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Distinct spatiotemporal accumulation of N-truncated and full-length amyloid-β42 in Alzheimer's disease.
Published in:
2017
By:
- Mitsuru Shinohara;
- Shunsuke Koga;
- Takuya Konno;
- Nix, Jeremy;
- Motoko Shinohara;
- Naoya Aoki;
- Das, Pritam;
- Parisi, Joseph E.;
- Petersen, Ronald C.;
- Rosenberry, Terrone L.;
- Dickson, Dennis W.;
- Guojun Bu;
- Shinohara, Mitsuru;
- Koga, Shunsuke;
- Konno, Takuya;
- Shinohara, Motoko;
- Aoki, Naoya;
- Bu, Guojun
Publication type:
journal article
APOE4-mediated amyloid-β pathology depends on its neuronal receptor LRP1.
Published in:
2019
By:
- Tachibana, Masaya;
- Holm, Marie-Louise;
- Chia-Chen Liu;
- Mitsuru Shinohara;
- Tomonori Aikawa;
- Hiroshi Oue;
- Yu Yamazaki;
- Martens, Yuka A.;
- Murray, Melissa E.;
- Sullivan, Patrick M.;
- Weyer, Kathrin;
- Glerup, Simon;
- Dickson, Dennis W.;
- Guojun Bu;
- Takahisa Kanekiyo;
- Liu, Chia-Chen;
- Shinohara, Mitsuru;
- Aikawa, Tomonori;
- Oue, Hiroshi;
- Yamazaki, Yu
Publication type:
journal article
Selective loss of cortical endothelial tight junction proteins during Alzheimer's disease progression.
Published in:
2019
By:
- Yamazaki, Yu;
- Shinohara, Mitsuru;
- Shinohara, Motoko;
- Yamazaki, Akari;
- Murray, Melissa E;
- Liesinger, Amanda M;
- Heckman, Michael G;
- Lesser, Elizabeth R;
- Parisi, Joseph E;
- Petersen, Ronald C;
- Dickson, Dennis W;
- Kanekiyo, Takahisa;
- Bu, Guojun
Publication type:
journal article
P3‐068: INCREASED LEVELS OF Aβ42 DECREASE THE LIFE SPAN OF OB/OB MICE WITH DYSREGULATION OF MICROGLIA AND ASTROCYTES.
Published in:
Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2019, v. 15, p. P952, doi. 10.1016/j.jalz.2019.06.3095
By:
- Shinohara, Mitsuru;
- Tashiro, Yoshitaka;
- Suzuki, Kaoru;
- Onishi-Takeya, Miyuki;
- Takeda, Shuko;
- Saito, Takashi;
- Fukumori, Akio;
- Saido, Takaomi C.;
- Morishita, Ryuichi;
- Sato, Naoyuki
Publication type:
Article
5-HT3 Antagonist Ondansetron Increases apoE Secretion by Modulating the LXR-ABCA1 Pathway.
Published in:
International Journal of Molecular Sciences, 2019, v. 20, n. 6, p. 1488, doi. 10.3390/ijms20061488
By:
- Zhao, Jing;
- Fu, Yuan;
- Liu, Chia-Chen;
- Shinohara, Motoko;
- Shinohara, Mitsuru;
- Kanekiyo, Takahisa;
- Bu, Guojun
Publication type:
Article
Upregulated expression of a subset of genes in APP;ob/ob mice: Evidence of an interaction between diabetes‐linked obesity and Alzheimer's disease.
Published in:
FASEB Bioadvances, 2021, v. 3, n. 5, p. 323, doi. 10.1096/fba.2020-00151
By:
- Shinohara, Mitsuru;
- Kikuchi, Masataka;
- Onishi‐Takeya, Miyuki;
- Tashiro, Yoshitaka;
- Suzuki, Kaoru;
- Noda, Yasuhiro;
- Takeda, Shuko;
- Mukouzono, Masahiro;
- Nagano, Seiichi;
- Fukumori, Akio;
- Morishita, Ryuichi;
- Nakaya, Akihiro;
- Sato, Naoyuki
Publication type:
Article
APOE2 is associated with longevity independent of Alzheimer's disease.
