Works by Metzger, Joseph M.

Results: 45

Dysregulation of Calcium Handling in Duchenne Muscular Dystrophy-Associated Dilated Cardiomyopathy: Mechanisms and Experimental Therapeutic Strategies.

Published in:

Journal of Clinical Medicine, 2020, v. 9, n. 2, p. 520, doi. 10.3390/jcm9020520

By:

Law, Michelle L.;
Cohen, Houda;
Martin, Ashley A.;
Angulski, Addeli Bez Batti;
Metzger, Joseph M.

Publication type:

Article

Dystrophic heart failure blocked by membrane sealant poloxamer.

Published in:

Nature, 2005, v. 436, n. 7053, p. 1025, doi. 10.1038/nature03844

By:

Yasuda, Soichiro;
Townsend, DeWayne;
Michele, Daniel E.;
Favre, Elizabeth G.;
Day, Sharlene M.;
Metzger, Joseph M.

Publication type:

Article

Rapid restitution of contractile dysfunction by synthetic copolymers in dystrophin-deficient single live skeletal muscle fibers.

Published in:

Skeletal Muscle, 2023, v. 13, n. 1, p. 1, doi. 10.1186/s13395-023-00318-y

By:

Hahn, Dongwoo;
Quick, Joseph D.;
Thompson, Brian R.;
Crabtree, Adelyn;
Hackel, Benjamin J.;
Bates, Frank S.;
Metzger, Joseph M.

Publication type:

Article

Muscle membrane integrity in Duchenne muscular dystrophy: recent advances in copolymer-based muscle membrane stabilizers.

Published in:

Skeletal Muscle, 2018, v. 8, n. 1, p. N.PAG, doi. 10.1186/s13395-018-0177-7

By:

Houang, Evelyne M.;
Sham, Yuk Y.;
Bates, Frank S.;
Metzger, Joseph M.

Publication type:

Article

Advancing physiological maturation in human induced pluripotent stem cell‐derived cardiac muscle by gene editing an inducible adult troponin isoform switch.

Published in:

Stem Cells, 2020, v. 38, n. 10, p. 1254, doi. 10.1002/stem.3235

By:

Wheelwright, Matthew;
Mikkila, Jennifer;
Bedada, Fikru B.;
Mandegar, Mohammad A.;
Thompson, Brian R.;
Metzger, Joseph M.

Publication type:

Article

An integrative genomics approach to infer causal associations between gene expression and disease.

Published in:

Nature Genetics, 2005, v. 37, n. 7, p. 710, doi. 10.1038/ng1589

By:

Schadt, Eric E.;
Lamb, John;
Yang, Xia;
Zhu, Jun;
Edwards, Steve;
Thakurta, Debraj Guha;
Sieberts, Solveig K.;
Monks, Stephanie;
Reitman, Marc;
Zhang, Chunsheng;
Pek Yee Lum;
Leonardson, Amy;
Thieringer, Rolf;
Metzger, Joseph M.;
Yang, Liming;
Castle, John;
Zhu, Haoyuan;
Kash, Shera F.;
Drake, Thomas A.;
Sachs, Alan

Publication type:

Article

Inactivation of the mouse melanocortin-3 receptor results in increased fat mass and reduced lean body mass.

Published in:

Nature Genetics, 2000, v. 26, n. 1, p. 97, doi. 10.1038/79254

By:

Chen, Airu S.;
Marsh, Donald J.;
Trumbauer, Myrna E.;
Frazier, Easter G.;
Guan, Xiao-Ming;
Yu, Hong;
Rosenblum, Charles I.;
Vongs, Aurawan;
Feng, Yue;
Cao, Linhai;
Metzger, Joseph M.;
Strack, Alison M.;
Camacho, Ramon E.;
Mellin, Theodore N.;
Nunes, Christian N.;
Min, William;
Fisher, Jill;
Gopal-Truter, Shobhna;
MacIntyre, D. Euan

Publication type:

Article

Chronic administration of membrane sealant prevents severe cardiac injury and ventricular dilatation in dystrophic dogs.

Published in:

2010

By:

Townsend, DeWayne;
Turner, Immanuel;
Yasuda, Soichiro;
Martindale, Joshua;
Davis, Jennifer;
Shillingford, Michael;
Kornegay, Joe N.;
Metzger, Joseph M.

