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NUPR1, a new target in liver cancer: implication in controlling cell growth, migration, invasion and sorafenib resistance.
- Published in:
- Cell Death & Disease, 2016, v. 7, n. 6, p. e2269, doi. 10.1038/cddis.2016.175
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- Article
Mutations in the catalytic subunit of class IA PI3K confer leukemogenic potential to hematopoietic cells.
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- Oncogene, 2008, v. 27, n. 29, p. 4096, doi. 10.1038/onc.2008.40
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- Article
Suppression of PTEN function increases breast cancer chemotherapeutic drug resistance while conferring sensitivity to mTOR inhibitors.
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- Oncogene, 2008, v. 27, n. 29, p. 4086, doi. 10.1038/onc.2008.49
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- Article
Regulation of the mitogen-activated protein kinase kinase (MEK)-1 by NAD<sup>+</sup>-dependent deacetylases.
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- Oncogene, 2015, v. 34, n. 6, p. 798, doi. 10.1038/onc.2014.39
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- Article
The mitotic kinase Aurora-A promotes distant metastases by inducing epithelial-to-mesenchymal transition in ERα<sup>+</sup> breast cancer cells.
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- Oncogene, 2014, v. 33, n. 5, p. 599, doi. 10.1038/onc.2012.628
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- Article
Activity of the pan-class I phosphoinositide 3-kinase inhibitor NVP-BKM120 in T-cell acute lymphoblastic leukemia.
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- Leukemia (08876924), 2014, v. 28, n. 6, p. 1196, doi. 10.1038/leu.2013.369
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- Article
Targeting the PI3K/Akt/mTOR signaling pathway in B-precursor acute lymphoblastic leukemia and its therapeutic potential.
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- 2014
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- journal article
Targeting the PI3K/Akt/mTOR signaling pathway in B-precursor acute lymphoblastic leukemia and its therapeutic potential.
- Published in:
- Leukemia (08876924), 2014, v. 28, n. 4, p. 739, doi. 10.1038/leu.2013.226
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- Article
Cytotoxic activity of the casein kinase 2 inhibitor CX-4945 against T-cell acute lymphoblastic leukemia: targeting the unfolded protein response signaling.
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- Leukemia (08876924), 2014, v. 28, n. 3, p. 543, doi. 10.1038/leu.2013.349
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- Article
STAT transcription factors in hematopoiesis and leukemogenesis: opportunities for therapeutic intervention.
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- Leukemia (08876924), 2014, v. 28, n. 2, p. 248, doi. 10.1038/leu.2013.192
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- Article
Multifaceted roles of GSK-3 and Wnt/β-catenin in hematopoiesis and leukemogenesis: opportunities for therapeutic intervention.
- Published in:
- 2014
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- journal article
Multifaceted roles of GSK-3 and Wnt/β-catenin in hematopoiesis and leukemogenesis: opportunities for therapeutic intervention.
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- Leukemia (08876924), 2014, v. 28, n. 1, p. 15, doi. 10.1038/leu.2013.184
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- Publication type:
- Article
Cytotoxic activity of the novel Akt inhibitor, MK-2206, in T-cell acute lymphoblastic leukemia.
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- Leukemia (08876924), 2012, v. 26, n. 11, p. 2336, doi. 10.1038/leu.2012.136
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- Article
MEK inhibition enhances ABT-737-induced leukemia cell apoptosis via prevention of ERK-activated MCL-1 induction and modulation of MCL-1/BIM complex.
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- Leukemia (08876924), 2012, v. 26, n. 4, p. 778, doi. 10.1038/leu.2011.287
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- Article
AMP-dependent kinase/mammalian target of rapamycin complex 1 signaling in T-cell acute lymphoblastic leukemia: therapeutic implications.
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- Leukemia (08876924), 2012, v. 26, n. 1, p. 91, doi. 10.1038/leu.2011.269
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- Article
Roles of the Ras/Raf/MEK/ERK pathway in leukemia therapy.
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- 2011
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- journal article
Targeting the translational apparatus to improve leukemia therapy: roles of the PI3K/PTEN/Akt/mTOR pathway.
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- 2011
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- journal article
Targeted inhibition of mTORC1 and mTORC2 by active-site mTOR inhibitors has cytotoxic effects in T-cell acute lymphoblastic leukemia.
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- Leukemia (08876924), 2011, v. 25, n. 5, p. 781, doi. 10.1038/leu.2011.20
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- Article
Erucylphosphohomocholine, the first intravenously applicable alkylphosphocholine, is cytotoxic to acute myelogenous leukemia cells through JNK- and PP2A-dependent mechanisms.
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- Leukemia (08876924), 2010, v. 24, n. 4, p. 687, doi. 10.1038/leu.2010.32
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- Article
Targeting the leukemic stem cell: the Holy Grail of leukemia therapy.
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- 2009
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- journal article
Involvement of p53 and Raf/MEK/ERK pathways in hematopoietic drug resistance.
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- 2008
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- journal article
The novel Akt inhibitor, perifosine, induces caspase-dependent apoptosis and downregulates P-glycoprotein expression in multidrug-resistant human T-acute leukemia cells by a JNK-dependent mechanism.
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- Leukemia (08876924), 2008, v. 22, n. 6, p. 1106, doi. 10.1038/leu.2008.79
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- Article
Sorafenib induces apoptosis of AML cells via Bim-mediated activation of the intrinsic apoptotic pathway.
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- 2008
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- journal article
Contributions of the Raf/MEK/ERK, PI3K/PTEN/Akt/mTOR and Jak/STAT pathways to leukemia.
