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Mind the gap? The platform trial as a working environment.
Published in:
2019
By:
- Morrell, Liz;
- Hordern, Joshua;
- Brown, Louise;
- Sydes, Matthew R.;
- Amos, Claire L.;
- Kaplan, Richard S.;
- Parmar, Mahesh K. B.;
- Maughan, Timothy S.
Publication type:
Letter
Germline variation in RASAL2 may predict survival in patients with RAS‐activated colorectal cancer.
Published in:
Genes, Chromosomes & Cancer, 2023, v. 62, n. 6, p. 332, doi. 10.1002/gcc.23133
By:
- Wills, Christopher;
- Watts, Katie;
- Maughan, Timothy S.;
- Fisher, David;
- Al‐Tassan, Nada A.;
- Houlston, Richard S.;
- Escott‐Price, Valentina;
- Cheadle, Jeremy P.
Publication type:
Article
Laparoscopic Cholecystectomy: Incidental Carcinoma of the Gallbladder with Abdominal Wall and Axillary Node Metastasis.
Published in:
HPB Surgery, 1997, v. 10, n. 3, p. 169, doi. 10.1155/1997/60975
By:
- JOHNSON, RICHARD C.;
- FLIGELSTONE, LOUIS J.;
- WHEELER, MALCOLM H.;
- HORGAN, KIERAN;
- MAUGHAN, TIMOTHY S.
Publication type:
Article
A robust multiplex immunofluorescence and digital pathology workflow for the characterisation of the tumour immune microenvironment.
Published in:
Molecular Oncology, 2020, v. 14, n. 10, p. 2384, doi. 10.1002/1878-0261.12764
By:
- Viratham Pulsawatdi, Amélie;
- Craig, Stephanie G.;
- Bingham, Victoria;
- McCombe, Kris;
- Humphries, Matthew P.;
- Senevirathne, Seedevi;
- Richman, Susan D.;
- Quirke, Phil;
- Campo, Leticia;
- Domingo, Enric;
- Maughan, Timothy S.;
- James, Jacqueline A.;
- Salto‐Tellez, Manuel
Publication type:
Article
The prognostic utility of pre‐treatment neutrophil‐to‐lymphocyte‐ratio (NLR) in colorectal cancer: A systematic review and meta‐analysis.
Published in:
Cancer Medicine, 2021, v. 10, n. 17, p. 5983, doi. 10.1002/cam4.4143
By:
- Naszai, Mate;
- Kurjan, Alina;
- Maughan, Timothy S.
Publication type:
Article
The polymorphic variant rs1800734 influences methylation acquisition and allele-specific TFAP4 binding in the MLH1 promoter leading to differential mRNA expression.
Published in:
Scientific Reports, 2019, v. 9, n. 1, p. N.PAG, doi. 10.1038/s41598-019-49952-x
By:
- Thomas, Rachael;
- Trapani, Davide;
- Goodyer-Sait, Lily;
- Tomkova, Marketa;
- Fernandez-Rozadilla, Ceres;
- Sahnane, Nora;
- Woolley, Connor;
- Davis, Hayley;
- Chegwidden, Laura;
- Kriaucionis, Skirmantas;
- Maughan, Timothy;
- Leedham, Simon;
- Palles, Claire;
- Furlan, Daniela;
- Tomlinson, Ian;
- Lewis, Annabelle
Publication type:
Article
Does student teaching harm or help cancer patients?
Published in:
2005
By:
- Finlay, Ilora;
- Maughan, Timothy;
- Williams, Susan
Publication type:
Other
Genetic variation in ST6GAL1 is a determinant of capecitabine and oxaliplatin induced hand‐foot syndrome.
Published in:
International Journal of Cancer, 2022, v. 151, n. 6, p. 957, doi. 10.1002/ijc.34046
By:
- Watts, Katie;
- Wills, Christopher;
- Madi, Ayman;
- Palles, Claire;
- Maughan, Timothy S.;
- Kaplan, Richard;
- Al‐Tassan, Nada A.;
- Kerr, Rachel;
- Kerr, David J.;
- Houlston, Richard S.;
- Escott‐Price, Valentina;
- Cheadle, Jeremy P.
Publication type:
Article
Genome‐wide association studies of toxicity to oxaliplatin and fluoropyrimidine chemotherapy with or without cetuximab in 1800 patients with advanced colorectal cancer.
