Works by Mike Ufer

Results: 41

Impact of the organic cation transporter 2 inhibitor cimetidine on the single-dose pharmacokinetics of the glucosylceramide synthase inhibitor lucerastat in healthy subjects.

Published in:

European Journal of Clinical Pharmacology, 2020, v. 76, n. 3, p. 431, doi. 10.1007/s00228-019-02808-9

By:

Boof, Marie-Laure;
Halabi, Atef;
Ufer, Mike;
Dingemanse, Jasper

Publication type:

Article

Interaction potential of the dual orexin receptor antagonist ACT-541468 with CYP3A4 and food: results from two interaction studies.

Published in:

European Journal of Clinical Pharmacology, 2019, v. 75, n. 2, p. 195, doi. 10.1007/s00228-018-2559-5

By:

Boof, Marie-Laure;
Ufer, Mike;
Dingemanse, Jasper;
Alatrach, Abir

Publication type:

Article

Relationship of drug metabolizing enzyme genotype to plasma levels as well as myelotoxicity of cyclophosphamide in breast cancer patients.

Published in:

European Journal of Clinical Pharmacology, 2012, v. 68, n. 4, p. 389, doi. 10.1007/s00228-011-1134-0

By:

Afsar, Nasir;
Ufer, Mike;
Haenisch, Sierk;
Remmler, Cornelia;
Mateen, Ahmed;
Usman, Ahmed;
Ahmed, Khwaja;
Ahmad, Hakimuddin;
Cascorbi, Ingolf

Publication type:

Article

Identification of cytochromes P450 2C9 and 3A4 as the major catalysts of phenprocoumon hydroxylation in vitro.

Published in:

European Journal of Clinical Pharmacology, 2004, v. 60, n. 3, p. 173, doi. 10.1007/s00228-004-0740-5

By:

Ufer, Mike;
Svensson, Jan O.;
Krausz, Kristopher W.;
Gelboin, Harry V.;
Rane, Anders;
Tybring, Gunnel

Publication type:

Article

Off-label paediatric prescribing in Stockholm (Sweden): a response to a letter to the editor.

Published in:

European Journal of Clinical Pharmacology, 2003, v. 59, n. 5/6, p. 493, doi. 10.1007/s00228-003-0644-9

By:

Ufer, Mike;
Bergman, Ulf

Publication type:

Article

Widespread off-label prescribing of topical but not systemic drugs for 350,000 paediatric outpatients in Stockholm.

Published in:

European Journal of Clinical Pharmacology, 2003, v. 58, n. 11, p. 779, doi. 10.1007/s00228-003-0560-z

By:

Ufer, Mike;
Rane, Anders;
Karlsson, Åke;
Kimland, Elin;
Bergman, Ulf

Publication type:

Article

Clinical Pharmacology of Clazosentan, a Selective Endothelin A Receptor Antagonist for the Prevention and Treatment of aSAH-Related Cerebral Vasospasm.

Published in:

Frontiers in Pharmacology, 2021, v. 11, p. N.PAG, doi. 10.3389/fphar.2020.628956

By:

Juif, Pierre-Eric;
Dingemanse, Jasper;
Ufer, Mike

Publication type:

Article

Clinical Pharmacology of the Reversible and Potent P2Y12 Receptor Antagonist ACT‐246475 After Single Subcutaneous Administration in Healthy Male Subjects.

Published in:

Journal of Clinical Pharmacology, 2019, v. 59, n. 1, p. 123, doi. 10.1002/jcph.1296

By:

Juif, Pierre‐Eric;
Boehler, Margaux;
Ufer, Mike;
Dingemanse, Jasper;
Dobrow, Michael

Publication type:

Article

Safety and Tolerability of Relugolix in Combination with Abiraterone or Apalutamide for Treatment of Patients with Advanced Prostate Cancer: Data from a 52-Week Clinical Trial.

