Works by Michor, Franziska

Results: 83

Optimization of Dosing for EGFR-Mutant Non-Small Cell Lung Cancer with Evolutionary Cancer Modeling.

Published in:

Science Translational Medicine, 2011, v. 3, n. 90, p. 1, doi. 10.1126/scitranslmed.3002356

By:

Chmielecki, Juliann;
Jasmine Foo;
Oxnard, Geoffrey R.;
Hutchinson, Katherine;
Ohashi, Kadoaki;
Somwar, Romel;
Lu Wang;
Amato, Katherine R.;
Arcila, Maria;
Sos, Martin L.;
Socci, Nicholas D.;
Viale, Agnes;
de Stanchina, Elisa;
Ginsberg, Michelle S.;
Thomas, Roman K.;
Kris, Mark G.;
Inoue, Akira;
Ladanyi, Marc;
Miller, Vincent A.;
Michor, Franziska

Publication type:

Article

Mathematical modeling of erythrocyte chimerism informs genetic intervention strategies for sickle cell disease.

Published in:

American Journal of Hematology, 2016, v. 91, n. 9, p. 931, doi. 10.1002/ajh.24449

By:

Altrock, Philipp M.;
Brendel, Christian;
Renella, Raffaele;
Orkin, Stuart H.;
Williams, David A.;
Michor, Franziska

Publication type:

Article

Dynamics of chronic myeloid leukaemia.

Published in:

2005

By:

Michor, Franziska;
Hughes, Timothy P.;
Iwasa, Yoh;
Branford, Susan;
Shah, Neil P.;
Sawyers, Charles L.;
Nowak, Martin A.

Publication type:

Letter

FGFR3 expression in primary and metastatic urothelial carcinoma of the bladder.

Published in:

Cancer Medicine, 2014, v. 3, n. 4, p. 835, doi. 10.1002/cam4.262

By:

Guancial, Elizabeth A.;
Werner, Lillian;
Bellmunt, Joaquim;
Bamias, Aristotle;
Choueiri, Toni K.;
Ross, Robert;
Schutz, Fabio A.;
Park, Rachel S.;
O'Brien, Robert J.;
Hirsch, Michelle S.;
Barletta, Justine A.;
Berman, David M.;
Lis, Rosina;
Loda, Massimo;
Stack, Edward C.;
Garraway, Levi A.;
Riester, Markus;
Michor, Franziska;
Kantoff, Philip W.;
Rosenberg, Jonathan E.

Publication type:

Article

Topological isolation of developmental regulators in mammalian genomes.

Published in:

Nature Communications, 2021, v. 12, n. 1, p. 1, doi. 10.1038/s41467-021-24951-7

By:

Wu, Hua-Jun;
Landshammer, Alexandro;
Stamenova, Elena K.;
Bolondi, Adriano;
Kretzmer, Helene;
Meissner, Alexander;
Michor, Franziska

Publication type:

Article

Identification of optimal dosing schedules of dacomitinib and osimertinib for a phase I/II trial in advanced EGFR-mutant non-small cell lung cancer.

Published in:

Nature Communications, 2021, v. 12, n. 1, p. 1, doi. 10.1038/s41467-021-23912-4

By:

Poels, Kamrine E.;
Schoenfeld, Adam J.;
Makhnin, Alex;
Tobi, Yosef;
Wang, Yuli;
Frisco-Cabanos, Heidie;
Chakrabarti, Shaon;
Shi, Manli;
Napoli, Chelsi;
McDonald, Thomas O.;
Tan, Weiwei;
Hata, Aaron;
Weinrich, Scott L.;
Yu, Helena A.;
Michor, Franziska

Publication type:

Article

Aberration in DNA Methylation in B-Cell Lymphomas Has a Complex Origin and Increases with Disease Severity.

Published in:

PLoS Genetics, 2013, v. 9, n. 1, p. 1, doi. 10.1371/journal.pgen.1003137

By:

Subhajyoti De;
Shaknovich, Rita;
Riester, Markus;
Elemento, Olivier;
Huimin Geng;
Kormaksson, Matthias;
Yanwen Jiang;
Woolcock, Bruce;
Johnson, Nathalie;
Polo, Jose M.;
Cerchietti, Leandro;
Gascoyne, Randy D.;
Melnick, Ari;
Michor, Franziska

Publication type:

Article

Cellular and genetic diversity in the progression of in situ human breast carcinomas to an invasive phenotype.