Published in:
eLife, 2020, p. 1, doi. 10.7554/eLife.62199
By:
- Mitsuru Shinohara;
- Takahisa Kanekiyo;
- Masaya Tachibana;
- Kurti, Aishe;
- Motoko Shinohara;
- Yuan Fu;
- Jing Zhao;
- Xianlin Han;
- Sullivan, Patrick M.;
- Rebeck, G. William;
- Fryer, John D.;
- Heckman, Michael G.;
- Guojun Bu
Publication type:
Article
REGIONAL DISTRIBUTION OF AMYLOID-BETA, SOLUBLE APP AND SYNAPTIC MARKERS IN HUMAN BRAINS.
Published in:
Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2016, v. 12, p. P556, doi. 10.1016/j.jalz.2016.06.1085
By:
- Shinohara, Mitsuru;
- Dickson, Dennis W.;
- Bu, Guojun
Publication type:
Article
Brain regional distribution of apolipoprotein E and beta-amyloid peptides in cognitively normal persons
Published in:
2012
By:
- Shinohara, Mitsuru;
- Dickson, Dennis;
- Bu, Guojun
Publication type:
Abstract
Diabetes mellitus exacerbated learning impairment via cerebrovascular inflammation and disturbance of brain insulin signaling in Alzheimer mouse models with diabetes
Published in:
2010
By:
- Takeda, Shuko;
- Sato, Naoyuki;
- Uchio-Yamada, Kozue;
- Sawada, Kyoko;
- Kunieda, Takanori;
- Shinohara, Mitsuru;
- Rakugi, Hiromi;
- Morishita, Ryuichi
Publication type:
Abstract
INCREASED INCIDENTAL DETECTION AND REDUCED MORTALITY IN RENAL CANCER-RECENT RETROSPECTIVE ANALYSIS AT EIGHT INSTITUTIONS.
Published in:
International Journal of Urology, 1995, v. 2, n. 2, p. 77, doi. 10.1111/j.1442-2042.1995.tb00428.x
By:
- Homma, Yukio;
- Kawabe, Kazuki;
- Kitamura, Tadaichi;
- Nishimura, Yoji;
- Shinohara, Mitsuru;
- Kondo, Yasushi;
- Saito, Isao;
- Minowada, Shigeru;
- Asakage, Yasuyuki
Publication type:
Article
Differential Regulation of Amyloid Precursor Protein/Presenilin 1 Interaction during Ab40/42 Production Detected Using Fusion Constructs.
Published in:
PLoS ONE, 2012, v. 7, n. 11, p. 1, doi. 10.1371/journal.pone.0048551
By:
- Sato, Naoyuki;
- Okochi, Masayasu;
- Shinohara, Mitsuru;
- Thinakaran, Gopal;
- Takeda, Shuko;
- Fukumori, Akio;
- Shinohara-Noma, Motoko;
- Mori-Ueda, Mari;
- Hamada, Hizuki;
- Takeda, Masatoshi;
- Rakugi, Hiromi;
- Morishita, Ryuichi
Publication type:
Article
Structures of liquid crystalline wholly aromatic copolyester films with different copolymer compositions.
Published in:
Journal of Applied Polymer Science, 1996, v. 62, n. 7, p. 1049, doi. 10.1002/(SICI)1097-4628(19961114)62:7<1049::AID-APP11>3.0.CO;2-1
By:
- Yonetake, Koichiro;
- Shinohara, Mitsuru;
- Masuko, Toru
Publication type:
Article
Dual Effects of Statins on Aβ Metabolism: Upregulation of the Degradation of APP-CTF and Aβ Clearance.