Publication type:

journal article

Antagonism of T-type calcium channels inhibits high-fat diet-induced weight gain in mice.

Published in:

2009

By:

Uebele, Victor N.;
Gotter, Anthony L.;
Nuss, Cindy E.;
Kraus, Richard L.;
Doran, Scott M.;
Garson, Susan L.;
Reiss, Duane R.;
Yuxing Li;
Barrow, James C.;
Reger, Thomas S.;
Zhi-Qiang Yang;
Ballard, Jeanine E.;
Cuyue Tang;
Metzger, Joseph M.;
Sheng-Ping Wang,4 Kenneth S. Koblan,4 and John J. Renger1;
Li, Yuxing;
Yang, Zhi-Qiang;
Tang, Cuyue;
Wang, Sheng-Ping;
Koblan, Kenneth S

Publication type:

journal article

Preclinical and translational evaluation of coagulation factor IXa as a novel therapeutic target.

Published in:

Pharmacology Research & Perspectives, 2016, v. 4, n. 1, p. n/a, doi. 10.1002/prp2.207

By:

Ankrom, Wendy;
Wood, Harold B.;
Xu, Jiayi;
Geissler, Wayne;
Bateman, Tom;
Chatterjee, Manash S.;
Feng, Kung‐I;
Metzger, Joseph M.;
Strapps, Walter R.;
Tadin‐Strapps, Marija;
Seiffert, Dietmar;
Andre, Patrick

Publication type:

Article

Colchicine Depolymerizes Microtubules, Increases Junctophilin-2, and Improves Right Ventricular Function in Experimental Pulmonary Arterial Hypertension.

Published in:

2017

By:

Prins, Kurt W.;
Tian, Lian;
Wu, Danchen;
Thenappan, Thenappan;
Metzger, Joseph M.;
Archer, Stephen L.

Publication type:

journal article

Sarcomere dynamics revealed by a myofilament integrated FRET-based biosensor in live skeletal muscle fibers.

Published in:

Scientific Reports, 2022, v. 12, n. 1, p. 1, doi. 10.1038/s41598-022-21425-8

By:

Martin, Ashley A.;
Thompson, Brian R.;
Davis, Jonathan P.;
Vang, Hluechy;
Hahn, Dongwoo;
Metzger, Joseph M.

Publication type:

Article

Cardiac involvement in the dystrophinopathies.

Published in:

Journal of Pediatric Rehabilitation Medicine, 2008, v. 1, n. 3, p. 211

By:

Hornyak, Joseph E.;
Russell, Mark W.;
Townsend, DeWayne;
Metzger, Joseph M.

Publication type:

Article

Cardiac Sarcomere Signaling in Health and Disease.

Published in:

2022

By:

Martin, Ashley A.;
Thompson, Brian R.;
Hahn, Dongwoo;
Angulski, Addeli Bez Batti;
Hosny, Nora;
Cohen, Houda;
Metzger, Joseph M.

Publication type:

Literature Review

Severe dystrophic cardiomyopathy caused by the enteroviral protease 2A–mediated C-terminal dystrophin cleavage fragment.

Published in:

Science Translational Medicine, 2015, v. 7, n. 294, p. 1, doi. 10.1126/scitranslmed.aaa4804

By:

Barnabei, Matthew S.;
Sjaastad, Frances V.;
Townsend, DeWayne;
Bedada, Fikru B.;
Metzger, Joseph M.

Publication type:

Article

Investigation of human iPSC-derived cardiac myocyte functional maturation by single cell traction force microscopy.

Published in:

PLoS ONE, 2018, v. 13, n. 4, p. 1, doi. 10.1371/journal.pone.0194909

By:

Wheelwright, Matthew;
Win, Zaw;
Mikkila, Jennifer L.;
Amen, Kamilah Y.;
Alford, Patrick W.;
Metzger, Joseph M.

Publication type:

Article

Single histidine-substituted cardiac troponin I confers protection from age-related systolic and diastolic dysfunction.

Published in:

Cardiovascular Research, 2008, v. 80, n. 2, p. 209, doi. 10.1093/cvr/cvn198

By:

Palpant, Nathan J.;
Day, Sharlene M.;
Herron, Todd J.;
Converso, Kimber L.;
Metzger, Joseph M.