Published in:
International Journal of Cancer, 2021, v. 149, n. 9, p. 1713, doi. 10.1002/ijc.33739
By:
- Watts, Katie;
- Wills, Christopher;
- Madi, Ayman;
- Palles, Claire;
- Maughan, Timothy S.;
- Kaplan, Richard;
- Al‐Tassan, Nada A.;
- Kerr, Rachel;
- Kerr, David;
- Gray, Victoria;
- West, Hannah;
- Houlston, Richard S.;
- Escott‐Price, Valentina;
- Cheadle, Jeremy P.
Publication type:
Article
Practical guidance for running late-phase platform protocols for clinical trials: lessons from experienced UK clinical trials units.
Published in:
Trials, 2022, v. 23, n. 1, p. 1, doi. 10.1186/s13063-022-06680-4
By:
- Love, Sharon B.;
- Cafferty, Fay;
- Snowdon, Claire;
- Carty, Karen;
- Savage, Joshua;
- Pallmann, Philip;
- McParland, Lucy;
- Brown, Louise;
- Masters, Lindsey;
- Schiavone, Francesca;
- Hague, Dominic;
- Townsend, Stephen;
- Amos, Claire;
- South, Annabelle;
- Sturgeon, Kate;
- Langley, Ruth;
- Maughan, Timothy;
- James, Nicholas;
- Hall, Emma;
- Kernaghan, Sarah
Publication type:
Article
Severe Prolonged Immunosuppression following Fludarabine and Rituximab Combination Therapy.
Published in:
Chemotherapy (0009-3157), 2008, v. 54, n. 3, p. 242, doi. 10.1159/000140469
By:
- Hudson, Emma;
- Westmoreland, Diana;
- Gorman, Christopher;
- Poynton, Christopher H.;
- Lester, Jason F.;
- Maughan, Timothy S.
Publication type:
Article
Evaluation of Continuous Tumor-Size–Based End Points as Surrogates for Overall Survival in Randomized Clinical Trials in Metastatic Colorectal Cancer.
Published in:
JAMA Network Open, 2019, v. 29, p. e1911750, doi. 10.1001/jamanetworkopen.2019.11750
By:
- Burzykowski, Tomasz;
- Coart, Elisabeth;
- Saad, Everardo D.;
- Shi, Qian;
- Sommeijer, Dirkje W.;
- Bokemeyer, Carsten;
- Díaz-Rubio, Eduardo;
- Douillard, Jean-Yves;
- Falcone, Alfredo;
- Fuchs, Charles S.;
- Goldberg, Richard M.;
- Hecht, J. Randolph;
- Hoff, Paulo M.;
- Hurwitz, Herbert;
- Kabbinavar, Fairooz F.;
- Koopman, Miriam;
- Maughan, Timothy S.;
- Punt, Cornelis J. A.;
- Saltz, Leonard;
- Schmoll, Hans-Joachim
Publication type:
Article
Combining Oncolytic Adenovirus with Radiation--A Paradigm for the Future of Radiosensitization.
Published in:
Frontiers in Oncology, 2017, p. 1, doi. 10.3389/fonc.2017.00153
By:
- O'Cathail, Sean M.;
- Pokrovska, Tzveta D.;
- Maughan, Timothy S.;
- Fisher, Kerry D.;
- Seymour, Leonard W.;
- Hawkins, Maria A.
Publication type:
Article
Study protocol: a multi-centre randomised study of induction chemotherapy followed by capecitabine ± nelfinavir with high- or standard-dose radiotherapy for locally advanced pancreatic cancer (SCALOP-2).
Published in:
2019
By:
- Strauss, Victoria Y.;
- Shaw, Rachel;
- Virdee, Pradeep S.;
- Hurt, Christopher N.;
- Ward, Elizabeth;
- Tranter, Bethan;
- Patel, Neel;
- Bridgewater, John;
- Parsons, Philip;
- Radhakrishna, Ganesh;
- O'Neill, Eric;
- Sebag-Montefiore, David;
- Hawkins, Maria;
- Corrie, Pippa G.;
- Maughan, Timothy;
- Mukherjee, Somnath
Publication type:
journal article
Clinicopathological and molecular characteristics of RSPO fusion-positive colorectal cancer.
Published in:
2022
By:
- Hashimoto, Taiki;
- Takayanagi, Daisuke;
- Yonemaru, Junpei;
- Naka, Tomoaki;
- Nagashima, Kengo;
- Yatabe, Yasushi;
- Shida, Dai;
- Hamamoto, Ryuji;
- Kleeman, Sam O.;
- Leedham, Simon J.;
- Maughan, Timothy;
- Takashima, Atsuo;
- Shiraishi, Kouya;
- Sekine, Shigeki
Publication type:
journal article
Molecular selection of therapy in metastatic colorectal cancer: the FOCUS4 molecularly stratified RCT.
