Works by Megson, Ian

Results: 51

Mechanism of action of novel NO-releasing furoxan derivatives of aspirin in human platelets.

Published in:

British Journal of Pharmacology, 2006, v. 148, n. 4, p. 517, doi. 10.1038/sj.bjp.0706743

By:

Turnbull, Catriona M.;
Cena, Clara;
Fruttero, Roberta;
Gasco, Alberto;
Rossi, Adriano G;
Megson, Ian L.

Publication type:

Article

Sildenafil offers protection against NSAID-induced gastric injury.

Published in:

British Journal of Pharmacology, 2005, v. 146, n. 4, p. 477, doi. 10.1038/sj.bjp.0706362

By:

Sawatzky, Deborah A.;
Megson, Ian L.;
Rossi, Adriano G.

Publication type:

Article

A potential role for extracellular nitric oxide generation in cGMP-independent inhibition of human platelet aggregation: biochemical and pharmacological considerations.

Published in:

British Journal of Pharmacology, 2005, v. 144, n. 6, p. 849, doi. 10.1038/sj.bjp.0706110

By:

Crane, Michael S.;
Rossi, Adriano G.;
Megson, Ian L.

Publication type:

Article

GEA 3162 decomposes to co-generate nitric oxide and superoxide and induces apoptosis in human neutrophils via a peroxynitrite-dependent mechanism.

Published in:

British Journal of Pharmacology, 2004, v. 143, n. 1, p. 179, doi. 10.1038/sj.bjp.0705909

By:

Taylor, Emma L.;
Rossi, Adriano G.;
Shaw, Catherine A.;
Dal Rio, Francesco P.;
Haslett, Christopher;
Megson, Ian L.

Publication type:

Article

S-Nitrosothiols cause prolonged, nitric oxide-mediated relaxation in human saphenous vein and internal mammary artery: therapeutic potential in bypass surgery.

Published in:

British Journal of Pharmacology, 2000, v. 131, n. 6, p. 1236, doi. 10.1038/sj.bjp.0703700

By:

Sogo, Naoki;
Campanella, Ciro;
Webb, David J;
Megson, Ian L

Publication type:

Article

Inducible nitric oxide synthase-derived superoxide contributes to hypereactivity in small mesenteric arteries from a rat model of chronic heart failure.

Published in:

British Journal of Pharmacology, 2000, v. 131, n. 1, p. 29, doi. 10.1038/sj.bjp.0703528

By:

Miller, Alyson A;
Megson, Ian L;
Gray, Gillian A

Publication type:

Article

In vivo speciation studies and antioxidant properties of bromine in Laminaria digitata reinforce the significance of iodine accumulation for kelps.

Published in:

Journal of Experimental Botany, 2013, v. 64, n. 10, p. 2653, doi. 10.1093/jxb/ert110

By:

Küpper, Frithjof C.;
Carpenter, Lucy J.;
Leblanc, Catherine;
Toyama, Chiaki;
Uchida, Yuka;
Maskrey, Benjamin H.;
Robinson, Joanne;
Verhaeghe, Elodie F.;
Malin, Gill;
Luther, George W.;
Kroneck, Peter M. H.;
Kloareg, Bernard;
Meyer-Klaucke, Wolfram;
Muramatsu, Yasuyuki;
Megson, Ian L.;
Potin, Philippe;
Feiters, Martin C.

Publication type:

Article

Intermittent exposure of cultured endothelial cells to physiologically relevant fructose concentrations has a profound impact on nitric oxide production and bioenergetics.

Published in:

PLoS ONE, 2022, v. 17, n. 5, p. 1, doi. 10.1371/journal.pone.0267675

By:

Fiorello, Maria Luisa;
Treweeke, Andrew T.;
Macfarlane, David P.;
Megson, Ian L.

Publication type:

Article

Does oxidative stress contribute to toxicity in acute organophosphorus poisoning? – a systematic review of the evidence.

Published in:

Clinical Toxicology (15563650), 2020, v. 58, n. 6, p. 437, doi. 10.1080/15563650.2019.1693589

By:

Rambabu, Lekaashree;
Megson, Ian L.;
Eddleston, Michael

Publication type:

Article

Risk factors and mechanisms of anaphylactoid reactions to acetylcysteine in acetaminophen overdose.

