Works by Mittapalli, Rajendar K.

Results: 16

An Integrated Population Pharmacokinetic Model Versus Individual Models of Depatuxizumab Mafodotin, an Anti‐EGFR Antibody Drug Conjugate, in Patients With Solid Tumors Likely to Overexpress EGFR.

Published in:

Journal of Clinical Pharmacology, 2019, v. 59, n. 9, p. 1225, doi. 10.1002/jcph.1418

By:

Mittapalli, Rajendar K.;
Stodtmann, Sven;
Friedel, Anna;
Menon, Rajeev M.;
Bain, Earle;
Mensing, Sven;
Xiong, Hao

Publication type:

Article

Strategies to improve delivery of anticancer drugs across the blood-brain barrier to treat glioblastoma.

Published in:

Neuro-Oncology, 2016, v. 18, n. 1, p. 27, doi. 10.1093/neuonc/nov164

By:

Oberoi, Rajneet K.;
Parrish, Karen E.;
Sio, Terence T.;
Mittapalli, Rajendar K.;
Elmquist, William F.;
Sarkaria, Jann N.

Publication type:

Article

INFLUENCE OF DRUG DELIVERY ON THERAPEUTIC BENEFIT IN GBM–CDK4 AND MDM2 INHIBITOR COMPARISON IN FLANK VERSUS ORTHOTOPIC MODELS AND COMPARISON OF BRAIN PENETRANT VERSUS IMPENETRANT PI3K/MTOR INHIBITORS.

Published in:

Neuro-Oncology, 2014, v. 16, n. suppl_3, p. iii33, doi. 10.1093/neuonc/nou208.40

By:

Sarkaria, Jann N.;
Pokorny, Jenny L.;
Mladek, Ann C.;
Parrish, Karen;
Oberoi, Rajneet;
Sio, Terence;
Mittapalli, Rajendar K.;
Elmquist, William F.

Publication type:

Article

Efficacy and safety results of depatuxizumab mafodotin (ABT-414) in patients with advanced solid tumors likely to overexpress epidermal growth factor receptor.

Published in:

2018

By:

Goss, Glenwood D.;
Vokes, Everett E.;
Gordon, Michael S.;
Gandhi, Leena;
Papadopoulos, Kyriakos P.;
Rasco, Drew W.;
Fischer, JuDee S.;
Chu, Katharine L.;
Ames, William W.;
Mittapalli, Rajendar K.;
Lee, Ho‐Jin;
Zeng, Jiewei;
Roberts‐Rapp, Lisa A.;
Loberg, Lise I.;
Ansell, Peter J.;
Reilly, Edward B.;
Ocampo, Christopher J.;
Holen, Kyle D.;
Tolcher, Anthony W.;
Lee, Ho-Jin

Publication type:

journal article

Landscape analysis of adverse events and dose intensity for FDA approved oncology small molecules.

Published in:

Cancer Chemotherapy & Pharmacology, 2025, v. 95, n. 1, p. 1, doi. 10.1007/s00280-024-04721-0

By:

Collins, Keagan P.;
Yin, Donghua;
Pithavala, Yazdi K.;
Mittapalli, Rajendar K.

Publication type:

Article

Oncology dose optimization paradigms: knowledge gained and extrapolated from approved oncology therapeutics.

Published in:

2022

By:

Mittapalli, Rajendar K.;
Guo, Cen;
Drescher, Stefanie K.;
Yin, Donghua

Publication type:

journal article

Starting dose selection and dose escalation for oncology small molecule first-in-patient trials: learnings from a survey of FDA-approved drugs.

Published in:

Cancer Chemotherapy & Pharmacology, 2021, v. 87, n. 1, p. 23, doi. 10.1007/s00280-020-04202-0

By:

Mittapalli, Rajendar K.;
Yin, Donghua;
Beaupre, Darrin;
Palaparthy, Rameshraja

Publication type:

Article

Evaluation of the effect of the EGFR antibody-drug conjugate ABT-414 on QT interval prolongation in patients with advanced solid tumors likely to over-express EGFR.