Published in:

2010

By:

So Yeon Park;
Gönen, Mithat;
Hee Jung Kim;
Michor, Franziska;
Polyak, Kornelia;
Park, So Yeon;
Gönen, Mithat;
Kim, Hee Jung

Publication type:

journal article

Proceedings of the third international molecular pathological epidemiology (MPE) meeting.

Published in:

2017

By:

Campbell, Peter;
Rebbeck, Timothy;
Nishihara, Reiko;
Beck, Andrew;
Begg, Colin;
Bogdanov, Alexei;
Cao, Yin;
Coleman, Helen;
Freeman, Gordon;
Heng, Yujing;
Huttenhower, Curtis;
Irizarry, Rafael;
Kip, N.;
Michor, Franziska;
Nevo, Daniel;
Peters, Ulrike;
Phipps, Amanda;
Poole, Elizabeth;
Qian, Zhi;
Quackenbush, John

Publication type:

journal article

Fitness variation in isogenic populations leads to a novel evolutionary mechanism for crossing fitness valleys.

Published in:

Communications Biology, 2018, v. 1, n. 1, p. N.PAG, doi. 10.1038/s42003-018-0160-1

By:

Van Egeren, Debra;
Madsen, Thomas;
Michor, Franziska

Publication type:

Article

Genomic analysis of early-stage lung cancer reveals a role for TP53 mutations in distant metastasis.

Published in:

Scientific Reports, 2022, v. 12, n. 1, p. 1, doi. 10.1038/s41598-022-21448-1

By:

Van Egeren, Debra;
Kohli, Khushi;
Warner, Jeremy L.;
Bedard, Philippe L.;
Riely, Gregory;
Lepisto, Eva;
Schrag, Deborah;
LeNoue-Newton, Michele;
Catalano, Paul;
Kehl, Kenneth L.;
Michor, Franziska;
for the AACR Project GENIE Consortium represented by Shawn Sweeney;
Fiandalo, Michael;
Foti, Margaret;
Khotskaya, Yekaterina;
Lee, Jocelyn;
Peters, Nicole;
Sweeney, Shawn;
Abraham, Jean;
Brenton, James D.

Publication type:

Article

Safety and efficacy of pulsed imatinib with or without G- CSF versus continuous imatinib in chronic phase chronic myeloid leukaemia patients at 5 years follow-up.

Published in:

British Journal of Haematology, 2013, v. 163, n. 5, p. 674, doi. 10.1111/bjh.12532

By:

Gallipoli, Paolo;
Stobo, Jon;
Heaney, Nicholas;
Nicolini, Franck E.;
Clark, Richard;
Wilson, George;
Tighe, Jane;
McLintock, Lorna;
Hughes, Timothy;
Michor, Franziska;
Paul, James;
Drummond, Mark;
Holyoake, Tessa L.

Publication type:

Article

In situ single-cell analysis identifies heterogeneity for PIK3CA mutation and HER2 amplification in HER2-positive breast cancer.

Published in:

Nature Genetics, 2015, v. 47, n. 10, p. 1212, doi. 10.1038/ng.3391

By:

Janiszewska, Michalina;
Liu, Lin;
Almendro, Vanessa;
Kuang, Yanan;
Paweletz, Cloud;
Reis-Filho, Jorge S;
Arteaga, Carlos L;
Michor, Franziska;
Polyak, Kornelia;
Sakr, Rita A;
King, Tari A;
Weigelt, Britta;
Hanker, Ariella B;
Chandarlapaty, Sarat;
Park, So Yeon

Publication type:

Article

Designing optimal allocations for cancer screening using queuing network models.

Published in:

PLoS Computational Biology, 2022, v. 18, n. 5, p. 1, doi. 10.1371/journal.pcbi.1010179

By:

Dean, Justin;
Goldberg, Evan;
Michor, Franziska

Publication type:

Article

Systematic tissue collection during clinical breast biopsy is feasible, safe and enables high-content translational analyses.

