Works matching AU McDonald, Neil Q.

Results: 25

The Mycobacterium tuberculosis ino1 gene is essential for growth and virulence.

Published in:

Molecular Microbiology, 2004, v. 51, n. 4, p. 1003, doi. 10.1046/j.1365-2958.2003.03900.x

By:

Movahedzadeh, Farahnaz;
Smith, Debbie A.;
Norman, Richard A.;
Dinadayala, Premkumar;
Murray-Rust, Judith;
Russell, David G.;
Kendall, Sharon L.;
Rison, Stuart C. G.;
McAlister, Mark S. B.;
Bancroft, Gregory J.;
McDonald, Neil Q.;
Daffe, Mamadou;
Av-Gay, Yossef;
Stoker, Neil G.

Publication type:

Article

Fluorescence-based incision assay for human XPF–ERCC1 activity identifies important elements of DNA junction recognition.

Published in:

Nucleic Acids Research, 2012, v. 40, n. 13, p. e101, doi. 10.1093/nar/gks284

By:

Bowles, Maureen;
Lally, John;
Fadden, Andrew J.;
Mouilleron, Stephane;
Hammonds, Timothy;
McDonald, Neil Q.

Publication type:

Article

A genetically-encoded crosslinker screen identifies SERBP1 as a PKCε substrate influencing translation and cell division.

Published in:

Nature Communications, 2021, v. 12, n. 1, p. 1, doi. 10.1038/s41467-021-27189-5

By:

Martini, Silvia;
Davis, Khalil;
Faraway, Rupert;
Elze, Lisa;
Lockwood, Nicola;
Jones, Andrew;
Xie, Xiao;
McDonald, Neil Q.;
Mann, David J.;
Armstrong, Alan;
Ule, Jernej;
Parker, Peter J.

Publication type:

Article

Oligonucleotide-Recognizing Topoisomerase Inhibitors (OTIs): Precision Gene Editors for Neurodegenerative Diseases?

Published in:

International Journal of Molecular Sciences, 2022, v. 23, n. 19, p. 11541, doi. 10.3390/ijms231911541

By:

Bax, Ben D.;
Sutormin, Dmitry;
McDonald, Neil Q.;
Burley, Glenn A.;
Shelkovnikova, Tatyana

Publication type:

Article

Recognition of an intra-chain tandem 14-3-3 binding site within PKCɛ.

Published in:

EMBO Reports, 2009, v. 10, n. 9, p. 983, doi. 10.1038/embor.2009.150

By:

Kostelecky, Brenda;
Saurin, Adrian T;
Purkiss, Andrew;
Parker, Peter J;
McDonald, Neil Q

Publication type:

Article

A heterozygous effect for PINK1 mutations in Parkinson's disease?

Published in:

Annals of Neurology, 2006, v. 60, n. 4, p. 414

By:

Patrick M. Abou‐Sleiman;
Miratul M. K. Muqit;
Neil Q. McDonald;
Yan Xiang Yang;
Sonia Gandhi;
Daniel G. Healy;
Kirsten Harvey;
Robert J. Harvey;
Emma Deas;
Kailash Bhatia;
Niall Quinn;
Andrew Lees;
David S. Latchman;
Nicholas W. Wood

Publication type:

Article

Optimized PAR-2 RING dimerization mediates cooperative and selective membrane binding for robust cell polarity.

Published in:

EMBO Journal, 2024, v. 43, n. 15, p. 3214, doi. 10.1038/s44318-024-00123-3

By:

Bland, Tom;
Hirani, Nisha;
Briggs, David C;
Rossetto, Riccardo;
Ng, KangBo;
Taylor, Ian A;
McDonald, Neil Q;
Zwicker, David;
Goehring, Nathan W

Publication type:

Article

Crystal structure of the MAPK phosphatase Pyst1 catalytic domain and implications for regulated activation.

Published in:

Nature Structural Biology, 1999, v. 6, n. 2, p. 174

By:

Stewart, Albert E.;
Dowd, Stephen;
Keyse, Stephen M.;
McDonald, Neil Q.

Publication type:

Article

Functional evaluation of tumour-specific variants of p16<sup>INK4a</sup>/CDKN2A: correlation with protein structure information.

Published in:

Oncogene, 1999, v. 18, n. 39, p. 5423, doi. 10.1038/sj.onc.1202918

By:

Ruas, Margarida;
Brookes, Sharon;
McDonald, Neil Q;
Peters, Gordon

Publication type:

Article

CARM1/PRMT4 facilitates XPF–ERCC1 heterodimer assembly and maintains nucleotide excision repair activity Open Access.

