Works by Mellon, Pamela L

Results: 33

Deletion of Vax1 from Gonadotropin-Releasing Hormone (GnRH) Neurons Abolishes GnRH Expression and Leads to Hypogonadism and Infertility.

Published in:

Journal of Neuroscience, 2016, v. 36, n. 12, p. 3506, doi. 10.1523/JNEUROSCI.2723-15.2016

By:

Hoffmann, Hanne M.;
Trang, Crystal;
Gong, Ping;
Kimura, Ikuo;
Pandolfi, Erica C.;
Mellon, Pamela L.

Publication type:

Article

A Point Mutation in an Otherwise Dispensable Upstream Fshb Enhancer Moderately Impairs Fertility in Female Mice.

Published in:

Endocrinology, 2025, v. 166, n. 6, p. 1, doi. 10.1210/endocr/bqaf073

By:

Bohaczuk, Stephanie C;
Tonsfeldt, Karen J;
Slaiwa, Theresa I;
Dunn, Geneva A;
Gillette, Dominique L M;
Yeo, Seung E;
Shi, Chengxian;
Cassin, Jessica;
Thackray, Varykina G;
Mellon, Pamela L

Publication type:

Article

Circadian Rhythms in the Neuronal Network Timing the Luteinizing Hormone Surge.

Published in:

Endocrinology, 2022, v. 163, n. 2, p. 1, doi. 10.1210/endocr/bqab268

By:

Tonsfeldt, Karen J;
Mellon, Pamela L;
Hoffmann, Hanne M

Publication type:

Article

Reproductive Deficits Induced by Prenatal Antimüllerian Hormone Exposure Require Androgen Receptor in Kisspeptin Cells.

Published in:

Endocrinology, 2021, v. 162, n. 12, p. 1, doi. 10.1210/endocr/bqab197

By:

Ho, Emily V;
Shi, Chengxian;
Cassin, Jessica;
He, Michelle Y;
Nguyen, Ryan D;
Ryan, Genevieve E;
Tonsfeldt, Karen J;
Mellon, Pamela L

Publication type:

Article

Distal Enhancer Potentiates Activin- and GnRH-Induced Transcription of FSHB.

Published in:

Endocrinology, 2021, v. 162, n. 7, p. 1, doi. 10.1210/endocr/bqab069

By:

Bohaczuk, Stephanie C;
Cassin, Jessica;
Slaiwa, Theresa I;
Thackray, Varykina G;
Mellon, Pamela L

Publication type:

Article

Growth Hormone Pulses and Liver Gene Expression Are Differentially Regulated by the Circadian Clock Gene Bmal1.

Published in:

Endocrinology, 2021, v. 162, n. 4, p. 1, doi. 10.1210/endocr/bqab023

By:

Schoeller, Erica L;
Tonsfeldt, Karen J;
Sinkovich, McKenna;
Shi, Rujing;
Mellon, Pamela L

Publication type:

Article

FSHB Transcription is Regulated by a Novel 5′ Distal Enhancer With a Fertility-Associated Single Nucleotide Polymorphism.

Published in:

Endocrinology, 2021, v. 162, n. 1, p. 1, doi. 10.1210/endocr/bqaa181

By:

Bohaczuk, Stephanie C;
Thackray, Varykina G;
Shen, Jia;
Skowronska-Krawczyk, Dorota;
Mellon, Pamela L

Publication type:

Article

Deletion of the Homeodomain Protein Six6 From GnRH Neurons Decreases GnRH Gene Expression, Resulting in Infertility.

Published in:

Endocrinology, 2019, v. 160, n. 9, p. 2151, doi. 10.1210/en.2019-00113

By:

Pandolfi, Erica C;
Tonsfeldt, Karen J;
Hoffmann, Hanne M;
Mellon, Pamela L

Publication type:

Article

Antiandrogen Treatment Ameliorates Reproductive and Metabolic Phenotypes in the Letrozole-Induced Mouse Model of PCOS.