Published in:

NPJ Precision Oncology, 2021, v. 5, n. 1, p. 1, doi. 10.1038/s41698-021-00224-w

By:

Koh, Siang-Boon;
Dontchos, Brian N.;
Bossuyt, Veerle;
Edmonds, Christine;
Cristea, Simona;
Melkonjan, Nsan;
Mortensen, Lindsey;
Ma, Annie;
Beyerlin, Kassidy;
Denault, Elyssa;
Niehoff, Elizabeth;
Hirz, Taghreed;
Sykes, David B.;
Michor, Franziska;
Specht, Michelle;
Lehman, Constance;
Ellisen, Leif W.;
Spring, Laura M.

Publication type:

Article

A field resource for the glioma cerebrospinal fluid proteome: Impacts of resection and location on biomarker discovery Open Access.

Published in:

Neuro-Oncology, 2025, v. 27, n. 4, p. 948, doi. 10.1093/neuonc/noae277

By:

Riviere-Cazaux, Cecile;
Graser, Christopher J;
Warrington, Arthur E;
Hoplin, Matthew D;
Andersen, Katherine M;
Malik, Noor;
Palmer, Elizabeth A;
Carlstrom, Lucas P;
Dasari, Surendra;
Munoz-Casabella, Amanda;
Ikram, Samar;
Ghadimi, Keyvan;
Himes, Benjamin T;
Jusue-Torres, Ignacio;
Sarkaria, Jann N;
Meyer, Fredric B;
Gompel, Jamie J Van;
Kizilbash, Sani H;
Sener, Ugur;
Michor, Franziska

Publication type:

Article

Phase I study of a novel glioblastoma radiation therapy schedule exploiting cell-state plasticity.

Published in:

Neuro-Oncology, 2023, v. 25, n. 6, p. 1100, doi. 10.1093/neuonc/noac253

By:

Dean, Jamie A;
Tanguturi, Shyam K;
Cagney, Daniel;
Shin, Kee-Young;
Youssef, Gilbert;
Aizer, Ayal;
Rahman, Rifaquat;
Hammoudeh, Lubna;
Reardon, David;
Lee, Eudocia;
Dietrich, Jorg;
Tamura, Kaoru;
Aoyagi, Masaru;
Wickersham, Lacey;
Wen, Patrick Y;
Catalano, Paul;
Haas-Kogan, Daphne;
Alexander, Brian M;
Michor, Franziska

Publication type:

Article

Breast cancer prevention by short-term inhibition of TGFβ signaling.

Published in:

Nature Communications, 2022, v. 13, n. 1, p. 1, doi. 10.1038/s41467-022-35043-5

By:

Alečković, Maša;
Cristea, Simona;
Gil Del Alcazar, Carlos R.;
Yan, Pengze;
Ding, Lina;
Krop, Ethan D.;
Harper, Nicholas W.;
Rojas Jimenez, Ernesto;
Lu, Donghao;
Gulvady, Anushree C.;
Foidart, Pierre;
Seehawer, Marco;
Diciaccio, Benedetto;
Murphy, Katherine C.;
Pyrdol, Jason;
Anand, Jayati;
Garza, Kodie;
Wucherpfennig, Kai W.;
Tamimi, Rulla M.;
Michor, Franziska

Publication type:

Article

Author Correction: Identification of optimal dosing schedules of dacomitinib and osimertinib for a phase I/II trial in advanced EGFR-mutant non-small cell lung cancer.

Published in:

2022

By:

Poels, Kamrine E.;
Schoenfeld, Adam J.;
Makhnin, Alex;
Tobi, Yosef;
Wang, Yuli;
Frisco-Cabanos, Heidie;
Chakrabarti, Shaon;
Shi, Manli;
Napoli, Chelsi;
McDonald, Thomas O.;
Tan, Weiwei;
Hata, Aaron;
Weinrich, Scott L.;
Yu, Helena A.;
Michor, Franziska

Publication type:

Correction Notice

Tutorial: integrative computational analysis of bulk RNA-sequencing data to characterize tumor immunity using RIMA.

Published in:

Nature Protocols, 2023, v. 18, n. 8, p. 2404, doi. 10.1038/s41596-023-00841-8

By:

Yang, Lin;
Wang, Jin;
Altreuter, Jennifer;
Jhaveri, Aashna;
Wong, Cheryl J.;
Song, Li;
Fu, Jingxin;
Taing, Len;
Bodapati, Sudheshna;
Sahu, Avinash;
Tokheim, Collin;
Zhang, Yi;
Zeng, Zexian;
Bai, Gali;
Tang, Ming;
Qiu, Xintao;
Long, Henry W.;
Michor, Franziska;
Liu, Yang;
Liu, X. Shirley

Publication type:

Article

Estimating mono- and bi-phasic regression parameters using a mixture piecewise linear Bayesian hierarchical model.

