Works by Melhem, Murad

Results: 25

Bendamustine pharmacokinetic profile and exposure-response relationships in patients with indolent non-Hodgkin's lymphoma.

Published in:

Cancer Chemotherapy & Pharmacology, 2010, v. 66, n. 6, p. 1039, doi. 10.1007/s00280-010-1254-8

By:

Owen, Joel S.;
Melhem, Murad;
Passarell, Julie A.;
D'Andrea, Denise;
Darwish, Mona;
Kahl, Bradley

Publication type:

Article

A bridging assay for detection and characterization of anti-drug antibodies to dostarlimab, a new anti-PD-1 therapeutic monoclonal antibody.

Published in:

AAPS Open, 2021, v. 7, n. 1, p. 1, doi. 10.1186/s41120-021-00045-y

By:

Patterson, Marilyn;
Beausang, Lee Anne;
Rup, Bonita;
Bowsher, Ronald R.;
Krug, Kim;
Melhem, Murad;
Lu, Sharon

Publication type:

Article

A competitive ligand-binding assay for the detection of neutralizing antibodies against dostarlimab (TSR-042).

Published in:

AAPS Open, 2021, v. 7, n. 1, p. 1, doi. 10.1186/s41120-021-00039-w

By:

Zhang, Xiaolong Tom;
Chen, Hong;
Shao, Weiping;
Lin, Zhongping John;
Melhem, Murad;
Lu, Sharon

Publication type:

Article

Clinical Pharmacokinetics and Pharmacodynamics of Etelcalcetide, a Novel Calcimimetic for Treatment of Secondary Hyperparathyroidism in PatientsWith Chronic Kidney Disease on Hemodialysis.

Published in:

Journal of Clinical Pharmacology, 2018, v. 58, n. 6, p. 717, doi. 10.1002/jcph.1090

By:

Wu, Benjamin;
Melhem, Murad;
Subramanian, Raju;
Chen, Ping;
Jaramilla Sloey, Bethlyn;
Fouqueray, Bruno;
Hock, M. Benjamin;
Skiles, Gary L.;
Chow, Andrew T.;
Lee, Edward

Publication type:

Article

Population pharmacokinetics analysis of AMG 416, an allosteric activator of the calcium-sensing receptor, in subjects with secondary hyperparathyroidism receiving hemodialysis.

Published in:

Journal of Clinical Pharmacology, 2015, v. 55, n. 6, p. 620, doi. 10.1002/jcph.460

By:

Chen, Ping;
Melhem, Murad;
Xiao, Jim;
Kuchimanchi, Mita;
Perez Ruixo, Juan Jose

Publication type:

Article

Prediction of Survival Benefit of Filgrastim in Adult and Pediatric Patients With Acute Radiation Syndrome.

Published in:

CTS: Clinical & Translational Science, 2020, v. 13, n. 4, p. 807, doi. 10.1111/cts.12777

By:

Harrold, John;
Gisleskog, Per Olsson;
Perez‐Ruixo, Juan Jose;
Delor, Isabelle;
Chow, Andrew;
Jacqmin, Philippe;
Melhem, Murad

Publication type:

Article

Data standards for model-informed drug development: an ISoP initiative.

Published in:

Journal of Pharmacokinetics & Pharmacodynamics, 2018, v. 45, n. 5, p. 659, doi. 10.1007/s10928-018-9595-8

By:

Radivojevic, Andrijana;
Corrigan, Brian;
Downie, Nicholas;
Fox, Robert;
Fiedler-Kelly, Jill;
Liu, Huan;
Melhem, Murad;
Radke, David;
Schaefer, Peter;
Su, Jing;
Swat, Maciej J.;
Teuscher, Nathan S.;
Thanneer, Neelima;
Zong, Alice;
Wilkins, Justin J.

Publication type:

Article

Drug disposition model of radiolabeled etelcalcetide in patients with chronic kidney disease and secondary hyperparathyroidism on hemodialysis.

Published in:

Journal of Pharmacokinetics & Pharmacodynamics, 2017, v. 44, n. 1, p. 43, doi. 10.1007/s10928-016-9503-z

By:

Wu, Liviawati;
Melhem, Murad;
Subramanian, Raju;
Wu, Benjamin

Publication type:

Article

Perivascular paclitaxel wraps block arteriovenous graft stenosis in a pig model.