Published in:

Endocrinology, 2018, v. 159, n. 4, p. 1734, doi. 10.1210/en.2017-03218

By:

Ryan, Genevieve E;
Malik, Shaddy;
Mellon, Pamela L

Publication type:

Article

Haploinsufficiency of Homeodomain Proteins Six3, Vax1, and Otx2 Causes Subfertility in Mice via Distinct Mechanisms.

Published in:

Neuroendocrinology, 2019, v. 109, n. 3, p. 200, doi. 10.1159/000494086

By:

Hoffmann, Hanne M.;
Pandolfi, Erica C.;
Larder, Rachel;
Mellon, Pamela L.

Publication type:

Article

Differential CRE Expression in Lhrh-cre and GnRH-cre Alleles and the Impact on Fertility in Otx2-Flox Mice.

Published in:

Neuroendocrinology, 2019, v. 108, n. 4, p. 328, doi. 10.1159/000497791

By:

Hoffmann, Hanne M.;
Larder, Rachel;
Lee, Jessica S.;
Hu, Rachael J.;
Trang, Crystal;
Devries, Brooke M.;
Clark, Daniel D.;
Mellon, Pamela L.

Publication type:

Article

Orexin A Induces GnRH Gene Expression and Secretion from GT1-7 Hypothalamic GnRH Neurons.

Published in:

Neuroendocrinology, 2006, v. 84, n. 6, p. 353, doi. 10.1159/000098333

By:

Sasson, Ravid;
Dearth, Robert K.;
White, Rachel S.;
Chappell, Patrick E.;
Mellon, Pamela L.

Publication type:

Article

The Insulin-Like Growth Factor System in the GT1-7 GnRH Neuronal Cell Line.

Published in:

Neuroendocrinology, 1999, v. 70, n. 5, p. 353, doi. 10.1159/000054496

By:

Anderson, Richard A.;
Zwain, Ismail H.;
Arroyo, Armando;
Mellon, Pamela L.;
Yen, Samuel S. C.

Publication type:

Article

Activin A Regulation of Gonadotropin-Releasing Hormone Synthesis and Release in vitro.

Published in:

Neuroendocrinology, 1999, v. 70, n. 4, p. 246, doi. 10.1159/000054483

By:

MacConell, Leigh A.;
Lawson, Mark A.;
Mellon, Pamela L.;
Roberts, Veronica J.

Publication type:

Article

Neural Tissue within Anterior Pituitary Tumors Generated by Oncogene Expression in Transgenic Mice.

Published in:

Neuroendocrinology, 1992, v. 56, n. 3, p. 300, doi. 10.1159/000126243

By:

Schechter, Joel;
Windle, Jolene J.;
Stauber, Claudia;
Mellon, Pamela L.

Publication type:

Article

Activin-A Modulates Gonadotropin-Releasing Hormone Secretion from a Gonadotropin-Releasing Hormone-Secreting Neuronal Cell Line.

Published in:

Neuroendocrinology, 1991, v. 54, n. 4, p. 373, doi. 10.1159/000125916

By:

González-Manchón, Consuelo;
Bilezikjian, Louise M.;
Corrigan, Anne Z.;
Mellon, Pamela L.;
Vale, Wylie

Publication type:

Article

Circadian Gene Expression Regulates Pulsatile Gonadotropin-Releasing Hormone (GnRH) Secretory Patterns in the Hypothalamic GnRH-Secreting GT1-7 Cell Line.

Published in:

Journal of Neuroscience, 2003, v. 23, n. 35, p. 11202, doi. 10.1523/JNEUROSCI.23-35-11202.2003

By:

Chappell, Patrick E.;
White, Rachel S.;
Mellon, Pamela L.

Publication type:

Article

Cytogenetic, Genomic, and Functional Characterization of Pituitary Gonadotrope Cell Lines.

Published in:

Journal of the Endocrine Society, 2019, v. 3, n. 5, p. 902, doi. 10.1210/js.2019-00064

By:

Ruf-Zamojski, Frederique;
Ge, Yongchao;
Pincas, Hanna;
Shan, Jidong;
Song, Yinghui;
Hines, Nika;
Kelley, Kevin;
Montagna, Cristina;
Nair, Pranav;
Toufaily, Chirine;
Bernard, Daniel J;
Mellon, Pamela L;
Nair, Venugopalan;
Turgeon, Judith L;
Sealfon, Stuart C

Publication type:

Article

The Contribution of the Circadian Gene Bmal1 to Female Fertility and the Generation of the Preovulatory Luteinizing Hormone Surge.