Published in:

Targeted Oncology, 2025, v. 20, n. 3, p. 503, doi. 10.1007/s11523-025-01139-3

By:

De La Cerda, Jose;
Belkoff, Laurence;
Courtney, Kevin D.;
Diamond, Elan;
D'Olimpio, James;
Dunshee, Curtis;
Gervasi, Lawrence;
Goodman, Michael;
Mittal, Kriti;
Morris, David;
Sieber, Paul;
Tutrone, Ronald;
Ryan, Michael;
Zhong, Yi;
Ufer, Mike;
Shore, Neal

Publication type:

Article

Absorption, distribution, metabolism, and excretion of cenerimod, a selective S1P1 receptor modulator in healthy subjects.

Published in:

Xenobiotica, 2020, v. 50, n. 8, p. 947, doi. 10.1080/00498254.2020.1736688

By:

Boof, Marie-Laure;
van Lier, Jan Jaap;
English, Stephen;
Fischer, Hartmut;
Ufer, Mike;
Dingemanse, Jasper

Publication type:

Article

Absorption, distribution, metabolism and excretion of the P2Y12 receptor antagonist selatogrel after subcutaneous administration in healthy subjects.

Published in:

Xenobiotica, 2020, v. 50, n. 4, p. 427, doi. 10.1080/00498254.2019.1646440

By:

Ufer, Mike;
Huynh, Christine;
van Lier, Jan Jaap;
Caroff, Eva;
Fischer, Hartmut;
Dingemanse, Jasper

Publication type:

Article

Determination of (R)- and (S)-phenprocoumon in human plasma by enantioselective liquid chromatography/electrospray ionisation tandem mass spectrometry.

Published in:

Rapid Communications in Mass Spectrometry: RCM, 2004, v. 18, n. 4, p. 458, doi. 10.1002/rcm.1354

By:

Bernd Kammerer;
Rainer Kahlich;
Mike Ufer;
Stefan Laufer;
Christoph H. Gleiter

Publication type:

Article

Transient Receptor Potential Channel Polymorphisms Are Associated with the Somatosensory Function in Neuropathic Pain Patients.

Published in:

PLoS ONE, 2011, v. 6, n. 3, p. 1, doi. 10.1371/journal.pone.0017387

By:

Binder, Andreas;
May, Denisa;
Baron, Ralf;
Maier, Christoph;
Tölle, Thomas R.;
Treede, Rolf-Detlef;
Berthele, Achim;
Faltraco, Frank;
Flor, Herta;
Gierthmühlen, Janne;
Haenisch, Sierk;
Huge, Volker;
Magerl, Walter;
Maihöfner, Christian;
Richter, Helmut;
Rolke, Roman;
Scherens, Andrea;
Uçeyler, Nurcan;
Ufer, Mike;
Wasner, Gunnar

Publication type:

Article

The challenges of clinical trials in fragile X syndrome.

Published in:

Psychopharmacology, 2014, v. 231, n. 6, p. 1237, doi. 10.1007/s00213-013-3289-0

By:

Jacquemont, Sébastien;
Berry-Kravis, Elizabeth;
Hagerman, Randi;
Raison, Florian;
Gasparini, Fabrizio;
Apostol, George;
Ufer, Mike;
Portes, Vincent;
Gomez-Mancilla, Baltazar

Publication type:

Article

Comparative pharmacokinetics of vitamin K antagonists: warfarin, phenprocoumon and acenocoumarol.

Published in:

2005

By:

Ufer, Mike

Publication type:

journal article

Impact of Daridorexant, a Dual Orexin Receptor Antagonist, on Cardiac Repolarization Following Bedtime Dosing: Results from a Thorough QT Study Using Concentration-QT Analysis.

Published in:

Clinical Drug Investigation, 2021, v. 41, n. 8, p. 711, doi. 10.1007/s40261-021-01062-1

By:

Schilling, Uta;
Henrich, Andrea;
Muehlan, Clemens;
Krause, Andreas;
Dingemanse, Jasper;
Ufer, Mike

Publication type:

Article

Genetic Variation in the CYP2C Monooxygenase Enzyme Subfamily Shows No Association With Longevity in a German Population.

Published in:

Journals of Gerontology Series A: Biological Sciences & Medical Sciences, 2011, v. 66A, n. 11, p. 1186, doi. 10.1093/gerona/glr117

By:

Flachsbart, Friederike;
Ufer, Mike;
Kleindorp, Rabea;
Nikolaus, Susanna;
Schreiber, Stefan;
Nebel, Almut

Publication type:

Article

Metabolite profiling in early clinical drug development: current status and future prospects.