Published in:

Clinical Toxicology (15563650), 2008, v. 46, n. 8, p. 697, doi. 10.1080/15563650802245497

By:

Pakravan, Nasrin;
Waring, W. Stephen;
Sharma, Sushma;
Ludlam, Christopher;
Megson, Ian;
Bateman, D. Nicholas

Publication type:

Article

Acetylcysteine has No Mechanistic Effect in Patients at Risk of Contrast‐Induced Nephropathy: A Failure of Academic Clinical Science.

Published in:

Clinical Pharmacology & Therapeutics, 2022, v. 111, n. 6, p. 1222, doi. 10.1002/cpt.2541

By:

Sandilands, Euan A.;
Rees, Jessica M. B.;
Raja, Khuram;
Dhaun, Neeraj;
Morrison, Emma E.;
Hickson, Kirsty;
Wraight, Jonathan;
Gray, Tanya;
Briody, Lesley;
Cameron, Sharon;
Thompson, Adrian P.;
Johnston, Neil R.;
Uren, Neal;
Goddard, Jane;
Treweeke, Andy;
Rushworth, Gordon;
Webb, David J.;
Bateman, D. Nicholas;
Norrie, John;
Megson, Ian L.

Publication type:

Article

Curcumin Restores Corticosteroid Function in Monocytes Exposed to Oxidants by Maintaining HDAC2.

Published in:

American Journal of Respiratory Cell & Molecular Biology, 2008, v. 39, n. 3, p. 312, doi. 10.1165/rcmb.2008-0012OC

By:

Meja, Koremu K.;
Rajendrasozhan, Saravanan;
Adenuga, David;
Biswas, Saibal K.;
Sundar, Isaac K.;
Spooner, Gillian;
Marwick, John A.;
Chakravarty, Probir;
Fletcher, Danielle;
Whittaker, Paul;
Megson, Ian L.;
Kirkham, Paul A.;
Rahman, Irfan

Publication type:

Article

Food Intake and Dietary Glycaemic Index in Free-Living Adults with and without Type 2 Diabetes Mellitus.

Published in:

2011

By:

McGeoch, Susan C.;
Holtrop, Grietje;
Fyfe, Claire;
Lobley, Gerald E.;
Pearson, Donald W. M.;
Abraham, Prakash;
Megson, Ian L.;
MacRury, Sandra M.;
Johnstone, Alexandra M.

Publication type:

Journal Article

A genetic study of the NOS3 gene for ischemic stroke in a Chinese population.

Published in:

International Journal of General Medicine, 2008, v. 1, p. 65

By:

Danhua Du;
Peng Gao;
Linsen Hu;
Yumei Yang;
Feng Wang;
Lin Ye;
Xuan Zhang;
Ming Chang;
Jiexu Zhao;
Jiang Wu;
Megson, Ian L.;
Jun Wei

Publication type:

Article

Associations between circulating IgG antibodies to Apolipoprotein B<sub>100</sub>-derived peptide antigens and acute coronary syndrome in a Chinese Han population.

Published in:

Bioscience Reports, 2018, v. 38, n. 6, p. 1, doi. 10.1042/BSR20180450

By:

Weina Hu;
Xueying Zhang;
Yunan Han;
Yong Wang;
Mingming Lei;
Megson, Ian L.;
Jun Wei;
Yuanzhe Jin

Publication type:

Article

SILAC-based quantitative proteomics to investigate the eicosanoid associated inflammatory response in activated macrophages.

Published in:

Journal of Inflammation, 2022, v. 19, n. 1, p. 1, doi. 10.1186/s12950-022-00309-8

By:

Brace, Nicole;
Megson, Ian L.;
Rossi, Adriano G.;
Doherty, Mary K.;
Whitfield, Phillip D.

Publication type:

Article

12-hydroxyeicosatetraenoic acid is associated with variability in aspirin-induced platelet inhibition.

