Works by Merkus, Daphne

Results: 84

Right ventricular phenotype, function, and failure: a journey from evolution to clinics.

Published in:

Heart Failure Reviews, 2021, v. 26, n. 6, p. 1447, doi. 10.1007/s10741-020-09982-4

By:

Taverne, Yannick J. H. J.;
Sadeghi, Amir;
Bartelds, Beatrijs;
Bogers, Ad J. J. C.;
Merkus, Daphne

Publication type:

Article

The microtubule signature in cardiac disease: etiology, disease stage, and age dependency.

Published in:

Journal of Comparative Physiology B: Biochemical, Systemic & Environmental Physiology, 2023, v. 193, n. 5, p. 581, doi. 10.1007/s00360-023-01509-1

By:

Algül, Sıla;
Dorsch, Larissa M.;
Sorop, Oana;
Vink, Aryan;
Michels, Michelle;
dos Remedios, Cristobal G.;
Dalinghaus, Michiel;
Merkus, Daphne;
Duncker, Dirk J.;
Kuster, Diederik W. D.;
van der Velden, Jolanda

Publication type:

Article

Can Measuring the 'Dual Anchors of Aorta' Enhance the Success Rate of TAVR?—A Single-Center Experience.

Published in:

Journal of Clinical Medicine, 2023, v. 12, n. 3, p. 1157, doi. 10.3390/jcm12031157

By:

Chen, Yang;
Ferdous, Md Misbahul;
Kottu, Lakshme;
Zhao, Jie;
Zhang, Hong-Liang;
Wang, Mo-Yang;
Niu, Guan-Nan;
Liu, Qing-Rong;
Zhou, Zheng;
Zhao, Zhen-Yan;
Zhang, Qian;
Feng, De-Jing;
Zhang, Bin;
Li, Zi-Ang;
Merkus, Daphne;
Lv, Bin;
Xu, Hai-Yan;
Song, Guang-Yuan;
Wu, Yong-Jian

Publication type:

Article

Lower Plasma Melatonin Levels Predict Worse Long-Term Survival in Pulmonary Arterial Hypertension.

Published in:

Journal of Clinical Medicine, 2020, v. 9, n. 5, p. 1248, doi. 10.3390/jcm9051248

By:

Cai, Zongye;
Klein, Theo;
Geenen, Laurie W.;
Tu, Ly;
Tian, Siyu;
van den Bosch, Annemien E.;
de Rijke, Yolanda B.;
Reiss, Irwin K. M.;
Boersma, Eric;
Duncker, Dirk J.;
Boomars, Karin A.;
Guignabert, Christophe;
Merkus, Daphne

Publication type:

Article

Intervening with the Nitric Oxide Pathway to Alleviate Pulmonary Hypertension in Pulmonary Vein Stenosis.

Published in:

Journal of Clinical Medicine, 2019, v. 8, n. 8, p. 1204, doi. 10.3390/jcm8081204

By:

van Duin, Richard W. B.;
Stam, Kelly;
Uitterdijk, André;
Bartelds, Beatrijs;
Danser, A. H. Jan;
Reiss, Irwin K. M.;
Duncker, Dirk J.;
Merkus, Daphne

Publication type:

Article

Uridine Adenosine Tetraphosphate-Induced Coronary Relaxation Is Blunted in Swine With Pressure Overload: A Role for Vasoconstrictor Prostanoids.

Published in:

Frontiers in Pharmacology, 2018, p. 1, doi. 10.3389/fphar.2018.00255

By:

Zhou, Zhichao;
Lankhuizen, Inge M.;
van Beusekom, Heleen M.;
Cheng, Caroline;
Duncker, Dirk J.;
Merkus, Daphne

Publication type:

Article

Endothelin-1 Regulation of Exercise-Induced Changes in Flow: Dynamic Regulation of Vascular Tone.

Published in:

Frontiers in Pharmacology, 2017, p. 1, doi. 10.3389/fphar.2017.00517

By:

Rapoport, Robert M.;
Merkus, Daphne

Publication type:

Article

Differential impact of severe familial hypercholesterolemia on regional skeletal muscle and organ blood flows during exercise: Effects of PDE5 inhibition.