Published in:
Efficacy & Mechanism Evaluation (EME), 2022, v. 9, n. 9, p. vii, doi. 10.3310/HTNB6908
By:
- Brown, Louise C.;
- Fisher, David;
- Adams, Richard;
- Seligmann, Jenny;
- Seymour, Matthew;
- Kaplan, Richard;
- Richman, Susan D.;
- Quirke, Philip;
- Butler, Rachel;
- Roberts, Helen;
- Graham, Janet;
- Wilson, Richard H.;
- Maughan, Timothy S.
Publication type:
Article
A proliferative subtype of colorectal liver metastases exhibits hypersensitivity to cytotoxic chemotherapy.
Published in:
NPJ Precision Oncology, 2022, v. 6, n. 1, p. 1, doi. 10.1038/s41698-022-00318-z
By:
- Spurr, Liam F.;
- Martinez, Carlos A.;
- Katipally, Rohan R.;
- Iyer, Soumya C.;
- Pugh, Sian A.;
- Bridgewater, John A.;
- Primrose, John N.;
- Domingo, Enric;
- Maughan, Timothy S.;
- D'Angelica, Michael I.;
- Talamonti, Mark;
- Posner, Mitchell C.;
- Connell, Philip P.;
- Weichselbaum, Ralph R.;
- Pitroda, Sean P.
Publication type:
Article
Erratum: A new GWAS and meta-analysis with 1000Genomes imputation identifies novel risk variants for colorectal cancer.
Published in:
Scientific Reports, 2015, p. 12372, doi. 10.1038/srep12372
By:
- Al-Tassan, Nada A.;
- Whiffin, Nicola;
- Hosking, Fay J.;
- Palles, Claire;
- Farrington, Susan M.;
- Dobbins, Sara E.;
- Harris, Rebecca;
- Gorman, Maggie;
- Tenesa, Albert;
- Meyer, Brian F.;
- Wakil, Salma M.;
- Kinnersley, Ben;
- Campbell, Harry;
- Martin, Lynn;
- Smith, Christopher G.;
- Idziaszczyk, Shelley;
- Barclay, Ella;
- Maughan, Timothy S.;
- Kaplan, Richard;
- Kerr, Rachel
Publication type:
Article
A new GWAS and meta-analysis with 1000Genomes imputation identifies novel risk variants for colorectal cancer.
Published in:
Scientific Reports, 2015, p. 10442, doi. 10.1038/srep10442
By:
- Al-Tassan, Nada A.;
- Whiffin, Nicola;
- Hosking, Fay J.;
- Palles, Claire;
- Farrington, Susan M.;
- Dobbins, Sara E.;
- Harris, Rebecca;
- Gorman, Maggie;
- Tenesa, Albert;
- Meyer, Brian F.;
- Wakil, Salma M.;
- Kinnersley, Ben;
- Campbell, Harry;
- Martin, Lynn;
- Smith, Christopher G.;
- Idziaszczyk, Shelley;
- Barclay, Ella;
- Maughan, Timothy S.;
- Kaplan, Richard;
- Kerr, Rachel
Publication type:
Article
Exome Resequencing Identifies Potential Tumor-Suppressor Genes that Predispose to Colorectal Cancer.
Published in:
Human Mutation, 2013, v. 34, n. 7, p. 1026, doi. 10.1002/humu.22333
By:
- Smith, Christopher G.;
- Naven, Marc;
- Harris, Rebecca;
- Colley, James;
- West, Hannah;
- Li, Ning;
- Liu, Yuan;
- Adams, Richard;
- Maughan, Timothy S.;
- Nichols, Laura;
- Kaplan, Richard;
- Wagner, Michael J.;
- McLeod, Howard L.;
- Cheadle, Jeremy P.
Publication type:
Article
NEOSCOPE: a randomised Phase II study of induction chemotherapy followed by either oxaliplatin/capecitabine or paclitaxel/carboplatin based chemoradiation as pre-operative regimen for resectable oesophageal adenocarcinoma.
Published in:
2015
By:
- Mukherjee, Somnath;
- Hurt, Christopher N;
- Gwynne, Sarah;
- Bateman, Andrew;
- Gollins, Simon;
- Radhakrishna, Ganesh;
- Hawkins, Maria;
- Canham, Jo;
- Lewis, Wyn;
- Grabsch, Heike I;
- Sharma, Ricky A;
- Wade, Wendy;
- Maggs, Rhydian;
- Tranter, Bethan;
- Roberts, Ashley;
- Sebag-Montefiore, David;
- Maughan, Timothy;
- Griffiths, Gareth;
- Crosby, Tom
Publication type:
journal article
Prognostic and Predictive Impact of Primary Tumor Sidedness for Previously Untreated Advanced Colorectal Cancer.
