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Resveratrol derivatives as a pharmacological tool.
- Published in:
- Annals of the New York Academy of Sciences, 2017, v. 1403, n. 1, p. 27, doi. 10.1111/nyas.13401
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- Article
The novel uncompetitive NMDA receptor antagonist esmethadone (REL-1017) has no meaningful abuse potential in recreational drug users.
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- Translational Psychiatry, 2023, v. 13, n. 1, p. 1, doi. 10.1038/s41398-023-02473-8
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- Article
Inhibition of a Mitochondrial Potassium Channel in Combination with Gemcitabine and Abraxane Drastically Reduces Pancreatic Ductal Adenocarcinoma in an Immunocompetent Orthotopic Murine Model.
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- Cancers, 2022, v. 14, n. 11, p. 2618, doi. 10.3390/cancers14112618
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- Article
Mitochondrial Kv1.3 Channels as Target for Treatment of Multiple Myeloma.
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- Cancers, 2022, v. 14, n. 8, p. 1955, doi. 10.3390/cancers14081955
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- Article
Multiple Mechanisms Converging on Transcription Factor EB Activation by the Natural Phenol Pterostilbene.
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- Oxidative Medicine & Cellular Longevity, 2021, p. 1, doi. 10.1155/2021/7658501
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- Article
Redox Properties and Cytotoxicity of Synthetic Isomeric Mitochondriotropic Derivatives of the Natural Polyphenol Quercetin.
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- European Journal of Organic Chemistry, 2011, v. 2011, n. 28, p. 5577, doi. 10.1002/ejoc.201100573
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- Article
A Synthetic Fluorescent Mitochondria‐Targeted Sensor for Ratiometric Imaging of Calcium in Live Cells.
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- Angewandte Chemie International Edition, 2019, v. 58, n. 29, p. 9917, doi. 10.1002/anie.201902272
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- Article
A Synthetic Fluorescent Mitochondria‐Targeted Sensor for Ratiometric Imaging of Calcium in Live Cells.
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- Angewandte Chemie, 2019, v. 131, n. 29, p. 10022, doi. 10.1002/ange.201902272
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- Article
Resveratrol and Health: The Starting Point.
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- ChemBioChem, 2012, v. 13, n. 9, p. 1256, doi. 10.1002/cbic.201200193
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- Article
A Mitochondriotropic Derivative of Quercetin: A Strategy to Increase the Effectiveness of Polyphenols.
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- ChemBioChem, 2008, v. 9, n. 16, p. 2633, doi. 10.1002/cbic.200800162
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- Article
N-Monosubstituted Methoxy-oligo(ethylene glycol) Carbamate Ester Prodrugs of Resveratrol.
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- Molecules, 2015, v. 20, n. 9, p. 16085, doi. 10.3390/molecules200916085
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- Article
A CXCR4 receptor agonist strongly stimulates axonal regeneration after damage.
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- Annals of Clinical & Translational Neurology, 2019, v. 6, n. 12, p. 2395, doi. 10.1002/acn3.50926
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- Article
An Agonist of the CXCR4 Receptor Strongly Promotes Regeneration of Degenerated Motor Axon Terminals.
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- Cells (2073-4409), 2019, v. 8, n. 10, p. 1183, doi. 10.3390/cells8101183
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- Article
Defective excitation-contraction coupling and mitochondrial respiration precede mitochondrial Ca<sup>2+</sup> accumulation in spinobulbar muscular atrophy skeletal muscle.
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- Nature Communications, 2023, v. 14, n. 1, p. 1, doi. 10.1038/s41467-023-36185-w
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- Article
The mitochondrial ATP-dependent potassium channel (mitoK<sub>ATP</sub>) controls skeletal muscle structure and function.
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- Cell Death & Disease, 2024, v. 15, n. 1, p. 1, doi. 10.1038/s41419-024-06426-x
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- Article
Pharmacological targeting of the mitochondrial calcium-dependent potassium channel KCa3.1 triggers cell death and reduces tumor growth and metastasis in vivo.