Published in:

Journal of Inflammation, 2014, v. 11, n. 1, p. 1, doi. 10.1186/s12950-014-0033-4

By:

Maskrey, Benjamin H.;
Rushworth, Gordon F.;
Law, Matthew H.;
Treweeke, Andrew T.;
Jun Wei;
Leslie, Stephen J.;
Megson, Ian L.;
Whitfield, Phillip D.

Publication type:

Article

Clearance of dying cells and autoimmunity.

Published in:

Autoimmunity, 2007, v. 40, n. 4, p. 267, doi. 10.1080/08916930701357208

By:

Michlewska, Sylwia;
McColl, Aisleen;
Rossi, Adriano G;
Megson, Ian L;
Dransfield, Ian

Publication type:

Article

Iodixanol Has a Favourable Fibrinolytic Profile Compared to Iohexol in Cardiac Patients Undergoing Elective Angiography: A Double-Blind, Randomized, Parallel Group Study.

Published in:

PLoS ONE, 2016, v. 11, n. 1, p. 1, doi. 10.1371/journal.pone.0147196

By:

Treweeke, Andrew T.;
Maskrey, Benjamin H.;
Hickson, Kirsty;
Miller, John H.;
Leslie, Stephen J.;
Megson, Ian L.

Publication type:

Article

Nitric Oxide and the Mechanism of Rat Vascular Smooth Muscle Photorelaxation.

Published in:

Journal of Physiology, 2003, v. 550, n. 3, p. 819, doi. 10.1113/jphysiol.2003.041970

By:

Flitney, Frederick Werner;
Megson, Ian L.

Publication type:

Article

Bioactive polyphenols and cardiovascular disease: chemical antagonists, pharmacological agents or xenobiotics that drive an adaptive response?

Published in:

2017

By:

Goszcz, Katarzyna;
Duthie, Garry G;
Stewart, Derek;
Leslie, Stephen J;
Megson, Ian L

Publication type:

journal article

Principal component and causal analysis of structural and acute in vitro toxicity data for nanoparticles.

Published in:

Nanotoxicology, 2014, v. 8, n. 5, p. 465, doi. 10.3109/17435390.2013.796534

By:

Wang, Xue Z.;
Yang, Yang;
Li, Ruifa;
Mcguinnes, Catherine;
Adamson, Janet;
Megson, Ian L.;
Donaldson, Kenneth

Publication type:

Article

Surface functionalization affects the zeta potential, coronal stability and membranolytic activity of polymeric nanoparticles.

Published in:

Nanotoxicology, 2014, v. 8, n. 2, p. 202, doi. 10.3109/17435390.2013.773465

By:

Cho, Wan-Seob;
Thielbeer, Frank;
Duffin, Rodger;
Johansson, Emma M. V.;
Megson, Ian L.;
MacNee, William;
Bradley, Mark;
Donaldson, Ken

Publication type:

Article

Differential pro-inflammatory effects of metal oxide nanoparticles and their soluble ions in vitro and in vivo; zinc and copper nanoparticles, but not their ions, recruit eosinophils to the lungs.

Published in:

Nanotoxicology, 2012, v. 6, n. 1, p. 22, doi. 10.3109/17435390.2011.552810

By:

Cho, Wan-Seob;
Duffin, Rodger;
Poland, Craig A.;
Duschl, Albert;
Oostingh, Gertie Janneke;
MacNee, William;
Bradley, Mark;
Megson, Ian L.;
Donaldson, Ken

Publication type:

Article

A novel S-nitrosothiol causes prolonged and selective inhibition of platelet adhesion at sites of vascular injury

Published in:

Cardiovascular Research, 2003, v. 57, n. 3, p. 853, doi. 10.1016/S0008-6363(02)00779-4

By:

Miller, Mark R.;
Hanspal, Inderraj S.;
Hadoke, Patrick W.F.;
Newby, David E.;
Rossi, Adriano G.;
Webb, David J.;
Megson, Ian L.

Publication type:

Article

Bioavailable Concentrations of Delphinidin and Its Metabolite, Gallic Acid, Induce Antioxidant Protection Associated with Increased Intracellular Glutathione in Cultured Endothelial Cells.

