Works by Medina, Igor

Results: 29

Editorial: SLC12A5-dependent neurological disorders.

Published in:

2025

By:

Medina, Igor;
McTague, Amy;
Di Scala, Coralie;
Rivera, Claudio

Publication type:

Editorial

A novel pathogenic SLC12A5 missense variant in epilepsy of infancy with migrating focal seizures causes impaired KCC2 chloride extrusion.

Published in:

Frontiers in Molecular Neuroscience, 2024, p. 1, doi. 10.3389/fnmol.2024.1372662

By:

Järvelä, Viivi;
Hamze, Mira;
Komulainen-Ebrahim, Jonna;
Rahikkala, Elisa;
Piispala, Johanna;
Kallio, Mika;
Kangas, Salla M.;
Nickl, Tereza;
Huttula, Marko;
Hinttala, Reetta;
Uusimaa, Johanna;
Medina, Igor;
Immonen, Esa-Ville

Publication type:

Article

A Rodada Uruguai e a África: Uma Crítica à Abordagem Liberal do Regime de Comércio.

Published in:

Contexto Internacional, 2014, v. 36, n. 2, p. 385, doi. 10.1590/S0102-85292014000200003

By:

Medina de Souza, Igor Abdalla

Publication type:

Article

Change in the shape and density of dendritic spines caused by overexpression of acidic calponin in cultured hippocampal neurons.

Published in:

Hippocampus, 2006, v. 16, n. 2, p. 183, doi. 10.1002/hipo.20145

By:

Rami, Guillaume;
Caillard, Olivier;
Medina, Igor;
Pellegrino, Christophe;
Fattoum, Abdellatif;
Ben-Ari, Yezekiel;
Ferhat, Lotfi

Publication type:

Article

Maturation of kainate-induced epileptiform activities in interconnected intact neonatal limbic structures in vitro.

Published in:

European Journal of Neuroscience, 1999, v. 11, n. 10, p. 3468, doi. 10.1046/j.1460-9568.1999.00768.x

By:

Khalilov, Ilgam;
Dzhala, Volodymyr;
Medina, Igor;
Leinekugel, Xavier;
Melyan, Zara;
Lamsa, Karri;
Khazipov, Roustem;
Ben‐Ari, Yehezkel

Publication type:

Article

Calcium-dependent inactivation of the monosynaptic NMDA EPSCs in rat hippocampal neurons in culture.

Published in:

European Journal of Neuroscience, 1999, v. 11, n. 7, p. 2422, doi. 10.1046/j.1460-9568.1999.00664.x

By:

Medina, Igor;
Leinekugel, Xavier;
Ben‐Ari, Yehezkel

Publication type:

Article

Mobilization of intracellular calcium stores participates in the rise of [Ca2+]i and the toxic actions of the HIV coat protein GP120.

Published in:

European Journal of Neuroscience, 1999, v. 11, n. 4, p. 1167, doi. 10.1046/j.1460-9568.1999.00550.x

By:

Medina, Igor;
Ghose, Sraboni;
Ben‐Ari, Yehezkel

Publication type:

Article

Pro-Brain-Derived Neurotrophic Factor Inhibits GABAergic Neurotransmission by Activating Endocytosis and Repression of GABAA Receptors.

Published in:

Journal of Neuroscience, 2014, v. 34, n. 40, p. 13516, doi. 10.1523/JNEUROSCI.2069-14.2014

By:

Riffault, Baptiste;
Medina, Igor;
Dumon, Camille;
Thalman, Carine;
Ferrand, Nadine;
Friedel, Perrine;
Jean-Luc Gaiarsa;
Porcher, Christophe

Publication type:

Article

K+/Cl- cotransporter 2 (KCC2) and Na+/HCO-3 cotransporter 1 (NBCe1) interaction modulates profile of KCC2 phosphorylation.

Published in:

Frontiers in Cellular Neuroscience, 2023, p. 1, doi. 10.3389/fncel.2023.1253424

By:

Pethe, Abhishek;
Hamze, Mira;
Giannaki, Marina;
Heimrich, Bernd;
Medina, Igor;
Hartmann, Anna-Maria;
Roussa, Eleni

Publication type:

Article

Contribution of Smoothened Receptor Signaling in GABAergic Neurotransmission and Chloride Homeostasis in the Developing Rodent Brain.