Published in:

2017

By:

Ufer, Mike;
Juif, Pierre-Eric;
Boof, Marie-Laure;
Muehlan, Clemens;
Dingemanse, Jasper

Publication type:

Editorial

Pharmacodynamics, pharmacokinetics, and safety of single-dose subcutaneous administration of selatogrel, a novel P2Y12 receptor antagonist, in patients with chronic coronary syndromes.

Published in:

European Heart Journal, 2020, v. 41, n. 33, p. 3132, doi. 10.1093/eurheartj/ehz807

By:

Storey, Robert F;
Gurbel, Paul A;
Berg, Jurrien ten;
Bernaud, Corine;
Dangas, George D;
Frenoux, Jean-Marie;
Gorog, Diana A;
Hmissi, Abdel;
Kunadian, Vijay;
James, Stefan K;
Tanguay, Jean-Francois;
Tran, Henry;
Trenk, Dietmar;
Ufer, Mike;
Harst, Pim Van der;
Hof, Arnoud W J Van't;
Angiolillo, Dominick J

Publication type:

Article

RESULTS FROM A 3-MONTH STUDY IN HEALTHY SUBJECTS AGED 60 YEARS WITH THE BACE INHIBITOR CNP520.

Published in:

Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2017, v. 13, p. P256, doi. 10.1016/j.jalz.2017.06.118

By:

Ufer, Mike;
Rouzade-Dominguez, Marie-Laure;
Huledal, Gunilla;
Pezous, Nicole;
Graf, Ana;
Lopez-Lopez, Cristina;
Neumann, Ulf;
Vormfelde, Stefan Viktor;
Legangneux, Eric

Publication type:

Article

RATIONALE FOR CNP520 DOSE SELECTION FOR THE PIVOTAL CLINICAL PROGRAM IN PRECLINICAL AD.

Published in:

Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2017, v. 13, p. P601, doi. 10.1016/j.jalz.2017.07.245

By:

Lopez-Lopez, Cristina;
Ufer, Mike;
Rouzade-Dominguez, Marie-Laure;
Pezous, Nicole;
David, Olivier;
Kolly, Carine;
Tariot, Pierre;
Reiman, Eric M.;
Vargas, Gabriel;
Lenz, Robert;
Graf, Ana;
Neumann, Ulf

Publication type:

Article

RESULTS FROM A FIRST-IN-HUMAN STUDY WITH THE BACE INHIBITOR CNP520.

Published in:

Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2016, v. 12, p. P200, doi. 10.1016/j.jalz.2016.06.351

By:

Ufer, Mike;
Rouzade-Dominguez, Marie-Laure;
Huledal, Gunilla;
Pezous, Nicole;
Avrameas, Alexandre;
David, Olivier;
Kretz, Sandrine;
Kucher, Klaus;
Neumann, Ulf;
Cha, Jang-Ho;
Graf, Ana;
Lopez-Lopez, Cristina

Publication type:

Article

Paediatric adverse drug reactions reported in Sweden from 1987 to 2001.

Published in:

Pharmacoepidemiology & Drug Safety, 2005, v. 14, n. 7, p. 493, doi. 10.1002/pds.1121

By:

Kimland, Elin;
Rane, Anders;
Ufer, Mike;
Panagiotidis, Georgios

Publication type:

Article

Adverse drug reactions and off-label prescribing for paediatric outpatients: a one-year survey of spontaneous reports in Sweden.

Published in:

Pharmacoepidemiology & Drug Safety, 2004, v. 13, n. 3, p. 147, doi. 10.1002/pds.858

By:

Mike Ufer;
Elin Kimland

Publication type:

Article

A Multipurpose First‐in‐Human Study With the Novel CXCR7 Antagonist ACT‐1004‐1239 Using CXCL12 Plasma Concentrations as Target Engagement Biomarker.