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- Cell Death & Disease, 2022, v. 13, n. 12, p. 1, doi. 10.1038/s41419-022-05463-8
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- Article
Sphingosine is involved in PAPTP-induced death of pancreas cancer cells by interfering with mitochondrial functions.
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- Journal of Molecular Medicine, 2024, v. 102, n. 7, p. 947, doi. 10.1007/s00109-024-02456-2
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- Article
Targeting the Potassium Channel Kv1.3 Kills Glioblastoma Cells.
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- NeuroSignals (Karger AG), 2018, v. 25, n. 1, p. 26, doi. 10.1159/000480643
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- Article
Hsp90 is involved in the entry of clostridial neurotoxins into the cytosol of nerve terminals.
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- Cellular Microbiology, 2017, v. 19, n. 2, p. n/a, doi. 10.1111/cmi.12647
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- Article
Pharmacological modulation of Kv1.3 potassium channel selectively triggers pathological B lymphocyte apoptosis in vivo in a genetic CLL model.
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- Journal of Experimental & Clinical Cancer Research (17569966), 2022, v. 41, n. 1, p. 1, doi. 10.1186/s13046-022-02249-w
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- Article
New Water-Soluble Carbamate Ester Derivatives of Resveratrol.
- Published in:
- Molecules, 2014, v. 19, n. 10, p. 15900, doi. 10.3390/molecules191015900
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- Article
Article Regioselective O-Derivatization of Quercetin via Ester Intermediates. An Improved Synthesis of Rhamnetin and Development of a New Mitochondriotropic Derivative.
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- Molecules, 2010, v. 15, n. 7, p. 4722, doi. 10.3390/molecules15074722
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- Article
Small-Molecule Modulators of Mitochondrial Channels as Chemotherapeutic Agents.
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- Cellular Physiology & Biochemistry (Cell Physiol Biochem Press GmbH & Co. KG), 2019, v. 53, p. 11, doi. 10.33594/000000192
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- Article
Regulation of Proliferation by a Mitochondrial Potassium Channel in Pancreatic Ductal Adenocarcinoma Cells.
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- Frontiers in Oncology, 2017, p. 1, doi. 10.3389/fonc.2017.00239
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- Article
Novel Mitochondria-Targeted Furocoumarin Derivatives as Possible Anti-Cancer Agents.
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- Frontiers in Oncology, 2018, p. 1, doi. 10.3389/fonc.2018.00122
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- Article
Pharmacokinetics, Tolerability, and Safety of Esmethadone in Subjects with Chronic Kidney Disease or Hepatic Impairment.
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- Drugs in R&D, 2024, v. 24, n. 2, p. 341, doi. 10.1007/s40268-024-00477-3
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- Article
Drug–Drug Interaction Studies of Esmethadone (REL-1017) Involving CYP3A4- and CYP2D6-Mediated Metabolism.
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- Drugs in R&D, 2024, v. 24, n. 1, p. 51, doi. 10.1007/s40268-023-00450-6
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- Article
Semicarbazone EGA Inhibits Uptake of Diphtheria Toxin into Human Cells and Protects Cells Articlefrom Intoxication.
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- Toxins, 2016, v. 8, n. 7, p. 221, doi. 10.3390/toxins8070221
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- Article
EGA Protects Mammalian Cells from Clostridiumdifficile CDT, Clostridium perfringens Iota Toxin and Clostridium botulinum C2 Toxin.
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- Toxins, 2016, v. 8, n. 4, p. 101, doi. 10.3390/toxins8040101
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- Article
Absorption and Metabolism of Resveratrol Carboxyesters and Methanesulfonate by Explanted Rat Intestinal Segments.