Published in:

Microcirculation, 2019, v. 26, n. 6, p. N.PAG, doi. 10.1111/micc.12539

By:

Aragonez, Christian G.;
Beer, Vincent J.;
Tharp, Darla L.;
Bowles, Douglas K.;
Laughlin, M. Harold;
Merkus, Daphne;
Duncker, Dirk J.;
Bender, Shawn B.

Publication type:

Article

DNGR1-Cre-mediated Deletion of Tnfaip3/A20 in Conventional Dendritic Cells Induces Pulmonary Hypertension in Mice.

Published in:

American Journal of Respiratory Cell & Molecular Biology, 2020, v. 63, n. 5, p. 665, doi. 10.1165/rcmb.2019-0443OC

By:

Koudstaal, Thomas;
van Hulst, Jennifer A. C.;
Das, Tridib;
Neys, Stefan F. H.;
Merkus, Daphne;
Bergen, Ingrid M.;
de Raaf, Michiel A.;
Bogaard, Harm Jan;
Boon, Louis;
van Loo, Geert;
Aerts, Joachim G. J. V.;
Boomars, Karin A.;
Kool, Mirjam;
Hendriks, Rudi W.

Publication type:

Article

The Function of the Kynurenine Pathway in the Placenta: A Novel Pharmacotherapeutic Target?

Published in:

International Journal of Environmental Research & Public Health, 2021, v. 18, n. 21, p. 11545, doi. 10.3390/ijerph182111545

By:

Broekhuizen, Michelle;
Danser, A. H. Jan;
Reiss, Irwin K. M.;
Merkus, Daphne

Publication type:

Article

Porcine models for studying complications and organ crosstalk in diabetes mellitus.

Published in:

Cell & Tissue Research, 2020, v. 380, n. 2, p. 341, doi. 10.1007/s00441-019-03158-9

By:

Renner, Simone;
Blutke, Andreas;
Clauss, Sebastian;
Deeg, Cornelia A.;
Kemter, Elisabeth;
Merkus, Daphne;
Wanke, Rüdiger;
Wolf, Eckhard

Publication type:

Article

Mechanobiology of Microvascular Function and Structure in Health and Disease: Focus on the Coronary Circulation.

Published in:

Frontiers in Physiology, 2021, v. 12, p. 1, doi. 10.3389/fphys.2021.771960

By:

Brandt, Maarten M.;
Cheng, Caroline;
Merkus, Daphne;
Duncker, Dirk J.;
Sorop, Oana

Publication type:

Article

Both male and female obese ZSF1 rats develop cardiac dysfunction in obesity-induced heart failure with preserved ejection fraction.

Published in:

PLoS ONE, 2020, v. 15, n. 5, p. 1, doi. 10.1371/journal.pone.0232399

By:

Nguyen, Isabel T. N.;
Brandt, Maarten M.;
van de Wouw, Jens;
van Drie, Ruben W. A.;
Wesseling, Marian;
Cramer, Maarten J.;
de Jager, Saskia C. A.;
Merkus, Daphne;
Duncker, Dirk J.;
Cheng, Caroline;
Joles, Jaap. A.;
Verhaar, Marianne C.

Publication type:

Article

Increasing heart rate in heart failure with preserved ejection fraction: a sensible way to go?

Published in:

European Heart Journal, 2025, v. 46, n. 21, p. 2027, doi. 10.1093/eurheartj/ehaf109

By:

Sen, Payel;
Sorop, Oana;
Merkus, Daphne

Publication type:

Article

Kynurenine metabolites predict survival in pulmonary arterial hypertension: A role for IL-6/IL-6Rα.

Published in:

Scientific Reports, 2022, v. 12, n. 1, p. 1, doi. 10.1038/s41598-022-15039-3

By:

Cai, Zongye;
Tian, Siyu;
Klein, Theo;
Tu, Ly;
Geenen, Laurie W.;
Koudstaal, Thomas;
van den Bosch, Annemien E.;
de Rijke, Yolanda B.;
Reiss, Irwin K. M.;
Boersma, Eric;
van der Ley, Claude;
Van Faassen, Martijn;
Kema, Ido;
Duncker, Dirk J.;
Boomars, Karin A.;
Tran-Lundmark, Karin;
Guignabert, Christophe;
Merkus, Daphne

Publication type:

Article

Quantification of myocardial blood flow by adenosine-stress CT perfusion imaging in pigs during various degrees of stenosis correlates well with coronary artery blood flow and fractional flow reserve.

