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Bithionol eliminates acute myeloid leukaemia stem-like cells by suppressing NF-κB signalling and inducing oxidative stress, leading to apoptosis and ferroptosis.
Published in:
Cell Death Discovery, 2024, v. 10, n. 1, p. 1, doi. 10.1038/s41420-024-02148-3
By:
- Dias, Ingrid R. S. B.;
- Costa, Rafaela G. A.;
- Rodrigues, Ana Carolina B. da C.;
- Silva, Suellen L. R.;
- Oliveira, Maiara de S.;
- Soares, Milena B. P.;
- Dias, Rosane B.;
- Valverde, Ludmila F.;
- Gurgel Rocha, Clarissa A.;
- Cairns, Lauren V.;
- Mills, Ken I.;
- Bezerra, Daniel P.
Publication type:
Article
Combination Therapies Targeting Apoptosis in Paediatric AML: Understanding the Molecular Mechanisms of AML Treatments Using Phosphoproteomics.
Published in:
International Journal of Molecular Sciences, 2023, v. 24, n. 6, p. 5717, doi. 10.3390/ijms24065717
By:
- Ali, Ahlam A.;
- Cairns, Lauren V.;
- Clarke, Kathryn M.;
- Blayney, Jaine K.;
- Lappin, Katrina M.;
- Mills, Ken I.
Publication type:
Article
Survivin' Acute Myeloid Leukaemia—A Personalised Target for inv(16) Patients.
Published in:
International Journal of Molecular Sciences, 2021, v. 22, n. 19, p. 10482, doi. 10.3390/ijms221910482
By:
- Greiner, Jochen;
- Brown, Elliott;
- Bullinger, Lars;
- Hills, Robert K.;
- Morris, Vanessa;
- Döhner, Hartmut;
- Mills, Ken I.;
- Guinn, Barbara-ann
Publication type:
Article
Multiplex Screening for Interacting Compounds in Paediatric Acute Myeloid Leukaemia.
Published in:
International Journal of Molecular Sciences, 2021, v. 22, n. 18, p. 10163, doi. 10.3390/ijms221810163
By:
- Cairns, Lauren V.;
- Lappin, Katrina M.;
- Mutch, Alexander;
- Ali, Ahlam;
- Matchett, Kyle B.;
- Mills, Ken I.
Publication type:
Article
Significance of NPM1 Gene Mutations in AML.
Published in:
International Journal of Molecular Sciences, 2021, v. 22, n. 18, p. 10040, doi. 10.3390/ijms221810040
By:
- Hindley, Andrew;
- Catherwood, Mark Alexander;
- McMullin, Mary Frances;
- Mills, Ken I.
Publication type:
Article
The Impact of Epigenetic Modifications in Myeloid Malignancies.
Published in:
International Journal of Molecular Sciences, 2021, v. 22, n. 9, p. 5013, doi. 10.3390/ijms22095013
By:
- Venney, Deirdra;
- Mohd-Sarip, Adone;
- Mills, Ken I;
- Fernandez, Agustin F.
Publication type:
Article
QUADrATiC: scalable gene expression connectivity mapping for repurposing FDA-approved therapeutics.
Published in:
BMC Bioinformatics, 2016, v. 17, p. 1, doi. 10.1186/s12859-016-1062-1
By:
- O'Reilly, Paul G.;
- Qing Wen;
- Bankhead, Peter;
- Dunne, Philip D.;
- McArt, Darragh G.;
- McPherson, Suzanne;
- Hamilton, Peter W.;
- Mills, Ken I.;
- Shu-Dong Zhang
Publication type:
Article
Erythropoietin in bone homeostasis—Implications for efficacious anemia therapy.
Published in:
Stem Cells Translational Medicine, 2021, v. 10, n. 6, p. 836, doi. 10.1002/sctm.20-0387
By:
- Lappin, Katrina M.;
- Mills, Ken I.;
- Lappin, Terence R.
Publication type:
Article
Influence of the major histocompatibility complex on age at onset of chronic lymphoid leukaemia.