Published in:
2021
By:
- Yin, Jun;
- Cohen, Romain;
- Jin, Zhaohui;
- Liu, Heshan;
- Pederson, Levi;
- Adams, Richard;
- Grothey, Axel;
- Maughan, Timothy S;
- Venook, Alan;
- Cutsem, Eric Van;
- Punt, Cornelis;
- Koopman, Miriam;
- Falcone, Alfredo;
- Tebbutt, Niall C;
- Seymour, Matthew T;
- Bokemeyer, Carsten;
- Rubio, Eduardo Diaz;
- Kaplan, Richard;
- Heinemann, Volker;
- Chibaudel, Benoist
Publication type:
journal article
BRAF V600E Mutation in First-Line Metastatic Colorectal Cancer: An Analysis of Individual Patient Data From the ARCAD Database.
Published in:
2021
By:
- Cohen, Romain;
- Liu, Heshan;
- Fiskum, Jack;
- Adams, Richard;
- Chibaudel, Benoist;
- Maughan, Timothy S;
- Cutsem, Eric Van;
- Venook, Alan;
- Douillard, Jean-Yves;
- Heinemann, Volker;
- Punt, Cornelis Ja;
- Falcone, Alfredo;
- Bokemeyer, Carsten;
- Kaplan, Richard;
- Lenz, Heinz-Josef;
- Koopman, Miriam;
- Yoshino, Takayuki;
- Zalcberg, John;
- Grothey, Alex;
- Gramont, Aimery de
Publication type:
journal article
HER2-HER3 Heterodimer Quantification by FRET-FLIM and Patient Subclass Analysis of the COIN Colorectal Trial.
Published in:
2020
By:
- Barber, Paul R;
- Weitsman, Gregory;
- Lawler, Katherine;
- Barrett, James E;
- Rowley, Mark;
- Rodriguez-Justo, Manuel;
- Fisher, David;
- Gao, Fangfei;
- Tullis, Iain D C;
- Deng, Jinhai;
- Brown, Louise;
- Kaplan, Richard;
- Hochhauser, Daniel;
- Adams, Richard;
- Maughan, Timothy S.;
- Vojnovic, Borivoj;
- Coolen, Anthony C C;
- Ng, Tony;
- Barrett, James
Publication type:
journal article
Pattern Recognition Receptor Polymorphisms as Predictors of Oxaliplatin Benefit in Colorectal Cancer.
Published in:
2019
By:
- Gray, Victoria;
- Briggs, Sarah;
- Palles, Claire;
- Jaeger, Emma;
- Iveson, Timothy;
- Kerr, Rachel;
- Saunders, Mark P;
- Paul, James;
- Harkin, Andrea;
- McQueen, John;
- Summers, Matthew G;
- Johnstone, Elaine;
- Wang, Haitao;
- Gatcombe, Laura;
- Maughan, Timothy S;
- Kaplan, Richard;
- Escott-Price, Valentina;
- Al-Tassan, Nada A;
- Meyer, Brian F;
- Wakil, Salma M
Publication type:
journal article
Personalizing Survival Predictions in Advanced Colorectal Cancer: The ARCAD Nomogram Project.
Published in:
2018
By:
- Sjoquist, Katrin M.;
- Renfro, Lindsay A.;
- Simes, R. John;
- Tebbutt, Niall C.;
- Clarke, Stephen;
- Seymour, Matthew T.;
- Adams, Richard;
- Maughan, Timothy S.;
- Saltz, Leonard;
- Goldberg, Richard M.;
- Schmoll, Hans-Joachim;
- Van Cutsem, Eric;
- Douillard, Jean-Yves;
- Hoff, Paulo M.;
- Hecht, Joel Randolph;
- Tournigand, Christophe;
- Punt, Cornelis J. A.;
- Koopman, Miriam;
- Hurwitz, Herbert;
- Heinemann, Volker
Publication type:
journal article
Re: Role of the Oxidative DNA Damage Repair Gene OGG1 in Colorectal Tumorigenesis.
