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Transcriptional immune suppression and up-regulation of double-stranded DNA damage and repair repertoires in ecDNA-containing tumors.
- Published in:
- eLife, 2024, p. 1, doi. 10.7554/eLife.88895
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- Publication type:
- Article
DNA hypomethylator phenotype reprograms glutamatergic network in receptor tyrosine kinase gene-mutated glioblastoma.
- Published in:
- Acta Neuropathologica Communications, 2024, v. 12, n. 1, p. 1, doi. 10.1186/s40478-024-01750-x
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- Publication type:
- Article
Metabolic and epigenetic reprogramming in the pathogenesis of glioblastoma: Toward the establishment of "metabolism‐based pathology".
- Published in:
- Pathology International, 2023, v. 73, n. 11, p. 533, doi. 10.1111/pin.13379
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- Publication type:
- Article
Extrachromosomal DNA (ecDNA): an origin of tumor heterogeneity, genomic remodeling, and drug resistance.
- Published in:
- Biochemical Society Transactions, 2022, v. 50, n. 6, p. 1911, doi. 10.1042/BST20221045
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- Publication type:
- Article
The metabolomic landscape plays a critical role in glioma oncogenesis.
- Published in:
- Cancer Science, 2022, v. 113, n. 5, p. 1555, doi. 10.1111/cas.15325
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- Publication type:
- Article
BAP1 methylation: a prognostic marker of uveal melanoma metastasis.
- Published in:
- NPJ Precision Oncology, 2021, v. 5, n. 1, p. 1, doi. 10.1038/s41698-021-00226-8
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- Publication type:
- Article
Loss of polycomb repressive complex 1 activity and chromosomal instability drive uveal melanoma progression.
- Published in:
- Nature Communications, 2021, v. 12, n. 1, p. 1, doi. 10.1038/s41467-021-25529-z
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- Publication type:
- Article
Protein Acetylation at the Interface of Genetics, Epigenetics and Environment in Cancer.
- Published in:
- Metabolites (2218-1989), 2021, v. 11, n. 4, p. 216, doi. 10.3390/metabo11040216
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- Publication type:
- Article
AmpliconReconstructor integrates NGS and optical mapping to resolve the complex structures of focal amplifications.
- Published in:
- Nature Communications, 2020, v. 11, n. 1, p. N.PAG, doi. 10.1038/s41467-020-18099-z
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- Publication type:
- Article
Author Correction: Longitudinal assessment of tumor development using cancer avatars derived from genetically engineered pluripotent stem cells.
- Published in:
- 2020
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- Publication type:
- Correction Notice
Longitudinal assessment of tumor development using cancer avatars derived from genetically engineered pluripotent stem cells.
- Published in:
- Nature Communications, 2020, v. 11, n. 1, p. 1, doi. 10.1038/s41467-020-14312-1
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- Publication type:
- Article
Targeting pyrimidine synthesis accentuates molecular therapy response in glioblastoma stem cells.
- Published in:
- Science Translational Medicine, 2019, v. 11, n. 504, p. 1, doi. 10.1126/scitranslmed.aau4972
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- Publication type:
- Article
Metabolic reprogramming in the pathogenesis of glioma: Update.
- Published in:
- Neuropathology, 2019, v. 39, n. 1, p. 3, doi. 10.1111/neup.12535
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- Publication type:
- Article
Exploring the landscape of focal amplifications in cancer using AmpliconArchitect.
- Published in:
- Nature Communications, 2019, v. 10, n. 1, p. 1, doi. 10.1038/s41467-018-08200-y
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- Publication type:
- Article
mTOR Complexes as a Nutrient Sensor for Driving Cancer Progression.
- Published in:
- International Journal of Molecular Sciences, 2018, v. 19, n. 10, p. 3267, doi. 10.3390/ijms19103267
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- Publication type:
- Article
Activation of ERBB4 in Glioblastoma Can Contribute to Increased Tumorigenicity and Influence Therapeutic Response.
- Published in:
- Cancers, 2018, v. 10, n. 8, p. 243, doi. 10.3390/cancers10080243
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- Publication type:
- Article
ViFi: accurate detection of viral integration and mRNA fusion reveals indiscriminate and unregulated transcription in proximal genomic regions in cervical cancer.