Published in:

2017

By:

Munasinghe, Wijith;
Mittapalli, Rajendar;
Li, Hong;
Hoffman, David;
Holen, Kyle;
Menon, Rajeev;
Xiong, Hao;
Munasinghe, Wijith P;
Mittapalli, Rajendar K;
Hoffman, David M;
Holen, Kyle D;
Menon, Rajeev M

Publication type:

journal article

Population pharmacokinetics of ABT-767 in BRCA1 or BRCA2 mutation carriers with advanced solid tumors or in subjects with high grade serous ovarian, primary peritoneal or fallopian tube cancer.

Published in:

2017

By:

Mittapalli, Rajendar;
Nuthalapati, Silpa;
Shepherd, Stacie;
Xiong, Hao;
Mittapalli, Rajendar K;
Shepherd, Stacie Peacock

Publication type:

journal article

Population Pharmacokinetics of Upadacitinib Using the Immediate-Release and Extended-Release Formulations in Healthy Subjects and Subjects with Rheumatoid Arthritis: Analyses of Phase I-III Clinical Trials.

Published in:

2019

By:

Klünder, Ben;
Mittapalli, Rajendar K.;
Mohamed, Mohamed-Eslam F.;
Friedel, Anna;
Noertersheuser, Peter;
Othman, Ahmed A.

Publication type:

journal article

Population Pharmacokinetics of ABT-806, an Investigational Anti-Epidermal Growth Factor Receptor (EGFR) Monoclonal Antibody, in Advanced Solid Tumor Types Likely to Either Over-Express Wild-Type EGFR or Express Variant III Mutant EGFR.

Published in:

2015

By:

Sharma, Shringi;
Mittapalli, Rajendar;
Holen, Kyle;
Xiong, Hao;
Mittapalli, Rajendar K;
Holen, Kyle D

Publication type:

journal article

Oncology Combination Dose‐Finding Study Design for Targeted and Immuno‐Oncology Therapies.

Published in:

Clinical Pharmacology & Therapeutics, 2024, v. 115, n. 1, p. 29, doi. 10.1002/cpt.3085

By:

Zhou, Li;
Reddy, Micaela B.;
Mittapalli, Rajendar K.;
Yang, Jing;
Yin, Donghua

Publication type:

Article

Assessment of the Utility of Physiologically-based Pharmacokinetic Model for prediction of Pharmacokinetics in Chinese and Japanese Populations.

Published in:

International Journal of Medical Sciences, 2021, v. 18, n. 16, p. 3718, doi. 10.7150/ijms.65040

By:

Yanke Yu;
Jian Lin;
Chieko Muto;
Yinhua Li;
Yuko Mori;
Mittapalli, Rajendar K.;
Tse, Susanna;
Jian Liu;
Bei Kang Ge;
Jing Liu

Publication type:

Article

A phase 1 study of PARP-inhibitor ABT-767 in advanced solid tumors with BRCA1/2 mutations and high-grade serous ovarian, fallopian tube, or primary peritoneal cancer.

Published in:

Investigational New Drugs, 2018, v. 36, n. 5, p. 828, doi. 10.1007/s10637-017-0551-z

By:

van der Biessen, Diane A. J.;
Gietema, Jourik A.;
de Jonge, Maja J. A.;
Desar, Ingrid M. E.;
den Hollander, Martha W.;
Dudley, Matthew;
Dunbar, Martin;
Hetman, Robert;
Serpenti, Camille;
Xiong, Hao;
Mittapalli, Rajendar K.;
Timms, Kirsten M.;
Ansell, Peter;
Ratajczak, Christine K.;
Shepherd, Stacie Peacock;
van Herpen, Carla M. L.

Publication type:

Article

Nicotine and cotinine increases the brain penetration of saquinavir in rat.

Published in:

Journal of Neurochemistry, 2010, v. 115, n. 6, p. 1495, doi. 10.1111/j.1471-4159.2010.07054.x

By:

Manda, Vamshi K.;
Mittapalli, Rajendar K.;
Bohn, Kaci A.;
Adkins, Chris E.;
Lockman, Paul R.

Publication type:

Article

Chronic exposure to nicotine and saquinavir decreases endothelial Notch-4 expression and disrupts blood-brain barrier integrity.

Published in:

Journal of Neurochemistry, 2010, v. 115, n. 2, p. 515, doi. 10.1111/j.1471-4159.2010.06948.x

By:

Manda, Vamshi K.;
Mittapalli, Rajendar K.;
Geldenhuys, Werner J.;
Lockman, Paul R.

Publication type:

Article