Works by Melki, Ronald

Results: 118

Sequential or Simultaneous Injection of Preformed Fibrils and AAV Overexpression of Alpha-Synuclein Are Equipotent in Producing Relevant Pathology and Behavioral Deficits.

Published in:

Journal of Parkinson's Disease, 2022, v. 12, n. 4, p. 1133, doi. 10.3233/JPD-212555

By:

Negrini, Matilde;
Tomasello, Giuseppe;
Davidsson, Marcus;
Fenyi, Alexis;
Adant, Cécile;
Hauser, Swantje;
Espa, Elena;
Gubinelli, Francesco;
Manfredsson, Fredric P.;
Melki, Ronald;
Heuer, Andreas

Publication type:

Article

Protein Quality Control Pathways at the Crossroad of Synucleinopathies.

Published in:

Journal of Parkinson's Disease, 2020, v. 10, n. 2, p. 369, doi. 10.3233/JPD-191790

By:

De Mattos, Eduardo P.;
Wentink, Anne;
Nussbaum-Krammer, Carmen;
Hansen, Christian;
Bergink, Steven;
Melki, Ronald;
Kampinga, Harm H.

Publication type:

Article

An Efficient Procedure for Removal and Inactivation of Alpha-Synuclein Assemblies from Laboratory Materials.

Published in:

Journal of Parkinson's Disease, 2016, v. 6, n. 1, p. 143, doi. 10.3233/JPD-150691

By:

Bousset, Luc;
Brundin, Patrik;
Böckmann, Anja;
Meierd, Beat;
Melki, Ronald

Publication type:

Article

Role of Different Alpha-Synuclein Strains in Synucleinopathies, Similarities with other Neurodegenerative Diseases.

Published in:

Journal of Parkinson's Disease, 2015, v. 5, n. 2, p. 217, doi. 10.3233/JPD-150543

By:

Melki, Ronald

Publication type:

Article

Die Konformation der Prionendomäne von Sup35: isoliert und im Kontext des Volllängen-Proteins.

Published in:

Angewandte Chemie, 2013, v. 125, n. 48, p. 12974, doi. 10.1002/ange.201304699

By:

Luckgei, Nina;
Schütz, Anne K.;
Bousset, Luc;
Habenstein, Birgit;
Sourigues, Yannick;
Gardiennet, Carole;
Meier, Beat H.;
Melki, Ronald;
Böckmann, Anja

Publication type:

Article

A Native-Like Conformation for the C-Terminal Domain of the Prion Ure2p within its Fibrillar Form.

Published in:

Angewandte Chemie, 2012, v. 124, n. 32, p. 8087, doi. 10.1002/ange.201202093

By:

Habenstein, Birgit;
Bousset, Luc;
Sourigues, Yannick;
Kabani, Mehdi;
Loquet, Antoine;
Meier, Beat H.;
Melki, Ronald;
Böckmann, Anja

Publication type:

Article

Peripheral Inflammation Regulates CNS Immune Surveillance Through the Recruitment of Inflammatory Monocytes Upon Systemic α-Synuclein Administration.

Published in:

Frontiers in Immunology, 2019, p. N.PAG, doi. 10.3389/fimmu.2019.00080

By:

Peralta Ramos, Javier María;
Iribarren, Pablo;
Bousset, Luc;
Melki, Ronald;
Baekelandt, Veerle;
Van der Perren, Anke

Publication type:

Article

Modeling native and seeded Synuclein aggregation and related cellular dysfunctions in dopaminergic neurons derived by a new set of isogenic iPSC lines with SNCA multiplications.

Published in:

Cell Death & Disease, 2022, v. 13, n. 10, p. 1, doi. 10.1038/s41419-022-05330-6

By:

Iannielli, Angelo;
Luoni, Mirko;
Giannelli, Serena Gea;
Ferese, Rosangela;
Ordazzo, Gabriele;
Fossati, Matteo;
Raimondi, Andrea;
Opazo, Felipe;
Corti, Olga;
Prehn, Jochen H. M.;
Gambardella, Stefano;
Melki, Ronald;
Broccoli, Vania

Publication type:

Article

Intranasal administration of α-synuclein preformed fibrils triggers microglial iron deposition in the substantia nigra of Macaca fascicularis.