Published in:

Nephrology Dialysis Transplantation, 2006, v. 21, n. 9, p. 2425, doi. 10.1093/ndt/gfl250

By:

Burnett Kelly;
Murad Melhem;
Jianhua Zhang;
Gerald Kasting;
Jinsong Li;
Mahesh Krishnamoorthy;
Sue Heffelfinger;
Steven Rudich;
Pankaj Desai;
Prabir Roy-Chaudhury

Publication type:

Article

Tutorial on Conditional Simulations With a Tumor Size‐Overall Survival Model to Support Oncology Drug Development.

Published in:

CPT: Pharmacometrics & Systems Pharmacology, 2025, v. 14, n. 4, p. 640, doi. 10.1002/psp4.70003

By:

Goulooze, Sebastiaan C.;
Muliaditan, Morris;
Franzese, Richard C.;
Mantero, Alejandro;
Visser, Sandra A. G.;
Melhem, Murad;
Post, Teun M.;
Rathi, Chetan;
Struemper, Herbert

Publication type:

Article

Comparative analysis of PD‐1 target engagement of dostarlimab and pembrolizumab in advanced solid tumors using ex vivo IL‐2 stimulation data.

Published in:

CPT: Pharmacometrics & Systems Pharmacology, 2023, v. 12, n. 1, p. 87, doi. 10.1002/psp4.12878

By:

Austin, Daren;
Melhem, Murad;
Gandhi, Yash;
Lu, Sharon;
Visser, Sandra

Publication type:

Article

Receiver Operating Characteristic Analysis and Clinical Trial Simulation to Inform Dose Titration Decisions.

Published in:

CPT: Pharmacometrics & Systems Pharmacology, 2018, v. 7, n. 11, p. 771, doi. 10.1002/psp4.12354

By:

Clements, John David;
Perez Ruixo, Juan Jose;
Gibbs, John P.;
Doshi, Sameer;
Perez Ruixo, Carlos;
Melhem, Murad

Publication type:

Article

Population pharmacokinetics and exposure–response relationships of dostarlimab in primary advanced or recurrent endometrial cancer in part 1 of RUBY.

Published in:

British Journal of Clinical Pharmacology, 2025, v. 91, n. 3, p. 841, doi. 10.1111/bcp.16325

By:

Kuchimanchi, Mita;
Jørgensen, Trine Lembrecht;
Hanze, Eva;
André, Thierry;
Jain, Angela;
Berton, Dominique;
Alskär, Oskar;
Zub, Oleksandr;
Oaknin, Ana;
Shahin, Mark S.;
Koliadi, Anthoula;
Pothuri, Bhavana;
Krivak, Tom;
Pishchyk, Mikalai;
Segev, Yakir;
Backes, Floor J.;
Gennigens, Christine;
Bouberhan, Sara;
Zajic, Stefan;
Melhem, Murad

Publication type:

Article

Dostarlimab, an anti‐programmed death‐1 monoclonal antibody, does not cause QT prolongation in patients with solid tumours: A concentration‐QT analysis.

Published in:

British Journal of Clinical Pharmacology, 2023, v. 89, n. 7, p. 2272, doi. 10.1111/bcp.15700

By:

Kuchimanchi, Mita;
Dabrowski, Christine;
Lu, Sharon;
Melhem, Murad

Publication type:

Article

Population pharmacokinetics and exposure–response of anti‐programmed cell death protein‐1 monoclonal antibody dostarlimab in advanced solid tumours.

Published in:

British Journal of Clinical Pharmacology, 2022, v. 88, n. 9, p. 4142, doi. 10.1111/bcp.15339

By:

Melhem, Murad;
Hanze, Eva;
Lu, Sharon;
Alskär, Oskar;
Visser, Sandra;
Gandhi, Yash

Publication type:

Article

Bridging adults and paediatrics with secondary hyperparathyroidism receiving haemodialysis: a pharmacokinetic‐pharmacodynamic analysis of cinacalcet.

Published in:

British Journal of Clinical Pharmacology, 2019, v. 85, n. 6, p. 1312, doi. 10.1111/bcp.13900

By:

Chen, Ping;
Sohn, Winnie;
Narayanan, Adimoolam;
Gisleskog, Per Olsson;
Melhem, Murad

Publication type:

Article

Pharmacokinetic–pharmacodynamic modelling of neutrophil response to G‐CSF in healthy subjects and patients with chemotherapy‐induced neutropenia.

Published in:

British Journal of Clinical Pharmacology, 2018, v. 84, n. 5, p. 911, doi. 10.1111/bcp.13504

By:

Melhem, Murad;
Delor, Isabelle;
Pérez‐Ruixo, Juan Jose;
Harrold, John;
Chow, Andrew;
Wu, Liviawati;
Jacqmin, Philippe

Publication type:

Article

Population Pharmacokinetic and Pharmacodynamic Modeling of Etelcalcetide in Patients with Chronic Kidney Disease and Secondary Hyperparathyroidism Receiving Hemodialysis.

