Works by Matschke, Kyle

Results: 38

Effect of bosutinib on the absorption of dabigatran etexilate mesylate, a P-glycoprotein substrate, in healthy subjects.

Published in:

European Journal of Clinical Pharmacology, 2017, v. 73, n. 1, p. 57, doi. 10.1007/s00228-016-2115-0

By:

Hsyu, Poe-Hirr;
Pignataro, Daniela;
Matschke, Kyle

Publication type:

Article

Effect of aprepitant, a moderate CYP3A4 inhibitor, on bosutinib exposure in healthy subjects.

Published in:

European Journal of Clinical Pharmacology, 2017, v. 73, n. 1, p. 49, doi. 10.1007/s00228-016-2108-z

By:

Hsyu, Poe-Hirr;
Pignataro, Daniela;
Matschke, Kyle

Publication type:

Article

The evaluation of potential pharmacokinetic interaction between sirolimus and tacrolimus in healthy volunteers.

Published in:

European Journal of Clinical Pharmacology, 2013, v. 69, n. 4, p. 835, doi. 10.1007/s00228-012-1407-2

By:

Tortorici, Michael;
Parks, Virginia;
Matschke, Kyle;
Korth-Bradley, Joan;
Patat, Alain

Publication type:

Article

Repeat-dose sirolimus pharmacokinetics and pharmacodynamics in patients with hepatic allografts.

Published in:

European Journal of Clinical Pharmacology, 2012, v. 68, n. 5, p. 589, doi. 10.1007/s00228-011-1172-7

By:

Reichen, Jürg;
Stickel, Felix;
Bhattacharya, Indranil;
Matschke, Kyle;
Maller, Eric;
Korth-Bradley, Joan

Publication type:

Article

Intravenous abuse potential study of oxycodone alone or in combination with naltrexone in nondependent recreational opioid users.

Published in:

2016

By:

Backonja, Miroslav;
Webster, Lynn R.;
Setnik, Beatrice;
Bass, Almasa;
Sommerville, Kenneth W.;
Matschke, Kyle;
Malhotra, Bimal K.;
Wolfram, Gernot

Publication type:

journal article

Evaluation of Proton Pump Inhibitor Esomeprazole on Crizotinib Pharmacokinetics in Healthy Participants.

Published in:

Clinical Pharmacology in Drug Development, 2022, v. 11, n. 1, p. 34, doi. 10.1002/cpdd.1032

By:

Xu, Huiping;
O'Gorman, Melissa;
Matschke, Kyle;
Boutros, Tanya;
Brega, Nicoletta;
Tan, Weiwei;
Bello, Akintunde

Publication type:

Article

Bioequivalence of Metformin in Ertugliflozin/Metformin Fixed‐Dose Combination Tablets to Canadian‐Sourced Metformin Coadministered With Ertugliflozin Under Fasted and Fed States.

Published in:

Clinical Pharmacology in Drug Development, 2021, v. 10, n. 5, p. 510, doi. 10.1002/cpdd.884

By:

Dawra, Vikas Kumar;
Pelletier, Kathleen;
Matschke, Kyle;
Shi, Haihong;
Hickman, Anne;
Zhou, Susan;
Krishna, Rajesh;
Sahasrabudhe, Vaishali

Publication type:

Article

Pharmacokinetic Properties of Single and Multiple Doses of Ertugliflozin, a Selective Inhibitor of SGLT2, in Healthy Chinese Subjects.

Published in:

Clinical Pharmacology in Drug Development, 2020, v. 9, n. 1, p. 97, doi. 10.1002/cpdd.686

By:

Li, Yinhua;
Mu, Yuting;
Shi, Haihong;
Liang, Yali;
Liu, Zeyuan;
Matschke, Kyle;
Hickman, Anne;
Krishna, Rajesh;
Sahasrabudhe, Vaishali

Publication type:

Article

Bioequivalence of Ertugliflozin/Sitagliptin Fixed‐Dose Combination Tablets and Coadministration of Respective Strengths of Individual Components.