Published in:
Neurodegenerative Diseases, 2012, v. 10, n. 1-4, p. 305, doi. 10.1159/000334534
By:
- Sato, Naoyuki;
- Shinohara, Mitsuru;
- Rakugi, Hiromi;
- Morishita, Ryuichi
Publication type:
Article
Author Correction: Soluble TREM2 ameliorates pathological phenotypes by modulating microglial functions in an Alzheimer's disease model.
Published in:
2019
By:
- Zhong, Li;
- Xu, Ying;
- Zhuo, Rengong;
- Wang, Tingting;
- Wang, Kai;
- Huang, Ruizhi;
- Wang, Daxin;
- Gao, Yue;
- Zhu, Yifei;
- Sheng, Xuan;
- Chen, Kai;
- Wang, Na;
- Zhu, Lin;
- Can, Dan;
- Marten, Yuka;
- Shinohara, Mitsuru;
- Liu, Chia-Chen;
- Du, Dan;
- Sun, Hao;
- Wen, Lei
Publication type:
Correction Notice
Soluble TREM2 ameliorates pathological phenotypes by modulating microglial functions in an Alzheimer's disease model.
Published in:
Nature Communications, 2019, v. 10, n. 1, p. N.PAG, doi. 10.1038/s41467-019-09118-9
By:
- Zhong, Li;
- Xu, Ying;
- Zhuo, Rengong;
- Wang, Tingting;
- Wang, Kai;
- Huang, Ruizhi;
- Wang, Daxin;
- Gao, Yue;
- Zhu, Yifei;
- Sheng, Xuan;
- Chen, Kai;
- Wang, Na;
- Zhu, Lin;
- Can, Dan;
- Marten, Yuka;
- Shinohara, Mitsuru;
- Liu, Chia-Chen;
- Du, Dan;
- Sun, Hao;
- Wen, Lei
Publication type:
Article
APOE ε2 is associated with increased tau pathology in primary tauopathy.
Published in:
Nature Communications, 2018, v. 9, p. 1, doi. 10.1038/s41467-018-06783-0
By:
- Zhao, Na;
- Liu, Chia-Chen;
- Van Ingelgom, Alexandra J.;
- Linares, Cynthia;
- Kurti, Aishe;
- Knight, Joshua A.;
- Heckman, Michael G.;
- Diehl, Nancy N.;
- Shinohara, Mitsuru;
- Martens, Yuka A.;
- Attrebi, Olivia N.;
- Petrucelli, Leonard;
- Fryer, John D.;
- Wszolek, Zbigniew K.;
- Graff-Radford, Neill R.;
- Caselli, Richard J.;
- Sanchez-Contreras, Monica Y.;
- Rademakers, Rosa;
- Murray, Melissa E.;
- Koga, Shunsuke
Publication type:
Article
Patient‐reported outcomes following neoadjuvant endocrine therapy, external beam radiation, and adjuvant continuous/intermittent endocrine therapy for locally advanced prostate cancer: A randomized phase III trial.
Published in:
Cancer Medicine, 2021, v. 10, n. 10, p. 3240, doi. 10.1002/cam4.3895
By:
- Yokomizo, Akira;
- Koga, Hirofumi;
- Ito, Kazuto;
- Takezawa, Yutaka;
- Komiyama, Motokiyo;
- Nishimura, Kazuo;
- Yonese, Junji;
- Hashine, Katsuyoshi;
- Masumori, Naoya;
- Arai, Gaku;
- Saito, Shiro;
- Shinohara, Mitsuru;
- Shimizu, Nobuaki;
- Yamauchi, Atsushi;
- Satoh, Takefumi;
- Tochigi, Tatsuo;
- Kobayashi, Mikio;
- Fujimoto, Hiroyuki;
- Kakimoto, Ken‐ichi;
- Fukui, Iwao
Publication type:
Article
Regional distribution of synaptic markers and APP correlate with distinct clinicopathological features in sporadic and familial Alzheimer's disease.
