Works matching AU Meyer-Almes, Franz-Josef

Results: 33

Novel fluorescence based receptor binding assay method for receptors lacking ligand conjugates with preserved affinity: Study on estrogen receptor α.

Published in:

Biopolymers, 2003, v. 72, n. 4, p. 256, doi. 10.1002/bip.10402

By:

Christoph, Silke;
Meyer-Almes, Franz-Josef

Publication type:

Article

The catalytic domain of free or ligand bound histone deacetylase 4 occurs in solution predominantly in closed conformation.

Published in:

Protein Science: A Publication of the Protein Society, 2024, v. 33, n. 3, p. 1, doi. 10.1002/pro.4917

By:

Schweipert, Markus;
Nehls, Thomas;
Frühauf, Anton;
Debarnot, Cecilé;
Kumar, Adarsh;
Knapp, Stefan;
Lermyte, Frederik;
Meyer‐Almes, Franz‐Josef

Publication type:

Article

Kinetically selective and potent inhibitors of HDAC8.

Published in:

Biological Chemistry, 2019, v. 400, n. 6, p. 733, doi. 10.1515/hsz-2018-0363

By:

Schweipert, Markus;
Jänsch, Niklas;
Sugiarto, Wisely Oki;
Meyer-Almes, Franz-Josef

Publication type:

Article

Azobenzene switch with a long-lived cis-state to photocontrol the enzyme activity of a histone deacetylase-like amidohydrolase.

Published in:

Biological Chemistry, 2014, v. 395, n. 4, p. 401, doi. 10.1515/hsz-2013-0246

By:

Korbus, Michael;
Balasubramanian, Ganesh;
Müller-Plathe, Florian;
Kolmar, Harald;
Meyer-Almes, Franz-Josef

Publication type:

Article

Significance of Five-Membered Heterocycles in Human Histone Deacetylase Inhibitors.

Published in:

Molecules, 2023, v. 28, n. 15, p. 5686, doi. 10.3390/molecules28155686

By:

Frühauf, Anton;
Behringer, Martin;
Meyer-Almes, Franz-Josef

Publication type:

Article

Non-Hydroxamate Zinc-Binding Groups as Warheads for Histone Deacetylases.

Published in:

Molecules, 2021, v. 26, n. 17, p. 5151, doi. 10.3390/molecules26175151

By:

Frühauf, Anton;
Meyer-Almes, Franz-Josef

Publication type:

Article

Discrimination between conformational selection and induced fit protein-ligand binding using Integrated Global Fit analysis.

Published in:

European Biophysics Journal, 2016, v. 45, n. 3, p. 245, doi. 10.1007/s00249-015-1090-1

By:

Meyer-Almes, Franz-Josef

Publication type:

Article

Synthesis and Biological Evaluation of Pyrazoline and Pyrrolidine‐2,5‐dione Hybrids as Potential Antitumor Agents.

Published in:

ChemMedChem, 2020, v. 15, n. 19, p. 1813, doi. 10.1002/cmdc.202000458

By:

Tilekar, Kalpana;
Upadhyay, Neha;
Meyer‐Almes, Franz‐Josef;
Loiodice, Fulvio;
Anisimova, Natalia Y.;
Spirina, Tatiana S.;
Sokolova, Darina V.;
Smirnova, Galina B.;
Choe, Jun‐yong;
Pokrovsky, Vadim S.;
Lavecchia, Antonio;
S Ramaa, C

Publication type:

Article

Determination of the binding mechanism of histone deacetylase inhibitors.

Published in:

Chemical Biology & Drug Design, 2019, v. 93, n. 6, p. 1214, doi. 10.1111/cbdd.13449

By:

Meyer‐Almes, Franz‐Josef

Publication type:

Article

Impact of binding mechanism on selective inhibition of histone deacetylase isoforms.

Published in:

Chemical Biology & Drug Design, 2017, v. 90, n. 6, p. 1215, doi. 10.1111/cbdd.13041

By:

Meyners, Christian;
Meyer‐Almes, Franz‐Josef

Publication type:

Article

A fluorescence lifetime-based binding assay for acetylpolyamine amidohydrolases from Pseudomonas aeruginosa using a [1,3]dioxolo[4,5- f][1,3]benzodioxole (DBD) ligand probe.