Published in:

Journal of the Endocrine Society, 2019, v. 3, n. 4, p. 716, doi. 10.1210/js.2018-00228

By:

Tonsfeldt, Karen J;
Schoeller, Erica L;
Brusman, Liza E;
Cui, Laura J;
Lee, Jinkwon;
Mellon, Pamela L

Publication type:

Article

A unique case of combined pituitary hormone deficiency caused by a PROP1 gene mutation (R120C) associated with normal height and absent puberty.

Published in:

Clinical Endocrinology, 2002, v. 57, n. 2, p. 283, doi. 10.1046/j.1365-2265.2002.01550.x

By:

Arroyo, Armando;
Pernasetti, Flavia;
Vasilyev, Vyacheslav V.;
Amato, Paula;
Yen, Samuel S. C.;
Mellon, Pamela L.

Publication type:

Article

A Novel Gonadotropin-Releasing Hormone 1 (Gnrh1) Enhancer-Derived Noncoding RNA Regulates Gnrh1 Gene Expression in GnRH Neuronal Cell Models.

Published in:

PLoS ONE, 2016, v. 11, n. 7, p. 1, doi. 10.1371/journal.pone.0158597

By:

Huang, Polly P.;
Brusman, Liza E.;
Iyer, Anita K.;
Webster, Nicholas J. G.;
Mellon, Pamela L.

Publication type:

Article

The transcription factors SIX3 and VAX1 are required for suprachiasmatic nucleus circadian output and fertility in female mice.

Published in:

Journal of Neuroscience Research, 2021, v. 99, n. 10, p. 2625, doi. 10.1002/jnr.24864

By:

Hoffmann, Hanne M.;
Meadows, Jason D.;
Breuer, Joseph A.;
Yaw, Alexandra M.;
Nguyen, Duong;
Tonsfeldt, Karen J.;
Chin, Austin Y.;
Devries, Brooke M.;
Trang, Crystal;
Oosterhouse, Haley J.;
Lee, Jessica Sora;
Doser, Jeffrey W.;
Gorman, Michael R.;
Welsh, David K.;
Mellon, Pamela L.

Publication type:

Article

Hypothalamic Dysregulation and Infertility in Mice Lacking the Homeodomain Protein Six6.

Published in:

Journal of Neuroscience, 2011, v. 31, n. 2, p. 426, doi. 10.1523/JNEUROSCI.1688-10.2011

By:

Larder, Rachel;
Clark, Daniel D.;
Miller, Nichol L. G.;
Mellon, Pamela L.

Publication type:

Article

Impaired Adrenocorticotropin-Adrenal Axis in Combined Pituitary Hormone Deficiency Caused by a Two-Base Pair Deletion (301–302delAG) in the Prophet of Pit-1 Gene.

Published in:

2000

By:

PERNASETTI, FLAVIA;
TOLEDO, SERGIO P. A.;
VASILYEV, VYACHESLAV V.;
HAYASHIDA, CESAR Y.;
COGAN, JOY D.;
FERRARI, CARMELA;
LOURENÇO, DELMAR M.;
MELLON, PAMELA L.

Publication type:

journal article

AP-2 family members regulate basal and cAMP-induced expression of human chorionic gonadotropin.

Published in:

Nucleic Acids Research, 2000, v. 28, n. 4, p. 1036, doi. 10.1093/nar/28.4.1036

By:

LiCalsi, Cynthia;
Christophe, Sylvie;
Steger, David J.;
Buescher, Marita;
Fischer, Wolfgang;
Mellon, Pamela L.

Publication type:

Article

The transcription factor VAX1 in VIP neurons of the suprachiasmatic nucleus impacts circadian rhythm generation, depressive-like behavior, and the reproductive axis in a sex-specific manner in mice.