Published in:
2014
By:
- Shinohara, Mitsuru;
- Fujioka, Shinsuke;
- Murray, Melissa E;
- Wojtas, Aleksandra;
- Baker, Matthew;
- Rovelet-Lecrux, Anne;
- Rademakers, Rosa;
- Das, Pritam;
- Parisi, Joseph E;
- Graff-Radford, Neill R;
- Petersen, Ronald C;
- Dickson, Dennis W;
- Bu, Guojun
Publication type:
journal article
Regional distribution of synaptic markers and APP correlate with distinct clinicopathological features in sporadic and familial Alzheimer’s disease.
Published in:
Brain: A Journal of Neurology, 2014, v. 137, n. 5, p. 1533, doi. 10.1093/brain/awu046
By:
- Shinohara, Mitsuru;
- Fujioka, Shinsuke;
- Murray, Melissa E.;
- Wojtas, Aleksandra;
- Baker, Matthew;
- Rovelet-Lecrux, Anne;
- Rademakers, Rosa;
- Das, Pritam;
- Parisi, Joseph E.;
- Graff-Radford, Neill R.;
- Petersen, Ronald C.;
- Dickson, Dennis W.;
- Bu, Guojun
Publication type:
Article
Increased levels of Aβ42 decrease the lifespan of ob/ob mice with dysregulation of microglia and astrocytes.
Published in:
FASEB Journal, 2020, v. 34, n. 2, p. 2425, doi. 10.1096/fj.201901028RR
By:
- Shinohara, Mitsuru;
- Tashiro, Yoshitaka;
- Shinohara, Motoko;
- Hirokawa, Junko;
- Suzuki, Kaoru;
- Onishi‐Takeya, Miyuki;
- Mukouzono, Masahiro;
- Takeda, Shuko;
- Saito, Takashi;
- Fukumori, Akio;
- Saido, Takaomi C.;
- Morishita, Ryuichi;
- Sato, Naoyuki
Publication type:
Article
Deletion of B-cell translocation gene 2 (BTG2) alters the responses of glial cells in white matter to chronic cerebral hypoperfusion.
Published in:
2021
By:
- Suzuki, Kaoru;
- Shinohara, Mitsuru;
- Uno, Yoshihiro;
- Tashiro, Yoshitaka;
- Gheni, Ghupurjan;
- Yamamoto, Miho;
- Fukumori, Akio;
- Shindo, Akihiko;
- Mashimo, Tomoji;
- Tomimoto, Hidekazu;
- Sato, Naoyuki
Publication type:
journal article
Spermatic Cord Metastases from Gastric Cancer with Elevation of Serum hCG- β: A Case Report.
Published in:
Japanese Journal of Clinical Oncology, 2000, v. 30, n. 5, p. 239, doi. 10.1093/jjco/hyd055
By:
- Ota, Tomonori;
- Shinohara, Mitsuru;
- Tanaka, Masahiko;
- Date, Yoji;
- Itakura, Hironao;
- Munakata, Akio;
- Kinoshita, Kenji;
- Hishima, Tsunekazu;
- Koike, Morio;
- Kitamura, Masatsugu
Publication type:
Article
Two Cases of Metastatic Bladder Cancers Showing Diffuse Thickening of the Bladder Wall.
Published in:
Japanese Journal of Clinical Oncology, 1999, v. 29, n. 6, p. 314, doi. 10.1093/jjco/29.6.314
By:
- Ota, Tomonori;
- Shinohara, Mitsuru;
- Kinoshita, Kenji;
- Sakoma, Takaaki;
- Kitamura, Masatsugu;
- Maeda, Yoshiharu
Publication type:
Article
APOE2 eases cognitive decline during Aging: Clinical and preclinical evaluations.