Published in:

2013

By:

Rossi, Alexia;
Uitterdijk, André;
Dijkshoorn, Marcel;
Klotz, Ernst;
Dharampal, Anoeshka;
van Straten, Marcel;
van der Giessen, Wim J.;
Mollet, Nico;
van Geuns, Robert-Jan;
Krestin, Gabriel P.;
Duncker, Dirk J.;
de Feyter, Pim J.;
Merkus, Daphne

Publication type:

Journal Article

Quantification of myocardial blood flow by adenosine-stress CT perfusion imaging in pigs during various degrees of stenosis correlates well with coronary artery blood flow and fractional flow reserve.

Published in:

European Heart Journal - Cardiovascular Imaging, 2013, v. 14, n. 4, p. 331, doi. 10.1093/ehjci/jes150

By:

Rossi, Alexia;
Uitterdijk, André;
Dijkshoorn, Marcel;
Klotz, Ernst;
Dharampal, Anoeshka;
Van Straten, Marcel;
Van Der Giessen, Wim J.;
Mollet, Nico;
Van Geuns, Robert-Jan;
Krestin, Gabriel P.;
Duncker, Dirk J.;
De Feyter, Pim J.;
Merkus, Daphne

Publication type:

Article

Taming the flame: SerpinB1 suppression of pyroptosis in pathological cardiac hypertrophy Free.

Published in:

Cardiovascular Research, 2025, v. 121, n. 1, p. 4, doi. 10.1093/cvr/cvae262

By:

Bartelds, Beatrijs;
Merkus, Daphne

Publication type:

Article

Experimental animal models of coronary microvascular dysfunction.

Published in:

Cardiovascular Research, 2020, v. 116, n. 4, p. 756, doi. 10.1093/cvr/cvaa002

By:

Sorop, Oana;
van de Wouw, Jens;
Chandler, Selena;
Ohanyan, Vahagn;
Tune, Johnathan D;
Chilian, William M;
Merkus, Daphne;
Bender, Shawn B;
Duncker, Dirk J

Publication type:

Article

Protease-activated receptor 1 as potential therapeutic target in pulmonary arterial hypertension.

Published in:

Cardiovascular Research, 2019, v. 115, n. 8, p. 1260, doi. 10.1093/cvr/cvz071

By:

Merkus, Daphne;
Beusekom, Heleen M M van;
Boomars, Karin A

Publication type:

Article

ROCK as amolecular bond connecting coronary microvascular and cardiac remodelling.

Published in:

Cardiovascular Research, 2017, v. 113, n. 11, p. 1273, doi. 10.1093/cvr/cvx139

By:

Merkus, Daphne;
Tune, Johnathan D.

Publication type:

Article

The microcirculation: a key player in obesity-associated cardiovascular disease.

Published in:

Cardiovascular Research, 2017, v. 113, n. 9, p. 1035, doi. 10.1093/cvr/cvx093

By:

Sorop, Oana;
Olver, T. Dylan;
van de Wouw, Jens;
Heinonen, Ilkka;
van Duin, Richard W.;
Duncker, Dirk J.;
Merkus, Daphne

Publication type:

Article

Farnesylation of RhoB: the cancer hypothesis of pulmonary hypertension revisited.

Published in:

2017

By:

Merkus, Daphne;
Schermuly, Ralph T.

Publication type:

Editorial

Proteomics- and Metabolomics-Based Analysis of Metabolic Changes in a Swine Model of Pulmonary Hypertension.

Published in:

International Journal of Molecular Sciences, 2023, v. 24, n. 5, p. 4870, doi. 10.3390/ijms24054870

By:

Sen, Payel;
Shashikadze, Bachuki;
Flenkenthaler, Florian;
Van de Kamp, Esther;
Tian, Siyu;
Meng, Chen;
Gigl, Michael;
Fröhlich, Thomas;
Merkus, Daphne

Publication type:

Article

Serially measured circulating microRNAs and adverse clinical outcomes in patients with acute heart failure.