Published in:

Frontiers in Endocrinology, 2024, p. 1, doi. 10.3389/fendo.2023.1269672

By:

Van Loh, Brooke M.;
Yaw, Alexandra M.;
Breuer, Joseph A.;
Jackson, Brooke;
Duong Nguyen;
Jang, Krystal;
Ramos, Fabiola;
Ho, Emily V.;
Cui, Laura J.;
Gillette, Dominique L. M.;
Sempere, Lorenzo F.;
Gorman, Michael R.;
Tonsfeldt, Karen J.;
Mellon, Pamela L.;
Hoffmann, Hanne M.

Publication type:

Article

GLUT1-mediated glycolysis supports GnRH-induced secretion of luteinizing hormone from female gonadotropes.

Published in:

Scientific Reports, 2020, v. 10, n. 1, p. 1, doi. 10.1038/s41598-020-69913-z

By:

Nicholas, Dequina A.;
Knight, Vashti S.;
Tonsfeldt, Karen J.;
Terasaka, Tomohiro;
Molinar-Inglis, Olivia;
Stephens, Shannon B. Z.;
Trejo, JoAnn;
Kauffman, Alexander S.;
Mellon, Pamela L.;
Lawson, Mark A.

Publication type:

Article

The Homeodomain Transcription Factors Vax1 and Six6 Are Required for SCN Development and Function.

Published in:

Molecular Neurobiology, 2020, v. 57, n. 2, p. 1217, doi. 10.1007/s12035-019-01781-9

By:

Pandolfi, Erica C.;
Breuer, Joseph A.;
Nguyen Huu, Viet Anh;
Talluri, Tulasi;
Nguyen, Duong;
Lee, Jessica Sora;
Hu, Rachael;
Bharti, Kapil;
Skowronska-Krawczyk, Dorota;
Gorman, Michael R.;
Mellon, Pamela L.;
Hoffmann, Hanne M.

Publication type:

Article

Haploinsufficiency of SIX3 Abolishes Male Reproductive Behavior Through Disrupted Olfactory Development, and Impairs Female Fertility Through Disrupted GnRH Neuron Migration.

Published in:

Molecular Neurobiology, 2018, v. 55, n. 11, p. 8709, doi. 10.1007/s12035-018-1013-0

By:

Pandolfi, Erica C.;
Hoffmann, Hanne M.;
Schoeller, Erica L.;
Gorman, Michael R.;
Mellon, Pamela L.

Publication type:

Article

Stem cell regionalization during olfactory bulb neurogenesis depends on regulatory interactions between Vax1 and Pax6.

Published in:

eLife, 2020, p. 1, doi. 10.7554/eLife.58215

By:

Coré, Nathalie;
Erni, Andrea;
Hoffmann, Hanne M.;
Mellon, Pamela L.;
Saurin, Andrew J.;
Beclin, Christophe;
Cremer, Harold

Publication type:

Article

Aberrant Development of the Suprachiasmatic Nucleus and Circadian Rhythms in Mice Lacking the Homeodomain Protein Six6.

Published in:

Journal of Biological Rhythms, 2013, v. 28, n. 1, p. 15, doi. 10.1177/0748730412468084

By:

Clark, Daniel D.;
Gorman, Michael R.;
Hatori, Megumi;
Meadows, Jason D.;
Panda, Satchidananda;
Mellon, Pamela L.

Publication type:

Article

Necdin, a Prader–Willi syndrome candidate gene, regulates gonadotropin-releasing hormone neurons during development.

Published in:

Human Molecular Genetics, 2009, v. 18, n. 2, p. 248

By:

Miller, Nichol L.G.;
Wevrick, Rachel;
Mellon, Pamela L.

Publication type:

Article

Chromatin status and transcription factor binding to gonadotropin promoters in gonadotrope cell lines.

Published in:

Reproductive Biology & Endocrinology, 2017, v. 15, p. 1, doi. 10.1186/s12958-017-0304-z

By:

Huimin Xie;
Hoffmann, Hanne M.;
Iyer, Anita K.;
Brayman, Melissa J.;
Cindy Ngo;
Sunshine, Mary Jean;
Mellon, Pamela L.

Publication type:

Article