Published in:

2018

By:

Chen, Ping;
Narayanan, Adimoolam;
Wu, Benjamin;
Gisleskog, Per;
Gibbs, John;
Chow, Andrew;
Melhem, Murad;
Gisleskog, Per Olsson;
Gibbs, John P;
Chow, Andrew T

Publication type:

journal article

Population Pharmacokinetic Analysis for Hydrocodone Following the Administration of Hydrocodone Bitartrate Extended-Release Capsules.

Published in:

Clinical Pharmacokinetics, 2013, v. 52, n. 10, p. 907, doi. 10.1007/s40262-013-0081-6

By:

Melhem, Murad;
Rubino, Christopher;
Farr, Stephen;
Robinson, Cynthia

Publication type:

Article

Mathematical modeling of herpes simplex virus-2 suppression with pritelivir predicts trial outcomes.

Published in:

Science Translational Medicine, 2016, v. 8, n. 324, p. 1, doi. 10.1126/scitranslmed.aad6654

By:

Schiffer, Joshua T.;
Swan, David A.;
Magaret, Amalia;
Corey, Lawrence;
Wald, Anna;
Ossig, Joachim;
Ruebsamen-Schaeff, Helga;
Stoelben, Susanne;
Timmler, Burkhard;
Zimmermann, Holger;
Melhem, Murad R.;
Van Wart, Scott A.;
Rubino, Christopher M.;
Birkmann, Alexander

Publication type:

Article

Quantification of Radiation Injury on Neutropenia and the Link between Absolute Neutrophil Count Time Course and Overall Survival in Nonhuman Primates Treated with G-CSF.

Published in:

Pharmaceutical Research, 2020, v. 37, n. 6, p. 1, doi. 10.1007/s11095-020-02839-3

By:

Harrold, John;
Gisleskog, Per Olsson;
Delor, Isabelle;
Jacqmin, Philippe;
Perez-Ruixo, Juan Jose;
Narayanan, Adimoolam;
Doshi, Sameer;
Chow, Andrew;
Yang, Bing-Bing;
Melhem, Murad

Publication type:

Article

Dose Optimization in Oncology Drug Development: An International Consortium for Innovation and Quality in Pharmaceutical Development White Paper.

Published in:

Clinical Pharmacology & Therapeutics, 2024, v. 116, n. 3, p. 531, doi. 10.1002/cpt.3298

By:

Samineni, Divya;
Venkatakrishnan, Karthik;
Othman, Ahmed A.;
Pithavala, Yazdi K.;
Poondru, Srinivasu;
Patel, Chirag;
Vaddady, Pavan;
Ankrom, Wendy;
Ramanujan, Saroja;
Budha, Nageshwar;
Wu, Michael;
Haddish‐Berhane, Nahor;
Fritsch, Holger;
Hussain, Azher;
Kanodia, Jitendra;
Li, Meng;
Li, Mengyao;
Melhem, Murad;
Parikh, Apurvasena;
Upreti, Vijay V.

Publication type:

Article

Quantitation of the impact of CYP3A5 A6986G polymorphism on quetiapine pharmacokinetics by simulation of target attainment.

Published in:

Clinical Pharmacology in Drug Development, 2015, v. 4, n. 5, p. 387, doi. 10.1002/cpdd.172

By:

Shilbayeh, Sireen A.R.;
Sy, Sherwin K.B.;
Melhem, Murad;
Zmeili, Rawan;
Derendorf, Hartmut

Publication type:

Article

Development of a Local Perivascular Paclitaxel Delivery System for Hemodialysis Vascular Access Dysfunction: Polymer Preparation and in vitroActivity.

Published in:

Blood Purification, 2006, v. 24, n. 3, p. 289, doi. 10.1159/000091346

By:

Murad Melhem;
Burnett Kelly;
Jianhua Zhang;
Gerald Kasting;
Jinsong Li;
Harold Davis;
Sue Heffelfinger;
Pankaj Desai;
Prabir Roy-Chaudhury

Publication type:

Article

Novel Therapies for Hemodialysis Vascular Access Dysfunction: Fact or Fiction!

Published in:

Blood Purification, 2005, v. 23, n. 1, p. 29, doi. 10.1159/000082008

By:

Roy-Chaudhury, Prabir;
Kelly, Burnett S.;
Melhem, Murad;
Zhang, Jianhua;
Li, Jinsong;
Desai, Pankaj;
Munda, Rino;
Heffelfinger, Sue C.

Publication type:

Article