Published in:

Analytical & Bioanalytical Chemistry, 2014, v. 406, n. 20, p. 4889, doi. 10.1007/s00216-014-7886-5

By:

Meyners, Christian;
Wawrzinek, Robert;
Krämer, Andreas;
Hinz, Steffen;
Wessig, Pablo;
Meyer-Almes, Franz-Josef

Publication type:

Article

Compact, cost-efficient microfluidics-based stopped-flow device.

Published in:

Analytical & Bioanalytical Chemistry, 2011, v. 399, n. 3, p. 1117, doi. 10.1007/s00216-010-4446-5

By:

Bleul, Regina;
Ritzi-Lehnert, Marion;
Höth, Julian;
Scharpfenecker, Nico;
Frese, Ines;
Düchs, Dominik;
Brunklaus, Sabine;
Hansen-Hagge, Thomas E.;
Meyer-Almes, Franz-Josef;
Drese, Klaus S.

Publication type:

Article

3‐Chloro‐5‐Substituted‐1,2,4‐Thiadiazoles (TDZs) as Selective and Efficient Protein Thiol Modifiers.

Published in:

ChemBioChem, 2022, v. 23, n. 21, p. 1, doi. 10.1002/cbic.202200417

By:

Jänsch, Niklas;
Frühauf, Anton;
Schweipert, Markus;
Debarnot, Cécile;
Erhardt, Miriam;
Brenner‐Weiss, Gerald;
Kirschhöfer, Frank;
Jasionis, Tomas;
Čapkauskaitė, Edita;
Zubrienė, Asta;
Matulis, Daumantas;
Meyer‐Almes, Franz‐Josef

Publication type:

Article

Assessment of Tractable Cysteines for Covalent Targeting by Screening Covalent Fragments.

Published in:

ChemBioChem, 2021, v. 22, n. 4, p. 743, doi. 10.1002/cbic.202000700

By:

Petri, László;
Ábrányi‐Balogh, Péter;
Tímea, Imre;
Pálfy, Gyula;
Perczel, András;
Knez, Damijan;
Hrast, Martina;
Gobec, Martina;
Sosič, Izidor;
Nyíri, Kinga;
Vértessy, Beáta G.;
Jänsch, Niklas;
Desczyk, Charlotte;
Meyer‐Almes, Franz‐Josef;
Ogris, Iza;
Golič Grdadolnik, Simona;
Iacovino, Luca Giacinto;
Binda, Claudia;
Gobec, Stanislav;
Keserű, György M.

Publication type:

Article

Potent and Selective Non-hydroxamate Histone Deacetylase 8 Inhibitors.

Published in:

ChemMedChem, 2016, v. 11, n. 23, p. 2598, doi. 10.1002/cmdc.201600528

By:

Kleinschek, Alexander;
Meyners, Christian;
Digiorgio, Eros;
Brancolini, Claudio;
Meyer‐Almes, Franz‐Josef

Publication type:

Article

Highly Ligand Efficient and Selective N-2-(Thioethyl)picolinamide Histone Deacetylase Inhibitors Inspired by the Natural Product Psammaplin A.

Published in:

ChemMedChem, 2013, v. 8, n. 1, p. 149, doi. 10.1002/cmdc.201200450

By:

Baud, Matthias G. J.;
Haus, Patricia;
Leiser, Thomas;
Meyer‐Almes, Franz‐Josef;
Fuchter, Matthew J.

Publication type:

Article

The cis-state of an azobenzene photoswitch is stabilized through specific interactions with a protein surface.

Published in:

Journal of Molecular Recognition, 2015, v. 28, n. 3, p. 201, doi. 10.1002/jmr.2415

By:

Korbus, Michael;
Backé, Sarah;
Meyer‐Almes, Franz‐Josef

Publication type:

Article

Thermodynamics of ligand binding to histone deacetylase like amidohydrolase from Bordetella/Alcaligenes.