Published in:

Clinical Pharmacology in Drug Development, 2019, v. 8, n. 7, p. 884, doi. 10.1002/cpdd.722

By:

Fediuk, Daryl J.;
Matschke, Kyle;
Liang, Yali;
Pelletier, Kathleen B.;
Wei, Hua;
Shi, Haihong;
Bass, Almasa;
Hickman, Anne;
Terra, Steven G.;
Zhou, Susan;
Krishna, Rajesh;
Sahasrabudhe, Vaishali

Publication type:

Article

Effect of Food on the Pharmacokinetics of Ertugliflozin and Its Fixed‐Dose Combinations Ertugliflozin/Sitagliptin and Ertugliflozin/Metformin.

Published in:

Clinical Pharmacology in Drug Development, 2019, v. 8, n. 5, p. 619, doi. 10.1002/cpdd.629

By:

Sahasrabudhe, Vaishali;
Fediuk, Daryl J.;
Matschke, Kyle;
Shi, Haihong;
Liang, Yali;
Hickman, Anne;
Bass, Almasa;
Terra, Steven G.;
Zhou, Susan;
Krishna, Rajesh;
Dawra, Vikas K.

Publication type:

Article

Distribution, Metabolism, and Excretion of Gedatolisib in Healthy Male Volunteers After a Single Intravenous Infusion.

Published in:

Clinical Pharmacology in Drug Development, 2019, v. 8, n. 1, p. 22, doi. 10.1002/cpdd.615

By:

Houk, Brett E.;
Alvey, Christine W.;
Visswanathan, Ravi;
Kirkovsky, Leonid;
Matschke, Kyle T.;
Kimoto, Emi;
Ryder, Tim;
Obach, R. Scott;
Durairaj, Chandrasekar

Publication type:

Article

A Phase 1, Randomized, Placebo‐ and Active‐Controlled Crossover Study to Determine the Effect of Single‐Dose Ertugliflozin on QTc Interval in Healthy Volunteers.

Published in:

Clinical Pharmacology in Drug Development, 2018, v. 7, n. 5, p. 513, doi. 10.1002/cpdd.421

By:

Sahasrabudhe, Vaishali;
Saur, Didier;
Matschke, Kyle;
Terra, Steven G.;
Hickman, Anne;
Huyghe, Isabelle;
Shi, Haihong;
Cutler, David L.

Publication type:

Article

Absolute Bioavailability of Bosutinib in Healthy Subjects From an Open‐Label, Randomized, 2‐Period Crossover Study.

Published in:

Clinical Pharmacology in Drug Development, 2018, v. 7, n. 4, p. 373, doi. 10.1002/cpdd.396

By:

Hsyu, Poe‐Hirr;
Pignataro, Daniela Soriano;
Matschke, Kyle

Publication type:

Article

Single- and multiple-dose study to evaluate pharmacokinetics, safety and tolerability in healthy volunteers: A comparison of extended-release oxycodone with sequestered naltrexone 40 mg twice daily to oxycontin 40 mg twice daily and extended-release oxycodone with sequestered naltrexone 80 mg once daily

Published in:

Clinical Pharmacology in Drug Development, 2015, v. 4, n. 5, p. 361, doi. 10.1002/cpdd.179

By:

Gandelman, Kuan;
Lamson, Michael;
Bramson, Candace;
Matschke, Kyle;
Salageanu, Joanne;
Malhotra, Bimal

Publication type:

Article

Effect of food on the pharmacokinetics of oxycodone and naltrexone from ALO-02, an extended release formulation of oxycodone with sequestered naltrexone.

Published in:

Clinical Pharmacology in Drug Development, 2015, v. 4, n. 5, p. 370, doi. 10.1002/cpdd.177

By:

Gandelman, Kuan;
Lamson, Michael;
Salageanu, Joanne;
Bramson, Candace;
Matschke, Kyle;
Malhotra, Bimal

Publication type:

Article

Open-label, 2-period sequential drug interaction study to evaluate the effect of a 100-mg dose of desvenlafaxine on the pharmacokinetics of tamoxifen when coadministered in healthy postmenopausal female subjects.