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- Cellular Physiology & Biochemistry (Karger AG), 2009, v. 24, n. 5/6, p. 557, doi. 10.1159/000257512
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- Article
Esmethadone-HCl (REL-1017): a promising rapid antidepressant.
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- European Archives of Psychiatry & Clinical Neuroscience, 2023, v. 273, n. 7, p. 1463, doi. 10.1007/s00406-023-01571-4
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- Publication type:
- Article
A Photo-Crosslinkable Biotin Derivative of the Phosphoantigen ( E)-4-Hydroxy-3-Methylbut-2-Enyl Diphosphate (HMBPP) Activates Vγ9Vδ2 T Cells and Binds to the HMBPP Site of BTN3A1.
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- Chemistry - A European Journal, 2017, v. 23, n. 49, p. 11945, doi. 10.1002/chem.201702650
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- Article
An agonist of the CXCR4 receptor is therapeutic for the neuroparalysis induced by Bungarus snakes envenoming.
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- Clinical & Translational Medicine, 2022, v. 12, n. 1, p. 1, doi. 10.1002/ctm2.651
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- Article
An agonist of the CXCR4 receptor accelerates the recovery from the peripheral neuroparalysis induced by Taipan snake envenomation.
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- PLoS Neglected Tropical Diseases, 2020, v. 14, n. 9, p. 1, doi. 10.1371/journal.pntd.0008547
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- Article
Subanalysis of Subjective Cognitive Measures From a Phase 2, Double-Blind, Randomized Trial of REL-1017 in Patients With Major Depressive Disorder.
- Published in:
- Primary Care Companion for CNS Disorders (2155-7772), 2023, v. 25, n. 1, p. e1, doi. 10.4088/PCC.22m03267
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- Article
A Novel Inhibitor Prevents the Peripheral Neuroparalysis of Botulinum Neurotoxins.
- Published in:
- Scientific Reports, 2015, p. 17513, doi. 10.1038/srep17513
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- Article
DA7R: A 7-Letter Zip Code to Target PDAC.
- Published in:
- Pharmaceutics, 2023, v. 15, n. 5, p. 1508, doi. 10.3390/pharmaceutics15051508
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- Publication type:
- Article
Pharmacological Comparative Characterization of REL-1017 (Esmethadone-HCl) and Other NMDAR Channel Blockers in Human Heterodimeric N-Methyl-D-Aspartate Receptors.
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- Pharmaceuticals (14248247), 2022, v. 15, n. 8, p. 997, doi. 10.3390/ph15080997
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- Publication type:
- Article
The N-Methyl-D-Aspartate Receptor Blocker REL-1017 (Esmethadone) Reduces Calcium Influx Induced by Glutamate, Quinolinic Acid, and Gentamicin.
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- Pharmaceuticals (14248247), 2022, v. 15, n. 7, p. N.PAG, doi. 10.3390/ph15070882
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- Article
Novel Small Molecule Inhibitors That Prevent the Neuroparalysis of Tetanus Neurotoxin.
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- Pharmaceuticals (14248247), 2021, v. 14, n. 11, p. 1134, doi. 10.3390/ph14111134
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- Publication type:
- Article
An Angiopep2-PAPTP Construct Overcomes the Blood-Brain Barrier. New Perspectives against Brain Tumors.
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- Pharmaceuticals (14248247), 2021, v. 14, n. 2, p. 129, doi. 10.3390/ph14020129
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- Article
Pharmacokinetics and tissue distribution of pterostilbene in the rat.
- Published in:
- Molecular Nutrition & Food Research, 2014, v. 58, n. 11, p. 2122, doi. 10.1002/mnfr.201400244
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- Article
Esmethadone (REL-1017) and Other Uncompetitive NMDAR Channel Blockers May Improve Mood Disorders via Modulation of Synaptic Kinase-Mediated Signaling.
- Published in:
- International Journal of Molecular Sciences, 2022, v. 23, n. 20, p. 12196, doi. 10.3390/ijms232012196
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- Article