Published in:

PLoS ONE, 2017, v. 12, n. 7, p. 1, doi. 10.1371/journal.pone.0180756

By:

Zhao, Rui;
Catalano, Paul;
Degruttola, Victor G.;
Michor, Franziska

Publication type:

Article

Distance in cancer gene expression from stem cells predicts patient survival.

Published in:

PLoS ONE, 2017, v. 12, n. 3, p. 1, doi. 10.1371/journal.pone.0173589

By:

Riester, Markus;
Wu, Hua-Jun;
Zehir, Ahmet;
Gönen, Mithat;
Moreira, Andre L.;
Downey, Robert J.;
Michor, Franziska

Publication type:

Article

Correction: (A)Symmetric Stem Cell Replication and Cancer.

Published in:

2007

By:

Dingli, David;
Traulsen, Arne;
Michor, Franziska

Publication type:

Correction Notice

ESTIpop: a computational tool to simulate and estimate parameters for continuous-time Markov branching processes.

Published in:

Bioinformatics, 2020, v. 36, n. 15, p. 4372, doi. 10.1093/bioinformatics/btaa526

By:

Roney, James P;
Ferlic, Jeremy;
Michor, Franziska;
McDonald, Thomas O

Publication type:

Article

DIFFpop: a stochastic computational approach to simulate differentiation hierarchies with single cell barcoding.

Published in:

Bioinformatics, 2019, v. 35, n. 19, p. 3849, doi. 10.1093/bioinformatics/btz074

By:

Ferlic, Jeremy;
Shi, Jiantao;
McDonald, Thomas O;
Michor, Franziska

Publication type:

Article

SIApopr: a computational method to simulate evolutionary branching trees for analysis of tumor clonal evolution.

Published in:

Bioinformatics, 2017, v. 33, n. 14, p. 2221, doi. 10.1093/bioinformatics/btx146

By:

McDonald, Thomas O.;
Michor, Franziska

Publication type:

Article

A computational strategy to adjust for copy number in tumor Hi-C data.

Published in:

Bioinformatics, 2016, v. 32, n. 24, p. 3695, doi. 10.1093/bioinformatics/btw540

By:

Hua-Jun Wu;
Michor, Franziska

Publication type:

Article

Linear Model of Colon Cancer Initiation.

Published in:

Cell Cycle, 2004, v. 3, n. 3, p. 358, doi. 10.4161/cc.3.3.690

By:

Michor, Franziska;
Iwasa, Yoh;
Rajagopalan, Harith;
Lengauer, Christoph;
Nowak, Martin A.

Publication type:

Article

What does physics have to do with cancer?

Published in:

2011

By:

Michor, Franziska;
Liphardt, Jan;
Ferrari, Mauro;
Widom, Jonathan

Publication type:

journal article

Dynamics of cancer progression.

Published in:

Nature Reviews Cancer, 2004, v. 4, n. 3, p. 197, doi. 10.1038/nrc1295

By:

Franziska Michor;
Yoh Iwasa;
Martin A.Nowak, Jiri

Publication type:

Article

DNA replication timing and higher-order nuclear organization determine single-nucleotide substitution patterns in cancer genomes.

Published in:

Nature Communications, 2013, v. 4, n. 2, p. 1502, doi. 10.1038/ncomms2502

By:

Liu, Lin;
De, Subhajyoti;
Michor, Franziska

Publication type:

Article

Computational modeling of pancreatic cancer patients receiving FOLFIRINOX and gemcitabine-based therapies identifies optimum intervention strategies.

Published in:

PLoS ONE, 2019, v. 14, n. 4, p. 1, doi. 10.1371/journal.pone.0215409

By:

Yamamoto, Kimiyo N.;
Nakamura, Akira;
Liu, Lin L.;
Stein, Shayna;
Tramontano, Angela C.;
Kartoun, Uri;
Shimizu, Tetsunosuke;
Inoue, Yoshihiro;
Asakuma, Mitsuhiro;
Haeno, Hiroshi;
Kong, Chung Yin;
Uchiyama, Kazuhisa;
Gonen, Mithat;
Hur, Chin;
Michor, Franziska

Publication type:

Article

An Evolutionary Approach for Identifying Driver Mutations in Colorectal Cancer.

