OpenURL Connection Search

Select item for more details and to access through your institution.

In vitro and in vivo characterization of NK3 receptors in the rabbit eye by use of selective non-peptide NK3 receptor antagonists.
Published in:
1997
By:
- Medhurst, Andrew D.;
- Hay, Douglas W. P.;
- Parsons, Andrew A.;
- Martin, Lenox D.;
- Griswold, Don E.;
- Medhurst, A D;
- Hay, D W;
- Parsons, A A;
- Martin, L D;
- Griswold, D E
Publication type:
journal article
hrIL-8-Induced Hyperresponsiveness in Guinea Pig Perfused Lungs.
Published in:
Annals of the New York Academy of Sciences, 1991, v. 629, n. 1, p. 419, doi. 10.1111/j.1749-6632.1991.tb38003.x
By:
- MEDHURST, A. D.;
- WESTWICK, J.;
- PIPER, P. J.
Publication type:
Article
Kinetic modification of the α1I subunit-mediated T-type Ca2+ channel by a human neuronal Ca2+ channel γ subunit.
Published in:
Journal of Physiology, 2001, v. 533, n. 2, p. 467, doi. 10.1111/j.1469-7793.2001.0467a.x
By:
- Green, P. J.;
- Warre, R.;
- Hayes, P. D.;
- McNaughton, N. C. L.;
- Medhurst, A. D.;
- Pangalos, M.;
- Duckworth, D. M.;
- Randall, A. D.
Publication type:
Article
Characterization of SB-269970-A, a selective 5-HT7 receptor antagonist.
Published in:
British Journal of Pharmacology, 2000, v. 130, n. 3, p. 539, doi. 10.1038/sj.bjp.0703357
By:
- Hagan, Jim J;
- Price, Gary W;
- Jeffrey, Phillip;
- Deeks, Nigel J;
- Stean, Tania;
- Piper, David;
- Smith, Martin I;
- Upton, Neil;
- Medhurst, Andrew D;
- Middlemiss, Derek N;
- Riley, Graham J;
- Lovell, Peter J;
- Bromidge, Steven M;
- Thomas, David R
Publication type:
Article
Molecular and pharmacological characterization of a functional tachykinin NK3 receptor cloned from the rabbit iris sphincter muscle.
Published in:
British Journal of Pharmacology, 1999, v. 128, n. 3, p. 627, doi. 10.1038/sj.bjp.0702854
By:
- Medhurst, Andrew D;
- Hirst, Warren D;
- Jerman, Jeffery C;
- Meakin, Jacqueline;
- Roberts, Jennifer C;
- Testa, Tania;
- Smart, Darren
Publication type:
Article
Characterization of NK3 receptors in rabbit isolated iris sphincter muscle.
Published in:
1997
By:
- Medhurst, A D;
- Parsons, A A;
- Roberts, J C;
- Hay, D W
Publication type:
journal article
P4-327: Effects of the novel 5-HT6 SB-742457 antagonist and the cholinesterase inhibitor donepezil in models of cognition
Published in:
2008
By:
- Ray, Alison M.;
- Hirst, Warren D.;
- Ahmed, Mahmood;
- Johnson, Christopher N.;
- Witty, David R.;
- Sunter, David;
- Quinn, Leann P.;
- Stean, Tania O.;
- Trail, Brenda K.;
- Foley, Andrew;
- Upton, Neil;
- Medhurst, Andrew D.;
- Chuang, Tsu T.
Publication type:
Abstract
IC-P-124: Pharmacological MRI of H3 receptor antagonist GSK189254 in the rat brain
Published in:
2006
By:
- Cash, Diana;
- Tilling, Lorna;
- Barjat, Herve;
- Debnam, Allison;
- Njeri, Catherine J.;
- Briggs, Mike A.;
- Roberts, Jenny C.;
- Irving, Elaine A.;
- Medhurst, Andy D.;
- Williams, Steve C.R.;
- Upton, Neil;
- James, Michael F.
Publication type:
Abstract
P4-387: 5-HT6 receptor antagonist SB-742457 as a novel cognitive enhancing agent for Alzheimer’s disease
Published in:
2006
By:
- Chuang, Aaron T.T.;
- Foley, Andrew;
- Pugh, Perdita L.;
- Sunter, David;
- Tong, Xin;
- Regan, Ciaran;
- Dawson, Lee A.;
- Medhurst, Andrew D.;
- Upton, Neil
Publication type:
Abstract
P3-426: An analysis of spatial, functional and species differences in C-terminal splice variants of the 5-HT4 serotonin receptor
Published in:
2006
By:
- Calver, Andy R.;
- Ray, Alison M.;
- Davis, Robert P.;
- Qian, Ying X.;
- Benson, Bill G.;