Published in:

Nucleic Acids Research, 2025, v. 53, n. 8, p. 1, doi. 10.1093/nar/gkaf355

By:

Niida, Hiroyuki;
Ito, Masahiko;
Iijima, Kenta;
Motegi, Akira;
Ogihara, Rin;
Akiyama, Hironobu;
Uchida, Chiharu;
Sakai, Satoshi;
Ohhata, Tatsuya;
Hatano, Atsushi;
Hirose, Michiko;
Ogura, Atsuo;
Matsumoto, Masaki;
McDonald, Neil Q;
Kitagawa, Masatoshi

Publication type:

Article

A winged helix domain in human MUS81 binds DNA and modulates the endonuclease activity of MUS81 complexes.

Published in:

Nucleic Acids Research, 2013, v. 41, n. 21, p. 9741, doi. 10.1093/nar/gkt760

By:

Fadden, Andrew J.;
Schalbetter, Stephanie;
Bowles, Maureen;
Harris, Richard;
Lally, John;
Carr, Antony M.;
McDonald, Neil Q.

Publication type:

Article

A secondary RET mutation in the activation loop conferring resistance to vandetanib.

Published in:

Nature Communications, 2018, v. 9, n. 1, p. 1, doi. 10.1038/s41467-018-02994-7

By:

Takashi Nakaoku;
Takashi Kohno;
Mitsugu Araki;
Seiji Niho;
Chauhan, Rakhee;
Knowles, Phillip P.;
Katsuya Tsuchihara;
Shingo Matsumoto;
Yoko Shimada;
Sachiyo Mimaki;
Genichiro Ishii;
Hitoshi Ichikawa;
Satoru Nagatoishi;
Kouhei Tsumoto;
Yasushi Okuno;
Kiyotaka Yoh;
McDonald, Neil Q.;
Koichi Goto

Publication type:

Article

Disruption of methylarginine metabolism impairs vascular homeostasis.

Published in:

Nature Medicine, 2007, v. 13, n. 2, p. 198, doi. 10.1038/nm1543

By:

Leiper, James;
Nandi, Manasi;
Torondel, Belen;
Murray-Rust, Judith;
Malaki, Mohammed;
O'Hara, Bernard;
Rossiter, Sharon;
Anthony, Shelagh;
Madhani, Melanie;
Selwood, David;
Smith, Caroline;
Wojciak-Stothard, Beata;
Rudiger, Alain;
Stidwill, Ray;
McDonald, Neil Q.;
Vallance, Patrick

Publication type:

Article

Molecular basis for G-actin binding to RPEL motifs from the serum response factor coactivator MAL.

Published in:

EMBO Journal, 2008, v. 27, n. 23, p. 3198, doi. 10.1038/emboj.2008.235

By:

Mouilleron, Stephane;
Guettler, Sebastian;
Langer, Carola A;
Treisman, Richard;
McDonald, Neil Q

Publication type:

Article

Structure of an XPF endonuclease with and without DNA suggests a model for substrate recognition.

Published in:

EMBO Journal, 2005, v. 24, n. 5, p. 895, doi. 10.1038/sj.emboj.7600581

By:

Newman, Matthew;
Murray-Rust, Judith;
Lally, John;
Rudolf, Jana;
Fadden, Andrew;
Knowles, Philip P.;
White, Malcolm F.;
McDonald, Neil Q.

Publication type:

Article

Mammal-restricted elements predispose human RET to folding impairment by HSCR mutations.

Published in:

Nature Structural & Molecular Biology, 2010, v. 17, n. 6, p. 726, doi. 10.1038/nsmb.1808

By:

Kjær, Svend;
Hanrahan, Sarah;
Totty, Nick;
McDonald, Neil Q.

Publication type:

Article

Into the fold: advances in understanding aPKC membrane dynamics.

Published in:

Biochemical Journal, 2023, v. 480, n. 24, p. 2037, doi. 10.1042/BCJ20230390

By:

Cobbaut, Mathias;
Parker, Peter J.;
McDonald, Neil Q.

Publication type:

Article

Co-ordinated control of the Aurora B abscission checkpoint by PKC<sub>ε</sub> complex assembly, midbody recruitment and retention.