Published in:

Journal of Molecular Recognition, 2014, v. 27, n. 3, p. 160, doi. 10.1002/jmr.2345

By:

Meyners, Christian;
Baud, Matthias G. J.;
Fuchter, Matthew J.;
Meyer‐Almes, Franz‐Josef

Publication type:

Article

Rapid Determination of Kinetic Constants for Slow-Binding Inhibitors and Inactivators of Human Histone Deacetylase 8.

Published in:

International Journal of Molecular Sciences, 2024, v. 25, n. 11, p. 5593, doi. 10.3390/ijms25115593

By:

Kopranovic, Aleksandra;
Meyer-Almes, Franz-Josef

Publication type:

Article

Design, Synthesis, and Biological Evaluation of Novel Quinazolin-4(3H)-One-Based Histone Deacetylase 6 (HDAC6) Inhibitors for Anticancer Activity.

Published in:

International Journal of Molecular Sciences, 2023, v. 24, n. 13, p. 11044, doi. 10.3390/ijms241311044

By:

Khetmalis, Yogesh Mahadu;
Fathima, Ashna;
Schweipert, Markus;
Debarnot, Cécile;
Bandaru, Naga Venkata Madhusudhan Rao;
Murugesan, Sankaranarayanan;
Jamma, Trinath;
Meyer-Almes, Franz-Josef;
Sekhar, Kondapalli Venkata Gowri Chandra

Publication type:

Article

Methionine 274 Is Not the Determining Factor for Selective Inhibition of Histone Deacetylase 8 (HDAC8) by L-Shaped Inhibitors.

Published in:

International Journal of Molecular Sciences, 2022, v. 23, n. 19, p. 11775, doi. 10.3390/ijms231911775

By:

Jänsch, Niklas;
Lang, Kim Leoni;
Meyer-Almes, Franz-Josef

Publication type:

Article

Transcriptomic and genomic studies classify NKL54 as a histone deacetylase inhibitor with indirect influence on MEF2-dependent transcription.

Published in:

Nucleic Acids Research, 2022, v. 50, n. 5, p. 2566, doi. 10.1093/nar/gkac081

By:

Minisini, Martina;
Di Giorgio, Eros;
Kerschbamer, Emanuela;
Dalla, Emiliano;
Faggiani, Massimo;
Franforte, Elisa;
Meyer-Almes, Franz-Josef;
Ragno, Rino;
Antonini, Lorenzo;
Mai, Antonello;
Fiorentino, Francesco;
Rotili, Dante;
Chinellato, Monica;
Perin, Stefano;
Cendron, Laura;
Weichenberger, Christian X;
Angelini, Alessandro;
Brancolini, Claudio

Publication type:

Article

A Fluorescence-Lifetime-Based Binding Assay for Class IIa Histone Deacetylases.

Published in:

Chemistry - A European Journal, 2017, v. 23, n. 13, p. 3107, doi. 10.1002/chem.201605140

By:

Meyners, Christian;
Mertens, Monique;
Wessig, Pablo;
Meyer‐Almes, Franz‐Josef

Publication type:

Article

Targeted anticancer pre-vinylsulfone covalent inhibitors of carbonic anhydrase IX.

Published in:

eLife, 2024, p. 1, doi. 10.7554/eLife.101401

By:

Vaškevičius, Aivaras;
Baronas, Denis;
Leitans, Janis;
Kvietkauskaitė, Agnė;
Rukšėnaitė, Audronė;
Manakova, Elena;
Toleikis, Zigmantas;
Kaupinis, Algirdas;
Kazaks, Andris;
Gedgaudas, Marius;
Mickevičiūtė, Aurelija;
Juozapaitienė, Vaida;
Schiöth, Helgi B.;
Jaudzems, Kristaps;
Valius, Mindaugas;
Tars, Kaspars;
Gražulis, Saulius;
Meyer-Almes, Franz-Josef;
Matulienė, Jurgita;
Zubrienė, Asta

Publication type:

Article

Mechanistic Insights into Binding of Ligands with Thiazolidinedione Warhead to Human Histone Deacetylase 4.