Published in:

Oxidative Medicine & Cellular Longevity, 2017, p. 1, doi. 10.1155/2017/9260701

By:

Goszcz, Katarzyna;
Deakin, Sherine J.;
Duthie, Garry G.;
Stewart, Derek;
Megson, Ian L.

Publication type:

Article

Oat-enriched diet reduces inflammatory status assessed by circulating cell-derived microparticle concentrations in type 2 diabetes.

Published in:

Molecular Nutrition & Food Research, 2014, v. 58, n. 6, p. 1322, doi. 10.1002/mnfr.201300820

By:

Zhang, Xuguang;
McGeoch, Susan C.;
Megson, Ian L.;
MacRury, Sandra M.;
Johnstone, Alexandra M.;
Abraham, Prakash;
Pearson, Donald W. M.;
Roos, Baukje;
Holtrop, Grietje;
O'Kennedy, Niamh;
Lobley, Gerald E.

Publication type:

Article

Emerging importance of omega-3 fatty acids in the innate immune response: Molecular mechanisms and lipidomic strategies for their analysis.

Published in:

Molecular Nutrition & Food Research, 2013, v. 57, n. 8, p. 1390, doi. 10.1002/mnfr.201200723

By:

Maskrey, Benjamin H.;
Megson, Ian L.;
Rossi, Adriano G.;
Whitfield, Phillip D.

Publication type:

Article

Platelet-derived microparticle count and surface molecule expression differ between subjects with and without type 2 diabetes, independently of obesity status.

Published in:

Journal of Thrombosis & Thrombolysis, 2014, v. 37, n. 4, p. 455, doi. 10.1007/s11239-013-1000-2

By:

Zhang, Xuguang;
McGeoch, Susan;
Johnstone, Alexandra;
Holtrop, Grietje;
Sneddon, Alan;
MacRury, Sandra;
Megson, Ian;
Pearson, Donald;
Abraham, Prakash;
Roos, Baukje;
Lobley, Gerald;
O'Kennedy, Niamh

Publication type:

Article

Zeta Potential and Solubility to Toxic Ions as Mechanisms of Lung Inflammation Caused by Metal/Metal Oxide Nanoparticles.

Published in:

Toxicological Sciences, 2012, v. 126, n. 2, p. 469, doi. 10.1093/toxsci/kfs006

By:

Cho, Wan-Seob;
Duffin, Rodger;
Thielbeer, Frank;
Bradley, Mark;
Megson, Ian L.;
MacNee, William;
Poland, Craig A.;
Tran, C. Lang;
Donaldson, Ken

Publication type:

Article

Surface Derivatization State of Polystyrene Latex Nanoparticles Determines both Their Potency and Their Mechanism of Causing Human Platelet Aggregation In Vitro.

Published in:

Toxicological Sciences, 2011, v. 119, n. 2, p. 359, doi. 10.1093/toxsci/kfq349

By:

McGuinnes, Catherine;
Duffin, Rodger;
Brown, Simon;
L. Mills, Nicholas;
Megson, Ian L.;
MacNee, William;
Johnston, Shonna;
Lu, Sen Lin;
Tran, Lang;
Li, Rufia;
Wang, Xue;
Newby, David E.;
Donaldson, Ken

Publication type:

Article

To clot or not to clot? That is a free radical question.

Published in:

Journal of Physiology, 2018, v. 596, n. 20, p. 4805, doi. 10.1113/JP276786

By:

Crabtree, Daniel R.;
Muggeridge, David;
Leslie, Stephen J.;
Megson, Ian L.;
Cobley, James N.

Publication type:

Article

Predictive value of in vitro assays depends on the mechanism of toxicity of metal oxide nanoparticles.

Published in:

Particle & Fibre Toxicology, 2013, v. 10, n. 1, p. 1, doi. 10.1186/1743-8977-10-55

By:

Wan-Seob Cho;
Duffin, Rodger;
Bradley, Mark;
Megson, Ian L.;
MacNee, William;
Jong Kwon Lee;
Jayoung Jeong;
Donaldson, Ken

Publication type:

Article

Detection of circulating IgG antibodies to apolipoprotein B100 in acute myocardial infarction.