Published in:
International Journal of Cancer, 1996, v. 65, n. 2, p. 134, doi. 10.1002/(SICI)1097-0215(19960117)65:2<134::AID-IJC2>3.0.CO;2-#
By:
- Dorak, M. Tevfik;
- Machulla, Helmut K. G.;
- Hentschel, Michael;
- Mills, Ken I.;
- Langner, Jürgen;
- Burnett, Alan K.
Publication type:
Article
Entinostat Prevents Leukemia Maintenance in a Collaborating Oncogene-Dependent Model of Cytogenetically Normal Acute Myeloid Leukemia.
Published in:
Stem Cells, 2013, v. 31, n. 7, p. 1434, doi. 10.1002/stem.1398
By:
- Ramsey, Joanne M.;
- Kettyle, Laura M.J.;
- Sharpe, Daniel J.;
- Mulgrew, Nuala M.;
- Dickson, Glenda J.;
- Bijl, Janet J.;
- Austin, Pamela;
- Mayotte, Nadine;
- Cellot, Sonia;
- Lappin, Terence R.J.;
- Zhang, Shu-Dong;
- Mills, Ken I.;
- Krosl, Jana;
- Sauvageau, Guy;
- Thompson, Alexander
Publication type:
Article
Serum profiling identifies ibrutinib as a treatment option for young adults with B‐cell acute lymphoblastic leukaemia.
Published in:
British Journal of Haematology, 2020, v. 189, n. 3, p. 500, doi. 10.1111/bjh.16407
By:
- Jordaens, Stephanie;
- Cooksey, Leah;
- Bonney, Stephanie;
- Orchard, Laurence;
- Coutinho, Matthew;
- Van Tendeloo, Viggo;
- Mills, Ken I.;
- Orchard, Kim;
- Guinn, Barbara‐ann
Publication type:
Article
Compositional analysis gives insight into leukaemia cell lines expression profiles compared to those within patient sub‐groups.
Published in:
British Journal of Haematology, 2018, v. 181, n. 6, p. 847, doi. 10.1111/bjh.14711
By:
- Blayney, Jaine K.;
- Mills, Ken I.
Publication type:
Article
High and low, but not intermediate, PRAME expression levels are poor prognostic markers in myelodysplastic syndrome at disease presentation.
Published in:
British Journal of Haematology, 2013, v. 162, n. 2, p. 282, doi. 10.1111/bjh.12352
By:
- Liberante, Fabio G.;
- Pellagatti, Andrea;
- Boncheva, Viktoriya;
- Bowen, David T.;
- Mills, Ken I.;
- Boultwood, Jacqueline;
- Guinn, Barbara‐Ann
Publication type:
Article
Application of the pMHC Array to Characterise Tumour Antigen Specific T Cell Populations in Leukaemia Patients at Disease Diagnosis.
Published in:
PLoS ONE, 2015, v. 10, n. 10, p. 1, doi. 10.1371/journal.pone.0140483
By:
- Brooks, Suzanne E.;
- Bonney, Stephanie A.;
- Lee, Cindy;
- Publicover, Amy;
- Khan, Ghazala;
- Smits, Evelien L.;
- Sigurdardottir, Dagmar;
- Arno, Matthew;
- Li, Demin;
- Mills, Ken I.;
- Pulford, Karen;
- Banham, Alison H.;
- van Tendeloo, Viggo;
- Mufti, Ghulam J.;
- Rammensee, Hans-Georg;
- Elliott, Tim J.;
- Orchard, Kim H.;
- Guinn, Barbara-ann
Publication type:
Article
Deregulation of Genes Related to Iron and Mitochondrial Metabolism in Refractory Anemia with Ring Sideroblasts.
Published in:
PLoS ONE, 2015, v. 10, n. 5, p. 1, doi. 10.1371/journal.pone.0126555
By:
- del Rey, Mónica;
- Benito, Rocío;
- Fontanillo, Celia;
- Campos-Laborie, Francisco J.;
- Janusz, Kamila;
- Velasco-Hernández, Talía;
- Abáigar, María;
- Hernández, María;
- Cuello, Rebeca;
- Borrego, Daniel;
- Martín-Zanca, Dionisio;
- De Las Rivas, Javier;
- Mills, Ken I.;
- Hernández-Rivas, Jesús M.