Published in:

Biochemical Journal, 2021, v. 478, n. 12, p. 2247, doi. 10.1042/BCJ20210283

By:

Watson, Lisa;
Soliman, Tanya N.;
Davis, Khalil;
Kelly, Joanna;
Lockwood, Nicola;
Xiaoping Yang;
Lynham, Steven;
Scott, John D.;
Crossland, Victoria;
McDonald, Neil Q.;
Mann, David J.;
Armstrong, Alan;
Eggert, Ulrike;
Parker, Peter J.

Publication type:

Article

Adenosine-binding motif mimicry and cellular effects of a thieno[2,3-d]pyrimidine-based chemical inhibitor of atypical protein kinase C isoenzymes.

Published in:

Biochemical Journal, 2013, v. 451, n. 2, p. 329, doi. 10.1042/BJ20121871

By:

KJÆR, Svend;
LINCH, Mark;
PURKISS, Andrew;
KOSTELECKY, Brenda;
KNOWLES, Phillip P.;
ROSSE, Carine;
RIOU, Philippe;
SOUDY, Christelle;
KAYE, Sarah;
PATEL, Bhavisha;
SORIANO, Erika;
MURRAY-RUST, Judith;
BARTON, Caroline;
DILLON, Christian;
ROFFEY, Jon;
PARKER, Peter J.;
MCDONALD, Neil Q.

Publication type:

Article

Cryo-EM structures of the XPF-ERCC1 endonuclease reveal how DNA-junction engagement disrupts an auto-inhibited conformation.

Published in:

Nature Communications, 2020, v. 11, p. 1, doi. 10.1038/s41467-020-14856-2

By:

Jones, Morgan;
Beuron, Fabienne;
Borg, Aaron;
Nans, Andrea;
Earl, Christopher P.;
Briggs, David C.;
Snijders, Ambrosius P.;
Bowles, Maureen;
Morris, Edward P.;
Linch, Mark;
McDonald, Neil Q.

Publication type:

Article

A Cancer-Associated Mutation in Atypical Protein Kinase Cɩ Occurs in a Substrate-Specific Recruitment Motif.

Published in:

Science Signaling, 2013, v. 6, n. 293, p. 1, doi. 10.1126/scisignal.2004068

By:

Linch, Mark;
Sanz-Garcia, Marta;
Soriano, Erika;
Yixiao Zhang;
Riou, Philippe;
Rosse, Carine;
Cameron, Angus;
Knowles, Phillip;
Purkiss, Andrew;
Kjaer, Svend;
McDonald, Neil Q.;
Parker, Peter J.

Publication type:

Article

Structure of a Pentavalent G-Actin1MRTF-A Complex Reveals How G-Actin Controls Nucleocytoplasmic Shuttling of a Transcriptional Coactivator.

Published in:

Science Signaling, 2011, v. 4, n. 177, p. 1, doi. 10.1126/scisignal.2001750

By:

Mouilleron, Stéphane;
Langer, Carola A.;
Guettler, Sebastian;
McDonald, Neil Q.;
Treisman, Richard

Publication type:

Article

Bimodal regulation of axonal transport by the GDNF-RET signalling axis in healthy and diseased motor neurons.

Published in:

Cell Death & Disease, 2022, v. 13, n. 7, p. 1, doi. 10.1038/s41419-022-05031-0

By:

Rhymes, Elena R.;
Tosolini, Andrew P.;
Fellows, Alexander D.;
Mahy, William;
McDonald, Neil Q.;
Schiavo, Giampietro

Publication type:

Article

Functional implications of assigned, assumed and assembled PKC structures.

Published in:

Biochemical Society Transactions, 2014, v. 42, n. 1, p. 35, doi. 10.1042/BST20130192

By:

Linch, Mark;
Riou, Philippe;
Claus, Jeroen;
Cameron, Angus J.;
de Naurois, Julien;
Larijani, Banafshe;
Ng, Tony;
McDonald, Neil Q.;
Parker, Peter J.

Publication type:

Article

Study of an FBXO7 patient mutation reveals Fbxo7 and PI31 co‐regulate proteasomes and mitochondria.

Published in:

FEBS Journal, 2024, v. 291, n. 12, p. 2565, doi. 10.1111/febs.17114

By:

Al Rawi, Sara;
Simpson, Lorna;
Agnarsdóttir, Guðrún;
McDonald, Neil Q.;
Chernuha, Veronika;
Elpeleg, Orly;
Zeviani, Massimo;
Barker, Roger A.;
Spiegel, Ronen;
Laman, Heike

Publication type:

Article