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- 2008
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- journal article
Targeting survival cascades induced by activation of Ras/Raf/MEK/ERK, PI3K/PTEN/Akt/mTOR and Jak/STAT pathways for effective leukemia therapy.
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- Leukemia (08876924), 2008, v. 22, n. 4, p. 708, doi. 10.1038/leu.2008.27
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- Article
Proapoptotic activity and chemosensitizing effect of the novel Akt inhibitor perifosine in acute myelogenous leukemia cells.
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- Leukemia (08876924), 2008, v. 22, n. 1, p. 147, doi. 10.1038/sj.leu.2404980
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- Article
The insulin-like growth factor-I receptor kinase inhibitor NVP-AEW541 induces apoptosis in acute myeloid leukemia cells exhibiting autocrine insulin-like growth factor-I secretion.
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- Leukemia (08876924), 2007, v. 21, n. 5, p. 886, doi. 10.1038/sj.leu.2404643
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- Article
Multidrug resistance-associated protein 1 expression is under the control of the phosphoinositide 3 kinase/Akt signal transduction network in human acute myelogenous leukemia blasts.
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- 2007
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- journal article
Synergy between an IGF-1R antibody and Raf/MEK/ERK and PI3K/Akt/mTOR pathway inhibitors in suppressing IGF-1R-mediated growth in hematopoietic cells.
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- Leukemia (08876924), 2006, v. 20, n. 7, p. 1254, doi. 10.1038/sj.leu.2404217
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- Article
Raf and VEGF: emerging therapeutic targets in Kaposi's sarcoma-associated herpesvirus infection and angiogenesis in hematopoietic and nonhematopoietic tumors.
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- Leukemia (08876924), 2005, v. 19, n. 1, p. 18, doi. 10.1038/sj.leu.2403532
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- Article
Inhibition of PI3K, mTOR and MEK signaling pathways promotes rapid apoptosis in B-lineage ALL in the presence of stromal cell support.
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- Leukemia (08876924), 2005, v. 19, n. 1, p. 98, doi. 10.1038/sj.leu.2403560
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- Article
Regulation and targeting of antiapoptotic XIAP in acute myeloid leukemia.
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- Leukemia (08876924), 2003, v. 17, n. 11, p. 2081, doi. 10.1038/sj.leu.2403113
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- Article
Signal transduction mediated by the Ras/Raf/MEK/ERK pathway from cytokine receptors to transcription factors: potential targeting for therapeutic intervention.
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- Leukemia (08876924), 2003, v. 17, n. 7, p. 1263, doi. 10.1038/sj.leu.2402945
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- Article
Requirement for the PI3K/Akt pathway in MEK1-mediated growth and prevention of apoptosis: identification of an Achilles heel in leukemia.
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- 2003
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- journal article
Involvement of PI3K/Akt pathway in cell cycle progression, apoptosis, and neoplastic transformation: a target for cancer chemotherapy.
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- Leukemia (08876924), 2003, v. 17, n. 3, p. 590, doi. 10.1038/sj.leu.2402824
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- Article
Elitek<sup>TM</sup>-rasburicase: an effective means to prevent and treat hyperuricemia associated with tumor lysis syndrome, a Meeting Report, Dallas, Texas, January 2002.
- Published in:
- Leukemia (08876924), 2003, v. 17, n. 3, p. 499, doi. 10.1038/sj.leu.2402847
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- Article
Diphtheria toxin-interleukin-3 fusion protein (DT<sub>388</sub>IL3) prolongs disease-free survival of leukemic immunocompromised mice.
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- Leukemia (08876924), 2003, v. 17, n. 1, p. 155, doi. 10.1038/sj.leu.2402744
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- Article
Enhanced ability of daniplestim and myelopoietin-1 to suppress apoptosis in human hematopoietic cells.
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- 2001
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- journal article
Suppression of apoptosis: role in cell growth and neoplasia.
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- 2001
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- journal article
Oncogene-dependent engraftment of human myeloid leukemia cells in immunosuppressed mice.
- Published in:
- 2001
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- journal article
Effects of inducible MEK1 activation on the cytokine dependency of lymphoid cells.
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- 2001
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- Publication type:
- journal article
Kinases: positive and negative regulators of apoptosis.
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- 2000
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- journal article
Effects of deregulated Raf activation on integrin, cytokine-receptor expression and the induction of apoptosis in hematopoietic cells.
- Published in:
- 2000
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- journal article
Synergy between Raf and BCL2 in abrogating the cytokine dependency of hematopoietic cells.
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- 2000
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- journal article
Combined effects of aberrant MEK1 activity and BCL2 overexpression on relieving the cytokine dependency of human and murine hematopoietic cells.
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- 2000
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- journal article
Differential abilities of the Raf family of protein kinases to abrogate cytokine dependency and prevent apoptosis in murine hematopoietic cells by a MEK1-dependent mechanism.
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- 2000
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- Publication type:
- journal article
Diphtheria toxin fused to human interleukin-3 is toxic to blasts from patients with myeloid leukemias.
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- 2000
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- journal article
Signal transduction, cell cycle regulatory, and anti-apoptotic pathways regulated by IL-3 in hematopoietic cells: possible sites for intervention with anti-neoplastic drugs.
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- 1999
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- journal article
Differential abilities of activated Raf oncoproteins to abrogate cytokine dependency, prevent apoptosis and induce autocrine growth factor synthesis in human hematopoietic cells.
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- 1998
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- Publication type:
- journal article
Characterization of proteins binding the 3' regulatory region of the IL-3 gene in IL-3-dependent and autocrine-transformed hematopoietic cells.
- Published in:
- 1998
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- Publication type:
- journal article