- Published in:
- Nucleic Acids Research, 2018, v. 46, n. 7, p. 3309, doi. 10.1093/nar/gky180
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- Publication type:
- Article
Molecular and Genetic Determinants of Glioma Cell Invasion.
- Published in:
- International Journal of Molecular Sciences, 2017, v. 18, n. 12, p. 2609, doi. 10.3390/ijms18122609
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- Publication type:
- Article
mTORC2 activity in brain cancer: Extracellular nutrients are required to maintain oncogenic signaling.
- Published in:
- BioEssays, 2016, v. 38, n. 9, p. 839, doi. 10.1002/bies.201600026
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- Publication type:
- Article
Challenges in identifying cancer genes by analysis of exome sequencing data.
- Published in:
- Nature Communications, 2016, v. 7, n. 7, p. 12096, doi. 10.1038/ncomms12096
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- Publication type:
- Article
Metabolic Reprogramming in Brain Cancer: A Coordinated Effort.
- Published in:
- Brain Pathology, 2015, v. 25, n. 6, p. 753, doi. 10.1111/bpa.12308
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- Publication type:
- Article
mTORC2 and Metabolic Reprogramming in GBM: at the Interface of Genetics and Environment.
- Published in:
- Brain Pathology, 2015, v. 25, n. 6, p. 755, doi. 10.1111/bpa.12307
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- Publication type:
- Article
A phase I dose-escalation study to assess safety, tolerability, pharmacokinetics, and preliminary efficacy of the dual mTORC1/mTORC2 kinase inhibitor CC-223 in patients with advanced solid tumors or multiple myeloma.
- Published in:
- 2015
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- Publication type:
- journal article
Significance of filamin A in mTORC2 function in glioblastoma.
- Published in:
- Molecular Cancer, 2015, v. 14, n. 1, p. 1, doi. 10.1186/s12943-015-0396-z
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- Publication type:
- Article
Significance of filamin A in mTORC2 function in glioblastoma
- Published in:
- Molecular Cancer, 2015, v. 14, n. 1, p. 127, doi. 10.1186/s12943-015-0396-z
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- Publication type:
- Article
Heterogeneity of epidermal growth factor receptor signalling networks in glioblastoma.
- Published in:
- Nature Reviews Cancer, 2015, v. 15, n. 5, p. 302, doi. 10.1038/nrc3918
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- Publication type:
- Article
Compensatory glutamine metabolism promotes glioblastoma resistance to mTOR inhibitor treatment.
- Published in:
- Journal of Clinical Investigation, 2015, v. 125, n. 4, p. 1591, doi. 10.1172/JCI78239
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- Publication type:
- Article
Brain Malignancy Steering Committee clinical trials planning workshop: Report from the Targeted Therapies Working Group.
- Published in:
- Neuro-Oncology, 2015, v. 17, n. 2, p. 180, doi. 10.1093/neuonc/nou154
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- Publication type:
- Article
Emerging function of mTORC2 as a core regulator in glioblastoma: metabolic reprogramming and drug resistance.
- Published in:
- Cancer Biology & Medicine, 2014, v. 11, n. 4, p. 255, doi. 2095-3941.2014.04.004
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- Publication type:
- Article
Silencing of protein kinase D2 induces glioma cell senescence via p53-dependent and -independent pathways.
- Published in:
- Neuro-Oncology, 2014, v. 16, n. 7, p. 933, doi. 10.1093/neuonc/not303
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- Publication type:
- Article
Protective Properties of Radio-Chemoresistant Glioblastoma Stem Cell Clones Are Associated with Metabolic Adaptation to Reduced Glucose Dependence.
- Published in:
- PLoS ONE, 2013, v. 8, n. 11, p. 1, doi. 10.1371/journal.pone.0080397
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- Publication type:
- Article
A tale of two approaches: complementary mechanisms of cytotoxic and targeted therapy resistance may inform next-generation cancer treatments.
- Published in:
- Carcinogenesis, 2013, v. 34, n. 4, p. 725, doi. 10.1093/carcin/bgt086
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- Publication type:
- Article
When Is Hub Gene Selection Better than Standard Meta-Analysis?
- Published in:
- PLoS ONE, 2013, v. 8, n. 4, p. 1, doi. 10.1371/journal.pone.0061505
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- Publication type:
- Article
Recurrent somatic mutation of FAT1 in multiple human cancers leads to aberrant Wnt activation.