Published in:

Cell Death & Disease, 2021, v. 12, n. 1, p. 1, doi. 10.1038/s41419-020-03369-x

By:

Guo, Jian-Jun;
Yue, Feng;
Song, Dong-Yan;
Bousset, Luc;
Liang, Xin;
Tang, Jing;
Yuan, Lin;
Li, Wen;
Melki, Ronald;
Tang, Yong;
Chan, Piu;
Guo, Chuang;
Li, Jia-Yi

Publication type:

Article

Further exploration of the conformational space of α-synuclein fibrils: solid-state NMR assignment of a high-pH polymorph.

Published in:

Biomolecular NMR Assignments, 2016, v. 10, n. 1, p. 5, doi. 10.1007/s12104-015-9628-9

By:

Verasdonck, Joeri;
Bousset, Luc;
Gath, Julia;
Melki, Ronald;
Böckmann, Anja;
Meier, Beat H.

Publication type:

Article

Solid-state NMR sequential assignments of the amyloid core of full-length Sup35p.

Published in:

Biomolecular NMR Assignments, 2014, v. 8, n. 2, p. 349, doi. 10.1007/s12104-013-9515-1

By:

Schütz, Anne;
Habenstein, Birgit;
Luckgei, Nina;
Bousset, Luc;
Sourigues, Yannick;
Nielsen, Anders;
Melki, Ronald;
Böckmann, Anja;
Meier, Beat

Publication type:

Article

Solid-state NMR sequential assignments of the amyloid core of Sup35pNM.

Published in:

Biomolecular NMR Assignments, 2014, v. 8, n. 2, p. 365, doi. 10.1007/s12104-013-9518-y

By:

Luckgei, Nina;
Schütz, Anne;
Habenstein, Birgit;
Bousset, Luc;
Sourigues, Yannick;
Melki, Ronald;
Meier, Beat;
Böckmann, Anja

Publication type:

Article

Yet another polymorph of α-synuclein: solid-state sequential assignments.

Published in:

Biomolecular NMR Assignments, 2014, v. 8, n. 2, p. 395, doi. 10.1007/s12104-013-9526-y

By:

Gath, Julia;
Bousset, Luc;
Habenstein, Birgit;
Melki, Ronald;
Meier, Beat;
Böckmann, Anja

Publication type:

Article

Solid-state NMR sequential assignments of α-synuclein.

Published in:

Biomolecular NMR Assignments, 2012, v. 6, n. 1, p. 51, doi. 10.1007/s12104-011-9324-3

By:

Gath, Julia;
Habenstein, Birgit;
Bousset, Luc;
Melki, Ronald;
Meier, Beat;
Böckmann, Anja

Publication type:

Article

Characterization of Monomeric Intermediates during VSV Glycoprotein Structural Transition.

Published in:

PLoS Pathogens, 2012, v. 8, n. 2, p. 1, doi. 10.1371/journal.ppat.1002556

By:

Albertini, Aurélie A.;
Mérigoux, Cécile;
Libersou, Sonia;
Madiona, Karine;
Bressanelli, Stéphane;
Roche, Stéphane;
Lepault, Jean;
Melki, Ronald;
Vachette, Patrice;
Gaudin, Yves

Publication type:

Article

Characterization of the cytoplasmic chaperonin containing TCP-1 from the Antarctic fish Notothenia coriiceps.

Published in:

Extremophiles, 2006, v. 10, n. 6, p. 537, doi. 10.1007/s00792-006-0528-x

By:

Pucciarelli, Sandra;
Parker, Sandra K.;
Detrich III, H.William;
Melki, Ronald

Publication type:

Article

Direct evidence of Parkinson pathology spread from the gastrointestinal tract to the brain in rats.