Publication type:

Article

Direct, convergent hypersensitivity of calcium-activated force generation produced by hypertrophic cardiomyopathy mutant α-tropomyosins in adult cardiac myocytes.

Published in:

Nature Medicine, 1999, v. 5, n. 12, p. 1413, doi. 10.1038/70990

By:

Michele, Daniel E.;
Albayya, Faris P.;
Metzger, Joseph M.

Publication type:

Article

Physiological consequences of tropomyosin mutations associated with cardiac and skeletal myopathies.

Published in:

Journal of Molecular Medicine, 2000, v. 78, n. 10, p. 543, doi. 10.1007/s001090000161

By:

Michele, Daniel E.;
Metzger, Joseph M.

Publication type:

Article

Age-dependent Dystrophin Loss and Genetic Reconstitution Establish a Molecular Link Between Dystrophin and Heart Performance During Aging.

Published in:

Molecular Therapy, 2011, v. 19, n. 10, p. 1821, doi. 10.1038/mt.2011.120

By:

Townsend, DeWayne;
Daly, Michael;
Chamberlain, Jeffrey S;
Metzger, Joseph M

Publication type:

Article

Double Oxygen–sensing Vector System for Robust Hypoxia/Ischemia-regulated Gene Induction in Cardiac Muscle In Vitro and In Vivo.

Published in:

Molecular Therapy, 2008, v. 16, n. 9, p. 1594, doi. 10.1038/mt.2008.136

By:

Fomicheva, Ekaterina V;
Turner, Immanuel I;
Edwards, Terri G;
Hoff, Janet;
Arden, Eric;
D'Alecy, Louis G;
Metzger, Joseph M

Publication type:

Article

Emergent Dilated Cardiomyopathy Caused by Targeted Repair of Dystrophic Skeletal Muscle.

Published in:

Molecular Therapy, 2008, v. 16, n. 5, p. 832, doi. 10.1038/mt.2008.52

By:

Townsend, DeWayne;
Yasuda, Soichiro;
Sheng Li;
Chamberlain, Jeffrey S.;
Metzger, Joseph M.

Publication type:

Article

Systemic Administration of Micro-dystrophin Restores Cardiac Geometry and Prevents Dobutamine-induced Cardiac Pump Failure.

Published in:

Molecular Therapy, 2007, v. 15, n. 6, p. 1086, doi. 10.1038/sj.mt.6300144

By:

Townsend, DeWayne;
Blankinship, Michael J.;
Allen, James M.;
Gregorevic, Paul;
Chamberlain, Jeffrey S.;
Metzger, Joseph M.

Publication type:

Article

Parvalbumin gene delivery improves diastolic function in the aged myocardium in vivo

Published in:

Molecular Therapy, 2004, v. 10, n. 2, p. 399, doi. 10.1016/j.ymthe.2004.05.011

By:

Michele, Daniel E.;
Szatkowski, Michael L.;
Albayya, Faris P.;
Metzger, Joseph M.

Publication type:

Article

Cell Biology of Sarcomeric Protein Engineering: Disease Modeling and Therapeutic Potential.

Published in:

Anatomical Record: Advances in Integrative Anatomy & Evolutionary Biology, 2014, v. 297, n. 9, p. 1663, doi. 10.1002/ar.22966

By:

Thompson, Brian R.;
Metzger, Joseph M.

Publication type:

Article

Modulation of Cardiac Performance by Motor Protein Gene Transfer.

Published in:

Annals of the New York Academy of Sciences, 2008, v. 1123, p. 96, doi. 10.1196/annals.1420.011

By:

Herron, Todd J.;
Devaney, Eric J.;
Metzger, Joseph M.

Publication type:

Article

Tuning cardiac performance in ischemic heart disease and failure by modulating myofilament function.

Published in:

Journal of Molecular Medicine, 2007, v. 85, n. 9, p. 911, doi. 10.1007/s00109-007-0181-6

By:

Day, Sharlene M.;
Westfall, Margaret V.;
Metzger, Joseph M.

Publication type:

Article

Inducing positive inotropy in human iPSC-derived cardiac muscle by gene editing-based activation of the cardiac α-myosin heavy chain.