Published in:
2016
By:
- Shinohara, Mitsuru;
- Kanekiyo, Takahisa;
- Yang, Longyu;
- Linthicum, Duane;
- Shinohara, Motoko;
- Fu, Yuan;
- Price, Laura;
- Frisch ‐ Daiello, Jessica L.;
- Han, Xianlin;
- Fryer, John D.;
- Bu, Guojun;
- Frisch-Daiello, Jessica L
Publication type:
journal article
Gastric diverticulum preoperatively diagnosed as one of two left adrenal adenomas.
Published in:
International Journal of Urology, 2006, v. 13, n. 1, p. 64, doi. 10.1111/j.1442-2042.2006.01236.x
By:
- Araki, Akihiro;
- Shinohara, Mitsuru;
- Yamakawa, Jun;
- Tanaka, Masahiko;
- Natsui, Shinsuke;
- Izumi, Yosuke
Publication type:
Article
APOE ∊4/∊4 diminishes neurotrophic function of human iPSC-derived astrocytes.
Published in:
Human Molecular Genetics, 2017, v. 26, n. 14, p. 2690, doi. 10.1093/hmg/ddx155
By:
- Jing Zhao;
- Davis, Mary D.;
- Martens, Yuka A.;
- Mitsuru Shinohara;
- Graff-Radford, Neill R.;
- Younkin, Steven G.;
- Wszolek, Zbigniew K.;
- Takahisa Kanekiyo;
- Guojun Bu
Publication type:
Article
Tau deposition drives neuropathological, inflammatory and behavioral abnormalities independently of neuronal loss in a novel mouse model.
Published in:
Human Molecular Genetics, 2015, v. 24, n. 21, p. 6198, doi. 10.1093/hmg/ddv336
By:
- Cook, Casey;
- Kang, Silvia S.;
- Carlomagno, Yari;
- Wen-Lang Lin;
- Mei Yue;
- Aishe Kurti;
- Mitsuru Shinohara;
- Jansen-West, Karen;
- Perkerson, Emilie;
- Castanedes-Casey, Monica;
- Rousseau, Linda;
- Phillips, Virginia;
- Guojun Bu;
- Dickson, Dennis W.;
- Petrucelli, Leonard;
- Fryer, John D.
Publication type:
Article
Impact of sex and APOE4 on cerebral amyloid angiopathy in Alzheimer's disease.
Published in:
Acta Neuropathologica, 2016, v. 132, n. 2, p. 225, doi. 10.1007/s00401-016-1580-y
By:
- Shinohara, Mitsuru;
- Murray, Melissa;
- Frank, Ryan;
- Shinohara, Motoko;
- DeTure, Michael;
- Yamazaki, Yu;
- Tachibana, Masaya;
- Atagi, Yuka;
- Davis, Mary;
- Liu, Chia-Chen;
- Zhao, Na;
- Painter, Meghan;
- Petersen, Ronald;
- Fryer, John;
- Crook, Julia;
- Dickson, Dennis;
- Bu, Guojun;
- Kanekiyo, Takahisa
Publication type:
Article
Brain regional correlation of amyloid-β with synapses and apolipoprotein E in non-demented individuals: potential mechanisms underlying regional vulnerability to amyloid-β accumulation.
Published in:
Acta Neuropathologica, 2013, v. 125, n. 4, p. 535, doi. 10.1007/s00401-013-1086-9
By:
- Shinohara, Mitsuru;
- Petersen, Ronald;
- Dickson, Dennis;
- Bu, Guojun
Publication type:
Article
Apolipoprotein E lipoprotein particles inhibit amyloid-β uptake through cell surface heparan sulphate proteoglycan.
Published in:
Molecular Neurodegeneration, 2016, v. 11, p. 1, doi. 10.1186/s13024-016-0099-y
By:
- Yuan Fu;
- Jing Zhao;
- Yuka Atagi;
- Nielsen, Henrietta M.;
- Chia-Chen Liu;
- Honghua Zheng;
- Mitsuru Shinohara;
- Takahisa Kanekiyo;
- Guojun Bu
Publication type:
Article
Hormonal therapy with external radiation therapy for metastatic spinal cord compression from newly diagnosed prostate cancer.