Published in:

Acta Neuropathologica, 2014, v. 128, n. 6, p. 805, doi. 10.1007/s00401-014-1343-6

By:

Holmqvist, Staffan;
Chutna, Oldriska;
Bousset, Luc;
Aldrin-Kirk, Patrick;
Li, Wen;
Björklund, Tomas;
Wang, Zhan-You;
Roybon, Laurent;
Melki, Ronald;
Li, Jia-Yi

Publication type:

Article

Transfer of human α-synuclein from the olfactory bulb to interconnected brain regions in mice.

Published in:

Acta Neuropathologica, 2013, v. 126, n. 4, p. 555, doi. 10.1007/s00401-013-1160-3

By:

Rey, Nolwen;
Petit, Geraldine;
Bousset, Luc;
Melki, Ronald;
Brundin, Patrik

Publication type:

Article

Altered vacuole membrane protein 1 (VMP1) expression is associated with increased NLRP3 inflammasome activation and mitochondrial dysfunction.

Published in:

Inflammation Research, 2024, v. 73, n. 4, p. 563, doi. 10.1007/s00011-024-01856-x

By:

Zack, Stephanie R.;
Venkatesan, Meghana;
Nikolaienko, Roman;
Cook, Ben;
Melki, Ronald;
Zima, Aleksey V.;
Campbell, Edward M.

Publication type:

Article

2D polarization imaging as a low-cost fluorescence method to detect α-synuclein aggregation ex vivo in models of Parkinson's disease.

Published in:

Communications Biology, 2018, v. 1, n. 1, p. N.PAG, doi. 10.1038/s42003-018-0156-x

By:

Camacho, Rafael;
Täuber, Daniela;
Hansen, Christian;
Shi, Juanzi;
Bousset, Luc;
Melki, Ronald;
Li, Jia-Yi;
Scheblykin, Ivan G.

Publication type:

Article

Neither alpha-synuclein fibril strain nor host murine genotype influences seeding efficacy.

Published in:

NPJ Parkinson's Disease, 2024, v. 10, n. 1, p. 1, doi. 10.1038/s41531-024-00679-1

By:

Walton, Sara;
Fenyi, Alexis;
Tittle, Tyler;
Sidransky, Ellen;
Pal, Gian;
Choi, Solji;
Melki, Ronald;
Killinger, Bryan A.;
Kordower, Jeffrey H.

Publication type:

Article

The interaction of Hsc70 protein with fibrillar αSynuclein and its therapeutic potential in Parkinson disease.

Published in:

Communicative & Integrative Biology, 2012, v. 5, n. 1, p. 94, doi. 10.4161/cib.18483

By:

Pemberton, Samantha;
Melki, Ronald

Publication type:

Article

The 26S Proteasome Degrades the Soluble but Not the Fibrillar Form of the Yeast Prion Ure2p In Vitro.

Published in:

PLoS ONE, 2015, v. 10, n. 6, p. 1, doi. 10.1371/journal.pone.0131789

By:

Wang, Kai;
Redeker, Virginie;
Madiona, Karine;
Melki, Ronald;
Kabani, Mehdi

Publication type:

Article

Ectosomes: A New Mechanism for Non-Exosomal Secretion of Tau Protein.

Published in:

PLoS ONE, 2014, v. 9, n. 6, p. 1, doi. 10.1371/journal.pone.0100760

By:

Dujardin, Simon;
Bégard, Séverine;
Caillierez, Raphaëlle;
Lachaud, Cédrick;
Delattre, Lucie;
Carrier, Sébastien;
Loyens, Anne;
Galas, Marie-Christine;
Bousset, Luc;
Melki, Ronald;
Aurégan, Gwennaëlle;
Hantraye, Philippe;
Brouillet, Emmanuel;
Buée, Luc;
Colin, Morvane

Publication type:

Article

Unlike Twins: An NMR Comparison of Two α-Synuclein Polymorphs Featuring Different Toxicity.

Published in:

PLoS ONE, 2014, v. 9, n. 3, p. 1, doi. 10.1371/journal.pone.0090659

By:

Gath, Julia;
Bousset, Luc;
Habenstein, Birgit;
Melki, Ronald;
Böckmann, Anja;
Meier, Beat H.