- Published in:
- Nature Genetics, 2013, v. 45, n. 3, p. 253, doi. 10.1038/ng.2538
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- Publication type:
- Article
Multiple functions of a glioblastoma fusion oncogene.
- Published in:
- Journal of Clinical Investigation, 2013, v. 123, n. 2, p. 934, doi. 10.1172/JCI67658
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- Publication type:
- Article
A Kinome-Wide RNAi Screen in Drosophila Glia Reveals That the RIO Kinases Mediate Cell Proliferation and Survival through TORC2-Akt Signaling in Glioblastoma.
- Published in:
- PLoS Genetics, 2013, v. 9, n. 2, p. 1, doi. 10.1371/journal.pgen.1003253
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- Publication type:
- Article
Identification of Retinol Binding Protein 1 Promoter Hypermethylation in Isocitrate Dehydrogenase 1 and 2 Mutant Gliomas.
- Published in:
- JNCI: Journal of the National Cancer Institute, 2012, v. 104, n. 19, p. 1458, doi. 10.1093/jnci/djs357
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- Publication type:
- Article
Longitudinal evaluation of MPIO-labeled stem cell biodistribution in glioblastoma using high resolution and contrast-enhanced MR imaging at 14.1Tesla.
- Published in:
- Neuro-Oncology, 2012, v. 14, n. 8, p. 1050, doi. 10.1093/neuonc/nos126
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- Publication type:
- Article
RNA-Binding Protein Musashi1 Modulates Glioma Cell Growth through the Post-Transcriptional Regulation of Notch and PI<sub>3</sub> Kinase/Akt Signaling Pathways.
- Published in:
- PLoS ONE, 2012, v. 7, n. 3, p. 1, doi. 10.1371/journal.pone.0033431
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- Publication type:
- Article
Determining PTEN Functional Status by Network Component Deduced Transcription Factor Activities.
- Published in:
- PLoS ONE, 2012, v. 7, n. 2, p. 1, doi. 10.1371/journal.pone.0031053
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- Publication type:
- Article
Alkylpurine--DNA--N-glycosylase confers resistance to temozolomide in xenograft models of glioblastoma multiforme and is associated with poor survival in patients.
- Published in:
- Journal of Clinical Investigation, 2012, v. 122, n. 1, p. 253, doi. 10.1172/JCI59334
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- Publication type:
- Article
Glucose deprivation activates a metabolic and signaling amplification loop leading to cell death.
- Published in:
- Molecular Systems Biology, 2012, v. 8, n. 1, p. 1, doi. 10.1038/msb.2012.20
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- Publication type:
- Article
Reversing Melanoma Cross-Resistance to BRAF and MEK Inhibitors by Co-Targeting the AKT/mTOR Pathway.
- Published in:
- PLoS ONE, 2011, v. 6, n. 12, p. 1, doi. 10.1371/journal.pone.0028973
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- Publication type:
- Article
Graded functional diffusion map–defined characteristics of apparent diffusion coefficients predict overall survival in recurrent glioblastoma treated with bevacizumab.
- Published in:
- Neuro-Oncology, 2011, v. 13, n. 10, p. 1151, doi. 10.1093/neuonc/nor079
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- Publication type:
- Article
CD44v6 Regulates Growth of Brain Tumor Stem Cells Partially through the AKT-Mediated Pathway.
- Published in:
- PLoS ONE, 2011, v. 6, n. 9, p. 1, doi. 10.1371/journal.pone.0024217
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- Publication type:
- Article
Lost - and found - in translation.
- Published in:
- 2011
- By:
- Publication type:
- editorial
Siomycin A targets brain tumor stem cells partially through a MELK-mediated pathway.
- Published in:
- Neuro-Oncology, 2011, v. 13, n. 6, p. 622, doi. 10.1093/neuonc/nor023
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- Publication type:
- Article
Quantitative volumetric analysis of conventional MRI response in recurrent glioblastoma treated with bevacizumab.
- Published in:
- Neuro-Oncology, 2011, v. 13, n. 4, p. 401, doi. 10.1093/neuonc/noq206
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- Publication type:
- Article
Combination therapy with vemurafenib (PLX4032/RG7204) and metformin in melanoma cell lines with distinct driver mutations.
- Published in:
- 2011
- By:
- Publication type:
- journal article
Charting the course across the blood-brain barrier.
- Published in:
- 2011
- By:
- Publication type:
- journal article