Published in:

European Journal of Heart Failure. Supplements, 2018, v. 20, n. 1, p. 89, doi. 10.1002/ejhf.950

By:

van Boven, Nick;
Kardys, Isabella;
van Vark, Laura C.;
Akkerhuis, K. Martijn;
de Ronde, Maurice W. J.;
Khan, Mohsin A. F.;
Merkus, Daphne;
Zhen Liu;
Voors, Adriaan A.;
Asselbergs, Folkert W.;
van den Bos, Ewout-Jan;
Boersma, Eric;
Hillege, Hans;
Duncker, Dirk J.;
Pinto, Yigal M.;
Postmus, Douwe

Publication type:

Article

Exercise hyperaemia in the heart: the search for the dilator mechanism.

Published in:

Journal of Physiology, 2007, v. 583, n. 3, p. 847, doi. 10.1113/jphysiol.2007.135525

By:

Duncker, Dirk J.;
Merkus, Daphne

Publication type:

Article

Alterations in endothelial control of the pulmonary circulation in exercising swine with secondary pulmonary hypertension after myocardial infarction.

Published in:

Journal of Physiology, 2007, v. 580, n. 3, p. 907, doi. 10.1113/jphysiol.2006.127118

By:

Merkus, Daphne;
Houweling, Birgit;
de Beer, Vincent J.;
Everon, Zaida;
Duncker, Dirk J.

Publication type:

Article

Role of endothelin receptor activation in secondary pulmonary hypertension in awake swine after myocardial infarction.

Published in:

Journal of Physiology, 2006, v. 574, n. 2, p. 615, doi. 10.1113/jphysiol.2006.107060

By:

Houweling, Birgit;
Merkus, Daphne;
Sorop, Oana;
Boomsma, Frans;
Duncker, Dirk J.

Publication type:

Article

Nitric oxide blunts the endothelin-mediated pulmonary vasoconstriction in exercising swine.

Published in:

Journal of Physiology, 2005, v. 568, n. 2, p. 629, doi. 10.1113/jphysiol.2005.094227

By:

Houweling, Birgit;
Merkus, Daphne;
Dekker, Marjolein M. D.;
Duncker, Dirk J.

Publication type:

Article

Pentoxifylline as a therapeutic option for pre-eclampsia: a study on its placental effects.

Published in:

2022

By:

Broekhuizen, Michelle;
de Vries, Rene;
Smits, Marja A. W.;
Dik, Willem A.;
Schoenmakers, Sam;
Koch, Birgit C. P.;
Merkus, Daphne;
Reiss, Irwin K. M.;
Danser, A. H. Jan;
Simons, Sinno H. P.;
Hitzerd, Emilie

Publication type:

journal article

Time course of VCAM-1 expression in reperfused myocardial infarction in swine and its relation to retention of intracoronary administered bone marrow-derived mononuclear cells.

Published in:

PLoS ONE, 2017, v. 12, n. 6, p. 1, doi. 10.1371/journal.pone.0178779

By:

Uitterdijk, André;
Groenendijk, Bianca C. W.;
Gorsse-Bakker, Charlotte;
Panasewicz, Anna;
Sneep, Stefan;
Tempel, Dennie;
Van De Kamp, Esther H.;
Merkus, Daphne;
Van Der Giessen, Willem J.;
Duncker, Dirk J.

Publication type:

Article

Sarcomeric dysfunction in heart failure.