Publication type:

Article

The Cytosolic Chaperonin CCT/TRiC and Cancer Cell Proliferation.

Published in:

PLoS ONE, 2013, v. 8, n. 4, p. 1, doi. 10.1371/journal.pone.0060895

By:

Boudiaf-Benmammar, Chafika;
Cresteil, Thierry;
Melki, Ronald

Publication type:

Article

Simultaneous Measurement of Amyloid Fibril Formation by Dynamic Light Scattering and Fluorescence Reveals Complex Aggregation Kinetics.

Published in:

PLoS ONE, 2013, v. 8, n. 1, p. 1, doi. 10.1371/journal.pone.0054541

By:

Streets, Aaron M.;
Sourigues, Yannick;
Kopito, Ron R.;
Melki, Ronald;
Quake, Stephen R.

Publication type:

Article

Polyglutamine Repeats Are Associated to Specific Sequence Biases That Are Conserved among Eukaryotes.

Published in:

PLoS ONE, 2012, v. 7, n. 2, p. 1, doi. 10.1371/journal.pone.0030824

By:

Ramazzotti, Matteo;
Monsellier, Elodie;
Kamoun, Choumouss;
Degl'Innocenti, Donatella;
Melki, Ronald

Publication type:

Article

Qualitative and Quantitative Multiplexed Proteomic Analysis of Complex Yeast Protein Fractions That Modulate the Assembly of the Yeast Prion Sup35p.

Published in:

PLoS ONE, 2011, v. 6, n. 9, p. 1, doi. 10.1371/journal.pone.0023659

By:

Redeker, Virginie;
Hughes, Chris;
Savistchenko, Jimmy;
Vissers, Johannes P. C.;
Melki, Ronald

Publication type:

Article

Structure and Assembly Properties of the N-Terminal Domain of the Prion Ure2p in Isolation and in Its Natural Context.

Published in:

PLoS ONE, 2010, v. 5, n. 3, p. 1, doi. 10.1371/journal.pone.0009760

By:

Bousset, Luc;
Bonnefoy, Jonathan;
Sourigues, Yannick;
Wien, Frank;
Melki, Ronald

Publication type:

Article

Clustering of Tau fibrils impairs the synaptic composition of α3‐Na+/K+‐ATPase and AMPA receptors.

Published in:

EMBO Journal, 2019, v. 38, n. 3, p. N.PAG, doi. 10.15252/embj.201899871

By:

Shrivastava, Amulya Nidhi;
Redeker, Virginie;
Pieri, Laura;
Bousset, Luc;
Renner, Marianne;
Madiona, Karine;
Mailhes‐Hamon, Caroline;
Coens, Audrey;
Buée, Luc;
Hantraye, Philippe;
Triller, Antoine;
Melki, Ronald

Publication type:

Article

Toxic effects of amyloid fibrils on cell membranes: the importance of ganglioside GM1.

Published in:

FASEB Journal, 2012, v. 26, n. 2, p. 818, doi. 10.1096/fj.11-189381

By:

Bucciantini, Monica;
Nosi, Daniele;
Forzan, Mario;
Russo, Edda;
Calamai, Martino;
Pieri, Laura;
Formigli, Lucia;
Quercioli, Franco;
Soria, Silvia;
Pavone, Francesco;
Savistchenko, Jimmy;
Melki, Ronald;
Stefani, Massimo

Publication type:

Article

CONFINE-MAS: a magic-angle spinning NMR probe that confines the sample in case of a rotor explosion.

Published in:

Journal of Biomolecular NMR, 2018, v. 72, n. 3/4, p. 171, doi. 10.1007/s10858-018-0218-x

By:

Wiegand, Thomas;
Hunkeler, Andreas;
Däpp, Alexander;
Verasdonck, Joeri;
Cadalbert, Riccardo;
Bousset, Luc;
Melki, Ronald;
Böckmann, Anja;
Meier, Beat H.

Publication type:

Article

Extensive de novo solid-state NMR assignments of the 33 kDa C-terminal domain of the Ure2 prion.