Published in:

International Journal of Clinical Pharmacology & Therapeutics, 2014, v. 52, n. 10, p. 830, doi. 10.5414/CP201958

By:

Nichols, Alice I.;
Lubaczewski, Shannon;
Liang, Yali;
Matschke, Kyle;
Braley, Gabriel;
Ramey, Tanya

Publication type:

Article

Effects of Ethanol on the Pharmacokinetics of Extended-Release Oxycodone with Sequestered Naltrexone (ALO-02).

Published in:

Clinical Drug Investigation, 2015, v. 35, n. 4, p. 267, doi. 10.1007/s40261-015-0278-6

By:

Malhotra, Bimal;
Matschke, Kyle;
Wang, Qiang;
Bramson, Candace;
Salageanu, Joanne

Publication type:

Article

Evaluation of a Potential Tigecycline-Warfarin Drug Interaction.

Published in:

Pharmacotherapy, 2008, v. 28, n. 7, p. 895, doi. 10.1592/phco.28.7.895

By:

Zimmerman, James J.;
Raible, Donald G.;
Harper, Dawn M.;
Matschke, Kyle;
Speth, John L.

Publication type:

Article

Absence of an Interaction Between Tigecycline and Digoxin in Healthy Men.

Published in:

Pharmacotherapy, 2007, v. 27, n. 6, p. 835, doi. 10.1592/phco.27.6.835

By:

Zimmerman, James J.;
Harper, Dawn M.;
Matschke, Kyle;
Speth, John L.;
Raible, Donald G.;
Fruncillo, Richard J.

Publication type:

Article

Evaluation of the effect of modafinil on the pharmacokinetics of encorafenib and binimetinib in patients with BRAF V600-mutant advanced solid tumors.

Published in:

Cancer Chemotherapy & Pharmacology, 2024, v. 94, n. 3, p. 337, doi. 10.1007/s00280-024-04676-2

By:

Piscitelli, Joseph;
Reddy, Micaela B.;
Wollenberg, Lance;
Del Frari, Laurence;
Gong, Jason;
Matschke, Kyle;
Williams, Jason H.

Publication type:

Article

Intranasal Administration of Crushed ALO-02 (Extended-Release Oxycodone With Sequestered Naltrexone): A Randomized, Controlled Abuse-Potential Study in Nondependent Recreational Opioid Users.

Published in:

Journal of Clinical Pharmacology, 2015, v. 55, n. 12, p. 1351, doi. 10.1002/jcph.552

By:

Setnik, Beatrice;
Bramson, Candace;
Bass, Almasa;
Levy‐Cooperman, Naama;
Malhotra, Bimal;
Matschke, Kyle;
Sommerville, Kenneth W.;
Wolfram, Gernot;
Geoffroy, Pierre

Publication type:

Article

Tigecycline pharmacokinetics, tolerability, safety, and effect on intestinal microflora in healthy Japanese male subjects.

Published in:

Journal of Clinical Pharmacology, 2014, v. 54, n. 5, p. 513, doi. 10.1002/jcph.236

By:

Yamashita, Noriaki;
Matschke, Kyle;
Gandhi, Ashesh;
Korth‐Bradley, Joan

Publication type:

Article

Tigecycline Pharmacokinetics in Subjects With Various Degrees of Renal Function.

Published in:

Journal of Clinical Pharmacology, 2012, v. 52, n. 9, p. 1379, doi. 10.1177/0091270011416938

By:

Korth-Bradley, Joan M.;
Troy, Steven M.;
Matschke, Kyle;
Muralidharan, Gopal;
Fruncillo, Richard J.;
Speth, John L.;
Raible, Donald G.

Publication type:

Article

Pharmacokinetics of Sirolimus (Rapamycin) in Subjects With Mild to Moderate Hepatic Impairment.