Publication type:
Article
New targets for therapy: antigen identification in adults with B-cell acute lymphoblastic leukaemia.
Published in:
Cancer Immunology, Immunotherapy, 2020, v. 69, n. 5, p. 867, doi. 10.1007/s00262-020-02484-0
By:
- Jordaens, Stephanie;
- Cooksey, Leah;
- Freire Boullosa, Laurie;
- Van Tendeloo, Viggo;
- Smits, Evelien;
- Mills, Ken I.;
- Orchard, Kim H.;
- Guinn, Barbara-ann
Publication type:
Article
Immunotherapy of myeloid leukaemia.
Published in:
Cancer Immunology, Immunotherapy, 2007, v. 56, n. 7, p. 943, doi. 10.1007/s00262-006-0267-y
By:
- Guinn, Barbara-Ann;
- Mohamedali, Azim;
- Thomas, N. Shaun B.;
- Mills, Ken I.
Publication type:
Article
Identification of the Antigens Recognised by Colorectal Cancer Patients Using Sera from Patients Who Exhibit a Crohn's-like Lymphoid Reaction.
Published in:
Biomolecules (2218-273X), 2022, v. 12, n. 8, p. 1058, doi. 10.3390/biom12081058
By:
- Boncheva, Viktoriya B.;
- Linnebacher, Michael;
- Kdimati, Said;
- Draper, Hannah;
- Orchard, Laurence;
- Mills, Ken I.;
- O'Sullivan, Gerald;
- Tangney, Mark;
- Guinn, Barbara-ann
Publication type:
Article
Identification of Genes Whose Expression Overlaps Age Boundaries and Correlates with Risk Groups in Paediatric and Adult Acute Myeloid Leukaemia.
Published in:
Cancers, 2020, v. 12, n. 10, p. 2769, doi. 10.3390/cancers12102769
By:
- Davis, Lindsay;
- Mills, Ken I.;
- Orchard, Kim H.;
- Guinn, Barbara-Ann
Publication type:
Article
Chronic loss of STAG2 leads to altered chromatin structure contributing to de-regulated transcription in AML.
Published in:
2020
By:
- Smith, James S.;
- Lappin, Katrina M.;
- Craig, Stephanie G.;
- Liberante, Fabio G.;
- Crean, Clare M.;
- McDade, Simon S.;
- Thompson, Alexander;
- Mills, Ken I.;
- Savage, Kienan I.
Publication type:
journal article
A compound combination screening approach with potential to identify new treatment options for paediatric acute myeloid leukaemia.
Published in:
Scientific Reports, 2020, v. 10, n. 1, p. N.PAG, doi. 10.1038/s41598-020-75453-3
By:
- Lappin, Katrina M.;
- Davis, Lindsay;
- Matchett, Kyle B.;
- Ge, Yubin;
- Mills, Ken I.;
- Blayney, Jaine K.
Publication type:
Article
Differential TERT promoter methylation and response to 5-aza-2′-deoxycytidine in acute myeloid leukemia cell lines: TERT expression, telomerase activity, telomere length, and cell death.
Published in:
Genes, Chromosomes & Cancer, 2012, v. 51, n. 8, p. 768, doi. 10.1002/gcc.21962
By:
- Pettigrew, Kerry A.;
- Armstrong, Richard N.;
- Colyer, Hilary A. A.;
- Zhang, Shu-Dong;
- Rea, Irene Maeve;
- Jones, Rhiannon E.;
- Baird, Duncan M.;
- Mills, Ken I.
Publication type:
Article
Identification of Gene Networks Associated with Acute Myeloid Leukemia by Comparative Molecular Methylation and Expression Profiling.