Published in:

Journal of Biomolecular NMR, 2011, v. 51, n. 3, p. 235, doi. 10.1007/s10858-011-9530-4

By:

Habenstein, Birgit;
Wasmer, Christian;
Bousset, Luc;
Sourigues, Yannick;
Schütz, Anne;
Loquet, Antoine;
Meier, Beat;
Melki, Ronald;
Böckmann, Anja

Publication type:

Article

Disease Mechanisms of Multiple System Atrophy: What a Parallel Between the Form of Pasta and the Alpha-Synuclein Assemblies Involved in MSA and PD Tells Us.

Published in:

Cerebellum, 2024, v. 23, n. 1, p. 13, doi. 10.1007/s12311-022-01417-0

By:

Melki, Ronald

Publication type:

Article

A role for the proteasome in the turnover of Sup35p and in [ PSI+] prion propagation.

Published in:

Molecular Microbiology, 2014, v. 92, n. 3, p. 507, doi. 10.1111/mmi.12572

By:

Kabani, Mehdi;
Redeker, Virginie;
Melki, Ronald

Publication type:

Article

A mutation within the C-terminal domain of Sup35p that affects [ PSI+] prion propagation.

Published in:

Molecular Microbiology, 2011, v. 81, n. 3, p. 640, doi. 10.1111/j.1365-2958.2011.07719.x

By:

Kabani, Mehdi;
Cosnier, Bruno;
Bousset, Luc;
Rousset, Jean-Pierre;
Melki, Ronald;
Fabret, Céline

Publication type:

Article

Overexpression of the calpain-specific inhibitor calpastatin reduces human alpha-Synuclein processing, aggregation and synaptic impairment in [A30P]αSyn transgenic mice.

Published in:

Human Molecular Genetics, 2014, v. 23, n. 15, p. 3975, doi. 10.1093/hmg/ddu112

By:

Diepenbroek, Meike;
Casadei, Nicolas;
Esmer, Hakan;
Saido, Takaomi C.;
Takano, Jiro;
Kahle, Philipp J.;
Nixon, Ralph A;
Rao, Mala V.;
Melki, Ronald;
Pieri, Laura;
Helling, Stefan;
Marcus, Katrin;
Krueger, Rejko;
Masliah, Eliezer;
Riess, Olaf;
Nuber, Silke

Publication type:

Article

LGALS3 (galectin 3) mediates an unconventional secretion of SNCA/α-synuclein in response to lysosomal membrane damage by the autophagic-lysosomal pathway in human midbrain dopamine neurons.

Published in:

Autophagy, 2022, v. 18, n. 5, p. 1020, doi. 10.1080/15548627.2021.1967615

By:

Burbidge, Kevin;
Rademacher, David J.;
Mattick, Jessica;
Zack, Stephanie;
Grillini, Andrea;
Bousset, Luc;
Kwon, Ochan;
Kubicki, Konrad;
Simon, Alexander;
Melki, Ronald;
Campbell, Edward M.

Publication type:

Article

Reactive astrocytes promote proteostasis in Huntington's disease through the JAK2-STAT3 pathway.

Published in:

Brain: A Journal of Neurology, 2023, v. 146, n. 1, p. 149, doi. 10.1093/brain/awac068

By:

Abjean, Laurene;
Haim, Lucile Ben;
Riquelme-Perez, Miriam;
Gipchtein, Pauline;
Derbois, Céline;
Palomares, Marie-Ange;
Petit, Fanny;
Hérard, Anne-Sophie;
Gaillard, Marie-Claude;
Guillermier, Martine;
Gaudin-Guérif, Mylène;
Aurégan, Gwennaëlle;
Sagar, Nisrine;
Héry, Cameron;
Dufour, Noëlle;
Robil, Noémie;
Kabani, Mehdi;
Melki, Ronald;
Grange, Pierre De la;
Bemelmans, Alexis P

Publication type:

Article

Host oligodendrogliopathy and α-synuclein strains dictate disease severity in multiple system atrophy.