Published in:
Journal of Orthopaedic Science, 2013, v. 18, n. 5, p. 819, doi. 10.1007/s00776-013-0409-y
By:
- Kato, So;
- Hozumi, Takahiro;
- Yamakawa, Kiyofumi;
- Higashikawa, Akiro;
- Goto, Takahiro;
- Shinohara, Mitsuru;
- Kondo, Taiji
Publication type:
Article
Oncological outcomes for patients with locally advanced prostate cancer treated with neoadjuvant endocrine and external‐beam radiation therapy followed by adjuvant continuous/intermittent endocrine therapy in an open‐label, randomized, phase 3 trial
Published in:
2020
By:
- Ito, Kazuto;
- Kobayashi, Mikio;
- Komiyama, Motokiyo;
- Naito, Seiji;
- Nishimura, Kazuo;
- Yonese, Junji;
- Hashine, Katsuyoshi;
- Saito, Shiro;
- Arai, Gaku;
- Shinohara, Mitsuru;
- Masumori, Naoya;
- Shimizu, Nobuaki;
- Satoh, Takefumi;
- Yamauchi, Atsushi;
- Tochigi, Tatsuo;
- Takezawa, Yutaka;
- Fujimoto, Hiroyuki;
- Yokomizo, Akira;
- Kakimoto, Ken‐Ichi;
- Fukui, Iwao
Publication type:
journal article
APOE2: protective mechanism and therapeutic implications for Alzheimer's disease.
Published in:
Molecular Neurodegeneration, 2020, v. 15, n. 1, p. N.PAG, doi. 10.1186/s13024-020-00413-4
By:
- Li, Zonghua;
- Shue, Francis;
- Zhao, Na;
- Shinohara, Mitsuru;
- Bu, Guojun
Publication type:
Article
ABCA7 Deficiency Accelerates Amyloid-β Generation and Alzheimer's Neuronal Pathology.
Published in:
Journal of Neuroscience, 2016, v. 36, n. 13, p. 3848, doi. 10.1523/JNEUROSCI.3757-15.2016
By:
- Sakae, Nobutaka;
- Chia-Chen Liu;
- Shinohara, Mitsuru;
- Frisch-Daiello, Jessica;
- Li Ma;
- Yu Yamazaki;
- Tachibana, Masaya;
- Younkin, Linda;
- Kurti, Aishe;
- Carrasquillo, Minerva M.;
- Zou, Fanggeng;
- Sevlever, Daniel;
- Bisceglio, Gina;
- Gan, Ming;
- Fol, Romain;
- Knight, Patrick;
- Miao Wang;
- Xianlin Han;
- Fryer, John D.;
- Fitzgerald, Michael L.
Publication type:
Article
Neuronal Clearance of Amyloid-ß by Endocytic Receptor LRP1.
Published in:
Journal of Neuroscience, 2013, v. 33, n. 49, p. 19276, doi. 10.1523/JNEUROSCI.3487-13.2013
By:
- Takahisa Kanekiyo;
- Cirrito, John R.;
- Chia-Chen Liu;
- Shinohara, Mitsuru;
- Jie Li;
- Schuler, Dorothy R.;
- Motoko Shinohara;
- Holtzman, David M.;
- Guojun Bu
Publication type:
Article
LRPl in Brain Vascular Smooth Muscle Cells Mediates Local Clearance of Alzheimer's Amyloid-ß.
Published in:
Journal of Neuroscience, 2012, v. 32, n. 46, p. 16458, doi. 10.1523/JNEUROSCI.3987-12.2012
By:
- Kanekiyo, Takahisa;
- Chia-Chen Liu;
- Shinohara, Mitsuru;
- Jie Li;
- Bu1, Guojun
Publication type:
Article

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