Published in:

Clinical Pharmacology & Therapeutics, 2021, v. 109, n. 6, p. 1648, doi. 10.1002/cpt.2154

By:

Huynh, Christine;
Henrich, Andrea;
Strasser, Daniel S.;
Boof, Marie‐Laure;
Al‐Ibrahim, Mohamed;
Meyer Zu Schwabedissen, Henriette E.;
Dingemanse, Jasper;
Ufer, Mike

Publication type:

Article

Effects of CYP2C9 polymorphisms on phenprocoumon anticoagulation status.

Published in:

2005

By:

Ufer, Mike

Publication type:

Letter

Transfer of the Oral Gonadotropin‐Releasing Hormone Receptor Antagonist Relugolix Into Breast Milk of Healthy Lactating Women.

Published in:

Pharmacology Research & Perspectives, 2025, v. 13, n. 1, p. 1, doi. 10.1002/prp2.70067

By:

Brimhall, Darin B.;
Chen, Yu‐Luan;
Lee, Sarah;
Yoshida, Kazumasa;
Ufer, Mike

Publication type:

Article

The BACE‐1 inhibitor CNP520 for prevention trials in Alzheimer's disease.

Published in:

EMBO Molecular Medicine, 2018, v. 10, n. 11, p. N.PAG, doi. 10.15252/emmm.201809316

By:

Neumann, Ulf;
Ufer, Mike;
Jacobson, Laura H;
Rouzade‐Dominguez, Marie‐Laure;
Huledal, Gunilla;
Kolly, Carine;
Lüönd, Rainer M;
Machauer, Rainer;
Veenstra, Siem J;
Hurth, Konstanze;
Rueeger, Heinrich;
Tintelnot‐Blomley, Marina;
Staufenbiel, Matthias;
Shimshek, Derya R;
Perrot, Ludovic;
Frieauff, Wilfried;
Dubost, Valerie;
Schiller, Hilmar;
Vogg, Barbara;
Beltz, Karen

Publication type:

Article

Association Between Vomiting and QT Hysteresis: Data from a TQT Study with the Endothelin A Receptor Antagonist Clazosentan.

Published in:

AAPS Journal, 2020, v. 22, n. 5, p. N.PAG, doi. 10.1208/s12248-020-00485-6

By:

Juif, Pierre-Eric;
Dingemanse, Jasper;
Voors-Pette, Christine;
Ufer, Mike

Publication type:

Article

Pharmacokinetics and Pharmacodynamics of Cenerimod, A Selective S1P1R Modulator, Are Not Affected by Ethnicity in Healthy Asian and White Subjects.

Published in:

CTS: Clinical & Translational Science, 2021, v. 14, n. 1, p. 143, doi. 10.1111/cts.12873

By:

Juif, Pierre‐Eric;
Dingemanse, Jasper;
Winkle, Peter;
Ufer, Mike

Publication type:

Article

A Pooled Analysis of Three Randomized Phase I/IIa Clinical Trials Confirms Absence of a Clinically Relevant Effect on the QTc Interval by Umibecestat.

Published in:

CTS: Clinical & Translational Science, 2020, v. 13, n. 6, p. 1316, doi. 10.1111/cts.12832

By:

Vormfelde, Stefan Viktor;
Pezous, Nicole;
Lefèvre, Gilbert;
Kolly, Carine;
Neumann, Ulf;
Jordaan, Pierre;
Ufer, Mike;
Legangneux, Eric

Publication type:

Article

Effect of Rifampin‐Mediated OATP1B1 and OATP1B3 Transporter Inhibition on the Pharmacokinetics of the P2Y12 Receptor Antagonist Selatogrel.

Published in:

CTS: Clinical & Translational Science, 2020, v. 13, n. 5, p. 886, doi. 10.1111/cts.12774

By:

Schilling, Uta;
Dingemanse, Jasper;
Voors‐Pette, Christine;
Romeijn, Christel;
Dogterom, Peter;
Ufer, Mike

Publication type:

Article

Influence of Rifampin‐Mediated Organic Anion‐Transporting Polypeptide 1B1/1B3 Inhibition on the Pharmacokinetics of Clazosentan.