Published in:
2014
By:
- SMITH, CHRISTOPHER G.;
- WEST, HANNAH;
- HARRIS, REBECCA;
- IDZIASZCZYK, SHELLEY;
- MAUGHAN, TIMOTHY S.;
- KAPLAN, RICHARD;
- RICHMAN, SUSAN;
- QUIRKE, PHILIP;
- SEYMOUR, MATTHEW;
- MOSKVINA, VALENTINA;
- STEINKE, ERENA;
- PROPPING, PETER;
- HES, FREDERIK J.;
- WIJNEN, JUUL;
- CHEADLE, JEREMY P.
Publication type:
Letter to the Editor
Response.
Published in:
2014
By:
- Smith, Christopher G;
- West, Hannah;
- Harris, Rebecca;
- Idziaszczyk, Shelley;
- Maughan, Timothy S;
- Kaplan, Richard;
- Richman, Susan;
- Quirke, Philip;
- Seymour, Matthew;
- Moskvina, Valentina;
- Steinke, Verena;
- Propping, Peter;
- Hes, Frederik J;
- Wijnen, Juul;
- Cheadle, Jeremy P
Publication type:
Letter
Role of the Oxidative DNA Damage Repair Gene OGG1 in Colorectal Tumorigenesis.
Published in:
JNCI: Journal of the National Cancer Institute, 2013, v. 105, n. 16, p. 1249, doi. 10.1093/jnci/djt183
By:
- Smith, Christopher G.;
- West, Hannah;
- Harris, Rebecca;
- Idziaszczyk, Shelley;
- Maughan, Timothy S.;
- Kaplan, Richard;
- Richman, Susan;
- Quirke, Philip;
- Seymour, Matthew;
- Moskvina, Valentina;
- Steinke, Verena;
- Propping, Peter;
- Hes, Frederik J.;
- Wijnen, Juul;
- Cheadle, Jeremy P.
Publication type:
Article
TEX264 coordinates p97- and SPRTN-mediated resolution of topoisomerase 1-DNA adducts.
Published in:
Nature Communications, 2020, v. 11, n. 1, p. 1, doi. 10.1038/s41467-020-15000-w
By:
- Fielden, John;
- Wiseman, Katherine;
- Torrecilla, Ignacio;
- Li, Shudong;
- Hume, Samuel;
- Chiang, Shih-Chieh;
- Ruggiano, Annamaria;
- Narayan Singh, Abhay;
- Freire, Raimundo;
- Hassanieh, Sylvana;
- Domingo, Enric;
- Vendrell, Iolanda;
- Fischer, Roman;
- Kessler, Benedikt M.;
- Maughan, Timothy S.;
- El-Khamisy, Sherif F.;
- Ramadan, Kristijan
Publication type:
Article
Experiences of running a stratified medicine adaptive platform trial: Challenges and lessons learned from 10 years of the FOCUS4 trial in metastatic colorectal cancer.
Published in:
Clinical Trials, 2022, v. 19, n. 2, p. 146, doi. 10.1177/17407745211069879
By:
- Brown, Louise C;
- Graham, Janet;
- Fisher, David;
- Adams, Richard;
- Seligmann, Jenny;
- Seymour, Matthew;
- Kaplan, Richard;
- Yates, Emma;
- Parmar, Mahesh;
- Richman, Susan D;
- Quirke, Philip;
- Butler, Rachel;
- Shiu, Kaikeen;
- Middleton, Gary;
- Samuel, Leslie;
- Wilson, Richard H;
- Maughan, Timothy S
Publication type:
Article
Testing many treatments within a single protocol over 10 years at MRC Clinical Trials Unit at UCL: Multi-arm, multi-stage platform, umbrella and basket protocols.
Published in:
Clinical Trials, 2017, v. 14, n. 5, p. 451, doi. 10.1177/1740774517725697
By:
- Parmar, Mahesh K. B.;
- Sydes, Matthew R.;
- Cafferty, Fay H.;
- Choodari-Oskooei, Babak;
- Langley, Ruth E.;
- Brown, Louise;
- Phillips, Patrick P. J.;
- Spears, Melissa R.;
- Rowley, Sam;
- Kaplan, Richard;
- James, Nicholas D.;
- Maughan, Timothy;
- Paton, Nicholas;
- Royston, Patrick J.
Publication type:
Article
FRAGMATIC: a randomised phase III clinical trial investigating the effect of fragmin added to standard therapy in patients with lung cancer.
Published in:
2009
By:
- Griffiths GO;
- Burns S;
- Noble SI;
- Macbeth FR;
- Cohen D;
- Maughan TS;
- Griffiths, Gareth O;
- Burns, Sarah;
- Noble, Simon I;
- Macbeth, Fergus R;
- Cohen, David;
- Maughan, Timothy S
Publication type:
journal article

Found: 33