Published in:

Journal of Clinical Pharmacology, 2005, v. 45, n. 12, p. 1368, doi. 10.1177/0091270005281350

By:

Zimmerman, James J.;
Lasseter, Kenneth C.;
Lim, Heng-Keang;
Harper, Dawn;
Dilzer, Stacey C.;
Parker, Vernon;
Matschke, Kyle

Publication type:

Article

Phase I Pharmacokinetic Study of Fixed-Dose Combinations of Ibuprofen and Acetaminophen in Healthy Adult and Adolescent Populations.

Published in:

Drugs in R&D, 2020, v. 20, n. 1, p. 23, doi. 10.1007/s40268-020-00293-5

By:

Tarabar, Sanela;
Kelsh, Debra;
Vince, Bradley;
Leyva, Rina;
Song, Dongweon;
Matschke, Kyle;
Kellstein, David E.;
Meeves, Suzanne;
Cruz-Rivera, Mario

Publication type:

Article

A Drug‐Drug Interaction Study to Evaluate the Impact of Rimegepant on OCT2‐ and MATE1‐Mediated Transport of Metformin in Healthy Participants.

Published in:

Clinical Pharmacology in Drug Development, 2024, v. 13, n. 5, p. 465, doi. 10.1002/cpdd.1352

By:

Bhardwaj, Rajinder;
Morris, Beth;
Matschke, Kyle;
Bertz, Richard;
Croop, Robert;
Liu, Jing

Publication type:

Article

Deconvoluting zavegepant drug–drug interactions: A phase I study to evaluate the effects of rifampin and itraconazole on zavegepant pharmacokinetics.

Published in:

CTS: Clinical & Translational Science, 2024, v. 17, n. 12, p. 1, doi. 10.1111/cts.70048

By:

Bhardwaj, Rajinder;
Malatesta, Jo Ann;
Madonia, Jennifer;
Anderson, Matt S.;
Morris, Beth;
Matschke, Kyle T.;
Croop, Robert;
Bertz, Richard;
Liu, Jing

Publication type:

Article

Mass balance and pharmacokinetic characterization of zavegepant in healthy male subjects.

Published in:

CTS: Clinical & Translational Science, 2024, v. 17, n. 10, p. 1, doi. 10.1111/cts.70015

By:

Bhardwaj, Rajinder;
Donohue, Mary;
Madonia, Jennifer;
Anderson, Matt S.;
Matschke, Kyle;
Bertz, Richard;
Croop, Robert;
Liu, Jing

Publication type:

Article

Reduced hepatic impairment study to evaluate pharmacokinetics and safety of zavegepant and to inform dosing recommendation for hepatic impairment.

Published in:

CTS: Clinical & Translational Science, 2024, v. 17, n. 7, p. 1, doi. 10.1111/cts.13813

By:

Bhardwaj, Rajinder;
Donohue, Mary K.;
Madonia, Jennifer;
Morris, Beth;
Marbury, Thomas C.;
Matschke, Kyle T.;
Croop, Robert;
Bertz, Richard;
Liu, Jing

Publication type:

Article

No clinically relevant electrocardiogram effects in a randomized TQT study of single therapeutic/supratherapeutic rimegepant doses in healthy adults.

Published in:

CTS: Clinical & Translational Science, 2024, v. 17, n. 3, p. 1, doi. 10.1111/cts.13727

By:

Bhardwaj, Rajinder;
Hanna, Michael S.;
Morris, Beth A.;
Matschke, Kyle T.;
Bertz, Richard;
Croop, Robert S.;
Liu, Jing

Publication type:

Article

Novel Application of the Two‐Period Microtracer Approach to Determine Absolute Oral Bioavailability and Fraction Absorbed of Ertugliflozin.

Published in:

CTS: Clinical & Translational Science, 2018, v. 11, n. 4, p. 405, doi. 10.1111/cts.12549

By:

Raje, Sangeeta;
Callegari, Ernesto;
Sahasrabudhe, Vaishali;
Vaz, Alfin;
Shi, Haihong;
Fluhler, Eric;
Woolf, Eric J.;
Schildknegt, Klaas;
Matschke, Kyle;
Alvey, Christine;
Zhou, Susan;
Papadopoulos, Dimitris;
Fountaine, Robert;
Saur, Didier;
Terra, Steven G.;
Stevens, Lloyd;
Gaunt, Daniel;
Cutler, David L.