- Medhurst, Andy D.
Publication type:
Abstract
P1-447: Pharmacological MRI of H3 receptor antagonist GSK189254 in the rat brain
Published in:
2006
By:
- Cash, Diana;
- Tilling, Lorna;
- Barjat, Herve;
- Debnam, Allison;
- Njeri, Catherine J.;
- Briggs, Mike A.;
- Roberts, Jenny C.;
- Medhurst, Andy D.;
- Irving, Elaine A.;
- Williams, Steve C.R.;
- Upton, Neil;
- James, Michael F.
Publication type:
Abstract
O3-05-01: GSK189254 - a novel H3 receptor antagonist that binds to H3 receptors in the human brain and improves cognitive performance in preclinical models
Published in:
2006
By:
- Medhurst, Andrew D.;
- Crook, Barry;
- Ociepka, Sandrine;
- Davies, Robert P.;
- Calver, Andrew;
- Ray, Alison;
- Stean, Tania;
- Trail, Brenda;
- Wadsworth, Graham;
- Brackenborough, Kim;
- Davis, Rebecca K.;
- Gonzalez, M. Isabel;
- Virley, David;
- Smith, Martin;
- Roberts, Jennifer;
- Ahmed, Sharlin;
- Heslop, Teresa;
- Schogger, Joanne;
- White, Trevor;
- Briggs, Michael
Publication type:
Abstract
IC-P-124: Pharmacological MRI of H3 receptor antagonist GSK189254 in the rat brain
Published in:
2006
By:
- Cash, Diana;
- Tilling, Lorna;
- Barjat, Herve;
- Debnam, Allison;
- Njeri, Catherine J.;
- Briggs, Mike A.;
- Roberts, Jenny C.;
- Irving, Elaine A.;
- Medhurst, Andy D.;
- Williams, Steve C.R.;
- Upton, Neil;
- James, Michael F.
Publication type:
Abstract
P4-387: 5-HT6 receptor antagonist SB-742457 as a novel cognitive enhancing agent for Alzheimer’s disease
Published in:
2006
By:
- Chuang, Aaron T.T.;
- Foley, Andrew;
- Pugh, Perdita L.;
- Sunter, David;
- Tong, Xin;
- Regan, Ciaran;
- Dawson, Lee A.;
- Medhurst, Andrew D.;
- Upton, Neil
Publication type:
Abstract
P3-426: An analysis of spatial, functional and species differences in C-terminal splice variants of the 5-HT4 serotonin receptor
Published in:
2006
By:
- Calver, Andy R.;
- Ray, Alison M.;
- Davis, Robert P.;
- Qian, Ying X.;
- Benson, Bill G.;
- Medhurst, Andy D.
Publication type:
Abstract
P1-447: Pharmacological MRI of H3 receptor antagonist GSK189254 in the rat brain
Published in:
2006
By:
- Cash, Diana;
- Tilling, Lorna;
- Barjat, Herve;
- Debnam, Allison;
- Njeri, Catherine J.;
- Briggs, Mike A.;
- Roberts, Jenny C.;
- Medhurst, Andy D.;
- Irving, Elaine A.;
- Williams, Steve C.R.;
- Upton, Neil;
- James, Michael F.
Publication type:
Abstract
O3-05-01: GSK189254 - a novel H3 receptor antagonist that binds to H3 receptors in the human brain and improves cognitive performance in preclinical models
Published in:
2006
By:
- Medhurst, Andrew D.;
- Crook, Barry;
- Ociepka, Sandrine;
- Davies, Robert P.;
- Calver, Andrew;
- Ray, Alison;
- Stean, Tania;
- Trail, Brenda;
- Wadsworth, Graham;
- Brackenborough, Kim;
- Davis, Rebecca K.;
- Gonzalez, M. Isabel;
- Virley, David;
- Smith, Martin;
- Roberts, Jennifer;
- Ahmed, Sharlin;
- Heslop, Teresa;
- Schogger, Joanne;
- White, Trevor;
- Briggs, Michael
Publication type:
Abstract
H3 Receptor Antagonism Enhances NCAM PSA-Mediated Plasticity and Improves Memory Consolidation in Odor Discrimination and Delayed Match-to-Position Paradigms.
Published in:
Neuropsychopharmacology, 2009, v. 34, n. 12, p. 2585, doi. 10.1038/npp.2009.89
By:
- Foley, Andrew G;
- Prendergast, Alison;
- Barry, Claire;
- Scully, Darren;
- Upton, Neil;
- Medhurst, Andrew D;
- Regan, Ciaran M
Publication type:
Article
11C-GSK189254: A Selective Radioligand for In Vivo Central Nervous System Imaging of Histamine H3 Receptors by PET.
Published in:
Journal of Nuclear Medicine, 2009, v. 50, n. 12, p. 2064, doi. 10.2967/jnumed.109.062919