Published in:

Frontiers in Physiology, 2021, v. 12, p. 1, doi. 10.3389/fphys.2021.798066

By:

Hamze, Mira;
Medina, Igor;
Delmotte, Quentin;
Porcher, Christophe

Publication type:

Article

Molecular cloning and biochemical characterization of two cation chloride cotransporter subfamily members of Hydra vulgaris.

Published in:

PLoS ONE, 2017, v. 12, n. 6, p. 1, doi. 10.1371/journal.pone.0179968

By:

Hartmann, Anna-Maria;
Pisella, Lucie I.;
Medina, Igor;
Nothwang, Hans Gerd

Publication type:

Article

Structure, G Protein Activation, and Functional Relevance of the Cardiac G Protein-Gated K+ Channel, IKACh.

Published in:

Annals of the New York Academy of Sciences, 1999, v. 868, n. 1, p. 386, doi. 10.1111/j.1749-6632.1999.tb11300.x

By:

WICKMAN, KEVIN;
KRAPIVINSKY, GRIGORY;
COREY, SHAWN;
KENNEDY, MATT;
NEMEC, JAN;
MEDINA, IGOR;
CLAPHAM, DAVID E.

Publication type:

Article

KCC2 regulates actin dynamics in dendritic spines via interaction with β-PIX.

Published in:

Journal of Cell Biology, 2015, v. 209, n. 5, p. 671, doi. 10.1083/jcb.201411008

By:

Llano, Olaya;
Smirnov, Sergey;
Soni, Shetal;
Golubtsov, Andrey;
Guillemin, Isabelle;
Hotulainen, Pirta;
Medina, Igor;
Gerd Nothwang, Hans;
Rivera, Claudio;
Ludwig, Anastasia

Publication type:

Article

Knocking down of the KCC2 in rat hippocampal neurons increases intracellular chloride concentration and compromises neuronal survival.

Published in:

Journal of Physiology, 2011, v. 589, n. 10, p. 2475, doi. 10.1113/jphysiol.2010.203703

By:

Pellegrino, Christophe;
Gubkina, Olena;
Schaefer, Michael;
Becq, Hélène;
Ludwig, Anastasia;
Mukhtarov, Marat;
Chudotvorova, Ilona;
Corby, Severine;
Salyha, Yuriy;
Salozhin, Sergey;
Bregestovski, Piotr;
Medina, Igor

Publication type:

Article

Opposing role of synaptic and extrasynaptic NMDA receptors in regulation of the extracellular signal-regulated kinases (ERK) activity in cultured rat hippocampal neurons.

Published in:

Journal of Physiology, 2006, v. 572, n. 3, p. 789, doi. 10.1113/jphysiol.2006.105510

By:

Ivanov, Anton;
Pellegrino, Christophe;
Rama, Sylvain;
Dumalska, Iryna;
Salyha, Yuriy;
Ben-Ari, Yehezkel;
Medina, Igor

Publication type:

Article

Early expression of KCC2 in rat hippocampal cultures augments expression of functional GABA synapses.

Published in:

Journal of Physiology, 2005, v. 566, n. 3, p. 671, doi. 10.1113/jphysiol.2005.089821

By:

Chudotvorova, Ilona;
Ivanov, Anton;
Rama, Sylvain;
Hübner, Christian A.;
Pellegrino, Christophe;
Ben-Ari, Yehezkel;
Medina, Igor

Publication type:

Article

Back-propagating action potential.

Published in:

Communicative & Integrative Biology, 2008, v. 1, n. 2, p. 153, doi. 10.4161/cib.1.2.7058

By:

Kuczewski, Nicola;
Porcher, Cristophe;
Lessmann, Volkmar;
Medina, Igor;
Gaiarsa, Jean-Luc

Publication type:

Article

Leptin increases GABAergic synaptogenesis through the Rho guanine exchange factor β-PIX in developing hippocampal neurons.

Published in:

Science Signaling, 2021, v. 14, n. 683, p. 1, doi. 10.1126/scisignal.abe4111

By:

Sahin, Gulcan Semra;
Luis Rodriguez-Llamas, Jose;
Dillon, Crystal;
Medina, Igor;
Appleyard, Suzanne M.;
Gaiarsa, Jean-Luc;
Wayman, Gary A.

Publication type:

Article

Mechanism of BDNF Modulation in GABAergic Synaptic Transmission in Healthy and Disease Brains.