Published in:
Biomarkers in Cancer, 2010, n. 2, p. 43
By:
- Dellett, Margaret;
- O'Hagan, Kathleen Ann;
- Colyer, Hilary Ann Alexandra;
- Mills, Ken I.
Publication type:
Article
Altered methylation levels in elderly acute myeloid leukaemia patients compared to elderly well individuals.
Published in:
British Journal of Haematology, 2013, v. 161, n. 2, p. 294, doi. 10.1111/bjh.12221
By:
- Dellett, Margaret;
- Colyer, Hilary A. A.;
- Pettigrew, Kerry A.;
- McMullin, Mary‐Frances;
- Rea, Irene Maeve;
- Mills, Ken I.
Publication type:
Article
Prognostic and therapeutic relevance of c- FLIP in acute myeloid leukaemia.
Published in:
British Journal of Haematology, 2013, v. 160, n. 2, p. 188, doi. 10.1111/bjh.12108
By:
- McLornan, Donal;
- Hay, Jodie;
- McLaughlin, Kirsty;
- Holohan, Caitriona;
- Burnett, Alan K.;
- Hills, Robert K.;
- Johnston, Patrick G.;
- Mills, Ken I.;
- McMullin, Mary Frances;
- Longley, Daniel B.
Publication type:
Article
An international standardization programme towards the application of gene expression profiling in routine leukaemia diagnostics: the Microarray Innovations in LEukemia study prephase.
Published in:
British Journal of Haematology, 2008, v. 142, n. 5, p. 802, doi. 10.1111/j.1365-2141.2008.07261.x
By:
- Kohlmann, Alexander;
- Kipps, Thomas J.;
- Rassenti, Laura Z.;
- Downing, James R.;
- Shurtleff, Sheila A.;
- Mills, Ken I.;
- Gilkes, Amanda F.;
- Hofmann, Wolf-Karsten;
- Basso, Giuseppe;
- Dell’Orto, Marta Campo;
- Foâ, Robin;
- Chiaretti, Sabina;
- De Vos, John;
- Rauhut, Sonja;
- Papenhausen, Peter R.;
- Hernández, Jesus M.;
- Lumbreras, Eva;
- Yeoh, Allen E.;
- Koay, Evelyn S.;
- Li, Rachel
Publication type:
Article
SSX2IP expression in acute myeloid leukaemia: an association with mitotic spindle failure in t(8;21), and cell cycle in t(15;17) patients.
Published in:
2008
By:
- Guinn, Barbara-ann;
- Bullinger, Lars;
- Thomas, N. Shaun B.;
- Mills, Ken I.;
- Greiner, Jochen
Publication type:
Letter
Comparison of the survival implications of tumour-associated versus cancer-testis antigen expression in acute myeloid leukaemia.
Published in:
2007
By:
- Guinn, Barbara-ann;
- Tobal, Khalid;
- Mills, Ken I.
Publication type:
Letter
The tumour antigens RAGE-1 and MGEA6 are expressed more frequently in the less lineage restricted subgroups of presentation acute myeloid leukaemia.
Published in:
2006
By:
- Guinn, Barbara-ann;
- Gilkes, Amanda F.;
- Mufti, Ghulam J.;
- Burnett, Alan K.;
- Mills, Ken I.
Publication type:
Letter
Rapid and sensitive detection of internal tandem duplication and activating loop mutations of FLT3.
Published in:
British Journal of Haematology, 2005, v. 130, n. 2, p. 203, doi. 10.1111/j.1365-2141.2005.05589.x
By:
- Mills, Ken I.;
- Gilkes, Amanda F.;
- Walsh, Val;
- Sweeney, Marion;
- Gale, Rosemary
Publication type:
Article
Homozygous MHC Genotypes and Longevity.
Published in:
Human Heredity, 1994, v. 44, n. 5, p. 271, doi. 10.1159/000154229
By:
- Tevfik Dorak, M.;
- Mills, Ken I.;
- Gaffney, Dairena;
- Wilson, David WL.;
- Galbraith, Ian;
- Henderson, Nancy;
- Burnett, Alan K.
Publication type:
Article

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