Published in:

CTS: Clinical & Translational Science, 2019, v. 12, n. 5, p. 440, doi. 10.1111/cts.12639

By:

Juif, Pierre‐Eric;
Voors‐Pette, Christine;
Ufer, Mike;
Dogterom, Peter;
Dingemanse, Jasper

Publication type:

Article

Development of and its potential for the treatment of fragile X syndrome.

Published in:

Expert Opinion on Investigational Drugs, 2014, v. 23, n. 1, p. 125, doi. 10.1517/13543784.2014.857400

By:

Gomez-Mancilla, Baltazar;
Berry-Kravis, Elizabeth;
Hagerman, Randi;
von Raison, Florian;
Apostol, George;
Ufer, Mike;
Gasparini, Fabrizio;
Jacquemont, Sébastien

Publication type:

Article

Cardiodynamic Interactions between Two S1P1 Receptor Modulators in an Experimental Clinical Setting: Different Pharmacokinetic Properties as an Opportunity to Mitigate First-Dose Heart Rate Effects.

Published in:

International Journal of Molecular Sciences, 2019, v. 20, n. 13, p. 3232, doi. 10.3390/ijms20133232

By:

Juif, Pierre-Eric;
Ufer, Mike;
Dingemanse, Jasper

Publication type:

Article

Stereospecific pharmacokinetic characterisation of phenprocoumon metabolites, and mass-spectrometric identification of two novel metabolites in human plasma and liver microsomes.

Published in:

Analytical & Bioanalytical Chemistry, 2005, v. 383, n. 6, p. 909, doi. 10.1007/s00216-005-0113-7

By:

Kammerer, Bernd;
Kahlich, Rainer;
Ufer, Mike;
Schenkel, Andreas;
Laufer, Stefan;
Gleiter, Christoph H.

Publication type:

Article

Effect of the novel dual orexin receptor antagonist daridorexant on night‐time respiratory function and sleep in patients with moderate chronic obstructive pulmonary disease.

Published in:

Journal of Sleep Research, 2021, v. 30, n. 4, p. 1, doi. 10.1111/jsr.13248

By:

Boof, Marie‐Laure;
Dingemanse, Jasper;
Brunke, Mareile;
Esselmann, Albert;
Heymer, Peter;
Kestermann, Olaf;
Lederer, Katharina;
Fietze, Ingo;
Ufer, Mike

Publication type:

Article

Genotype Frequencies of Selected Drug Metabolizing Enzymes and ABC Drug Transporters among Breast Cancer Patients on FAC Chemotherapy.

Published in:

Basic & Clinical Pharmacology & Toxicology, 2010, v. 107, n. 1, p. 570, doi. 10.1111/j.1742-7843.2009.00531.x

By:

Afsar, Nasir Ali;
Haenisch, Sierk;
Mateen, Ahmed;
Usman, Ahmed;
Ufer, Mike;
Ahmed, Khwaja Zafar;
Ahmad, Hakimuddin Razi;
Cascorbi, Ingolf

Publication type:

Article

Transition from Syringe to Autoinjector Based on Bridging Pharmacokinetics and Pharmacodynamics of the P2Y12 Receptor Antagonist Selatogrel in Healthy Subjects.

Published in:

Clinical Pharmacokinetics, 2022, v. 61, n. 5, p. 687, doi. 10.1007/s40262-021-01097-9

By:

Zenklusen, Isabelle;
Hsin, Chih-Hsuan;
Schilling, Uta;
Kankam, Martin;
Krause, Andreas;
Ufer, Mike;
Dingemanse, Jasper

Publication type:

Article

Pharmacokinetics and Pharmacodynamics of Approved and Investigational P2Y12 Receptor Antagonists.

Published in:

2020

By:

Schilling, Uta;
Dingemanse, Jasper;
Ufer, Mike

Publication type:

journal article

Effect of Fluconazole Coadministration and CYP2C9 Genetic Polymorphism on Siponimod Pharmacokinetics in Healthy Subjects.

Published in:

2019

By:

Gardin, Anne;
Ufer, Mike;
Legangneux, Eric;
Rossato, Gianluca;
Jin, Yi;
Su, Zhenzhong;
Pal, Parasar;
Li, Wenkui;
Shakeri-Nejad, Kasra

Publication type:

journal article