Published in:

Frontiers in Cellular Neuroscience, 2018, p. N.PAG, doi. 10.3389/fncel.2018.00273

By:

Porcher, Christophe;
Medina, Igor;
Gaiarsa, Jean-Luc

Publication type:

Article

Regulation of Neuronal Chloride Homeostasis by Pro- and Mature Brain-Derived Neurotrophic Factor (BDNF) via KCC2 Cation–Chloride Cotransporters in Rat Cortical Neurons.

Published in:

International Journal of Molecular Sciences, 2024, v. 25, n. 11, p. 6253, doi. 10.3390/ijms25116253

By:

Hamze, Mira;
Brier, Cathy;
Buhler, Emmanuelle;
Zhang, Jinwei;
Medina, Igor;
Porcher, Christophe

Publication type:

Article

Impaired regulation of KCC2 phosphorylation leads to neuronal network dysfunction and neurodevelopmental pathology.

Published in:

Science Signaling, 2019, v. 12, n. 603, p. 1, doi. 10.1126/scisignal.aay0300

By:

Pisella, Lucie I.;
Gaiarsa, Jean-Luc;
Diabira, Diabé;
Zhang, Jinwei;
Khalilov, Ilgam;
Duan, JingJing;
Kahle, Kristopher T.;
Medina, Igor

Publication type:

Article

WNK1-regulated inhibitory phosphorylation of the KCC2 cotransporter maintains the depolarizing action of GABA in immature neurons.

Published in:

Science Signaling, 2015, v. 8, n. 383, p. 1, doi. 10.1126/scisignal.aaa0354

By:

Friedel, Perrine;
Kahle, Kristopher T.;
Jinwei Zhang;
Hertz, Nicholas;
Pisella, Lucie I.;
Buhler, Emmanuelle;
Schaller, Fabienne;
JingJing Duan;
Khanna, Arjun R.;
Bishop, Paul N.;
Shokat, Kevan M.;
Medina, Igor

Publication type:

Article

Activity-Dependent Dendritic Release of BDNF and Biological Consequences.

Published in:

Molecular Neurobiology, 2009, v. 39, n. 1, p. 37, doi. 10.1007/s12035-009-8050-7

By:

Kuczewski, Nicola;
Porcher, Christophe;
Lessmann, Volkmar;
Medina, Igor;
Gaiarsa, Jean-Luc

Publication type:

Article

Backpropagating Action Potentials Trigger Dendritic Release aof BDNF during Spontaneous Network Activity.

Published in:

Journal of Neuroscience, 2008, v. 28, n. 27, p. 7013, doi. 10.1523/JNEUROSCI.1673-08.2008

By:

Kuczewski, Nicola;
Porcher, Christophe;
Ferrand, Nadine;
Fiorentino, Hervé;
Pellegrino, Christophe;
Kolarow, Richard;
Lessmann, Volkmar;
Medina, Igor;
Gaiarsa, Jean-Luc

Publication type:

Article

The Power of Law or the Law of Power? A Critique of the Liberal Approach to the Dispute Settlement Understanding.

Published in:

Meridiano 47 - Boletim de Análise de Conjuntura em Relações Internacionais, 2015, v. 16, n. 150, p. 34, doi. 10.20889/M47e16022

By:

Medina de Souza, Igor Abdalla

Publication type:

Article

Staurosporine and NEM mainly impair WNK-SPAK/OSR1 mediated phosphorylation of KCC2 and NKCC1.

Published in:

PLoS ONE, 2020, v. 15, n. 5, p. 1, doi. 10.1371/journal.pone.0232967

By:

Zhang, Jinwei;
Cordshagen, Antje;
Medina, Igor;
Nothwang, Hans Gerd;
Wisniewski, Jacek R.;
Winklhofer, Michael;
Hartmann, Anna-Maria

Publication type:

Article

Expression of Nocardia brasiliensis superoxide dismutase during the early infection of murine peritoneal macrophages.

Published in:

Canadian Journal of Microbiology, 2006, v. 52, n. 12, p. 1255, doi. 10.1139/W06-075

By:

Revol, Agnès;
Espinoza-Ruiz, Marisol;
Medina-Villanueva, Igor;
Salinas-Carmona, Mario Cesar

Publication type:

Article

AAV-mediated expression of wild-type and ALS-linked mutant VAPB selectively triggers death of motoneurons through a Ca2+-dependent ER-associated pathway.