Published in:

PLoS Computational Biology, 2015, v. 11, n. 9, p. 1, doi. 10.1371/journal.pcbi.1004350

By:

Foo, Jasmine;
Liu, Lin L;
Leder, Kevin;
Riester, Markus;
Iwasa, Yoh;
Lengauer, Christoph;
Michor, Franziska

Publication type:

Article

Histone Modifications Are Associated with Transcript Isoform Diversity in Normal and Cancer Cells.

Published in:

PLoS Computational Biology, 2014, v. 10, n. 6, p. 1, doi. 10.1371/journal.pcbi.1003611

By:

Podlaha, Ondrej;
De, Subhajyoti;
Gonen, Mithat;
Michor, Franziska

Publication type:

Article

Patterns of Proliferative Activity in the Colonic Crypt Determine Crypt Stability and Rates of Somatic Evolution.

Published in:

PLoS Computational Biology, 2013, v. 9, n. 6, p. 1, doi. 10.1371/journal.pcbi.1003082

By:

Zhao, Rui;
Michor, Franziska

Publication type:

Article

A Race between Tumor Immunoescape and Genome Maintenance Selects for Optimum Levels of (epi)genetic Instability.

Published in:

PLoS Computational Biology, 2012, v. 8, n. 2, p. 1, doi. 10.1371/journal.pcbi.1002370

By:

Iwami, Shingo;
Haeno, Hiroshi;
Michor, Franziska

Publication type:

Article

A Mathematical Methodology for Determining the Temporal Order of Pathway Alterations Arising during Gliomagenesis.

Published in:

PLoS Computational Biology, 2012, v. 8, n. 1, p. 1, doi. 10.1371/journal.pcbi.1002337

By:

Cheng, Yu-Kang;
Beroukhim, Rameen;
Levine, Ross L.;
Mellinghoff, Ingo K.;
Holland, Eric C.;
Michor, Franziska

Publication type:

Article

A Differentiation-Based Phylogeny of Cancer Subtypes.

Published in:

PLoS Computational Biology, 2010, v. 6, n. 5, p. 1, doi. 10.1371/journal.pcbi.1000777

By:

Riester, Markus;
Stephan-Otto Attolini, Camille;
Downey, Robert J.;
Singer, Samuel;
Michor, Franziska

Publication type:

Article

Evolution of Resistance to Targeted Anti-Cancer Therapies during Continuous and Pulsed Administration Strategies.

Published in:

PLoS Computational Biology, 2009, v. 5, n. 11, p. 1, doi. 10.1371/journal.pcbi.1000557

By:

Foo, Jasmine;
Michor, Franziska

Publication type:

Article

Eradication of Chronic Myeloid Leukemia Stem Cells: A Novel Mathematical Model Predicts No Therapeutic Benefit of Adding G-CSF to Imatinib.

Published in:

PLoS Computational Biology, 2009, v. 5, n. 9, p. 1, doi. 10.1371/journal.pcbi.1000503

By:

Foo, Jasmine;
Drummond, Mark W.;
Clarkson, Bayard;
Holyoake, Tessa;
Michor, Franziska

Publication type:

Article

Evolutionary Theory of Cancer.

Published in:

Annals of the New York Academy of Sciences, 2009, v. 1168, p. 23, doi. 10.1111/j.1749-6632.2009.04880.x

By:

Attolini, Camille Stephan‐Otto;
Michor, Franziska

Publication type:

Article

Bisulfite-independent analysis of CpG island methylation enables genome-scale stratification of single cells.

Published in:

Nucleic Acids Research, 2017, v. 45, n. 10, p. 1, doi. 10.1093/nar/gkx026

By:

Lin Han;
Hua-Jun Wu;
Haiying Zhu;
Kun-Yong Kim;
Marjani, Sadie L.;
Riester, Markus;
Euskirchen, Ghia;
Xiaoyuan Zi;
Yang, Jennifer;
Han, Jasper;
Snyder, Michael;
Park, In-Hyun;
Irizarry, Rafael;
Weissman, Sherman M.;
Michor, Franziska;
Fan, Rong;
Xinghua Pan

Publication type:

Article

Unravelling subclonal heterogeneity and aggressive disease states in TNBC through single-cell RNA-seq.