Published in:

Scientific Reports, 2024, v. 14, n. 1, p. 1, doi. 10.1038/s41598-024-53395-4

By:

Bedada, Fikru B.;
Thompson, Brian R.;
Mikkila, Jennifer L.;
Chan, Sunny S.-K.;
Choi, Si Ho;
Toso, Erik A.;
Kyba, Michael;
Metzger, Joseph M.

Publication type:

Article

Noncanonical EF-hand motif strategically delays Ca2+ buffering to enhance cardiac performance.

Published in:

Nature Medicine, 2013, v. 19, n. 3, p. 305, doi. 10.1038/nm.3079

By:

Wang, Wang;
Barnabei, Matthew S;
Asp, Michelle L;
Heinis, Frazer I;
Arden, Erik;
Davis, Jennifer;
Braunlin, Elizabeth;
Li, Qi;
Davis, Jonathan P;
Potter, James D;
Metzger, Joseph M

Publication type:

Article

Histidine button engineered into cardiac troponin I protects the ischemic and failing heart.

Published in:

Nature Medicine, 2006, v. 12, n. 2, p. 181, doi. 10.1038/nm1346

By:

Day, Sharlene M.;
Westfall, Margaret V.;
Fomicheva, Ekaterina V.;
Hoyer, Kirsten;
Yasuda, Soichiro;
Cross, Nathan C. La;
D'Alecy, Louis G.;
Ingwall, Joanne S.;
Metzger, Joseph M.

Publication type:

Article

Development of Capabilities for Simultaneous Measurement of Pulmonary and Systemic Pressure to Support Evaluation of Pulmonary Hypertension Therapies.

Published in:

FASEB Journal, 2013, v. 27, p. lb608, doi. 10.1096/fasebj.27.1_supplement.lb608

By:

Zhao, Huawei;
Sun, Shu‐Yu;
Shen, Xiaolan;
Hong, Xueninh;
Yang, Liming;
Ping, Xiaoli;
Wang, Bo;
Davis, Christopher A;
Metzger, Joseph M;
Small, Kersten M;
Madwed, Jeffrey B

Publication type:

Article

Distinct pathophysiological mechanisms of cardiomyopathy in hearts lacking dystrophin or the sarcoglycan complex.

Published in:

FASEB Journal, 2011, v. 25, n. 9, p. 3106, doi. 10.1096/fj.10-178913

By:

Townsend, DeWayne;
Yasuda, Soichiro;
McNally, Elizabeth;
Metzger, Joseph M.

Publication type:

Article

Ca2+-independent positive molecular inotropy for failing rabbit and human cardiac muscle by α-myosin motor gene transfer.

Published in:

FASEB Journal, 2010, v. 24, n. 2, p. 415, doi. 10.1096/fj.09-140566

By:

Herron, Todd J.;
Devaney, Eric;
Mundada, Lakshmi;
Arden, Erik;
Day, Sharlene;
Guerrero-Serna, Guadalupe;
Turner, Immanuel;
Westfall, Margaret;
Metzger, Joseph M.

Publication type:

Article

FGF21 Analogs of Sustained Action Enabled by Orthogonal Biosynthesis Demonstrate Enhanced Antidiabetic Pharmacology in Rodents.

Published in:

Diabetes, 2012, v. 61, n. 2, p. 505, doi. 10.2337/db11-0838

By:

Mu, James;
Pinkstaff, Jason;
Zhihua Li;
Skidmore, Lillian;
Nina Li;
Myler, Heather;
Dallas-Yang, Qing;
Putnam, Anna-Maria;
Jun Yao;
Bussell, Stuart;
Wu, Margaret;
Norman, Thea C.;
Rodriguez, Carlos G.;
Kimmel, Bruce;
Metzger, Joseph M.;
Manibusan, Anthony;
Lee, Darin;
Zaller, Dennis M.;
Zhang, Bei B.;
DiMarchi, Richard D.

Publication type:

Article

Investigations of an inducible intact dystrophin gene excision system in cardiac and skeletal muscle in vivo.

Published in:

Scientific Reports, 2020, v. 10, n. 1, p. 1, doi. 10.1038/s41598-020-67372-0

By:

Bez Batti Angulski, Addeli;
Bauer, John;
Cohen, Houda;
Kobuke, Kazuhiro;
Campbell, Kevin P.;
Metzger, Joseph M.