Published in:

Cardiovascular Research, 2008, v. 77, n. 4, p. 649, doi. 10.1093/cvr/cvm079

By:

Hamdani, Nazha;
Kooij, Viola;
van Dijk, Sabine;
Merkus, Daphne;
Paulus, Walter J.;
Remedios, Cris dos;
Duncker, Dirk J.;
Stienen, Ger J.M.;
van der Velden, Jolanda

Publication type:

Article

Exercise unmasks autonomic dysfunction in swine with a recent myocardial infarction

Published in:

Cardiovascular Research, 2005, v. 65, n. 4, p. 889, doi. 10.1016/j.cardiores.2004.12.010

By:

Duncker, Dirk J.;
Haitsma, David B.;
Liem, David A.;
Verdouw, Pieter D.;
Merkus, Daphne

Publication type:

Article

Contribution of endothelin and its receptors to the regulation of vascular tone during exercise is different in the systemic, coronary and pulmonary circulation

Published in:

Cardiovascular Research, 2003, v. 59, n. 3, p. 745, doi. 10.1016/S0008-6363(03)00479-6

By:

Merkus, Daphne;
Houweling, Birgit;
Mirza, Amran;
Boomsma, Frans;
van den Meiracker, Anton H.;
Duncker, Dirk J.

Publication type:

Article

Chronic cardiac denervation affects the speed of coronary vascular regulation.

Published in:

Cardiovascular Research, 1999, v. 44, n. 3, p. 615, doi. 10.1016/S0008-6363(99)00257-6

By:

Vergroesen, Isabelle;
Merkus, Daphne;
van Teeffelen, Jurgen W.G.E;
Dankelman, Jenny;
Spaan, Jos A.E;
van Wezel, Harry B;
Noble, Mark I.M;
Drake-Holland, Angela J

Publication type:

Article

Endothelial dysfunction enhances the pulmonary and systemic vasodilator effects of phosphodiesterase-5 inhibition in awake swine at rest and during treadmill exercise.

Published in:

Experimental Biology & Medicine, 2012, v. 237, n. 2, p. 201, doi. 10.1258/ebm.2011.011232

By:

Houweling, Birgit;
Quispel, Johan;
Beier, Norbert;
Verdouw, Pieter D.;
Duncker, Dirk J.;
Merkus, Daphne

Publication type:

Article

Myofilament dysfunction in cardiac disease from mice to men.

Published in:

Journal of Muscle Research & Cell Motility, 2008, v. 29, n. 6-8, p. 189, doi. 10.1007/s10974-008-9160-y

By:

Nazha Hamdani;
Monique de Waard;
Andrew Messer;
Nicky Boontje;
Viola Kooij;
Sabine van Dijk;
Amanda Versteilen;
Regis Lamberts;
Daphne Merkus;
Cris dos Remedios;
Dirk Duncker;
Zoltan Papp;
Walter Paulus;
Ger Stienen;
Steven Marston;
Jolanda van der Velden

Publication type:

Article

Purinergic Dysfunction in Pulmonary Arterial Hypertension.

Published in:

2020

By:

Zongye Cai;
Ly Tu;
Guignabert, Christophe;
Merkus, Daphne;
Cai, Zongye;
Tu, Ly;
Zhou, Zhichao

Publication type:

journal article

Predicting protective gene biomarker of acute coronary syndrome by the circRNA-associated competitive endogenous RNA regulatory network.

Published in:

Frontiers in Genetics, 2022, v. 13, p. 1, doi. 10.3389/fgene.2022.1030510

By:

Hengliang Zhang;
Merkus, Daphne;
Pei Zhang;
Huifeng Zhang;
Yanyu Wang;
Laijing Du;
Kottu, Lakshme

Publication type:

Article

Reactive Oxygen Species: Radical Factors in the Evolution of Animal Life.

Published in:

BioEssays, 2018, v. 40, n. 3, p. 1, doi. 10.1002/bies.201700158

By:

Taverne, Yannick J.;
Merkus, Daphne;
Bogers, Ad J.;
Halliwell, Barry;
Duncker, Dirk J.;
Lyons, Timothy W.

Publication type:

Article

Retinoic acid modulation guides human-induced pluripotent stem cell differentiation towards left or right ventricle-like cardiomyocytes.

Published in:

Stem Cell Research & Therapy, 2024, v. 15, n. 1, p. 1, doi. 10.1186/s13287-024-03741-0

By:

Zhang, Hengliang;
Sen, Payel;
Hamers, Jules;
Sittig, Theresa;
Woestenburg, Brent;
Moretti, Allessandra;
Dendorfer, Andreas;
Merkus, Daphne

Publication type:

Article

Validation of 4D flow CMR against simultaneous invasive hemodynamic measurements: a swine study.