By:
- Plisson, Christophe;
- Gunn, Roger N.;
- Cunningham, Vincent J.;
- Bender, Dirk;
- Salinas, Cristian A.;
- Medhurst, Andrew D.;
- Roberts, Jennifer C.;
- Laruelle, Marc;
- Gee, Antony D.
Publication type:
Article
Differential effects of acute and repeat dosing with the H3 antagonist GSK189254 on the sleep-wake cycle and narcoleptic episodes in Ox-/- mice.
Published in:
2009
By:
- Guo, R. X.;
- Anaclet, C.;
- Roberts, J. C.;
- Parmentier, R.;
- Zhang, M.;
- Guidon, G.;
- Buda, C.;
- Sastre, J. P.;
- Feng, J. Q.;
- Franco, P.;
- Brown, S. H.;
- Upton, N.;
- Medhurst, A. D.;
- Lin, J. S.
Publication type:
journal article
Characterization of histamine H3 receptors in Alzheimer's Disease brain and amyloid over-expressing TASTPM mice.
Published in:
2009
By:
- Medhurst, A. D.;
- Roberts, J. C.;
- Lee, J.;
- Chen, C. P. L.-H.;
- Brown, S. H.;
- Roman, S.;
- Lai, M. K. P.
Publication type:
journal article
The PPARgamma agonist pioglitazone is effective in the MPTP mouse model of Parkinson's disease through inhibition of monoamine oxidase B.
Published in:
2008
By:
- Quinn, L. P.;
- Crook, B.;
- Hows, M. E.;
- Vidgeon-Hart, M.;
- Chapman, H.;
- Upton, N.;
- Medhurst, A. D.;
- Virley, D. J.
Publication type:
journal article
Heterogeneity of histaminergic neurons in the tuberomammillary nucleus of the rat.
Published in:
European Journal of Neuroscience, 2009, v. 29, n. 12, p. 2363, doi. 10.1111/j.1460-9568.2009.06765.x
By:
- Giannoni, Patrizia;
- Passani, Maria‐Beatrice;
- Nosi, Daniele;
- Chazot, Paul L.;
- Shenton, Fiona C.;
- Medhurst, Andrew D.;
- Munari, Leonardo;
- Blandina, Patrizio
Publication type:
Article
MPTP treatment of common marmosets impairs proteasomal enzyme activity and decreases expression of structural and regulatory elements of the 26S proteasome.
Published in:
European Journal of Neuroscience, 2006, v. 23, n. 7, p. 1766, doi. 10.1111/j.1460-9568.2006.04718.x
By:
- Zeng, B‐Y.;
- Iravani, M. M.;
- Lin, S‐T.;
- Irifune, M.;
- Kuoppamäki, M.;
- Al‐Barghouthy, G.;
- Smith, L.;
- Jackson, M. J.;
- Rose, S.;
- Medhurst, A. D.;
- Jenner, P.
Publication type:
Article
PNEUMOCONIOSIS IN IRON AND STEEL FOUNDRY WORKERS.
Published in:
Canadian Medical Association Journal, 1957, v. 76, n. 5, p. 414
By:
- MEDHURST, J. D.
Publication type:
Article
MULTIPHASIC SCREENING.
Published in:
Canadian Medical Association Journal, 1956, v. 74, n. 11, p. 925
By:
- MEDHURST, J. D.
Publication type:
Article
SILICOSIS IN ONTARIO.
Published in:
Canadian Medical Association Journal, 1955, v. 73, n. 10, p. 842
By:
- MEDHURST, J. D.
Publication type:
Article
Relationship between microglial activation and dopaminergic neuronal loss in the substantia nigra: a time course study in a 6-hydroxydopamine model of Parkinson’s disease.
Published in:
Journal of Neurochemistry, 2009, v. 110, n. 3, p. 966, doi. 10.1111/j.1471-4159.2009.06189.x
By:
- Marinova-Mutafchieva, Lilia;
- Sadeghian, Mona;
- Broom, Lauren;
- Davis, John B.;
- Medhurst, Andrew D.;
- Dexter, David T.
Publication type:
Article
Pharmacological and immunohistochemical characterization of the APJ receptor and its endogenous ligand apelin.
Published in:
Journal of Neurochemistry, 2003, v. 84, n. 5, p. 1162, doi. 10.1046/j.1471-4159.2003.01587.x
By:
- Medhurst, Andrew D.;
- Jennings, Carol A.;
- Robbins, Melanie J.;
- Davis, Robert P.;
- Ellis, Catherine;
- Winborn, Kim Y.;
- Lawrie, Kenneth W. M.;
- Hervieu, Guillaume;
- Riley, Graham;
- Bolaky, Jane E.;
- Herrity, Nicole C.;
- Murdock, Paul;
- Darker, John G.
Publication type:
Article