Published in:

FEBS Open Bio, 2015, v. 5, p. 712, doi. 10.1016/j.fob.2015.08.006

By:

Zhang, Xueying;
Zhang, Xiaohong;
Lei, Mingming;
Lin, Yingzi;
Megson, Ian L.;
Wei, Jun;
Yu, Bo;
Jin, Yuanzhe

Publication type:

Article

Simultaneous Gas Storage and Catalytic Gas Production Using Zeolites—A New Concept for Extending Lifetime Gas Delivery.

Published in:

Topics in Catalysis, 2009, v. 52, n. 1/2, p. 35, doi. 10.1007/s11244-008-9137-5

By:

Boës, Astrid-Karla;
Bo Xiao;
Megson, Ian;
Morris, Russell

Publication type:

Article

Co-ingestion of Antioxidant Drinks With an Unhealthy Challenge Meal Fails to Prevent Post-prandial Endothelial Dysfunction: An Open-Label, Crossover Study in Older Overweight Volunteers.

Published in:

Frontiers in Physiology, 2019, p. 1, doi. 10.3389/fphys.2019.01293

By:

Muggeridge, David J.;
Goszcz, Katarzyna;
Treweeke, Andrew;
Adamson, Janet;
Hickson, Kirsty;
Crabtree, Daniel;
Megson, Ian L.

Publication type:

Article

Macrophage phagocytosis of apoptotic neutrophils is critically regulated by the opposing actions of pro-inflammatory and anti-inflammatory agents: key role for TNF-α.

Published in:

FASEB Journal, 2009, v. 23, n. 3, p. 844, doi. 10.1096/fj.08-121228

By:

Michlewska, Sylwia;
Dransfield, Ian;
Megson, Ian L.;
Rossi, Adriano G.

Publication type:

Article

Cyclic GMP protects human macrophages against peroxynitrite-induced apoptosis.

Published in:

Journal of Inflammation, 2009, v. 6, p. 1, doi. 10.1186/1476-9255-6-14

By:

Shaw, Catherine A.;
Webb, David J.;
Rossi, Adriano G.;
Megson, Ian L.

Publication type:

Article

A novel hybrid aspirin-NO-releasing compound inhibits TNFalpha release from LPS-activated human monocytes and macrophages.

Published in:

Journal of Inflammation, 2008, v. 5, p. 1, doi. 10.1186/1476-9255-5-12

By:

Turnbull, Catriona M.;
Marcarino, Paolo;
Sheldrake, Tara A.;
Lazzarato, Loretta;
Cena, Clara;
Fruttero, Roberta;
Gasco, Alberto;
Fox, Sarah;
Megson, Ian L.;
Rossi, Adriano G.

Publication type:

Article

A novel electron paramagnetic resonance-based assay for prostaglandin H synthase-1 activity.

Published in:

Journal of Inflammation, 2006, v. 3, p. 12, doi. 10.1186/1476-9255-3-12

By:

Turnbull, Catriona M.;
McClure, Danny;
Rossi, Adriano G.;
Megson, Ian L.

Publication type:

Article

The impact of glucose exposure on bioenergetics and function in a cultured endothelial cell model and the implications for cardiovascular health in diabetes.

Published in:

Scientific Reports, 2020, v. 10, n. 1, p. N.PAG, doi. 10.1038/s41598-020-76505-4

By:

Fiorello, Maria Luisa;
Treweeke, Andrew T.;
Macfarlane, David P.;
Megson, Ian L.

Publication type:

Article

2-arachidonyl glycerol activates platelets via conversion to arachidonic acid and not by direct activation of cannabinoid receptors.

Published in:

British Journal of Clinical Pharmacology, 2010, v. 70, n. 2, p. 180, doi. 10.1111/j.1365-2125.2010.03697.x

By:

Keown, Oliver P.;
Winterburn, Timothy J.;
Wainwright, Cherry L.;
Macrury, Sandra M.;
Neilson, Ilene;
Barrett, Fiona;
Leslie, Stephen J.;
Megson, Ian L.

