5, p. 513, doi. 10.1111/j.1365-2443.2006.00958.x

By:

Mladenov, Emil;
Anachkova, Boyka;
Tsaneva, Irina

Publication type:

Article

DNA Ligases I and III Cooperate in Alternative Non-Homologous End-Joining in Vertebrates.

Published in:

PLoS ONE, 2013, v. 8, n. 3, p. 1, doi. 10.1371/journal.pone.0059505

By:

Paul, Katja;
Wang, Minli;
Mladenov, Emil;
Bencsik-Theilen, Alena;
Bednar, Theresa;
Wu, Wenqi;
Arakawa, Hiroshi;
Iliakis, George

Publication type:

Article

Measurement of complex DNA damage induction and repair in human cellular systems after exposure to ionizing radiations of varying linear energy transfer (LET).

Published in:

Free Radical Research, 2016, v. 50, p. S64, doi. 10.1080/10715762.2016.1232484

By:

Nikitaki, Zacharenia;
Nikolov, Vladimir;
Mavragani, Ifigeneia V.;
Mladenov, Emil;
Mangelis, Anastasios;
Laskaratou, Danae A.;
Fragkoulis, Georgios I.;
Hellweg, Christine E.;
Martin, Olga A.;
Emfietzoglou, Dimitris;
Hatzi, Vasiliki I.;
Terzoudi, Georgia I.;
Iliakis, George;
Georgakilas, Alexandros G.

Publication type:

Article

Reduced contribution of thermally labile sugar lesions to DNA double strand break formation after exposure to heavy ions.

Published in:

Radiation Oncology, 2013, v. 8, n. 1, p. 1, doi. 10.1186/1748-717X-8-77

By:

Singh, Satyendra K.;
Bencsik-Theilen, Alena;
Mladenov, Emil;
Jakob, Burkhard;
Taucher-Scholz, Gisela;
Iliakis, George

Publication type:

Article

Reduced contribution of thermally labile sugar lesions to DNA double strand break formation after exposure to heavy ions.

Published in:

2013

By:

Singh, Satyendra K;
Bencsik-Theilen, Alena;
Mladenov, Emil;
Jakob, Burkhard;
Taucher-Scholz, Gisela;
Iliakis, George

Publication type:

journal article

Nuclear matrix binding site in the Rad51 recombinase.

Published in:

Journal of Cellular Physiology, 2009, v. 219, n. 1, p. 202, doi. 10.1002/jcp.21665

By:

MLADENOV, EMIL V.;
KALEV, PETER S.;
ANACHKOVA, BOYKA B.

Publication type:

Article

DNA Damage Clustering after Ionizing Radiation and Consequences in the Processing of Chromatin Breaks.

Published in:

Molecules, 2022, v. 27, n. 5, p. 1540, doi. 10.3390/molecules27051540

By:

Mladenova, Veronika;
Mladenov, Emil;
Stuschke, Martin;
Iliakis, George

Publication type:

Article

The imprinted NPAP1/C15orf2 gene in the Prader–Willi syndrome region encodes a nuclear pore complex associated protein.

Published in:

Human Molecular Genetics, 2012, v. 21, n. 18, p. 4038, doi. 10.1093/hmg/dds228

By:

Neumann, Lisa C.;
Markaki, Yolanda;
Mladenov, Emil;
Hoffmann, Daniel;
Buiting, Karin;
Horsthemke, Bernhard

Publication type:

Article

SCFSKP2 regulates APC/CCDH1-mediated degradation of CTIP to adjust DNA-end resection in G2-phase.

Published in:

Cell Death & Disease, 2020, v. 11, n. 7, p. 1, doi. 10.1038/s41419-020-02755-9

By:

Li, Fanghua;
Mladenov, Emil;
Mortoga, Sharif;
Iliakis, George

Publication type:

Article