Published in:

Journal of Neurochemistry, 2010, v. 114, n. 3, p. 795, doi. 10.1111/j.1471-4159.2010.06806.x

By:

Langou, Karine;
Moumen, Anice;
Pellegrino, Christophe;
Aebischer, Julianne;
Medina, Igor;
Aebischer, Patrick;
Raoul, Cédric

Publication type:

Article

Characterization in Cultured Cerebellar Granule Cells and in the Developing Rat Brain of mRNA Variants for the NMDA Receptor 2C Subunit.

Published in:

Journal of Neurochemistry, 2000, v. 74, n. 5, p. 1798, doi. 10.1046/j.1471-4159.2000.0741798.x

By:

Rafiki, Amina;
Bernard, Anne;
Medina, Igor;
Gozlan, Henri;
Khrestchatisky, Michael

Publication type:

Article

Works by Medina, Igor

Editorial: SLC12A5-dependent neurological disorders.

A novel pathogenic SLC12A5 missense variant in epilepsy of infancy with migrating focal seizures causes impaired KCC2 chloride extrusion.

A Rodada Uruguai e a África: Uma Crítica à Abordagem Liberal do Regime de Comércio.

Change in the shape and density of dendritic spines caused by overexpression of acidic calponin in cultured hippocampal neurons.

Maturation of kainate-induced epileptiform activities in interconnected intact neonatal limbic structures in vitro.

Calcium-dependent inactivation of the monosynaptic NMDA EPSCs in rat hippocampal neurons in culture.

Mobilization of intracellular calcium stores participates in the rise of [Ca<sup>2+</sup>]<sub>i</sub> and the toxic actions of the HIV coat protein GP120.

Pro-Brain-Derived Neurotrophic Factor Inhibits GABAergic Neurotransmission by Activating Endocytosis and Repression of GABA<sub>A</sub> Receptors.

K<sup>+</sup>/Cl<sup>-</sup> cotransporter 2 (KCC2) and Na<sup>+</sup>/HCO<sup>-</sup><sub>3</sub> cotransporter 1 (NBCe1) interaction modulates profile of KCC2 phosphorylation.

Contribution of Smoothened Receptor Signaling in GABAergic Neurotransmission and Chloride Homeostasis in the Developing Rodent Brain.

Molecular cloning and biochemical characterization of two cation chloride cotransporter subfamily members of Hydra vulgaris.

Structure, G Protein Activation, and Functional Relevance of the Cardiac G Protein-Gated K<sup>+</sup> Channel, I<sub>KACh</sub>.

KCC2 regulates actin dynamics in dendritic spines via interaction with β-PIX.

Knocking down of the KCC2 in rat hippocampal neurons increases intracellular chloride concentration and compromises neuronal survival.

Opposing role of synaptic and extrasynaptic NMDA receptors in regulation of the extracellular signal-regulated kinases (ERK) activity in cultured rat hippocampal neurons.

Early expression of KCC2 in rat hippocampal cultures augments expression of functional GABA synapses.

Back-propagating action potential.

Leptin increases GABAergic synaptogenesis through the Rho guanine exchange factor β-PIX in developing hippocampal neurons.

Mechanism of BDNF Modulation in GABAergic Synaptic Transmission in Healthy and Disease Brains.

Regulation of Neuronal Chloride Homeostasis by Pro- and Mature Brain-Derived Neurotrophic Factor (BDNF) via KCC2 Cation–Chloride Cotransporters in Rat Cortical Neurons.

Impaired regulation of KCC2 phosphorylation leads to neuronal network dysfunction and neurodevelopmental pathology.

WNK1-regulated inhibitory phosphorylation of the KCC2 cotransporter maintains the depolarizing action of GABA in immature neurons.

Activity-Dependent Dendritic Release of BDNF and Biological Consequences.

Backpropagating Action Potentials Trigger Dendritic Release aof BDNF during Spontaneous Network Activity.

The Power of Law or the Law of Power? A Critique of the Liberal Approach to the Dispute Settlement Understanding.

Staurosporine and NEM mainly impair WNK-SPAK/OSR1 mediated phosphorylation of KCC2 and NKCC1.

Expression of Nocardia brasiliensis superoxide dismutase during the early infection of murine peritoneal macrophages.

AAV-mediated expression of wild-type and ALS-linked mutant VAPB selectively triggers death of motoneurons through a Ca<sup>2+</sup>-dependent ER-associated pathway.

Characterization in Cultured Cerebellar Granule Cells and in the Developing Rat Brain of mRNA Variants for the NMDA Receptor 2C Subunit.