Published in:

Pharmaceuticals (14248247), 2021, v. 14, n. 10, p. 1032, doi. 10.3390/ph14101032

By:

Schweipert, Markus;
Jänsch, Niklas;
Upadhyay, Neha;
Tilekar, Kalpana;
Wozny, Ewelina;
Basheer, Sidra;
Wurster, Eva;
Müller, Marlene;
C S, Ramaa;
Meyer-Almes, Franz-Josef

Publication type:

Article

The Proapoptotic Influenza A Virus Protein PB1-F2 Forms a Nonselective Ion Channel.

Published in:

PLoS ONE, 2010, v. 5, n. 6, p. 1, doi. 10.1371/journal.pone.0011112

By:

Henkel, Michael;
Mitzner, David;
Henklein, Peter;
Meyer-Almes, Franz-Josef;
Moroni, Anna;
DiFrancesco, Mattia L.;
Henkes, Leonhard M.;
Kreim, Michael;
Kast, Stefan M.;
Schubert, Ulrich;
Thiel, Gerhard

Publication type:

Article

Inhibitor-mediated stabilization of the conformational structure of a histone deacetylase-like amidohydrolase.

Published in:

FEBS Journal, 2007, v. 274, n. 14, p. 3578, doi. 10.1111/j.1742-4658.2007.05887.x

By:

Kern, Stefanie;
Riester, Daniel;
Hildmann, Christian;
Schwienhorst, Andreas;
Meyer-Almes, Franz-Josef

Publication type:

Article

Switching the Switch: Ligand Induced Disulfide Formation in HDAC8.

Published in:

Chemistry - A European Journal, 2020, v. 26, n. 58, p. 13249, doi. 10.1002/chem.202001712

By:

Jänsch, Niklas;
Sugiarto, Wisely Oki;
Muth, Marius;
Kopranovic, Aleksandra;
Desczyk, Charlotte;
Ballweg, Matthias;
Kirschhöfer, Frank;
Brenner‐Weiss, Gerald;
Meyer‐Almes, Franz‐Josef

Publication type:

Article

Design and synthesis of peptides as stabilizers of histone deacetylase 4.

Published in:

Journal of Peptide Science, 2024, v. 30, n. 9, p. 1, doi. 10.1002/psc.3603

By:

Lill, Annika;
Schweipert, Markus;
Nehls, Thomas;
Wurster, Eva;
Lermyte, Frederik;
Meyer‐Almes, Franz‐Josef;
Schmitz, Katja

Publication type:

Article

HDAC4 Inhibitors with Cyclic Linker and Non‐hydroxamate Zinc Binding Group: Design, Synthesis, HDAC Screening and in vitro Cytotoxicity evaluation.

Published in:

ChemistrySelect, 2021, v. 6, n. 26, p. 6748, doi. 10.1002/slct.202102061

By:

Tilekar, Kalpana;
Hess, Jessica D.;
Upadhyay, Neha;
Schweipert, Markus;
Flath, Felix;
Gutierrez, Denisse A.;
Loiodice, Fulvio;
Lavecchia, Antonio;
Meyer‐Almes, Franz‐Josef;
Aguilera, Renato J.;
Ramaa, C. S.

Publication type:

Article

Carbonic anhydrase as drug target – thermodynamics and structure of inhibitor binding: edited by Daumantas Matulis, Switzerland, Springer Nature, 2019, 353 pp., EUR149.99 (hardback), ISBN: 978-3-030-12778-7.

Published in:

2021

By:

Meyer-Almes, Franz-Josef

Publication type:

Book Review

Class IIa HDACs repressive activities on MEF2-depedent transcription are associated with poor prognosis of ER<sup>+</sup> breast tumors.

Published in:

FASEB Journal, 2013, v. 27, n. 3, p. 942, doi. 10.1096/fj.12-209346

By:

Clocchiatti, Andrea;
Di Giorgio, Eros;
Ingrao, Sabrina;
Meyer-Almes, Franz-Josef;
Tripodo, Claudio;
Brancolini, Claudio

Publication type:

Article

Substrate specificity and function of acetylpolyamine amidohydrolases from Pseudomonas aeruginosa.

Published in:

BMC Biochemistry, 2016, v. 17, p. 1, doi. 10.1186/s12858-016-0063-z

By:

Krämer, Andreas;
Herzer, Jan;
Overhage, Joerg;
Meyer-Almes, Franz-Josef

Publication type:

Article