Publication type:

Article

The 2011 Survey on Hypertensive Disorders of Pregnancy (HDP) in China: Prevalence, Risk Factors, Complications, Pregnancy and Perinatal Outcomes.

Published in:

PLoS ONE, 2014, v. 9, n. 6, p. 1, doi. 10.1371/journal.pone.0100180

By:

Ye, Chun;
Ruan, Yan;
Zou, Liying;
Li, Guanghui;
Li, Changdong;
Chen, Yi;
Jia, Chaoxia;
Megson, Ian L.;
Wei, Jun;
Zhang, Weiyuan

Publication type:

Article

Association between Exposure to Environmental Tobacco Smoke and Biomarkers of Oxidative Stress Among Patients Hospitalised with Acute Myocardial Infarction.

Published in:

PLoS ONE, 2013, v. 8, n. 12, p. 1, doi. 10.1371/journal.pone.0081209

By:

Megson, Ian L.;
Haw, Sally J.;
Newby, David E.;
Pell, Jill P.

Publication type:

Article

Direct Impairment of Vascular Function by Diesel Exhaust Particulate through Reduced Bioavailability of Endothelium-Derived Nitric Oxide Induced by Superoxide Free Radicals.

Published in:

Environmental Health Perspectives, 2009, v. 117, n. 4, p. 611, doi. 10.1289/ehp.0800235

By:

Miller, Mark R.;
Borthwick, Stephen J.;
Shaw, Catherine A.;
McLean, Steven G.;
McClure, Daniel;
Mills, Nicholas L.;
Duffin, Rodger;
Donaldson, Ken;
Megson, Ian L.;
Hadoke, Patrick W. F.;
Newby, David E.

Publication type:

Article

A study of IgG antibodies to the ApoB protein in non-ST segment elevation acute coronary syndrome.

Published in:

Scandinavian Cardiovascular Journal, 2015, v. 49, n. 3, p. 136, doi. 10.3109/14017431.2015.1023344

By:

Zhang, Xueying;
Yu, Bo;
Jin, Yuanzhe;
Lei, Mingming;
Zhang, Xiaohong;
Duan, Zhiying;
Lin, Yingzi;
Megson, Ian L.;
Wei, Jun

Publication type:

Article

A novel S-nitrosothiol (RIG200) causes prolonged relaxation in dorsal hand veins with damaged endothelium<sup>*</sup>.

Published in:

Clinical Pharmacology & Therapeutics, 2000, v. 68, n. 1, p. 75, doi. 10.1067/mcp.2000.107049

By:

Sogo, Naoki;
Wilkinson, Ian B.;
MacCallum, Helen;
Khan, Sohail Q.;
Strachan, Fiona E.;
Newby, David E.;
Megson, Ian L.;
Webb, David J.

Publication type:

Article

Search for schizophrenia susceptibility variants at the HLA-DRB1 locus among a British population.

Published in:

Immunogenetics, 2013, v. 65, n. 1, p. 1, doi. 10.1007/s00251-012-0652-y

By:

Halley, Lorna;
Doherty, Mary;
Megson, Ian;
McNamara, Neil;
Gadja, Andy;
Wei, Jun

Publication type:

Article

Col4a1 mutation in mice causes defects in vascular function and low blood pressure associated with reduced red blood cell volume.

Published in:

Human Molecular Genetics, 2010, v. 19, n. 6, p. 1119, doi. 10.1093/hmg/ddp584

By:

Van Agtmael, Tom;
Bailey, Matthew A.;
Schlötzer-Schrehardt, Ursula;
Craigie, Eilidh;
Jackson, Ian J.;
Brownstein, David G.;
Megson, Ian L.;
Mullins, John J.

Publication type:

Article

Endothelial cell oxidative stress in diabetes: a key driver of cardiovascular complications?

Published in:

Biochemical Society Transactions, 2014, v. 42, n. 4, p. 928, doi. 10.1042/BST20140113

By:

Shaw, Andrew;
Doherty, Mary K.;
Mutch, Nicola J.;
MacRury, Sandra M.;
Megson, Ian L.

Publication type:

Article