Published in:

2019

By:

Stam, Kelly;
Chelu, Raluca G.;
van der Velde, Nikki;
van Duin, Richard;
Wielopolski, Piotr;
Nieman, Koen;
Merkus, Daphne;
Hirsch, Alexander

Publication type:

journal article

Early detection of left ventricular diastolic dysfunction using conventional and speckle tracking echocardiography in a large animal model of metabolic dysfunction.

Published in:

2018

By:

van den Dorpel, Mark M. P.;
Heinonen, Ilkka;
Snelder, Sanne M.;
Vos, Hendrik J.;
Sorop, Oana;
van Domburg, Ron T.;
Merkus, Daphne;
Duncker, Dirk J.;
van Dalen, Bas M.

Publication type:

journal article

Erratum to: Exercise training in adverse cardiac remodeling.

Published in:

2016

By:

Duncker, Dirk;
Deel, Elza;
Waard, Monique;
Boer, Martine;
Merkus, Daphne;
Velden, Jolanda

Publication type:

Erratum

Exercise training in adverse cardiac remodeling.

Published in:

Pflügers Archiv: European Journal of Physiology, 2014, v. 466, n. 6, p. 1079, doi. 10.1007/s00424-014-1464-8

By:

Duncker, Dirk;
Deel, Elza;
Waard, Monique;
Boer, Martine;
Merkus, Daphne;
Velden, Jolanda

Publication type:

Article

Standardizing submaximal exercise intensities for use of supine push–pull exercise during cardiovascular magnetic resonance.

Published in:

Clinical Physiology & Functional Imaging, 2023, v. 43, n. 1, p. 10, doi. 10.1111/cpf.12784

By:

Steenhorst, Jarno J.;
Hirsch, Alexander;
van den Berg, Linda E. M.;
Kamphuis, Lieke S.;
Merkus, Daphne;
Boersma, Eric;
Helbing, Willem A.

Publication type:

Article

Cardiac remodelling in a swine model of chronic thromboembolic pulmonary hypertension: comparison of right vs. left ventricle.

Published in:

Journal of Physiology, 2019, v. 597, n. 17, p. 4465, doi. 10.1113/JP277896

By:

Stam, Kelly;
Cai, Zongye;
der Velde, Nikki;
Duin, Richard;
Lam, Esther;
der Velden, Jolanda;
Hirsch, Alexander;
Duncker, Dirk J;
Merkus, Daphne

Publication type:

Article

Transition from post‐capillary pulmonary hypertension to combined pre‐ and post‐capillary pulmonary hypertension in swine: a key role for endothelin.

Published in:

Journal of Physiology, 2019, v. 597, n. 4, p. 1157, doi. 10.1113/JP275987

By:

Duin, Richard W. B.;
Stam, Kelly;
Cai, Zongye;
Uitterdijk, André;
Garcia‐Alvarez, Ana;
Ibanez, Borja;
Danser, A. H. Jan;
Reiss, Irwin K. M.;
Duncker, Dirk J.;
Merkus, Daphne

Publication type:

Article

Reduced contribution of endothelin to the regulation of systemic and pulmonary vascular tone in severe familial hypercholesterolaemia.

Published in:

Journal of Physiology, 2014, v. 592, n. 8, p. 1757, doi. 10.1113/jphysiol.2013.267351

By:

Bender, Shawn B.;
Beer, Vincent J.;
Tharp, Darla L.;
Deel, Elza D.;
Bowles, Douglas K.;
Duncker, Dirk J.;
Laughlin, M. Harold;
Merkus, Daphne

Publication type:

Article

'Integrative Physiology 2.0': integration of systems biology into physiology and its application to cardiovascular homeostasis.

Published in:

Journal of Physiology, 2011, v. 589, n. 5, p. 1037, doi. 10.1113/jphysiol.2010.201533

By:

Kuster, Diederik W. D.;
Merkus, Daphne;
van der Velden, Jolanda;
Verhoeven, Adrie J. M.;
Duncker, Dirk J.

Publication type:

Article