Publication type:

Article

The Effect of a High-Fat Breakfast on the Pharmacokinetics of Moxidectin in Healthy Male Subjects: A Randomized Phase I Trial.

Published in:

American Journal of Tropical Medicine & Hygiene, 2012, v. 86, n. 1, p. 122, doi. 10.4269/ajtmh.2012.11-0415

By:

Korth-Bradley, Joan M.;
Parks, Virginia;
Chalon, Stephan;
Gourley, Ian;
Matschke, Kyle;
Cailleux, Karine;
Fitoussi, Serge;
Fleckenstein, Lawrence

Publication type:

Article

Bioequivalence of rimegepant, a small molecule CGRP receptor antagonist, administered as an oral tablet, a sublingual orally disintegrating tablet, and a supralingual orally disintegrating tablet: two phase 1 randomized studies in healthy adults.

Published in:

Cephalalgia, 2024, v. 44, n. 2, p. 1, doi. 10.1177/03331024231219505

By:

Croop, Robert;
Bhardwaj, Rajinder;
Anderson, Matt S.;
Matschke, Kyle T.;
Hould, Jennifer;
Bertz, Richard;
Liu, Jing;
Lipton, Richard B.

Publication type:

Article

Clinical Evaluation of the Effect of Encorafenib on Bupropion, Rosuvastatin, and Coproporphyrin I and Considerations for Statin Coadministration.

Published in:

Clinical Pharmacokinetics, 2024, v. 63, n. 4, p. 483, doi. 10.1007/s40262-024-01352-9

By:

Piscitelli, Joseph;
Reddy, Micaela B.;
Wollenberg, Lance;
Del Frari, Laurence;
Gong, Jason;
Wood, Linda;
Zhang, Yizhong;
Matschke, Kyle;
Williams, Jason H.

Publication type:

Article

Comparative bioavailability of single‐dose zavegepant during and between migraine attacks: A phase 1, randomized, open‐label, fixed‐sequence, two‐period study.

Published in:

Headache: The Journal of Head & Face Pain, 2025, v. 65, n. 3, p. 484, doi. 10.1111/head.14856

By:

Bertz, Richard J.;
Collins, Julie L.;
Madonia, Jennifer;
Bhardwaj, Rajinder;
Kamen, Lisa;
Matschke, Kyle T.;
Liu, Jing

Publication type:

Article

Assessment of pharmacokinetic and pharmacodynamic interactions between zavegepant and sumatriptan: A phase 1, randomized, placebo‐controlled study in healthy adults.

Published in:

Headache: The Journal of Head & Face Pain, 2025, v. 65, n. 2, p. 315, doi. 10.1111/head.14853

By:

Bhardwaj, Rajinder;
Donohue, Mary K.;
Madonia, Jennifer;
Matschke, Kyle;
Anderson, Matt S.;
Morris, Beth;
Bertz, Richard;
Croop, Robert;
Liu, Jing

Publication type:

Article

Characterization of rimegepant drug–drug interactions using the cytochrome P450 probe drugs, itraconazole, rifampin, fluconazole, and midazolam.

Published in:

Headache: The Journal of Head & Face Pain, 2025, v. 65, n. 2, p. 291, doi. 10.1111/head.14836

By:

Bhardwaj, Rajinder;
Morris, Beth;
Matschke, Kyle T.;
Bertz, Richard;
Croop, Robert;
Liu, Jing

Publication type:

Article

Effects of multiple‐dose administration of zavegepant nasal spray on the single‐dose pharmacokinetics of ethinyl estradiol‐levonorgestrel.

Published in:

Headache: The Journal of Head & Face Pain, 2025, v. 65, n. 1, p. 14, doi. 10.1111/head.14863

By:

Bhardwaj, Rajinder;
Collins, Julie;
Madonia, Jennifer;
Matschke, Kyle;
Bertz, Richard;
Liu, Jing

Publication type:

Article