Published in:

Brain: A Journal of Neurology, 2023, v. 146, n. 1, p. 237, doi. 10.1093/brain/awac061

By:

Torre-Muruzabal, Teresa;
Perren, Anke Van der;
Coens, Audrey;
Gelders, Géraldine;
Janer, Anna Barber;
Camacho-Garcia, Sara;
Klingstedt, Therése;
Nilsson, Peter;
Stefanova, Nadia;
Melki, Ronald;
Baekelandt, Veerle;
Peelaerts, Wouter

Publication type:

Article

Prying into the Prion Hypothesis for Parkinson's Disease.

Published in:

Journal of Neuroscience, 2017, v. 37, n. 41, p. 9808, doi. 10.1523/JNEUROSCI.1788-16.2017

By:

Brundin, Patrik;
Melki, Ronald

Publication type:

Article

Increased Immune Activation by Pathologic α-Synuclein in Parkinson's Disease.

Published in:

2019

By:

Grozdanov, Veselin;
Bousset, Luc;
Hoffmeister, Meike;
Bliederhaeuser, Corinna;
Meier, Christoph;
Madiona, Karine;
Pieri, Laura;
Kiechle, Martin;
McLean, Pamela J.;
Kassubek, Jan;
Behrends, Christian;
Ludolph, Albert C.;
Weishaupt, Jochen H.;
Melki, Ronald;
Danzer, Karin M.

Publication type:

journal article

α-Synuclein propagates from mouse brain to grafted dopaminergic neurons and seeds aggregation in cultured human cells.

Published in:

2011

By:

Hansen, Christian;
Angot, Elodie;
Bergstrom, Ann-Louise;
Steiner, Jennifer A.;
Pieri, Laura;
Paul, Gesine;
Outeiro, Tiago F.;
Melki, Ronald;
Kallunki, Pekka;
Fog, Karina;
Jia-Yi Li;
Brundin, Patrik;
Bergström, Ann-Louise;
Li, Jia-Yi

Publication type:

journal article

Tunneling nanotube (TNT)-mediated neuron-to neuron transfer of pathological Tau protein assemblies.

Published in:

Acta Neuropathologica Communications, 2016, v. 4, p. 1, doi. 10.1186/s40478-016-0386-4

By:

Tardivel, Meryem;
Bégard, Séverine;
Bousset, Luc;
Dujardin, Simon;
Coens, Audrey;
Melki, Ronald;
Buée, Luc;
Colin, Morvane

Publication type:

Article

Alpha-synuclein spreading in M83 mice brain revealed by detection of pathological α-synuclein by enhanced ELISA.

Published in:

Acta Neuropathologica Communications, 2014, v. 2, n. 1, p. 1, doi. 10.1186/2051-5960-2-29

By:

Bétemps, Dominique;
Verchère, Jérémy;
Brot, Sébastien;
Morignat, Eric;
Bousset, Luc;
Gaillard, Damien;
Lakhdar, Latifa;
Melki, Ronald;
Baron, Thierry

Publication type:

Article

Nanomechanical properties of distinct fibrillar polymorphs of the protein α-synuclein.

Published in:

Scientific Reports, 2016, p. 37970, doi. 10.1038/srep37970

By:

Makky, Ali;
Bousset, Luc;
Polesel-Maris, Jérôme;
Melki, Ronald

Publication type:

Article

Structural and functional properties of prefibrillar α-synuclein oligomers.

Published in:

Scientific Reports, 2016, p. 24526, doi. 10.1038/srep24526

By:

Pieri, Laura;
Madiona, Karine;
Melki, Ronald

Publication type:

Article

α-Synuclein and huntingtin exon 1 amyloid fibrils bind laterally to the cellular membrane.

Published in:

Scientific Reports, 2016, p. 19180, doi. 10.1038/srep19180

By:

Monsellier, Elodie;
Bousset, Luc;
Melki, Ronald

Publication type:

Article

A prolonged chronological lifespan is an unexpected benefit of the [PSI+] prion in yeast.

Published in:

PLoS ONE, 2017, v. 12, n. 9, p. 1, doi. 10.1371/journal.pone.0184905

By:

Wang, Kai;
Melki, Ronald;
Kabani, Mehdi

Publication type:

Article