Published in:

Nature Communications, 2018, v. 9, n. 1, p. 1, doi. 10.1038/s41467-018-06052-0

By:

Karaayvaz, Mihriban;
Cristea, Simona;
Gillespie, Shawn M.;
Patel, Anoop P.;
Mylvaganam, Ravindra;
Luo, Christina C.;
Specht, Michelle C.;
Bernstein, Bradley E.;
Michor, Franziska;
Ellisen, Leif W.

Publication type:

Article

A PDGFRα-driven mouse model of glioblastoma reveals a stathmin1-mediated mechanism of sensitivity to vinblastine.

Published in:

Nature Communications, 2018, v. 9, n. 1, p. 1, doi. 10.1038/s41467-018-05036-4

By:

Jun, Hyun Jung;
Appleman, Vicky A.;
Wu, Hua-Jun;
Rose, Christopher M.;
Pineda, Javier J.;
Yeo, Alan T.;
Delcuze, Bethany;
Lee, Charlotte;
Gyuris, Aron;
Zhu, Haihao;
Woolfenden, Steve;
Bronisz, Agnieszka;
Nakano, Ichiro;
Chiocca, Ennio A.;
Bronson, Roderick T.;
Ligon, Keith L.;
Sarkaria, Jann N.;
Gygi, Steve P.;
Michor, Franziska;
Mitchison, Timothy J.

Publication type:

Article

Studying clonal dynamics in response to cancer therapy using high-complexity barcoding.

Published in:

Nature Medicine, 2015, v. 21, n. 5, p. 440, doi. 10.1038/nm.3841

By:

Bhang, Hyo-eun C;
Ruddy, David A;
Krishnamurthy Radhakrishna, Viveksagar;
Caushi, Justina X;
Zhao, Rui;
Hims, Matthew M;
Singh, Angad P;
Kao, Iris;
Rakiec, Daniel;
Shaw, Pamela;
Balak, Marissa;
Raza, Alina;
Ackley, Elizabeth;
Keen, Nicholas;
Schlabach, Michael R;
Palmer, Michael;
Leary, Rebecca J;
Chiang, Derek Y;
Sellers, William R;
Michor, Franziska

Publication type:

Article

Mathematical modeling identifies optimum lapatinib dosing schedules for the treatment of glioblastoma patients.

Published in:

PLoS Computational Biology, 2018, v. 14, n. 1, p. 1, doi. 10.1371/journal.pcbi.1005924

By:

Stein, Shayna;
Zhao, Rui;
Haeno, Hiroshi;
Vivanco, Igor;
Michor, Franziska

Publication type:

Article

DNA secondary structures and epigenetic determinants of cancer genome evolution.

Published in:

Nature Structural & Molecular Biology, 2011, v. 18, n. 8, p. 950, doi. 10.1038/nsmb.2089

By:

De, Subhajyoti;
Michor, Franziska

Publication type:

Article

Immunology tomorrow.

Published in:

2002

By:

Michor, Franziska;
Nowak, Martin A.

Publication type:

Book Review

The good, the bad and the lonely.

Published in:

Nature, 2002, v. 419, n. 6908, p. 677, doi. 10.1038/419677a

By:

Michor, Franziska;
Nowak, Martin A.

Publication type:

Article

T-REX17 is a transiently expressed non-coding RNA essential for human endoderm formation.

Published in:

eLife, 2023, p. 1, doi. 10.7554/eLife.83077

By:

Landshammer, Alexandro;
Bolondi, Adriano;
Kretzmer, Helene;
Much, Christian;
Buschow, René;
Rose, Alina;
Hua-Jun;
Mackowiak, Sebastian D.;
Braendl, Bjoern;
Giesselmann, Pay;
Tornisiello, Rosaria;
Parsi, Krishna Mohan;
Huey, Jack;
Mielke, Thorsten;
Meierhofer, David;
Maehr, René;
Hnisz, Denes;
Michor, Franziska;
Rinn, John L.;
Meissner, Alexander

Publication type:

Article