Found: 29

In vitro and in vivo characterization of NK3 receptors in the rabbit eye by use of selective non-peptide NK3 receptor antagonists.

hrIL-8-Induced Hyperresponsiveness in Guinea Pig Perfused Lungs.

Kinetic modification of the α<sub>1I</sub> subunit-mediated T-type Ca<sup>2+</sup> channel by a human neuronal Ca<sup>2+</sup> channel γ subunit.

Characterization of SB-269970-A, a selective 5-HT<sub>7</sub> receptor antagonist.

Molecular and pharmacological characterization of a functional tachykinin NK<sub>3</sub> receptor cloned from the rabbit iris sphincter muscle.

Characterization of NK3 receptors in rabbit isolated iris sphincter muscle.

P4-327: Effects of the novel 5-HT<sub>6</sub> SB-742457 antagonist and the cholinesterase inhibitor donepezil in models of cognition

IC-P-124: Pharmacological MRI of H3 receptor antagonist GSK189254 in the rat brain

P4-387: 5-HT<sub>6</sub> receptor antagonist SB-742457 as a novel cognitive enhancing agent for Alzheimer’s disease

P3-426: An analysis of spatial, functional and species differences in C-terminal splice variants of the 5-HT4 serotonin receptor

P1-447: Pharmacological MRI of H3 receptor antagonist GSK189254 in the rat brain

O3-05-01: GSK189254 - a novel H3 receptor antagonist that binds to H3 receptors in the human brain and improves cognitive performance in preclinical models

IC-P-124: Pharmacological MRI of H3 receptor antagonist GSK189254 in the rat brain

P4-387: 5-HT<sub>6</sub> receptor antagonist SB-742457 as a novel cognitive enhancing agent for Alzheimer’s disease

P3-426: An analysis of spatial, functional and species differences in C-terminal splice variants of the 5-HT4 serotonin receptor

P1-447: Pharmacological MRI of H3 receptor antagonist GSK189254 in the rat brain

O3-05-01: GSK189254 - a novel H3 receptor antagonist that binds to H3 receptors in the human brain and improves cognitive performance in preclinical models

H<sub>3</sub> Receptor Antagonism Enhances NCAM PSA-Mediated Plasticity and Improves Memory Consolidation in Odor Discrimination and Delayed Match-to-Position Paradigms.

<sup>11</sup>C-GSK189254: A Selective Radioligand for In Vivo Central Nervous System Imaging of Histamine H<sub>3</sub> Receptors by PET.

Differential effects of acute and repeat dosing with the H3 antagonist GSK189254 on the sleep-wake cycle and narcoleptic episodes in Ox-/- mice.

Characterization of histamine H3 receptors in Alzheimer's Disease brain and amyloid over-expressing TASTPM mice.

The PPARgamma agonist pioglitazone is effective in the MPTP mouse model of Parkinson's disease through inhibition of monoamine oxidase B.

Heterogeneity of histaminergic neurons in the tuberomammillary nucleus of the rat.

MPTP treatment of common marmosets impairs proteasomal enzyme activity and decreases expression of structural and regulatory elements of the 26S proteasome.

PNEUMOCONIOSIS IN IRON AND STEEL FOUNDRY WORKERS.

MULTIPHASIC SCREENING.

SILICOSIS IN ONTARIO.

Relationship between microglial activation and dopaminergic neuronal loss in the substantia nigra: a time course study in a 6-hydroxydopamine model of Parkinson’s disease.

Pharmacological and immunohistochemical characterization of the APJ receptor and its endogenous ligand apelin.