Publication type:

Article

Duchenne muscular dystrophy: disease mechanism and therapeutic strategies.

Published in:

Frontiers in Physiology, 2023, p. 1, doi. 10.3389/fphys.2023.1183101

By:

Batti Angulski, Addeli Bez;
Hosny, Nora;
Cohen, Houda;
Martin, Ashley A.;
Dongwoo Hahn;
Bauer, Jack;
Metzger, Joseph M.

Publication type:

Article

Early Detection of Myocardial Bioenergetic Deficits: A 9.4 Tesla Complete Non Invasive 31P MR Spectroscopy Study in Mice with Muscular Dystrophy.

Published in:

PLoS ONE, 2015, v. 10, n. 8, p. 1, doi. 10.1371/journal.pone.0135000

By:

Cui, Weina;
Jang, Albert;
Zhang, Pengyuan;
Thompson, Brian;
Townsend, DeWayne;
Metzger, Joseph M.;
Zhang, Jianyi

Publication type:

Article

Prominent Heart Organ-Level Performance Deficits in a Genetic Model of Targeted Severe and Progressive SERCA2 Deficiency.

Published in:

PLoS ONE, 2013, v. 8, n. 11, p. 1, doi. 10.1371/journal.pone.0079609

By:

Heinis, Frazer I.;
Andersson, Kristin B.;
Christensen, Geir;
Metzger, Joseph M.

Publication type:

Article

Direct, Differential Effects of Tamoxifen, 4-Hydroxytamoxifen, and Raloxifene on Cardiac Myocyte Contractility and Calcium Handling.

Published in:

PLoS ONE, 2013, v. 8, n. 10, p. 1, doi. 10.1371/journal.pone.0078768

By:

Asp, Michelle L.;
Martindale, Joshua J.;
Metzger, Joseph M.

Publication type:

Article

Ex Vivo Stretch Reveals Altered Mechanical Properties of Isolated Dystrophin-Deficient Hearts.

Published in:

PLoS ONE, 2012, v. 7, n. 3, p. 1, doi. 10.1371/journal.pone.0032880

By:

Barnabei, Matthew S.;
Metzger, Joseph M.

Publication type:

Article

Combinatorial Effects of Double Cardiomyopathy Mutant Alleles in Rodent Myocytes: A Predictive Cellular Model of Myofilament Dysregulation in Disease.

Published in:

PLoS ONE, 2010, v. 5, n. 2, p. 1, doi. 10.1371/journal.pone.0009140

By:

Davis, Jennifer;
Metzger, Joseph M.

Publication type:

Article

Artificial Selection for Whole Animal Low Intrinsic Aerobic Capacity Co-Segregates with Hypoxia-Induced Cardiac Pump Failure.

Published in:

PLoS ONE, 2009, v. 4, n. 7, p. 1, doi. 10.1371/journal.pone.0006117

By:

Palpant, Nathan J.;
Szatkowski, Michael L.;
Wang Wang;
Townsend, DeWayne;
Bedada, Fikru B.;
Koch, Lauren G.;
Britton, Steven L.;
Metzger, Joseph M.

Publication type:

Article

Cardiac myocyte intrinsic contractility and calcium handling deficits underlie heart organ dysfunction in murine cancer cachexia.

Published in:

Scientific Reports, 2021, v. 11, n. 1, p. 1, doi. 10.1038/s41598-021-02688-z

By:

Law, Michelle L.;
Metzger, Joseph M.

Publication type:

Article

Troponin I isoform expression is developmentally regulated in differentiating embryonic stem cell-derived cardiac myocytes.

Published in:

Developmental Dynamics, 1996, v. 206, n. 1, p. 24, doi. 10.1002/(SICI)1097-0177(199605)206:1<24::AID-AJA3>3.0.CO;2-2

By:

Westfall, Margaret V.;
Samuelson, Linda C.;
Metzger, Joseph M.

Publication type:

Article

Molecular inotropy mediated by cardiac miR-based PDE4D/PRKAR1α/phosphoprotein signaling.

Published in:

Scientific Reports, 2016, p. 36803, doi. 10.1038/srep36803

By:

Bedada, Fikru B.;
Martindale, Joshua J.;
Arden, Erik;
Metzger, Joseph M.

Publication type:

Article